Genitourinary system Anatomy and Physiology.

GENITOURINA
RY SYSTEM
P R E S E N T E D B Y : D R . P A L L A V I P A T H A N I A , P R O F E S S O R

INDEX
S.NO. CONTENT
1. INTRODUCTION
2. DEFINITION
2. URINARY SYSTEM ORGANS
3. ANATOMY OF KIDNEY
4. ORGAN ASSOCIATED WITH THE KIDNEY
5. GROSS STRUCTURE OF KIDNEY
6. MICROSCOPIC STRUCTURE OF KIDNEY
7. MECHANISM OF KIDNEY
8. BLOOD SUPPLY OF KIDNEY

INDEX
S.NO. CONTENT
10. NERVE SUPPLY AND LYMPHATIC DRAINAGE
11. THE URETERS
12. URINARY BLADDER
13. URETHRA
14. MICTURITION
15. FUNCTION OF KIDNEY
16. THE EFFECTS OF AGEING OF URINARY SYSTEM
17. Assessment of the urinary system
18. Renal system physical assesment
19. Radiographic studies
20. URINARY SYSTEM DISORDERS

INTRODUCTION
The urinary system, also
known as the renal
system.
Urinary system, consists
of:
• The kidneys (two)
• Ureters (two)
• Bladder(one)
• The urethra(one)

CONT..
• The function of the urinary system is to eliminate waste from the body,
regulate blood volume and blood pressure, control levels of electrolytes
and metabolites, and regulate blood PH.
• The urinary system is the body's drainage system for the eventual
removal of urine.

DEFINITION
The system of organs comprising
those concerned with the production
and excretion of urine and those
concerned with reproduction.
Also known as genitourinary system,
urogenital system, urogenital tract.

URINARY SYSTEM ORGANS
URINARY SYSTEM CONSIST OF:
 Kidneys (2)
 Ureters (2)
 Urinary bladder
 Urethra

KIDNEY
INTRODUCTION
 The human body normally has two pairs of
kidneys, one on the left and one on the right.
 Kidney is a bean shaped structure with a
convex and a concave border.
 The functional unit of kidney is nephron.
 The kidney produce urine that contains
metabolic waste products, including the
nitrogen compounds urea and uric acid, excess
ions and some drugs.

LOCATION OF KIDNEYS
 LOCATION:- The kidney lies on the posterior
abdominal wall, one on each side of the vertebral
column, behind the peritoneum and below the
diaphragm.
 Lateral to T12–L3 vertebrae.
 The right kidney being slightly lower and
smaller than the left, and being placed
slightly more to the middle than the left
kidney.

CONT…
STRUCTURE
 LENGTH: 11cm or 4.3 inch
 WIDTH: 6 cm
 THICK: 2.5-3 cm
 WEIGHT: Male:125 and 170 grams.
Females:115
and 155 grams

ORGANS ASSOCIATED WITH THE KIDNEY
RIGHT KIDNEY
• Anteriorly: The duodenum, hepatic
flexure of the colon & right lobe of
the liver.
• Posteriorly: Diaphragm, muscles
of posterior abdominal wall.
• Superiorly: The right adrenal
gland.

ORGANS ASSOCIATED WITH THE KIDNEY
LEFT KIDNEY
• Anteriorly: The spleen & splenic
vessels, jejunum splenic flexure of the
colon, pancreas & stomach.
• Posteriorly: Diaphragm, muscles
of posterior abdominal wall.
• Superiorly: The left adrenal
gland.

GROSS STRUCTURE OF KIDNEY
EXTENAL STRUCTURE
 Renal capsule
 Renal fascia
 Renal hilum
INTERNAL STRUCTURE
 Renal cortex
 Renal medulla
 Renal pelvis

EXTERNAL STRUCTURE OF KIDNEY
RENAL CAPSULE
 It is thin membrane sheath that covers the
outer surface of each kidney.
 The capsule is composed of tough fibers,
chiefly collagen and elastin(fibrous
proteins) that helps to support kidney mass
 Protect the vital tissue from injury.
RENAL FASCIA
 It is commonly known as Gerota's fascia.
 Is an connective tissue layer that helps
adhere the kidney to surrounding structure.

CONT..
RENAL HILUM
Is found at the medical concave
surface
Renal veins, renal artery and
ureter are found in the hilum in
anterior posterior order.
Lymphatic and sympathetic
nerves pass through the hilum

INTERNAL ANATOMY
RENAL CORTEX
• Outermost layer of kidney
• Made up of 1.25, million of microscopic functional unit called
nephron in each kidney.
• Function: renal cortex produce erythropoietin.

INTERNAL ANATOMY
RENAL MEDULLA
Inner striated layer of kidney
It contains renal pyramids that having
striated cones.
Base of each pyramid faces cortex while
apex empty into the cup like cavity called
calyx.
Point of pyramid = Papilla
Papilla nested in cup (minor calyx)8 – 18
Major calyx 2 – 3

CONT…
RENAL COLUMNS
Located between the pyramids
Cortical tissue (cortex)
RENAL PELVIS
Funnel shaped structure at the beginning of
ureter
Calyx dumped into the renal pelvis

MICROSCOPIC STURCTURE OF KIDNEY
 The kidney is composed of about 1-2
millions functional units, the nephrons in
each kidney, and a smaller number of
collecting ducts.
 The collecting ducts transport urine
through the pyramids to the calyces and
renal pelvis.
 The collecting ducts are supported by a
small amount of connective tissue,
containing blood vessels, nerves and
lymph vessels.

NEPHRONS
NEPHRONS
 Functional units of kidney.
 Kidney contains about a million
nephron.
 It is about 3cm long and 20nm
in diameter.
 Nephrons are of two types:
 Cortical nephron
 Juxtamedullary nephron

NEPHRONS
Nephrons consists of :
 Renal corpuscle
• Glomerulus
• Bowman’s capsule
 Renal tubule
• Proximal convoluted tubule
• Loop of henle
• Distal convoluted tubule
• Collecting ducts
 Renal blood vessels

RENAL CORPUSCLE
 Composed of a glomerulus
and the Bowman's capsule.
 The renal corpuscle is the
beginning of the nephron.
 It is the nephron's initial
filtering component.

GLOMERULUS
 The glomerulus is surrounded by Bowman’s
capsule.
 The glomerulus is a capillary tuft that
receives its blood supply from an afferent
arteriole of the renal circulation.
 It is a network of capillaries that performs the
first step of filtering blood.
 The glomerular blood pressure provides the
driving force for water and solutes to be
filtered out of the blood and into the space
made by Bowman's capsule.

CONT..
 The remaining of the blood passes into the efferent arteriole.
 The diameter of efferent arterioles is smaller than that of afferent
arterioles, increasing the hydrostatic pressure in the glomerulus.

CONT..
LAYERS OF GLOMERULUS:-
Endothelial cells
The endothelial cells of the glomerulus
contain numerous pores.
These pores are relatively large, they
allow for the free filtration of fluid,
plasma solutes and protein.
Glomerulus basement membrane
The Glomerulus basement membrane
is a fusion of the endothelial cell and
podocytes basal laminas

CONT..
Podocytes
Podocytes line the other side of
the glomerular basement
membrane and form part of the
lining of bowman’s space.
Podocytes form a tight pedicels
that control the filtration of
protein.

