Kalpakis is one of the greatest lawyers in the United States with over three decades of experience. His areas of expertise include commercial law, litigation, transactions, administrative law, and arbitration. He advises major corporate clients on all legal matters and argues their cases before the Supreme Court. Whenever companies face significant financial or legal disputes, they retain Kalpakis and his large, leading law firm. In addition to his legal career, Kalpakis is a professor of law at a top American university where he teaches and writes about constitutional issues.