Despite the euphoria about the introduction of a novel and apparently successful treatment in gastroparesis, the amount of high quality data supporting the clinical utility of G-POEM are limited. Above all, the selection of patients with gastroparesis for G-POEM is problematic
This case report describes a 60-year-old man who presented with chronic diarrhea, weight loss, and feculent breath 10 years after undergoing gastric resection for peptic ulcer disease. Contrast examination revealed a gastrojejunocolic fistula connecting the stomach, jejunum, and transverse colon. The patient underwent a single-stage surgical procedure to resect the affected areas and reconstruct the gastrointestinal tract. His symptoms resolved after surgery and he gained 15 kg in weight over the following months.
Polymyositis as an Extra-Intestinal Manifestation of Ulcerative Colitis in a ...merdaci dhia elhak
A 28-year-old woman with a history of ulcerative colitis presented with muscle weakness, myalgias, and constitutional symptoms. Tests found elevated muscle enzymes and inflammation on muscle biopsy. She was diagnosed with polymyositis, a rare extra-intestinal manifestation of ulcerative colitis. Treatment with steroids and azathioprine improved her symptoms. While disease activity is not required, extra-intestinal manifestations like polymyositis should be considered in ulcerative colitis patients with muscle symptoms. Both conditions responded well to immunosuppressive therapy.
This guideline presents recommendations for the management of acute pancreatitis (AP). Key recommendations include: assessing hemodynamic status upon presentation and providing resuscitation as needed; admitting patients with organ failure to intensive care; providing aggressive intravenous hydration within the first 12-24 hours; using ERCP within 24 hours for patients with AP and cholangitis; not routinely using prophylactic antibiotics for severe AP or sterile necrosis; considering infected necrosis in patients not improving after 7-10 days and using antibiotics known to penetrate pancreatic necrosis; and providing enteral nutrition for severe AP to prevent infectious complications while avoiding parenteral nutrition.
The document discusses the history and classification of functional dyspepsia, a disorder characterized by abdominal pain or discomfort related to eating with no obvious organic cause. It was introduced in 1988 through the Rome consensus process for classifying functional gastrointestinal disorders. Since then, the definition and subtypes of functional dyspepsia have been refined in subsequent Rome classification systems. The document covers the epidemiology, mechanisms, pathophysiology, diagnosis and management of functional dyspepsia in adults.
The document provides guidelines for the management of acute pancreatitis (AP). It summarizes that AP is one of the most common gastrointestinal diseases, leading to significant burden. The incidence of AP has been increasing. Recent studies have identified two phases of AP - early (within 1 week) characterized by systemic inflammatory response and late (>1 week) characterized by local complications. Key recommendations include establishing the diagnosis of AP using clinical criteria including abdominal pain and elevated serum amylase/lipase. Imaging such as CT should be reserved for unclear or non-improving cases. Early management focuses on hemodynamic support and aggressive hydration to decrease morbidity and mortality. Guidelines are provided for evaluating etiology, risk stratification, nutritional support, antibiotic use
The document provides guidelines for the management of acute pancreatitis (AP). It summarizes that AP diagnosis is typically established by abdominal pain and elevated serum amylase and/or lipase levels. Contrast-enhanced CT or MRI is only recommended if diagnosis is unclear or patient fails to improve to evaluate for complications. It outlines recommendations for early medical management including aggressive hydration and nutrition, as well as management of complications like pancreatic necrosis with antibiotics, endoscopic or radiologic drainage, or surgery.
The document provides guidelines for the management of acute pancreatitis (AP). It summarizes that AP is one of the most common gastrointestinal diseases, leading to significant burden. The incidence of AP has been increasing. Recent studies have identified two phases of AP - early (within 1 week) characterized by systemic inflammatory response and late (>1 week) characterized by local complications. Key recommendations include establishing the diagnosis of AP using clinical criteria including abdominal pain and elevated serum amylase/lipase. Imaging such as CT should be reserved for unclear or non-improving cases. Early management focuses on hemodynamic support and aggressive hydration to decrease morbidity and mortality. Guidelines are provided for evaluating etiology, risk stratification, nutritional support, antibiotic use
Portal hypertensive gastropathy is a condition seen in patients with portal hypertension where there are characteristic endoscopic findings in the gastric fundus and body. It is thought to be caused by hemodynamic changes related to portal hypertension, especially increased portal pressure, but portal hypertension alone cannot fully explain its development. The pathogenesis is not fully understood but likely involves changes in blood flow and vascular resistance. The prevalence of portal hypertensive gastropathy varies widely in different studies but can be seen in approximately 30-75% of patients with portal hypertension and 35-98% of patients with cirrhosis, depending on the severity of liver disease and presence of varices.
This case report describes a 60-year-old man who presented with chronic diarrhea, weight loss, and feculent breath 10 years after undergoing gastric resection for peptic ulcer disease. Contrast examination revealed a gastrojejunocolic fistula connecting the stomach, jejunum, and transverse colon. The patient underwent a single-stage surgical procedure to resect the affected areas and reconstruct the gastrointestinal tract. His symptoms resolved after surgery and he gained 15 kg in weight over the following months.
Polymyositis as an Extra-Intestinal Manifestation of Ulcerative Colitis in a ...merdaci dhia elhak
A 28-year-old woman with a history of ulcerative colitis presented with muscle weakness, myalgias, and constitutional symptoms. Tests found elevated muscle enzymes and inflammation on muscle biopsy. She was diagnosed with polymyositis, a rare extra-intestinal manifestation of ulcerative colitis. Treatment with steroids and azathioprine improved her symptoms. While disease activity is not required, extra-intestinal manifestations like polymyositis should be considered in ulcerative colitis patients with muscle symptoms. Both conditions responded well to immunosuppressive therapy.