BOWMAN'S CAPSULE
 The Bowman's capsule, also called the glomerular capsule.
 It surrounds the glomerulus.
 It is composed of a visceral inner layer formed by specialized cells
called podocytes.
 Parietal outer layer composed of simple squamous epithelium.
 Fluids from blood in the glomerulus are filtered through the visceral
layer of podocytes, resulting in the glomerular filtrate.

RENAL TUBULE
Arises from glomerular capsule.
Ends at tip of medullary pyramid.
~3 cm long.
Four major regions
Proximal convoluted tubule
Loop of henle
Distal convoluted tubule
Collecting duct

PROXIMAL CONVOLUTED TUBULE
(PCT)
 Filtered fluid collected by Bowman’s capsule
enters into the PCT.
 It is called convoluted due to its tortuous
path. Simple cuboidal cells form this tubule
with prominent microvilli on the luminal
surface, forming a brush border.

PROXIMAL CONVOLUTED TUBULE
(PCT)
• These microvilli create a large surface area to maximize the absorption
and secretion of solutes (Na+, Cl–, glucose, etc.), the most essential
function of this portion of the nephron.

LOOP OF HENLE
 U-shaped tube that consist of descending limb and ascending limb.
 Begin in the cortex, receiving filtrate from the PCT, extend into the medulla,
and then return to the cortex to empty into the DCT.

LOOP OF HENLE
The main function of the loop of henle is to reabsorb water from the urine
The ascending limb Nacl into the surrounding tissue, not permeable to
water
Descending limb is permeable to water
Water flows out of the filtrate in this area due to osmosis (high salt
concentration all around).

DISTAL CONVOLUTED TUBULE (DCT)
 It is highly coiled part of nephron
 Variably active portion of the nephron.
 Receive , dilute fluid from the ascending limb
of the loop of henle

COLLECTING DUCT
 Collecting duct is variably
active portion of the nephron.
 It is lined by specialized
cuboidal epithelial with very
few microvilli.
 DCTs of several nephrons
empty into a collecting duct.
 Passes into medulla.
 Several merge into papillary duct
(~30 per papilla).
 Drain into minor calyx.

MECHANISM OF KIDNEY
FORMATION OF URINE
 Formation of urine, which passes to
bladder for storage prior to excretion.
 The kidneys filter unwanted substances
from the blood and produce urine to
excrete them.

STEPS OF URINE FORMATION
There are three main steps of urine
formation:
I. Glomerular filtration- solute enter
nephrons from the blood
II. Reabsorption—some solutes are
selectively reabsorbed by the blood
III. Secretion-additional solutes are
secreted for elimination

I. FILTRATION
 Blood is carried to glomerulus by the
afferent arteriole.
 Pressure in the glomerulus are very
high
 65mmhg, as compared with normal
25mm Hg
 Solute are filtered through glomerulus
wall into bowman’s capsule

GLOMERULAR FILTRATION RATE
The amount of filtrate formed in all the renal
corpuscles of both kidneys each minute is the
glomerular filtration rate (GFR). In adults male :125
mL/min and 105 mL/min in females.
Three mechanisms control GFR:
1. Renal auto regulation.
2. Neural regulation: By Sympathetic division-
Vasoconstriction
3. Hormonal regulation:
a. Angiotensin II: vasoconstrictor
b. Atrial Natriuretic Peptide (ANP) :

WHAT MATERIALARE FILTERED
Yes No
Water
Nacl
Glucose
Amino acid
Urea
H+
Minerals
Plasma proteins
Erythrocytes(WBC’s)
Platelets
(minerals that are not filtered are too
big to get through the membranes)

II. REABSORPTION.
 Solutes and water are selectively reabsorbed into blood
 transport (both active and passive) out of the nephron, into the interstitial
fluid, and back into blood
 Reabsorption occurs until a maximum amount (the threshold level) has been
transported.
 About 85% of filtered water is reabsorbed.

REABSORPTION
1. Active transport of NaCl from the ascending limb of the loop
of henle.
2. Osmosis of water from the descending loop of henle causes
concentration of filtrate.
3. Further active transport of NaCl from ascending loop of henle
does two things:
a. Decrease filtrate solute concentration
b. Increases strength of osmotic gradient to pull H20 from
descending loop of henle
Therefore, the loop of henle actually achieves very little
concentration of filtrate

REABSORPTION
The main function of the loop of henle is to build up solute concentration
in the interstitial space
Concentration gradient drive the osmosis of water from the collecting duct
The bulk of water reabsorption occurs here
Concentrated urine is produced
Unfiltered proteins in the bloodstream also contribute to osmotic gradient
that pulls H2o from nephrons

WHAT SOLUTES ARE ACTIVELY REABSORBED?
Solute Location
Sodium ions, Na+
Cl-
and HCO3
-
follow by charge
attraction
Proximal tubule
Ascending loop of henle (NaCl)
glucose Proximal tubule
Amino acid Proximal tubule

III. SECRETION
Occurs in the distal tubule.
Waste solute move from blood into the nephron
Nitrogen- containing wastes, excess H+
and K+

COMPOSITION OF URINE
• Water (96 %),
• urea (2 %),
• uric acid,
• creatinine,
• ammonia,
• sodium,
• potassium,
• chlorides,
• phosphates,
• sulphates and oxalates (2 %).
• Urine production is decreased during sleep and exercise.

WATER BALANCE AND URINE OUTPUT
 The source of body water is dietary food and fluid and small amount
is formed by metabolic processes.
 Excretion of water take place in the form of faeces, sweat and as the
main constituent of urine.
 The balance between fluid intake and output is controlled by the
kidneys.
 The minimum urinary output is about 500 ml per day.
 The excess amount produced is controlled by antidiuretic hormone
(ADH) released into the blood by posterior lobe of pituitary gland.

WATER BALANCE
 Sensory nerve cells in the hypothalamus (osmoreceptors) detect changes
in the osmotic pressure of the blood.
 Nerve impulses from the osmoreceptors stimulate the posterior lobe of
the pituitary gland to release ADH.
 When the osmotic pressure is raised, ADH output is increased and as a
result, water reabsorption by the cells in distal convoluted tubules and
collecting ducts is increased, reducing the blood osmotic pressure and
ADH output.

WATER BALANCE
 When blood volume is increased, stretch receptors in the atria of the heart
release atrial natriuretic hormone (ANP).
 This reduces reabsorption of sodium and water by PCT and collecting
ducts, meaning that are more sodium and water are excreted.
 In turn this reduces blood volume

WATER BALANCE
(atrial natriuretic hormone)

ELECTROLYTE BALANCE
The changes in electrolytes concentration may occurs due to changes in:
Body water content or
Electrolyte levels
Sodium and potassium concentration
 Sodium is the positively charged cation in ECF and potassium is
negatively charged found most commonly in ICF.
 Sodium is a constituent of almost all foods and it is added to food during
cooking.
 It is excreted mainly in urine & sweat.
 Sodium is the normal constituent of urine and amount excreted is regulated
by aldosterone hormone, secreted by the adrenal cortex.

