Diploma and Certificate in English and Arabic

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Western Australian School of Nursing Deploma Nurses Board of Western Australia Certificate of Registration Legally translated from English to Arabic

Health & Medicine

Diploma and Certificate in English and Arabic

Fexofenadine is sold under the brand name Allegra. It is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and causes lesser sedation, as compared to first-generation antihistamines. It is on the World Health Organization's List of Essential Medicines. Fexofenadine has been manufactured in generic form since 2011.

PGx Analysis in VarSeq: A User’s Perspective

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Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings. The purpose of this webcast is to: Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis. Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting. Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.

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Pharmacology of Prostaglandins, Thromboxanes and Leukotrienes

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This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.

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CLASSIFICATION OF H1 ANTIHISTAMINICS- FIRST GENERATION ANTIHISTAMINICS- 1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE 3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE TRIPROLIDINE,CLEMASTINE SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE, LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE, AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics- These drugs competitively antagonize actions of histamine at the H1 receptors. Pharmacological actions- Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized. 2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent. 4) Anticholinergic action- many H1 blockers in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects

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