This guideline presents recommendations for the management of acute pancreatitis (AP). Key recommendations include: assessing hemodynamic status upon presentation and providing resuscitation as needed; admitting patients with organ failure to intensive care; providing aggressive intravenous hydration within the first 12-24 hours; using ERCP within 24 hours for patients with AP and cholangitis; not routinely using prophylactic antibiotics for severe AP or sterile necrosis; considering infected necrosis in patients not improving after 7-10 days and using antibiotics known to penetrate pancreatic necrosis; and providing enteral nutrition for severe AP to prevent infectious complications while avoiding parenteral nutrition.
The document discusses the history and classification of functional dyspepsia, a disorder characterized by abdominal pain or discomfort related to eating with no obvious organic cause. It was introduced in 1988 through the Rome consensus process for classifying functional gastrointestinal disorders. Since then, the definition and subtypes of functional dyspepsia have been refined in subsequent Rome classification systems. The document covers the epidemiology, mechanisms, pathophysiology, diagnosis and management of functional dyspepsia in adults.
The document provides guidelines for the management of acute pancreatitis (AP). It summarizes that AP is one of the most common gastrointestinal diseases, leading to significant burden. The incidence of AP has been increasing. Recent studies have identified two phases of AP - early (within 1 week) characterized by systemic inflammatory response and late (>1 week) characterized by local complications. Key recommendations include establishing the diagnosis of AP using clinical criteria including abdominal pain and elevated serum amylase/lipase. Imaging such as CT should be reserved for unclear or non-improving cases. Early management focuses on hemodynamic support and aggressive hydration to decrease morbidity and mortality. Guidelines are provided for evaluating etiology, risk stratification, nutritional support, antibiotic use
The document provides guidelines for the management of acute pancreatitis (AP). It summarizes that AP diagnosis is typically established by abdominal pain and elevated serum amylase and/or lipase levels. Contrast-enhanced CT or MRI is only recommended if diagnosis is unclear or patient fails to improve to evaluate for complications. It outlines recommendations for early medical management including aggressive hydration and nutrition, as well as management of complications like pancreatic necrosis with antibiotics, endoscopic or radiologic drainage, or surgery.
The document provides guidelines for the management of acute pancreatitis (AP). It summarizes that AP is one of the most common gastrointestinal diseases, leading to significant burden. The incidence of AP has been increasing. Recent studies have identified two phases of AP - early (within 1 week) characterized by systemic inflammatory response and late (>1 week) characterized by local complications. Key recommendations include establishing the diagnosis of AP using clinical criteria including abdominal pain and elevated serum amylase/lipase. Imaging such as CT should be reserved for unclear or non-improving cases. Early management focuses on hemodynamic support and aggressive hydration to decrease morbidity and mortality. Guidelines are provided for evaluating etiology, risk stratification, nutritional support, antibiotic use
Portal hypertensive gastropathy is a condition seen in patients with portal hypertension where there are characteristic endoscopic findings in the gastric fundus and body. It is thought to be caused by hemodynamic changes related to portal hypertension, especially increased portal pressure, but portal hypertension alone cannot fully explain its development. The pathogenesis is not fully understood but likely involves changes in blood flow and vascular resistance. The prevalence of portal hypertensive gastropathy varies widely in different studies but can be seen in approximately 30-75% of patients with portal hypertension and 35-98% of patients with cirrhosis, depending on the severity of liver disease and presence of varices.
The document discusses pediatric pancreatitis. It begins by noting the increasing incidence of acute pancreatitis in pediatric patients, which now approaches rates in adults. The main types of pancreatitis - acute and chronic - are described. Acute pancreatitis is reversible while chronic pancreatitis is irreversible. For causes of acute pancreatitis in children, the document lists common causes as biliary disorders, systemic conditions, medications, trauma and idiopathic cases. Less common causes include infection, metabolic diseases and genetic/hereditary disorders. The document provides details on the pathophysiology of acute pancreatitis and the various etiologies.
Role of h.pylori in congestive gastropathy with pepsinogen,docShendy Sherif
This study investigated the role of H. pylori eradication and other treatments on portal hypertensive gastropathy in liver cirrhosis patients. 64 patients were divided into 3 groups: Group 1 received H. pylori eradication therapy; Group 2 received Daflon and sucralfait; Group 3 received propranolol and verapamil. All treatments significantly improved clinical symptoms and portal hypertensive gastropathy. Serum pepsinogen levels were lower in Group 1 pre-treatment but increased after H. pylori eradication, indicating pepsinogens may be a prognostic marker. Eradication therapy also significantly improved oesophageal varices in Group 1 compared to other groups
Comparison of BLUMGART vs. Dunking Pancreatico-Jejunostomy Anastomosissemualkaira
Dunking anastomosis is the most commonly
performed method for pancreatojejunostomy (PJ) in the Whipple
procedure. However, the postoperative pancreatic fistula (POPF)
rate was high in this procedure. Blumgart and his colleagues introduced a method for PJ to reduce POPF.
Comparison of BLUMGART vs. Dunking Pancreatico-Jejunostomy Anastomosissemualkaira
Dunking anastomosis is the most commonly
performed method for pancreatojejunostomy (PJ) in the Whipple
procedure. However, the postoperative pancreatic fistula (POPF)
rate was high in this procedure. Blumgart and his colleagues introduced a method for PJ to reduce POPF.