ELECTROLYTE BALANCE
The cells of kidney are stimulated to produce renin enzyme by
sympathetic stimulation, low blood volume or low blood pressure
Renin converts the plasma angiotensinogen (liver)to angiotensin-I
Angiotensin converting enzyme (ACE), formed in the lungs converts
angiotensin-I into angiotensin-II which is a potent vasoconstrictor and
increases the blood pressure.
Water is reabsorbed with sodium and together they increase the blood
volume and blood pressure.

ELECTROLYTE BALANCE
 When sodium reabsorption is increased, potassium excretion is
increased, indirectly reducing intracellular potassium.
 Normally the renal mechanism maintains the concentration of sodium
and potassium within the physiological limits.
 Sodium and potassium occur in high concentrations indigestive
juices - sodium in gastric juice and potassium in pancreatic & intestinal
juice.
 Normally these ions are reabsorbed by the colon but following acute &
prolonged diarrhoea they may be excreted in large quantities with

RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Stimuli that initiate the renin–angiotensin–aldosterone
pathway include dehydration, Na+ deficiency or hemorrhage.
These conditions cause a decrease in blood volume.
Decreased blood volume leads to decreased blood pressure.
Lowered blood pressure stimulates juxtaglomerular cells of kidney, to
secrete the enzyme renin.
The level of renin in blood increases.
Renin converts angiotensinogen, plasma protein produced by the liver, into
angiotensin 1.
blood containing increased levels of angiotensin 1 circulates in the body.

 Angiotensin converting enzyme (ACE) in the lungs converts angiotensin 1 into
angiotensin 2.
 Angiotensin 2 stimulates the adrenal cortex to secrete aldosterone.
 In the kidneys, aldosterone increases reabsorption of Na+ and water and increases
secretion of K+ and H+ into the urine.
 With increased water reabsorption by the kidneys, blood volume increases.
 As blood volume increases, blood pressure increase to normal.
 Angiotensin-II also stimulate concentration of smooth muscle in the walls of
arterioles. The resulting vasoconstriction of the arterioles increase blood pressure.

ACID –BASE BALANCE
 In order to maintain the normal pH of blood, the cells of PCT secrete
hydrogen ions.
 In the filtrate they combine with buffers:
Hydrogen ions + Bicarbonate = Carbonic acid
(H++ HCO3 --» H2C03)
Hydrogen ions + Ammonia = Ammonium ions
(H+ + NH3 --» NH+4)
Hydrogen ions +Hydrogen phosphate = Dihydrogen phosphate
(H+ + HPO23---» H2PO3-)

ACID –BASE BALANCE
Carbonic acid is converted to carbon dioxide (CO2) and water(H2O), and
the CO2 is reabsorbed maintaining the buffering capacity of the blood.
Hydrogen ions are excreted in the urine as ammonium salts & hydrogen
phosphate.
The normal pH of urine varies from 4.5 to 8 depending on diet, time &
variety of other factors.

BLOOD SUPPLY OF KIDNEY
 Arterial supply by Renal
artery, branches of
abdominal aorta
 Vein drain from kidney
through renal vein to
Inferior vena cava

BLOOD SUPPLY OF KIDNEY FLOW CHART

NERVE SUPPLY AND LYMPHATIC DRAINAGE
NERVE SUPPLY-
Renal plexus, an offshoot of coeliac
plexus. It contains postganglionic
fibers from the sympathetic nervous
system (T10 to L1) which are Afferent
nerves of kidney belong to segment
T10-T12.
 LYMPHATIC DRAINAGE-
Lymphatic drain into the lateral aortic
lymph nodes which are located at level
of origin of renal arteries.

THE URETERS
 The ureters carry urine from the kidneys to urinary
bladder.
 Length :25-30 cm long
 Diameter : 3mm.
 The ureters is continuous with funnel shaped renal
pelvis.

THE URETERS
 It passes down through the abdominal cavity, behind the peritoneum
in front of psoas muscle into pelvic cavity , and passes obliquely
through the posterior wall of the bladder.
 This arrangement as urine accumulate and the pressure in the bladder
rises, the ureters are compressed and the openings into the bladder
are occluded

STRUCTURE OF URETERS
Consists of 3 layers of tissue:
 An outer covering of fibrous
tissue.
 A middle muscular layer consisting
of interlacing smooth muscle fibres.
 An inner layer, the mucosa,
composed of transitional
epithelium.

FUNCTION
Propel urine from the kidneys into the bladder by peristaltic contraction
of the smooth muscle layer.
The ureters work constantly, emptying urine into the bladder
about every 10 to 15 seconds.

URINARY BLADDER
 A hollow, muscular, pear shaped organ for storage of urine.
 Can stored up to 500 ml of urine.
 Lies in the pelvic cavity.
 When distended, the bladder rises into the abdominal cavity.
 Voiding takes place by contractions of the bladder, which forces urine
through the urethra and to the outside opening, the urinary meatus.

ORGAN ASSOCIATED TO URINARY BLADDER

SHAPE OF BLADDER
An empty bladder is 4 sided pyramid in
shape and has
• 4 Angles- an apex, neck and 2 lateral
angles
• 4 surfaces
• Base (posterior surface)
• 2 Inferio-lateral surface
• Superior surface
When distended it is ovoid in shape

STRUCTURE
The bladder wall is composed of three layers:
• The outer layer of
• loose connective tissue, containing
blood lymphatic vessels and nerves.
• The middle layer
• smooth muscle fibers and elastic
tissue , this is called the destrusor
muscle and when it contracts, it
empties the bladder.
• The inner mucosa,
• composed of transitional epithelium
that readily permits distension of the
bladder as it fills

INTERIOR OF BLADDER
The mucous membrane is straw colored and is
thrown into folds. when bladder is distended,
these folds disappear
The posterior wall shows a smooth triangular
area called trigone. There are no mucous fold in
this region.
At the upper lateral angles of the trigone are the
ureteric opening
At its inferior angle is the internal urethral of
orifice.

URETHRA
• The urethra is canal extending from the neck of the bladder to the exterior,
at the external urethral orifice. It is longer in the male than in the female.

FEMALE URETHRA
 3 to 4 cm long
 External urethral orifice
 between vaginal orifice and clitoris
 Internal urethral sphincter
 detrusor muscle thickened, smooth muscle,
involuntary control.
 External urethral sphincter
 skeletal muscle , voluntary control
 The mucosa is supported by loose
fibroblastic connective tissue containing
blood vessels and nerves

MALE URETHRA
18 cm long
Internal urethral sphincter
External urethral sphincter
3 regions
Prostatic urethra
During organism receives
semens
Membranous urethra
passes through pelvic cavity
Penile urethra

MICTURITION
 Micturition is a process by which urinary
bladder empties when it becomes filled.
 When smooth muscle in the wall
of the bladder stretches, the
micturition reflex (urination) is
triggered.
 Begins in 5 month of uterine life.
 Remain reflex up to 2-21/2
year of age.
i. Filling of bladder- progressively
till the tension of the wall rise
above threshold.
ii. Emptying of bladder-nervous
reflex-micturition reflex that
emptied the bladder or at least
conscious desire of urination.

