What can healthcare learn from Formula One racing? According to Dr. Sadiqa Mahmood, SVP of medical affairs and life sciences for Health Catalyst, race support teams leverage about 30TB of baseline data to create a digital twin of the car, track, and racer for simulation models that drive decisions at each race. Applied in the healthcare setting, a digital twin can help clinicians better understand each patient and their health conditions and circumstances in real time and make comprehensive, informed care decisions. But for the healthcare digital twin to happen, the industry must move away from data silos and towards a digital learning healthcare ecosystem.

1. Harnessing the Power of Data: Are We There Yet?
Delivering Outcomes Using Real-World Data
Dr. Sadiqa Mahmood
SVP, Medical Affairs
Life Sciences
Health Catalyst
© Health Catalyst Nov 2019

2. Formula 1 Race Support Room
2
• 300 sensors that measure all aspects of the car contributing 10TB data for each race weekend for a racing team.
• 30TB of baseline data from race to race around the world.
• Each gear change adds up to 100 data points; there are 100 or so gear changes per lap, so you can get into millions of data points
right away.
Ref: Mercedes AMG Petronas
Motorsport Race Weekend

3. Think about your healthcare digital twin...
3
https://insights.thirdrepublic.com/digital-twins/

4. This is our CTO. This is healthcare’s digital view of his life.
4
Our Digital Understanding of Patients Is Poor
Citation: Dale Sanders, CIO, Northwestern
Medicine. Calculating annual storage
requirements for the Northwestern electronic
health record, 2011

5. This is the data we need…now let’s go after it.
Standards, sensors, networks, analytics, AI… massive employment and economic opportunity
5

6. Why we exist
as a company
Health Catalyst Mission
Be the catalyst for massive, measurable, data-informed healthcare improvement
Data
Integrate data in a flexible, open,
and scalable platform to power
healthcare’s digital transformation.
Analytics
Deliver analytics applications
that generate insight on how to
measurably improve.
Expertise
Provide analytical, clinical,
financial, and operational
experts who enable and
accelerate improvement.
Engagement
Attract, develop, and retain world-
class team members by being a
best place to work.
66© Health Catalyst Nov 2019

7. A Decade to an IPO2008
2011
2013
2014
Health Catalyst
founded by
Steve Barlow
and Tom
Burton
5+ customers 1st Best Place
to Work award
10+ customers
2015
100+
documented
measurable
improvements
2018
40 Best
Place to Work
awards
100+ customers
650+
documented
measurable
improvements
Hosted 1st annual
industry conference
2016
2017
$40M+
revenue
1st recurring
Professional
Services
contract
Started transition to
subscription
contracting model
Introduced
next-generation
Data Operating
System (DOS)
Acquired
Medicity
Started software analytics applications development
40+ customers
Data platform development2008
$110M+
LTM revenue
2019
Started analytics accelerators development2012
2016
Continued industry
recognition from
KLAS, Chilmark
and others
90%+
recurring
revenue
Continued to launch
software analytics
applications, including
Patient Safety
Monitor &
Touchstone
77© Health Catalyst Nov 2019

8. Health Catalyst at a Glance
HQ Salt Lake City, UT
150M+
Patients
Data from
>1T
Facts
Encompassing
120+ Client Healthcare Organizations Including:
>200
Success Stories
Founded 2008 800 team members
Offices in 7 States Growing globally
Data
Platform
$100M Investment
300+ Data Sources
Analytics
Applications
8 App Suites + Libraries
Services
Expertise
>250 Domain, Data Science,
& Analytics SMEs
45+ Analytics
Accelerators
50+ Machine Learning
Models
History Technology Results
Documented
Improvements
>650
Hospitals
Clinics
>500
>5,000
Awards
#1 SMALL & MEDIUM
BUSINESS
“Best Places
to Work”
>50 Awards
2015 – 2018 Gallup
Overall Satisfaction Score
95th-99th
PERCENTILE
More Than a Decade of Documented Improvements – Millions of Dollars and Patients Lives Saved or Improved
88© Health Catalyst Nov 2019

9. Ecosystem
Life Sciences Focus on Real-World Data, Evidence & Ecosystem
Data
99© Health Catalyst Nov 2019
Only 8% of data required for driving outcomes, population health, and precision medicine strategy resides in today’s EHRs.
• More than 70 multi-payer and
geographically diverse provider clients.
• 5000+ Clinics.
• 500+ Hospitals.
• 300+ Data Sources.
• 6900+ Active Trials.
• 150+ Million Patients.
• 44+ Trillion Facts.
Data relating to patient health status and/or
the delivery of healthcare routinely collected
from different sources.
Evidence
• Enable understanding of RWD and its strengths
and gaps; identify opportunities and
partnerships to address gaps.
• Our formal business andtechnology models with
partner companies enable their accelerated
integration into a broader client solution.
Clinical evidence regarding the usage and potential
benefits or risks of a medical product derived from
analysis of RWD.
Achieve healthcare transformation by developing a
global healthcare ecosystem.
• Partner and collaborate with all critical
stakeholders: providers, biopharma, digital
medicine companies, payers, and regulators.

10. A Global Healthcare Ecosystem
14 1010© Health Catalyst Nov 2019

11. 11
I- Use RWD and analytic applications to inform:
• Selection of appropriate patient .
• Integration with clinical workflow.
• Tracking clinical endpoints comparable to standard-of-care
outcomes and costs.
II- Enable digital twin and overcome gaps in clinical data.
Digital Medicine

12. Case Study: Precision Medicine
Genomics Cohort Selection
• Sampled 9 IDNs.
• 4k+ patients have molecular labs
indicating JAK2 testing occurred.
• 800 patients were tested for a
specific mutation (V617F).
• Molecular pipeline found 189 patients
with a positive result in structured lab
data, and 185 patients with a result
detailed in unstructured text.
• Final cohort could reach ~350
patients across 5 sites.
1212© Health Catalyst Nov 2019
Precision Medicine for Patients with JAK2 Mutations

13. Future of Digital
HealthCare

14. Thank you
14© Health Catalyst Nov 2019