This document summarizes a study examining the relationship between esophageal motor disorders (EMDs) and Barrett's esophagus (BE) in patients with gastroesophageal reflux disease (GERD). The study included 201 GERD patients who underwent high-resolution esophageal manometry and endoscopy. In univariate analysis, male gender, alcohol consumption, hiatal hernia, and EMDs were associated with BE. In multivariate analysis, three independent factors for BE were identified: presence of EMDs (odds ratio 3.99), presence of hiatal hernia (odds ratio 5.60), and Helicobacter pylori infection (odds ratio 0.08). The study concludes that the presence of EMD
This document describes a retrospective case-control study that evaluated whether the presence of esophageal motor disorders (EMD) is an independent risk factor associated with Barrett's esophagus (BE) in patients with gastroesophageal reflux disease (GERD). The study included 201 GERD patients who underwent high-resolution esophageal manometry and endoscopy. In multivariate analysis, the presence of EMD, presence of hiatal hernia, and H. pylori infection were identified as independent factors associated with BE. Specifically, ineffective motor syndrome and lower esophageal sphincter hypotonia were strong independent risk factors for BE. The findings suggest that systematically searching for EMD in GERD patients could help optimize endoscopic
UF College of Medicine Research Poster Session TOGADebdeep Banerjee
This pilot study examined the use of supplemental oxygen therapy for 5 patients with acute colonic pseudo-obstruction or ileus. Four out of the 5 patients showed clinical improvement of symptoms and decreased bowel distension after 6 hours of 100% oxygen supplementation as measured by abdominal radiographs. One patient failed to improve but was later found to have a partial small bowel obstruction. No patients experienced complications from their underlying conditions. The study demonstrates that supplemental oxygen therapy may be a safe, cost-effective approach to improve outcomes for patients with acute colonic pseudo-obstruction or ileus. Larger prospective studies are still needed.
A prospective randomized controlled trial assessing the efficacy of omentopex...Ricky Costa
This study aimed to assess whether attaching the omentum (fatty tissue) to the stomach during laparoscopic sleeve gastrectomy (LSG) surgery could help reduce post-operative gastrointestinal (GI) symptoms like nausea and vomiting. The study involved 60 patients undergoing LSG who were randomly assigned to either have LSG alone or LSG with omentopexy. Patients completed surveys assessing GI symptoms at several time points after surgery. The study found that attaching the omentum did not significantly reduce post-operative GI symptoms or food intolerance compared to LSG alone. Patients with omentopexy did require more anti-nausea medication initially but had no difference in other outcomes. The study concludes that
1) A 17-year-old girl presented with chronic epigastric pain and was found to have a large trichobezoar in her stomach.
2) During surgery to remove the bezoar, the doctors also found extensive pneumatosis intestinalis (intramural gas within the bowel walls) in her small intestine.
3) This case presents a rare association between trichobezoar and pneumatosis intestinalis that has not been previously reported. As the pneumatosis was not causing symptoms, no treatment was needed for it.
This document provides guidelines for the management of acute pancreatitis (AP). It summarizes key recommendations regarding the diagnosis, etiology, risk stratification, and management of AP. The diagnosis of AP is usually established by abdominal pain and elevated serum amylase and/or lipase levels. Contrast-enhanced CT or MRI is only recommended if the diagnosis is unclear or the patient fails to improve. Patients should be stratified based on the presence of organ failure or systemic inflammatory response syndrome and those with organ failure admitted to intensive care. Aggressive intravenous hydration within the first 24 hours and assessment of fluid status is important. Guidelines are also provided for managing gallstone pancreatitis, infectious complications, and interventions.
AbstractIntestinal cystic pneumatosis is a rare condition characterized by the presence of gaseous cysts in the intestinal wall.We report the observation of a 51-year-old patient with dyspepsia syndrome and recurrent episodes of abdominal pain who had a three-day cessation of materials and gas for three days.
A 51-year-old man presented with abdominal pain and cessation of bowel movements for three days. Imaging showed pneumoperitoneum and distension of the small intestine upstream of a large mass. Exploratory laparotomy revealed gas cysts in the small intestine and a volvulus. Resection of the affected small intestine segment showed intestinal cystic pneumatosis. Intestinal cystic pneumatosis is a rare condition characterized by gas-filled cysts in the intestinal wall. It is usually mild but can cause complications like volvulus requiring surgery. Treatment is typically medical but surgery is needed for complicated cases.
We report the observation of a 51-year-old patient with dyspepsia syndrome and recurrent episodes
of abdominal pain who had a three-day cessation of materials and gas for three days. The clinical examination on admission showed a slightly distended abdomen, an empty rectal bulb with digital rectal
examination. The biological assessment was without abnormality, the radiography of the abdomen
without preparation showed central hydro-aeric levels of the hail-like type with a gaseous crescent
inter hepato-diaphragmatic. The abdominal CT objectified a pneumoperitoneum with aerobilia, an
upper digestive distension with probable proximal digestive volvulus. The patient was admitted to
the block and an exploratory laparotomy was performed which revealed the presence of a gas cyst in
several places in the small intestine with distension of the latter upstream of a large mass of benign
appearance. Taking a segment of the jejunum. We carried out an anastomosis resection of the small
intestine carrying out the mass which we sent to the pathological anatomy laboratory and the result
of which returned in favor of intestinal cystic pneumatosis. The postoperative suites were simple with
good evolution and resumption of transit at end of the third day
A 51-year-old man presented with abdominal pain and cessation of bowel movements for three days. Imaging showed pneumoperitoneum and distension of the small intestine upstream of a mass. Exploratory laparotomy revealed gas cysts in the small intestine and a volvulus. Resection of the affected small intestine segment showed intestinal cystic pneumatosis.
Intestinal cystic pneumatosis typically presents as mild and is often secondary to other conditions. Imaging such as CT can diagnose it by showing gas-filled cysts in the intestinal wall. While usually treated medically, complicated or resistant cases require surgical resection.