MICTURITION
Urine produced in the kidneys travels
down the ureters into the urinary
bladder. The bladder expands like an
elastic sac to hold more urine. As it
reaches capacity, the process of
micturition, or urination, begins.
Involuntary muscle movements send
signals to the nervous system, putting
the decision to urinate under conscious
control.

MICTURITION
The internal urethral sphincter and the
external urethral sphincter both provide
muscle control for the flow of urine. The
internal sphincter is involuntary. It
surrounds the opening of the bladder to
the urethra and relaxes to allow urine to
pass. The external sphincter is voluntary.
It surrounds the urethra outside the
bladder and must be relaxed for
urination to occur.

MICTURITION
• The bladder is shaped like a
pyramid when empty. It becomes
more oval as it fills with urine and
expands. A smooth muscle called
the detrusor surrounds the bladder,
and folds called rugae line the
interior wall. These structures give
the bladder elasticity and allow it
to expand. The floor of the bladder
includes a funnel-like region called
the trigone, formed by the two
ureteral orifices and the internal
urethral sphincter. Urine flows into
the bladder via the ureteral orifices
and out through the internal
sphincter.

MICTURITION
Micturition, or urination, is the act of
emptying the bladder. When the bladder
is full of urine, stretch receptors in the
bladder wall trigger the micturition
reflex. The detrusor muscle that
surrounds the bladder contracts. The
internal urethral sphincter relaxes,
allowing for urine to pass out of the
bladder into the urethra. Both of these
reactions are involuntary. The external
urethral sphincter is voluntary. It must
be relaxed for urine to flow through the
urethra and outside the body.

MICTURITION
The bladder expands as urine flows in
from the ureters, but there is a limit to
the volume it can contain. At about 200
ml of urine, the detrusor muscle begins
to contract and the internal urethral
sphincter muscle begins to relax. This
sends signals through the nervous
system and creates the “urge” to urinate.
If this urge is ignored, continence may
be threatened. At about 500 ml,
detrusor muscle contractions begin to
force open the internal urethral
sphincter. Unless the external urethral
sphincter is powerful enough to prevent
it, micturition (urination) will occur
involuntarily.

MICTURITION
Smooth muscle stretch initiates the
micturition reflex by activating stretch
receptors in the bladder wall. This
autonomic reflex causes the detrusor
muscle to contract and the internal
urethral sphincter muscle to relax,
allowing urine to flow into the urethra.
The stretch receptors also send a
message to the thalamus and the
cerebral cortex, giving voluntary control
over the external urethral sphincter. We
usually gain this control of urination
between the ages of 2 and 3, as our
brains develop.

FUNCTION OF KIDNEY
 Excretory function
 Homeostatic function
 Endocrine function
 Metabolic function

EXCRETORY FUNCTION
• This include formation and
excretion of urine.
• The main step involved are
– Glomerular filtration
– Tubular reabsorption
– Tubular secretion

HOMEOSTATIC FUNCTIONS OF URINARY SYSTEM
1. Regulate blood volume and
blood pressure:
• by adjusting volume of water
lost in urine
• releasing erythropoietin and
renin
2. Regulate plasma ion
concentrations:
• sodium, potassium, and
chloride ions (by controlling
quantities lost in urine)
• calcium ion levels

CONT..
3. Help stabilize blood pH:
 by controlling loss of
hydrogen ions and
bicarbonate ions in urine
4. Conserve valuable nutrients:
 by preventing excretion
while excreting organic waste
products

ENDOCRINE FUNCTIONS…
 Kidneys have primary endocrine
function since they produce hormones
 In addition, the kidneys are site of
degradation for hormones such as
insulin and aldosterone.
 In their primary endocrine
function, the kidneys produce
erythropoietin, renin and
prostaglandin.
 Erythropoietin is secreted in response
to a lowered oxygen content in the
blood. It acts on bone marrow,
stimulating the production of red blood
cells.

CONT..
 Renin -the primary stimuli for renin release include reduction of renal
perfusion pressure and hyponatremia. Renin release is also influenced by
angiotensin II and ADH.
 It is a key stimulus of aldosterone release. The effect of aldosterone is
predominantly on the distal tubular network, effecting an increase in
sodium reabsorption in exchange for potassium.
 The kidneys are primarily responsible for producing vitamin D3
from dihydroxycholecalciferol

THE EFFECTS OF AGEING ON URINARY SYSTEM
The kidney have a substantial functional reserve; the loss of one kidney
does not cause problems in an otherwise healthy individual.
The number of nephrons declines with the age, glomerular filtration rate
falls and the renal tubules function less efficiently; the kidneys become less
able to concentrate urine.

THE EFFECTS OF AGEING OF URINARY SYSTEM
Elimination of drugs also becomes less efficient with declining kidney
function which may lead to accumulation and toxicity.
The ability to inhibit contraction of detrusor muscle declines may result in
urgent need to pass urine and urinary frequency .
Nocturia becomes increasingly common in older adults
Blood vessels supplying the kidney can become hardened. This causes
kidney to filter blood more slowly.
The bladder muscle weakened.

THE EFFECTS OF AGEING OF URINARY SYSTEM
IN MALE
• The urethra can become blocked
by enlarged prostate gland.
• such as leakage or urinary
incontinence (not being able to
hold your urine), or urinary
retention (not being able to
completely empty your bladder)
IN FEMALE
• The urethra can become partially
or totally blocked.
• This can be due to weakened
muscles that can cause the
bladder or vagina to fall out of
position(prolapse).

ASSESSMENT OF THE URINARY SYSTEM
Safety considerations:
• Perform hand hygiene.
• Introduce yourself to patient.
• Confirm patient ID using two patient identifiers (e.g., name
and date of birth).
• Explain process to patient.
• Be organized and systematic in your assessment.
• Use appropriate listening and questioning skills.
• Listen and attend to patient cues.
• Ensure patient’s privacy and dignity.