A 51-year-old man presented with abdominal pain and cessation of bowel movements for three days. Imaging showed pneumoperitoneum and distension of the small intestine upstream of a mass. Exploratory laparotomy revealed gas cysts in the small intestine and a volvulus. Resection of the affected small intestine segment showed intestinal cystic pneumatosis.
Intestinal cystic pneumatosis typically presents as mild and is often secondary to other conditions. Imaging such as CT is used for diagnosis and shows gas-filled cysts in the intestinal wall. Treatment is usually medical but surgery is needed for complications like volvulus.
This document discusses nutritional challenges after gastric resection surgery. It describes the two main types of gastric resection - partial gastrectomy and total gastrectomy. Common side effects after surgery include dumping syndrome, fat maldigestion, gastric stasis, and lactose intolerance, which can lead to weight loss. Long-term, nutrient deficiencies can develop, most commonly anemia from iron, B12 or folate deficiency, or bone disease. The document provides guidelines for managing nutritional intolerances through diet and supplements, and monitoring for deficiencies. Frequent nutrition follow-up is important to prevent malnutrition after gastric resection surgery.
1. Gastroparesis is a condition characterized by delayed gastric emptying without mechanical obstruction, often accompanied by nausea, vomiting, early satiety, and abdominal pain.
2. It can be diagnosed by demonstrating delayed gastric emptying on scintigraphy using a standardized meal, as well as evaluating symptoms.
3. The diagnosis requires ruling out other potential causes and confirming that symptoms are consistent with delayed gastric emptying. Interpreting mild delays cautiously is important to avoid misdiagnosing functional dyspepsia as gastroparesis.
Anemia is a common condition of cancer patients. This is because cancers cause inflammation that decrease red blood cell production. In addition, many chemotherapies are myelosuppressive, meaning they slow down the production of new blood cells by the bone marrow.
Drug Repurposing: Recent Advancements, Challenges, and Future Therapeutics fo...JohnJulie1
Cancer is a prime public health burden that accounts for approximately 9.9 million deaths worldwide. Despite recent advances in treatment regimen and huge capital investment in the pharmaceutical sector, there has been little success in improving the chances of survival of cancer patients.
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Similar to G-POEM in Patients with Gastro paresis – Gambling for Healing or Bigger Armamentarium?
The document discusses pediatric pancreatitis. It begins by noting the increasing incidence of acute pancreatitis in pediatric patients, which now approaches rates in adults. The main types of pancreatitis - acute and chronic - are described. Acute pancreatitis is reversible while chronic pancreatitis is irreversible. For causes of acute pancreatitis in children, the document lists common causes as biliary disorders, systemic conditions, medications, trauma and idiopathic cases. Less common causes include infection, metabolic diseases and genetic/hereditary disorders. The document provides details on the pathophysiology of acute pancreatitis and the various etiologies.
Role of h.pylori in congestive gastropathy with pepsinogen,docShendy Sherif
This study investigated the role of H. pylori eradication and other treatments on portal hypertensive gastropathy in liver cirrhosis patients. 64 patients were divided into 3 groups: Group 1 received H. pylori eradication therapy; Group 2 received Daflon and sucralfait; Group 3 received propranolol and verapamil. All treatments significantly improved clinical symptoms and portal hypertensive gastropathy. Serum pepsinogen levels were lower in Group 1 pre-treatment but increased after H. pylori eradication, indicating pepsinogens may be a prognostic marker. Eradication therapy also significantly improved oesophageal varices in Group 1 compared to other groups
Comparison of BLUMGART vs. Dunking Pancreatico-Jejunostomy Anastomosissemualkaira
Dunking anastomosis is the most commonly
performed method for pancreatojejunostomy (PJ) in the Whipple
procedure. However, the postoperative pancreatic fistula (POPF)
rate was high in this procedure. Blumgart and his colleagues introduced a method for PJ to reduce POPF.
Comparison of BLUMGART vs. Dunking Pancreatico-Jejunostomy Anastomosissemualkaira
Dunking anastomosis is the most commonly
performed method for pancreatojejunostomy (PJ) in the Whipple
procedure. However, the postoperative pancreatic fistula (POPF)
rate was high in this procedure. Blumgart and his colleagues introduced a method for PJ to reduce POPF.
This document summarizes a study examining the relationship between esophageal motor disorders (EMDs) and Barrett's esophagus (BE) in patients with gastroesophageal reflux disease (GERD). The study included 201 GERD patients who underwent high-resolution esophageal manometry and endoscopy. In univariate analysis, male gender, alcohol consumption, hiatal hernia, and EMDs were associated with BE. In multivariate analysis, three independent factors for BE were identified: presence of EMDs (odds ratio 3.99), presence of hiatal hernia (odds ratio 5.60), and Helicobacter pylori infection (odds ratio 0.08). The study concludes that the presence of EMD
This document describes a retrospective case-control study that evaluated whether the presence of esophageal motor disorders (EMD) is an independent risk factor associated with Barrett's esophagus (BE) in patients with gastroesophageal reflux disease (GERD). The study included 201 GERD patients who underwent high-resolution esophageal manometry and endoscopy. In multivariate analysis, the presence of EMD, presence of hiatal hernia, and H. pylori infection were identified as independent factors associated with BE. Specifically, ineffective motor syndrome and lower esophageal sphincter hypotonia were strong independent risk factors for BE. The findings suggest that systematically searching for EMD in GERD patients could help optimize endoscopic
UF College of Medicine Research Poster Session TOGADebdeep Banerjee
This pilot study examined the use of supplemental oxygen therapy for 5 patients with acute colonic pseudo-obstruction or ileus. Four out of the 5 patients showed clinical improvement of symptoms and decreased bowel distension after 6 hours of 100% oxygen supplementation as measured by abdominal radiographs. One patient failed to improve but was later found to have a partial small bowel obstruction. No patients experienced complications from their underlying conditions. The study demonstrates that supplemental oxygen therapy may be a safe, cost-effective approach to improve outcomes for patients with acute colonic pseudo-obstruction or ileus. Larger prospective studies are still needed.
A prospective randomized controlled trial assessing the efficacy of omentopex...Ricky Costa
This study aimed to assess whether attaching the omentum (fatty tissue) to the stomach during laparoscopic sleeve gastrectomy (LSG) surgery could help reduce post-operative gastrointestinal (GI) symptoms like nausea and vomiting. The study involved 60 patients undergoing LSG who were randomly assigned to either have LSG alone or LSG with omentopexy. Patients completed surveys assessing GI symptoms at several time points after surgery. The study found that attaching the omentum did not significantly reduce post-operative GI symptoms or food intolerance compared to LSG alone. Patients with omentopexy did require more anti-nausea medication initially but had no difference in other outcomes. The study concludes that
1) A 17-year-old girl presented with chronic epigastric pain and was found to have a large trichobezoar in her stomach.
2) During surgery to remove the bezoar, the doctors also found extensive pneumatosis intestinalis (intramural gas within the bowel walls) in her small intestine.
3) This case presents a rare association between trichobezoar and pneumatosis intestinalis that has not been previously reported. As the pneumatosis was not causing symptoms, no treatment was needed for it.
This document provides guidelines for the management of acute pancreatitis (AP). It summarizes key recommendations regarding the diagnosis, etiology, risk stratification, and management of AP. The diagnosis of AP is usually established by abdominal pain and elevated serum amylase and/or lipase levels. Contrast-enhanced CT or MRI is only recommended if the diagnosis is unclear or the patient fails to improve. Patients should be stratified based on the presence of organ failure or systemic inflammatory response syndrome and those with organ failure admitted to intensive care. Aggressive intravenous hydration within the first 24 hours and assessment of fluid status is important. Guidelines are also provided for managing gallstone pancreatitis, infectious complications, and interventions.
AbstractIntestinal cystic pneumatosis is a rare condition characterized by the presence of gaseous cysts in the intestinal wall.We report the observation of a 51-year-old patient with dyspepsia syndrome and recurrent episodes of abdominal pain who had a three-day cessation of materials and gas for three days.
A 51-year-old man presented with abdominal pain and cessation of bowel movements for three days. Imaging showed pneumoperitoneum and distension of the small intestine upstream of a large mass. Exploratory laparotomy revealed gas cysts in the small intestine and a volvulus. Resection of the affected small intestine segment showed intestinal cystic pneumatosis. Intestinal cystic pneumatosis is a rare condition characterized by gas-filled cysts in the intestinal wall. It is usually mild but can cause complications like volvulus requiring surgery. Treatment is typically medical but surgery is needed for complicated cases.
We report the observation of a 51-year-old patient with dyspepsia syndrome and recurrent episodes
of abdominal pain who had a three-day cessation of materials and gas for three days. The clinical examination on admission showed a slightly distended abdomen, an empty rectal bulb with digital rectal
examination. The biological assessment was without abnormality, the radiography of the abdomen
without preparation showed central hydro-aeric levels of the hail-like type with a gaseous crescent
inter hepato-diaphragmatic. The abdominal CT objectified a pneumoperitoneum with aerobilia, an
upper digestive distension with probable proximal digestive volvulus. The patient was admitted to
the block and an exploratory laparotomy was performed which revealed the presence of a gas cyst in
several places in the small intestine with distension of the latter upstream of a large mass of benign
appearance. Taking a segment of the jejunum. We carried out an anastomosis resection of the small
intestine carrying out the mass which we sent to the pathological anatomy laboratory and the result
of which returned in favor of intestinal cystic pneumatosis. The postoperative suites were simple with
good evolution and resumption of transit at end of the third day
A 51-year-old man presented with abdominal pain and cessation of bowel movements for three days. Imaging showed pneumoperitoneum and distension of the small intestine upstream of a mass. Exploratory laparotomy revealed gas cysts in the small intestine and a volvulus. Resection of the affected small intestine segment showed intestinal cystic pneumatosis.
Intestinal cystic pneumatosis typically presents as mild and is often secondary to other conditions. Imaging such as CT can diagnose it by showing gas-filled cysts in the intestinal wall. While usually treated medically, complicated or resistant cases require surgical resection.
A 51-year-old man presented with abdominal pain and cessation of bowel movements for three days. Imaging showed pneumoperitoneum and distension of the small intestine upstream of a mass. Exploratory laparotomy revealed gas cysts in the small intestine and a volvulus. Resection of the affected small intestine segment showed intestinal cystic pneumatosis.
Intestinal cystic pneumatosis typically presents as mild and is often secondary to other conditions. Imaging such as CT is used for diagnosis and shows gas-filled cysts in the intestinal wall. Treatment is usually medical but surgery is needed for complications like volvulus.
This document discusses nutritional challenges after gastric resection surgery. It describes the two main types of gastric resection - partial gastrectomy and total gastrectomy. Common side effects after surgery include dumping syndrome, fat maldigestion, gastric stasis, and lactose intolerance, which can lead to weight loss. Long-term, nutrient deficiencies can develop, most commonly anemia from iron, B12 or folate deficiency, or bone disease. The document provides guidelines for managing nutritional intolerances through diet and supplements, and monitoring for deficiencies. Frequent nutrition follow-up is important to prevent malnutrition after gastric resection surgery.
1. Gastroparesis is a condition characterized by delayed gastric emptying without mechanical obstruction, often accompanied by nausea, vomiting, early satiety, and abdominal pain.
2. It can be diagnosed by demonstrating delayed gastric emptying on scintigraphy using a standardized meal, as well as evaluating symptoms.