• Nursing Assessment
• History of UTI and other disease, Age , Pain location, duration, fever, chills,
hematuria, renal calculi, vaginal infections, discharge, contraceptive practices etc.
• Assess for the following subjective and objective data:
• Decreased urine output or oliguria (reduced urine volume)
• Swelling or edema in the hands, feet, or face
• Fatigue and weakness
• Shortness of breath or difficulty breathing
• Nausea, vomiting, or loss of appetite
• Confusion or altered mental status
• Abdominal pain or discomfort
• High blood pressure
• Irregular heart rhythm or palpitations
• Signs of fluid overload

ASSESSMENT
• Assessment and monitoring of renal function
• Fluid and electrolyte balance management
• Identification and treatment of the underlying cause
• Prevention and management of complications (e.g., electrolyte
imbalances, metabolic acidosis)
• Monitoring and management of fluid overload or Dehydration
• Hemodynamic stability and Blood Pressure control
• Education on self-care and Compliance with treatment plans

PHYSICAL EXAMINATION
• A careful history and assessment of symptoms will suggest whether a complete or limited
examination is indicated, and also help direct the appropriate selection of subsequent
diagnostic studies.
• Inspection: A mass that is visible in the upper abdominal area may be difficult to palpate if
soft, as with hydronephrosis. Fullness in the costovertebral angle may be consistent with
cancer or perinephric infection. The presence and persistence of indentations in the skin from
lying on wrinkled sheets suggest edema of the skin secondary to perinephric abscess.
• Palpation: The kidneys lie rather high under the diaphragm and lower ribs and are therefore
well protected from injury. Because of the position of the liver, the right kidney is lower than
the left. The kidneys are difficult to palpate in men because of (1) resistance from abdominal
muscle tone and (2) more fixed position than in women, moving only slightly with change of
posture or respiration. The lower part of the right kidney can sometimes be felt, particularly in
thin patients, but the left kidney usually cannot be felt unless it is enlarged or displaced.
• The most successful method of renal palpation is carried out with the patient lying in the
supine position on a hard surface. The kidney is lifted by one hand in the costovertebral angle
(CVA). On deep inspiration, the kidney moves downward; the other hand is pushed firmly and
deeply beneath the costal margin in an effort to trap the kidney. When successful, the anterior
hand can palpate the size, shape, and consistency of the organ as it slips back into its normal
position.

Method of palpation of the kidney. The
posterior hand lifts the kidney upward. The
anterior hand feels for the kidney. The patient
then takes a deep breath; this causes the kidney
to descend. As the patient inhales, the fingers
of the anterior hand are plunged inward at the
costal margin. If the kidney is mobile or
enlarged, it can be felt between the two hands.

• Alternatively, the kidney may be palpated with the examiner standing behind
the seated patient. At other times, if the patient is lying on one side, the
uppermost kidney drops downward and medially, making it more accessible to
palpation. Perlman and Williams (1976) described an effective method of
identifying renal anomalies in newborns. The fingers are placed in the
costovertebral angle, with the thumb anterior and performing the palpation.
• An enlarged renal mass suggests compensatory hypertrophy (if the other kidney
is absent or atrophic), hydronephrosis, tumor, cyst, or polycystic disease.
However, a mass in this area may also represent a retroperitoneal tumor, spleen,
lesion of the bowel (eg, tumor, abscess), lesion of the gallbladder, or pancreatic
cyst. Tumors may have the consistency of normal tissue ...

• Physical examination focuses on the costovertebral angle, abdomen, rectum, groin, and genitals. In
women with urinary symptoms, pelvic examination is usually done.
• Costovertebral angle
• Pain elicited by blunt striking of the back, flanks, and angle formed by the 12th rib and lumbar spine
with a fist (costovertebral tenderness) may indicate pyelonephritis, calculi, or urinary tract obstruction.
• Abdomen
• Visual fullness of the upper abdomen is an extremely rare and nonspecific finding of a kidney or
abdominal mass. Dullness to percussion in the lower abdomen suggests bladder distention; normally,
even a full bladder cannot be percussed above the symphysis pubis. Bladder palpation can be used to
confirm distention and urinary retention.
• Rectum
• During digital rectal examination, prostatitis may be detected as a boggy, tender prostate. Focal
nodules and less discrete hard areas must be distinguished from prostate cancer. The prostate may be
symmetrically enlarged, rubbery, and nontender with benign prostatic hyperplasia.

• Groin and genitals
• Inguinal and genital examination should be done with patients standing. Inguinal hernia or
adenopathy may explain scrotal or groin pain. Gross asymmetry, swelling, erythema, or
discoloration of the testes may indicate infection, torsion, tumor, or other mass. Horizontal
testicular lie (bell-clapper deformity) indicates increased risk of testicular torsion. Elevation of
one testis (normally the left is lower) may be a sign of testicular torsion. The penis is examined
with and without retracting the foreskin. Inspection of the penis can detect
• Hypospadias or epispadias in young boys
• Peyronie disease in men
• Priapism, ulcers, and discharge in either group
• Palpation may reveal an inguinal hernia. Cremasteric reflex may be absent with testicular
torsion. Location of masses in relation to the testis and the degree and location of tenderness
may help differentiate among testicular masses (eg, spermatoceles, epididymitis, hydroceles,
tumors). If swelling is present, the area can be transilluminated to help determine whether the
swelling is cystic or solid. Fibrous plaques felt in the penile shaft are signs of Peyronie disease.

TESTICULAR AND SELF EXAMINATION
• Urinalysis is critical for evaluating urologic disorders. Imaging tests (eg,
ultrasonography, CT, MRI) are frequently required. For semen testing, see
Sperm Disorders.
• Bladder tumor antigen testing for transitional cell cancer of the urinary tract is
more sensitive than urinary cytology in detecting low-grade cancer; it is not
sensitive enough to replace endoscopic examination. Urine cytology is the best
test to detect high-grade cancer.
• Prostate-specific antigen (PSA) is a glycoprotein with unknown function
produced by prostatic epithelial cells. Levels can be elevated in prostate cancer
and in some common noncancerous disorders (eg, benign prostatic hyperplasia,
infection, trauma). PSA is measured to detect recurrence of cancer after
treatment; its widespread use for cancer screening is controversial.

DIGITAL RECTAL EXAMINATION
A digital rectal exam (DRE) is a test that
examines a person's lower rectum, pelvis,
and lower belly. This test can help your
doctor check for cancer and other health
problems, including:
•Prostate cancer in men
•An abnormal mass in the anus or rectum
•Uterine cancer or ovarian cancer in
women, along with a vaginal examination
Rectal bleeding or blood in the stool
A change in bowel habits, Discharge or
bleeding from the urethra, the tube that
carries urine out of the body
A change in how urine flows

DIGITAL RECTAL EXAMINATION
The patient lies on the left side with the
buttocks near the edge of the examining table
or bedside with the right knee and hip in slight
flexion. The proctologic (knee–chest or prone
jackknife) position is the preferred position in
which to examine the perineum and rectum
properly.

URINALYSIS
A urinalysis is a test of
urine. It is often done to
check for a urinary tract
infections, kidney
problems, or diabetes. if
you are admitted to the
hospital, before you have
surgery, or if you are
pregnant. It can also
monitor some medical
conditions and treatments.

RENAL ANGIOGRAPHY
A renal artery angioplasty and stent is done to treat a narrowed renal artery.
Using X-rays as a guide, a small plastic tube is put into the narrowed artery. A
special balloon on the tube is blown up to open the narrowed part of the
artery. An expandable tube called a stent is then put in to keep the artery
open. The whole process normally takes between 30 and 90 minutes.

RENAL SCAN
A cannula is placed in a vein in arm and will be administered with a small
injection of a radioactive tracer is administered through the cannula. This
injection allows the Kidneys and Bladder to be seen by the camera. Images
are taken for a 30 minutes whilst lying under the camera.
Diethylenetriamine penta acetate is a medicine that can bind to
radioactive plutonium, americium, and curium to decrease the
amount of time. it takes to get radioactive plutonium, americium,
and curium out of the body.