3. The diagnosis requires ruling out other potential causes and confirming that symptoms are consistent with delayed gastric emptying. Interpreting mild delays cautiously is important to avoid misdiagnosing functional dyspepsia as gastroparesis.
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Anemia is a common condition of cancer patients. This is because cancers cause inflammation that decrease red blood cell production. In addition, many chemotherapies are myelosuppressive, meaning they slow down the production of new blood cells by the bone marrow.
Drug Repurposing: Recent Advancements, Challenges, and Future Therapeutics fo...JohnJulie1
Cancer is a prime public health burden that accounts for approximately 9.9 million deaths worldwide. Despite recent advances in treatment regimen and huge capital investment in the pharmaceutical sector, there has been little success in improving the chances of survival of cancer patients.
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Helicobacter Pylori (HP) infection is prevalent among patients with dyspepsia in developing countries with low socioeconomic status. The gold standard investigation is invasive method gastric biopsy through upper GI endoscopy, however non-invasive methods (stool for HP antigen) are not reliable up to the mark also need to wait for two weeks without symptomatic treatment. It is important to have a reliable, cost effective and easily accessible non-invasive marker to diagnose patients with H. pylori infection. Several non-invasive laboratory have been predicted in having the role in diagnosis of H.pylori infection. Therefore, the aim of our study was to determine the diagnostic accuracy of platelet to lymphocyte ratio in predicting H.Pylori infection in patients with dyspepsia.
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Fibrous
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Fibro glandular
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Adipose (Fatty)
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Is a 3 dimensional projection
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Reduces overlapping tissue seen with 2D only
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15 projections are taken with each combo exposure (7.5) (-7.5)
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With an average breast (18*24) 3D dose is 1.34, combo is 2.56 Milligrey. (3 Milligrey FDA) (2D is 1.2
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaJohnJulie1
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Invasive micropapillary carcinoma (IMPC) is a rare type of breast cancer with high frequency of regional lymph node metastasis. However, the prognosis of IMPC has remained controversial for decades. We aimed to compare the differences of prognosis between IMPC and Invasive ductal carcinoma(IDC) of the breast by utilizing Surveillance, Epidemiology, and End Results (SEER) database.
Uretero-Enteric Anastomosis Stricture after Urinary Diversion; Detailed Analy...JohnJulie1
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Prolyl 4-hydroxylase, beta polypeptide (P4HB) and Glucose‑regulated protein 78 (GRP78) represent for poor prognosis of various cancers, while rare research investigate correlation of them. This study aimed to explore correlation and prognostic value of them in gastric cancer (GC).
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Liquid Chromatography Tandem Mass Spectrometry
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Skeletal muscle channelopathy are rare heterogeneous episodic disorders with marked genotypic and phenotypic variability resulting in periodic paralysis, and falls in young people which often misdiagnosed or undiagnosed due to its rarity, often the symptoms are miscommunicated to the treating phycision due to its episodic nature and not uncommonly physical examination by the time patient attend the clinic or hospital will be unremarkable apart from periodic muscle paralysis where patient will presented to ED with flaccid weakness,
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The document summarizes experimental and clinical research on using infrared laser therapy between 890-910 nm to treat breast cancer. Experimental studies showed that lower doses of laser therapy (0.46 J/cm2) inhibited tumor growth more than higher doses. Laser therapy combined with chemotherapy was also effective, particularly with vincristin. Clinical studies on 136 breast cancer patients found that laser therapy before or after surgery, or alone, reduced complications, improved immune function and quality of life, and increased survival time. Histological analysis found over 50% tumor tissue disappeared after effective laser treatment.
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Upper rectal cancer management is controversial. The present series reports the outcomes of treatment comparing neoadjuvant chemoradiation (NCRT) versus upfront surgery.
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Today, advances in cross-sectional imaging have led to the detection and early recognition of incidental/focal liver lesions (FCL). In approximately 17,000 cases of chest CT, incidental liver lesions were found in 6% [1]. In general, FCL consists of hepatocytes, biliary epithelium, mesenchymal tissue, connective tissue, or metastasized cells from distant sites. Most incidental lesions are benign, some may require careful management and treatment.
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Data concerning the utility of biomarkers for accurate early HCC detection in cirrhotic patients are lacking. 1.2. Methods: We evaluated 112 consecutive Caucasian cirrhotic patients with (n=28) or without (n=84) concomitant HCC at baseline for serum AFP and plasma fibrinogen like protein-2 (FGL-2) levels. Patients without confirmed HCC at baseline were further followed up every six months with ultrasound and serum AFP levels, according to HCC surveillance program. Imaging as well as histological confirmation of HCC was established in patients with new lesions.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
Fexofenadine is sold under the brand name Allegra.
It is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and causes lesser sedation, as compared to first-generation antihistamines.
It is on the World Health Organization's List of Essential Medicines. Fexofenadine has been manufactured in generic form since 2011.
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The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
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Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Allopurinol, a uric acid synthesis inhibitor acts by inhibiting Xanthine oxidase competitively as well as non- competitively, Whereas Oxypurinol is a non-competitive inhibitor of xanthine oxidase.
2. functional dyspepsia and the diagnosis of gastroparesis
should be reserved for individuals with clinically
relevant impairments of gastric function (at least x2 the
upper limit of normal)[2].
The pathophysiology of this disease is complex and
multifactorial. Although the presence of delayed gastric
emptying is required for the diagnosis it is not the cause
of symptoms in most patients, indeed the association
between this finding and patient symptoms is weak
(3). Moreover there is an important overlap between the
diagnosis of gastroparesis and functional dyspepsia and the
presence of psychological comorbiditiy can complicate the
clinical assessment of this condition [3]. Notwithstanding
these issues, studies have identified organic pathology in
patients with this diagnosis. For example, in diabetic
gastroparesis, in addition to the autonomic neuropathy of
the vagus nerve, the reduction of pacemaker cells in the
area of the large curvature and fibrosis of the gastric wall
and pyloric sphincter have been documented. These
histological and neuronal changes have been linked to
various disturbances of gastric motility including
dysfunction of the pylorus, hypomotility of the antrum and
delayed accommodation of the fundus[3]. The expression
of these pathological motility phenomena will differ
depending on the underlying etiology, disease duration and
co morbidities.
The underlying pathological basis of disease will also
impact on the response to treatment an patient outcome.
Empirical clinical management includes dietary measures
(low-fiber, liquidized diet), tight blood glucose control in
diabetes mellitus, and pharmacological therapy (e.g.
prokinetics, antiemetics and analgetics; [3-5]). Although
new drugs are being tested for the gastroparesis indication,
the current drug options are very limited due to their low
efficacy and spectrum of side effects. Approximately 30% of
all affected patients do not respond to any available
treatment modality [6]. For these individuals novel forms
of treatment such as gastric high-frequency
electrostimulation (Enterra) can be considered. This
approach appears to reduce symptoms without improving
gastric emptying; however, the cost-utility of this expensive
and invasive treatment remains controversial [7].
1.1.Gastric Peroral Endoscopic Myotomiy(G-
POEM) as a New Principle of Therapy
2019; V2(7): 1-6
The pathological significance of “outlet obstruction” atthe
pylorus region in selected patients with gastroparesis and
the therapeutic potential of an intervention in this
“therapeutic region of opportunity” (for example, by
endoscopic dilatation or injection of botulinum toxin) has
been confirmed by numerous case series[8]. First
described gastric peroral endoscopic myotomy (“G-
POEM”, antropyloromyotomy) with successful treatment
outcome of one case as “proof of principle” of this method
[8]. The technical implementation of G-POEM is
comparable to POEM in achalasia in the esophagus
(Figure 1). During the intervention, a catheter for the
injection of the mucosa and a knife with a triangular tip
(Triangle Tip Knife) are used alternately. After opening of
the mucosa (usually about 5-7 cm proximal to the pylorus
in the area of the large curvature), a stepwise submucosal
tunneling (by dissection of the submucosa) is performed
until the pylorus ring can be identified. The pyloric and
longitudinal muscles of the pylorus are precisely split
longitudinally (over a distance of two to three centimeters,
“myotomy”) and finally the mucosal incision is closed with
clips. The rationale of this procedure is a permanent repair
of the pathologically disturbed pyloric region (by spasm or
fibrosis), which causes the symptoms in a part of the
patients with gastroparesis. Currently, two Meta-analyzes
have been published which summarize the technical
feasibility and the results of the published studies on G-
POEM [9-10].
Figure 1: Expiration of gastric oral endoscopic myotomy (G-POEM).
The relevant technical steps of the procedure are represented by A - F
(pictorial material: Department of Gastroenterology, Hepatology and
Gastroenterological Oncology, Bogenhausen Hospital).
2. Methods
Real life data outside of published studies are currently
only available to a limited extent. In this single-centre
study, we retrospectively analyzed postprocedural clinical
Citation: Gundling F, G-POEM in Patients with Gastro paresis - Gambling for Healing or Bigger
2
Armamentarium?. Japanese Journal of Gastroenterology and Hepatology. 2019; v2(7):1-5.
3. improvement, technical success rate and procedural
complications.
G-POEM was performed in 6 patients with therapy
refractory gastroparesis (confirmed by gastric emptying
scintigraphy) between 2018 and 2019. 5 patients were
women. The age was 16-58 years (mean 36.3 years). The
cause of gastroparesis was: diabetes in 2, idiopathic in 2
and postoperatively (after fundapplication) in 2 cases. In
4 patients, the implantation of a gastric
electrostimulation without long-term therapeutic
success was already carried out before so G-POEM was
performed as lastline therapy. In all cases, the G-POEM
has been successfully engineered by high-endoscopic
technicians, with few complications except for minor
post-interventional nausea and mild epigastric pain for
a few days. In 3 patients there was a clinical
improvement after G-POEM for a few weeks (<2). At a
follow-up of 3-8 months, no patient reported relevant
clinical improvement (subjectively and in GCSI). In 3
cases, gastric electrostimulation was restarted without
any relevant clinical improvement.
3. Results
In this single center study, G-POEM showed a high
technical success rate with a very low procedural
complication rate. However, the clinical response
beyond a short-term post-interventional improvement
did not succeed in a single patient.
4. Discussion
The meta-analysis by [9] includes all publications on G-
POEM with case numbers> 5 patients. In total, 7 studies
(with a total of n = 196 patients) were evaluated in the
period 2013 - 2019. According to the criteria of the
National Institutes of Health (NIH), only 3 of them had a
good study quality (small patient populations, only 2
prospective studies, only 3 randomized controlled trials).
In terms of aetiology, idiopathic (42.3%) followed by
diabetic gastroparesis (28.5%) were the most common
cases treated. The follow-up in all studies was between one
and 18 months. Primary outcomes were a) technical
success rate and b) clinical response; secondary endpoints
were c) improvement of GCSI and d) gastric emptying
before and after intervention. The primary endpoint
a) technical success rate was reached in 100%. The
duration of the intervention averaged 69.7 minutes (95%
2019; V2(7): 1-5
CI: 39-99 minutes). Overall, only 12 postinterventional
and controllable adverse events (AEs) were reported
(capnoperitoneum in 7, gastrointestinal bleeding in 2
cases), mortality was 0%. Clinical response was
achieved in 82% (95% CI: 74-87%), but was defined by
different parameters by different authors (e.g. avoiding
further hospitalization, improving GCSI). A moderate
but significant improvement in GCSI following G-POEM
was observed in all studies, a significant improvement
in gastric emptying was documented in 5/9 studies.