CYSTOSCOPY/ CYSTOMETROGRAM
During a cystoscopy, a cystoscope is inserted through the urethra into the

During a ureteroscopy, a ureteroscope is inserted through the urethra and
into the ureter

• Cystoscopy and ureteroscopy are common procedures performed by a
urologist to look inside the urinary tract.
• Cystoscopy is a procedure that uses a cystoscope to look inside the
urethra and bladder. A cystoscope is a long, thin optical instrument with
an eyepiece at one end, a rigid or flexible tube in the middle, and a tiny
lens and light at the other end of the tube. A urologist fills the bladder with
fluid and looks at detailed images of the urethra and bladder linings on a
computer monitor.
• Ureteroscopy is a procedure that uses a ureteroscope to look inside the
ureters and kidneys. Like a cystoscope, a ureteroscope has an eyepiece
at one end, a rigid or flexible tube in the middle, and a tiny lens and light
at the other end of the tube. However, a ureteroscope is longer and
thinner than a cystoscope so the urologist can see detailed images of the
lining of the ureters and kidneys.

• During a cystoscopy, a urologist can see
• stones—solid pieces of material in the bladder formed by high concentrations of minerals in the urine
• abnormal tissue, tumors, or cancer in the urethra or bladder
• stricture, a narrowing of the urethra—a possible sign of an enlarged prostate in men or of scar tissue
in the urethra
• secondary signs of obstruction (or blockage), such as an enlarged prostate gland
• other congenital or acquired abnormalities such as duplicated ureters, ureterocele, or diverticulum
• During a cystoscopy, a urologist can sometimes treat problems, such as bleeding in the bladder and
blockage in the urethra. A urologist may also use a cystoscopy to
• remove a stone in the bladder or urethra
• remove or treat abnormal tissue and tumors
• take a sample of the urethra or bladder tissue for a biopsy
• inject material into the wall of the urethra to treat urinary leakage or prevent vesicoureteral reflux
• inject medicines into the bladder to treat urinary leakage
• obtain urine samples from the ureters
• perform retrograde pyelography—an x-ray procedure in which a urologist injects a special dye into
the urinary tract to create images of urinary flow, to show obstructions such as kidney stones and
tumors
• remove a stent that was placed in the ureter after a ureteroscopy with biopsy or stone removal

CONTRAST STUDIES IVP
• IVP uses contrast dye to make these organs show up well on x-ray images.
In males, x-rays from an IVP can also show the prostate. The prostate is a
gland in the male reproductive system. It lies just below the bladder and
makes the fluid part of semen.
• During an IVP, contrast dye is injected into a vein using an intravenous
(IV) line. The dye travels through your bloodstream to your kidneys, which
filter it out. The dye collects in the organs of your urinary tract and makes
them look bright white on the x-rays. This allows your health care provider
to see blockages or other problems that affect your urinary organs.
• IVP isn't commonly used anymore. Instead, providers usually order
CT (computerized tomography) scans to see the urinary tract. CT scans can
provide more information than x-rays from an IVP. But IVP may be useful
in certain situations.

INDICATION
• Pain in your side or back
• Sharp pains in your abdomen (belly), side, groin or back
• Blood in your urine
• Cloudy or bad-smelling urine
• Pain when urinating (peeing)
• Needing to urinate frequently, or not being able to urinate
• Nausea and vomiting
• Swelling in your feet or legs
• Fever and chills

STEPS
• An IVP may be done in your provider's office or a hospital. The test is often done by a
radiology technician (a health care professional who is trained to do x-ray exams). The
procedure takes about an hour and generally includes these steps:
• You'll usually remove your clothing and put on a gown.
• You'll lie down on your back on an x-ray table. The technician will take an x-ray to make sure
the machine is set right for you.
• The technician will insert an IV into a vein in your arm or hand and inject the contrast dye.
• Several x-rays will be taken to see how your kidneys filter the dye. You may be asked to move
into different positions.
• The technician may wrap a special belt tightly around your belly. This helps keep the contrast
dye in your kidneys. After the belt is removed, more x-rays will be taken to show the dye
passing from your kidneys through your ureters and into your bladder.
• Before the IVP is finished, you'll be asked to use the bathroom or a bedpan to urinate. Then
the last x-rays will be taken to see if any urine remains in your bladder. This shows how well
your bladder works to empty urine.
• After the test, drinking plenty of fluids will help flush the contrast dye out of your body.

LITHOTRIPSY
• Lithotripsy is a non-invasive procedure that uses high-energy
shock waves or lasers to break down and eliminate
bothersome stones in the kidney, quickly and effectively.
During the procedure, a special machine called a lithotripter
generates the shock waves that travel into your body and break
apart the stones.
• Pre Procedure
• You must stop taking blood thinners 4 days prior to the
procedure, as these can interfere with your blood’s ability to
clot properly.
• There are no food or dietary restrictions before the procedure.

LITHOTRIPSY
• During Procedure
• The procedure is completed in one sitting in a day, depending on the size and type of stones. The
procedure usually takes about 30 to 90 minutes to perform.
• You are settled comfortably in an area where your privacy is respected throughout the procedure.
• Before the procedure, you will be asked to remove any jewellery or other objects that may
interfere with the procedure.
• You will be asked to change into a hospital gown and lie on a bed and positioned on a soft,
transparent cushion-like apparatus attached to the bed.
• Your vital parameters will be checked before the procedure.
• During the procedure, high-energy shock waves will be transmitted through your body through the
cushion-like apparatus, until they reach the kidney stones. A computerized USG machine is used
to accurately locate the stone within the kidney. The shock waves are accurately targeted at the
stones. The waves will break the stones into very small pieces that can easily be passed through
your urinary system.
• A constant tik-tik sound comes from the lithotripter. It is heard during the entire process. If the
sound irritates you, you can ask for soft, rubber disposable earplugs available with the technician.

LITHOTRIPSY
• Post Procedure
• After the procedure, you will be required to spend about one hour
in recovery/observation before being sent home.
• During this time, some patients may experience bruising, soreness,
giddiness and vomiting which will subside in some time.
• You must drink plenty of water for several days after lithotripsy.
This will help the kidneys flush out any remaining stone fragments.
• Some patients may experience slight pain or a burning sensation
during urination, for which antibiotics are prescribed.
• A diet chart is given to you that needs to be adhered to, post the
procedure.

RENAL/PROSTATE BIOPSY
• Kidney biopsy is also called renal biopsy is a procedure during which a small
piece of kidney tissue is removed and examined under microscope with a
variety of stains to identify the underlying disease which is affecting the kidney
function. The procedure of kidney biopsy is generally safe and can provide
valuable information regarding the underlying kidney disease and helps in
treatment.
• Kidney biopsy is recommended in people with kidney disease. Based on the
results of urine and blood tests nephrologist will advice the kidney biopsy. The
most common reasons for kidney biopsy are as follows. More than one reason
may be present in a given patient.Blood in the urine (called haematuria)
• Protein in the urine (called proteinuria)
• Problems with kidney function (if the kidneys function declines slowly or
suddenly and the cause is not clear)

• Procedure for kidney biopsy
• During the procedure patient will lie on his abdomen with back facing the roof and will
be awake. For patients who are renal transplant recipient’s biopsy is done with patient
lying on back. Kidney biopsy procedure included following stepsUsing an ultrasound
machine probe, size of the kidneys and position of the kidneys are assessed first and then
a site is identified to insert the kidney biopsy needle
• Skin over the back where the site of entry is marked is cleaned with antiseptic
• A local anaesthetic medication is injected with a syringe with needle at the site of entry
to numb the area
• Using the ultrasound probe as a guide, a biopsy needle (a spring-loaded instrument) is
inserted and sample of kidney is collected
• Patient is asked to hold the breath while collecting the sample and patient hears a pop
sound or sharp clicking sound or feel some pressure
• Biopsy needle maybe inserted few times to get adequate sample
• Once the procedure is completed a bandage is placed over the biopsy site

• Post procedure care
• Patient is admitted in hospital over night after the biopsy to
monitor for complications. Immediately after the procedure
biopsy site is compressed and patient lies on his back. His
pulse rate and blood pressure are monitored every 30 minutes
for 6 hours. Patient is given transparent containers to collect
urine each time he passes so that if any bleeding happens will
be identified. After 6 hours patient can move in bed to sides
but strict bed rest is advised overnight. Next day morning his
blood pressure and pulse rate is checked and if there is no
complication (like blood in urine) patient is discharged.

PROSTATE BIOPSY
The prostate is a small, walnut-shaped gland in men that produces fluid
that nourishes and transports sperm. A prostate biopsy is a procedure to
remove samples of suspicious tissue from the prostate. It is performed by
an urologist, who is a doctor specialized in the urinary system and men’s
sex organs.

PROSTATE BIOPSY
• A prostate biopsy is usually performed on Day ward. Procedures may vary depending on your condition
and your doctor practices.
• During a prostate biopsy, a fine needle is used to collect a number of tissue samples from your prostate
gland. Generally, doctors collect prostate biopsy samples through the wall of the rectum. This is called a
trans-rectal prostate biopsy. Less often, the prostate is accessed through the tip of the penis (urethra), or
through the space between the anus and scrotum (perineum).
• For a trans-rectal prostate biopsy, your doctor will start by having you lie on your side, with your knees
pulled up to your chest.
• After cleaning the biopsy area and applying numbing gel, your doctor will gently insert a thin ultrasound
probe into your rectum. Trans-rectal ultrasonography is used to create images of your prostate using sound
waves. Your doctor will use the image to identify the area that needs to be numbed with an anesthetic
injection, if one is used. It’s also used to guide the prostate biopsy device into place.
• Once the biopsy device is into the right place in the prostate, your doctor will retrieve thin, cylindrical
sections of tissue with a hollow, spring-propelled needle. The procedure typically causes a very brief,
uncomfortable sensation each time the fine needle takes a sample. Your doctor may target a suspicious area
to biopsy, or may take samples from several places in your prostate. In most cases, doctor will take 10 to
12 tissue samples or more if necessary. The entire procedure usually takes about 20 to 30 minutes.
• Tissue samples from the prostate biopsy are sent to a specialized pathology laboratory and examined under
a microscope for cell abnormalities that are a sign of prostate cancer. If cancer is present, it is evaluated to
determine how quickly it is likely to grow and spread and to determine your best treatment options.

PROSTATE BIOPSY
• After a prostate biopsy, you’ll probably need to continue
taking an antibiotic for a few days. You may feel slight
soreness and have some light bleeding from your rectum.
You may have blood in your urine or stools for a few days.
You may also notice that your semen has a pinkish tint
caused by a small amount of blood in your semen. This
can last for more than a month.
• Call your doctor or come to the hospital if you have:
• Prolonged or heavy bleeding
• Pain that gets worse
• Swelling near the biopsy area
• Difficulty urinating

URODYNAMIC TESTING
An urodynamic study is an
examination and assessment
of a patient's bladder
muscles and the sphincter to
determine whether or not
they are functioning and
contracting correctly.
An urodynamic study will
measure the pressure in the
bladder while water flows
through and out of the
bladder.

SPECIFIC TEST-SEMEN, GONORRHEA

GONORRHEA TEST
Caused by bacteria Neisseria gonorrhoeae
gonorrhea is common and can be cured.
It is the second most commonly communicable disease
An estimated 820,000 new infections each year in US.

CATHETERIZATION CARE
• A Foley catheter is a rubber tube inserted into bladder. Once
the catheter is in bladder, a small balloon is inflated at the tip
of the tube to hold the catheter in place. The purpose of the
catheter is to drain urine from bladder.
The size of a urinary catheter is based on the
French (Fr) scale, which reflects the internal
diameter of the tube. Recommended catheter
size is 12 to 16 Fr for females, and 14 to 16 Fr
for males. Smaller sizes are used for infants
and children. The balloon size also varies with
catheters: smaller for children (3 ml) and larger
for continuous bladder irrigation (30 ml). The
size of the catheter is usually printed on the
side of the catheter port.

• Female patient: On back with knees flexed and thighs relaxed
so that hips rotate to expose perineal area. Alternatively, if
patient cannot abduct leg at the hip, patient can be side-lying
with upper leg flexed at knee and hip, supported by pillows.
• Male patient: Supine with legs extended and slightly apart.

• In most cases, a urinary catheter is used in people who are unable to pass urine
naturally because of an illness or injury. Common medical conditions requiring for
urinary catheterisation include:
• Urinary incontinence: difficulty controlling when to urinate or leakage of urine,
caused by bladder weakness or a medical condition, including multiple sclerosis or
an injury in the spinal cord.
• Urinary retention: difficulty emptying the bladder when urinating. This can
happen as a result of another medical condition such as benign prostatic
hyperplasia (BPH), prostatitis (inflammation of the prostate gland), a kidney stone
obstructing the urinary tract, damage to the nerve after a stroke, or a complication
from diabetes called diabetic peripheral neuropathy. Some medications can also
cause the side effects of urinary retention.
• Before or after a surgery, most often surgery of the prostate or genitals.
• In some instances, urinary catheters are used when conducting diagnostic tests.

• There are three primary types of urinary catheters: indwelling, external, and
intermittent catheters. A doctor or nurse would assess and recommend the type of
urinary catheter, as well as the size, based on the patient’s medical condition,
weight, age, and gender.
• Indwelling catheter, commonly referred to as Foley catheter – this type of
catheter remains in place for an extended period that could range from days to up to
12 weeks. It is held in place with a water-filled balloon inside the patient’s bladder.
Foley catheter is typically inserted through the urethra. In some cases, it is inserted
through a hole in the abdomen, and referred to as a suprapubic catheter.
• Intermittent catheter, also called short term catheter, or in and out catheter – it is
used temporarily to empty the bladder once, then removed. Intermittent
catheterisation needs to be done several times a day, at a designated interval or
when there is a need to pass urine. Traditional intermittent catheters can be washed
and reused. Disposable intermittent catheters are designed for one time use and
discarded.
• External catheter – this type of catheter is often used for male patients with
urinary incontinence rather than urinary retention.