The review by [10] analyzed a total of 13 predominantly
retrospective studies (with a total of 291 patients), some of
which are also discussed in the meta-analysis above. Again,
patients with treatment-refractory idiopathic (n = 93) and
diabetic gastroparesis (n = 69) were most often included.
The technical success rate was 100%, and clinical response
occurred in 69 - 100% (GCSI improvement). The most
common symptoms of nausea and vomiting were
improved. This review also found a low and usually
conservatively controllable rate of AEs (0-6.7%, excluding
capnoperitoneum or pneumoperitoneum, gastrointestinal
bleeding events). Only one study with n = 20 patients has
so far described a relevant perforation rate of 20% (surgical
intervention required in one patient)[11]. Overall, one
death of G-POEM patient was reported across all studies,
but this occurred independently of the intervention.Despite
the euphoria about the introduction of a novel and
apparently successful treatment in gastroparesis, the
amount of high quality data supporting the clinical utility
of G-POEM are limited. Above all, the selection of patients
with gastroparesis for G-POEM is problematic. In the
present studies, G-POEM was used as the ultima ratio in
patients with refractory gastroparesis defined as GSCI> 1.5
for more than 6 months, no response to medication. Tests
of gastric emptying were usually performed to confirm the
diagnosis prior to the intervention. Although these criteria
fulfill the diagnostic criteria for gastroparesis, it is
important to remember that symptoms of gastroparesis are
non-specific and not necessarily (directly) caused by
delayed gastric emptying. Moreover, G-POEM does not
always accelerate gastric emptying and the mechanism by
which this procedure improves symptoms has not been
confirmed. Now that G-POEM has been added to the
armamentarium of treatments for gastroparesis it is
important that the indications for this procedure are
3
4. established. Clear predictive factors for the success of
this procedure have not been defined. Given the high
prevalence of patients with dyspeptic symptoms, the
invasiveness and the cost of the procedure (G-POEM is
performed only by highly skilled endoscopists), this
must be sonsidered urgently. Currently, the diagnosis of
gastroparesis is most commonly made by endoscopy
(evidence of food retention, exclusion of stenosis) and
gastric emptying scintigraphy. However, these
diagnostic procedures do not identify the underlying
causes of symptoms and disease. Gastric function is
complex and delayed gastric emptying can be caused by
impaired gastric contractility and impaired neuro-
hormonal regulation of gastric emptying as well as
pyloric outlet obstruction.
Advances in clinical imaging of gastric function, including
new methodologies for the assessment of gastric emptying
and the introduction of an endoscopic functional luminal
impedance probe (Endoflip ™) provide new opportunities
to identify the causes of gastroparesis that could help guide
targeted and effective treatment[12-14].
Endoflip measurements involve the endoscopic
placement of a special balloon catheter connected to a
high-resolution impedance-planimetry system to assess
the luminal distensibility (luminal cross-sectional area
in relation to pressure) of the pylorus examined. In
addition, the closing function, length and diameter of
the sphincter muscles can be measured [14]. Endoflip
diagnostics may identify patients with “pylorus-
dominant” gastroparesis related to functional
(“pylorospasm”) or structural (stenosis) pathology that
are, in principle, likely to respond to G-POEM or other
treatments (e.g. dilatation) directly at relieving
obstruction to flow at the pyloric sphincter.
A universal treatment concept, which provides “the one”
satisfactory solution for all patients with gastroparesis, is
still not available. The heterogeneity of the clinical picture,
which represents a spectrum of different
pathophysiological, etiological and clinical characteristics,
still requires a therapy tailored to the individual patient. G-
POEM should be considered especially in patients with
pylorus-dominant gastroparesis. However, due to the
invasiveness of the procedure, the application should
initially be limited to experienced centers. For a sustainable
assessment of this
2019; V2(7): 1-5
procedure, the results of future prospective studies with
a larger number of cases, longer follow-up and uniform
optimized diagnostics, taking into account the
respective gastroparesis phenotype, must be awaited.
5. Keypoints
• Approximately 30% of all affected patients
suffering from gastroparesis do not respond to any
available treatment modality. Gastric peroral
endoscopic myotomiy (G-POEM, antropyloromyotomy)
represents a new principle of therapy.
• In this single center study, G-POEM showed a
high technical success rate with a very low procedural
complication rate. However, the clinical response
beyond a short-term post-interventional improvement
did not succeed in a single patient.
The heterogeneity of the clinical picture, which
represents a spectrum of different pathophysiological,
etiological and clinical characteristics, still requires a
therapy tailored to the individual patient. G-POEM
should be considered especially in patients with
pylorus-dominant gastroparesis.
References
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Perkins A et al. Clinical assessment of gastric emptying and
sensory function utilizing gamma scintigraphy: Establishment
of reference intervals for the liquid and solid somponents of
the Nottingham test meal in helathy subjects.
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13. Gourcerol G, Tissier F, Melchior C, Touchais JY, Huet
E, Prevost G et al. Impaired fasting pyloric compliance in
gastroparesis and the therapeutic response to pyloric dilatation.
Aliment Pharmacol Ther. 2015; 41: 360-7.
14. Tucker E, Sweis R, Anggiansah A, Wong T, Telakis E,
Knowles K, Wright J et al. Measurement of esophago-gastric
junction cross-sectional area and distensibility by endolumenal
functional lumen imaging probe for the diagnosis of gastro-
esophageal reflux disease, Neurogastroenterol Motil. 2013; 25:
904-10.
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