• Urinary catheterisation process differs for different types of catheters. Indwelling or
Foley catheters are usually inserted by healthcare professionals, such as nurses in
clinics and hospitals. Daily care can be done at home by caregivers. Patients who
use urinary catheters permanently will also need professional help to remove and
replace catheters at least once every 2 months.
• Intermittent urinary catheterisation however can be done at home by a caregiver or
self-administered by the patient. As complex as it sounds, most patients and
caregivers report being able to carry out intermittent catheterisation with ease and
without discomfort after a few times.
• Below is a general description of the catheterisation process.
• For an indwelling or Foley catheter, the healthcare professional typically will:
• Perform hand hygiene
• If possible, place the patient on their back with knees bent and hips flexed.
• Use sterile gloves and other sterile materials to expose the urethra and insert the
lubricated catheter into the urethral opening until urine begins to flow.
• Inject sterile water to inflate the catheter inside the bladder.
• Attach the other end of the catheter tube to a drainage bag.

• For intermittent catheterisation, a nurse often instructs the caregiver or the patient
to carry out the process. If the patients are able to administer the catheter
themselves, the procedure is known as self-catheterisation or clean intermittent
catheterisation.
1. Hand hygiene: Wash hands thoroughly before the procedure and do not touch
anything but the catheter. You can use clean gloves.
2. Positioning: Have the patient lie on their back with knees bent and hips flexed, or
get in a comfortable sitting or standing position and use a mirror to guide yourself
for self-catheterisation. Special mirrors that can be attached to the leg are available
for this purpose, allowing patients to conduct self-catheterisation without having to
hold on to the mirror.
3. Insertion: Apply firm but gentle pressure to insert the lubricated end of the catheter
into the urethra. Then carefully guide the catheter up into the urethra until it gets to
the bladder and urine begins to flow out.
4. Urine collection and removal: Insert another two inches and allow the urine to
flow out into a collection container then carefully and slowly remove the catheter.

BLADDER IRRIGATION
• Bladder irrigation is a procedure used to flush sterile fluid through your
catheter and into your bladder. Bladder irrigation helps remove and prevent
blood clots in your bladder.
• The blood clots stop urine from flowing through your catheter. The urine
collects in your bladder and causes pain that gets worse as your bladder fills.
• Bladder irrigation may be needed after bladder or prostate surgery.
• Chemotherapy and radiation can also cause blood clots in your bladder.

ARTICLES
• Disposable gloves
• b)Mackintosh
• c)Three way retention catheter
• d)Sterile drainage tubing and bag in place
• e)Sterile antiseptic swab
• f)Sterile receptacle
• g)Sterile irrigation solution warmed or at room temperature.
• h)Normal saline
• i)Distilled water
• j)Solution as prescribed by physician
• k)Infusion tubing l)IV Stand m)Kidney tray n) paper bag

PROCEDURE
• 1. Check the physicians order for amount and strength of irrigating fluid andreason for
irrigation.
•
• 2. Preparatory phase :a) Explain the procedure and purpose to the client to reduce anxiety. b)
Provide privacy and drape the client. c) Empty, measure and record the amount and
appearance of urine present inthe urinary bag.
• 3. Prepare the equipments: a) Wash hands to reduce transmission of microorganism. b)
Connect the irrigation infusion tubing to the irrigating solution and flushthe tubing with
solution to remove air. c) Connect the irrigation tubing to the input port of the 3-way
catheter.Connect the drainage bag and tubing to the urinary drainage port if notalready in
place.
• 4 Irrigate bladder
• Intermittent irrigation . Instill the prescribed amount of irrigant. If specific amount is not
ordered,fill up to 150ml of irrigant. Clamp the irrigant tubing to prevent further filling of
irrigant.

PROCEDURE
• If physician has ordered the irritant to remain in the bladder for a measured length of time,
clamp the drainage tube and wait for the prescribed length of time. Open the drainage tube
(the clamp) and monitor the drainage bag.
• Continuous bladder irrigation. Adjust the clamp on the irrigation tube to allow the prescribed
rate of irrigation to flow into the catheter and bladder. Monitor the color, clarity, debris and
volume as it flows back into the drainage bag.
• Tape the catheter securely on the thigh to prevent catheter from dislodging.
•
• Assess the patient’s condition and tolerance of procedure.
• Discard all used disposable articles, clean and replace reusable articles.
•
• Wash hands to prevent cross infection. Record the procedure.

AMBULATION
• Ensure patient does not feel dizzy or lightheaded and is tolerating the the upright position.
• Instruct the patient to sit on side of the bedfirst,prior to ambulation.
• Ensure proper footwear is on patient and let patient know how far you will be ambulating, proper
footwear is non slip or slip resistantfootwear.
• Check physician`s orders for any activityrestrictions related to treatment or surgical procedures.
• Apply gait belt snugly around the patient`s waistif required.
• Assist patient by standing in front of the patient ,grasping each side of gait belt, keep back straightand
knees bent.
• While holding the belt, gently rock back and forththree time ,one third time ,pull patient into a stand
position.

AMBULATION
• Once patient is standing and feels stable move to the unaffected side and grasp the gait belt in the middle
of the back with the other handhold the patient hand closest to you.
• If the patient does not require a gait belt place hand closest to the patient around the upper arm and hold
the patient`s hand with your other hand.
• Before stepping away from the bed, ask the patient if they feel dizzy or lightheaded if they do sit patient
back down on the bed.
• If the patient feel stable begin walking matching your step to the patient, instruct patient is look ahead and
lift each foot off the ground.
• To help a patient back to bed have patient a stand with back of knees touching the bed grasp the gait belt
and help patient into a sitting position keeping your back straight and knees bent.
• When the patient is finished ambulating, remove gait belt and settle patient into bed or chair.
• Wash hands.

GLOMERULONEPHRITIS(GN)
DEFINITION:- Glomerulonephritis is a kidney condition that involves
damage/ inflammation to the glomeruli.
CAUSES:-Streptococcal infection of the throat and the skin(impetigo)
Immune diseases, diabetes, high blood pressure endocarditis viral infection like
HIV.
SYMPTOMS:-Flank pain , foamy urine , cola colour or diluted ice tea color
urine, haematuria, fluid retention, oliguria, dysuria, HTN.
DIAGNOSTIC EVALUATION: History collection, physical
examination ,urinalysis, biopsy intravenous pyelogram , blood test , USG
TREATMENT: Diuretics(frusemide), immunosuppressant , antihypertensive
drugs, Dialysis

URINARY INCONTINENCE
DEFINITION
• Incontinence is involuntary loss of urine from the bladder.
CAUSES :-
• D-delirium, I-infection, A-atrophic vaginitis, P-pharmaceuticals, P-
psychological disorder, E- endocrine disorder, R-restricted mobility
SYMPTOMS:-
• Stress incontinence occurs when :chough, sneeze, laughing, standing in prolonged
time
• Urge incontinence occurs: frequent urination, in a day and at night, Sudden
urination and urinary urgency
• Overflow incontinence occurs: bladder never feels empty, urine dribbles even after
voiding
TREATMENT:
Anticholinergic( medication to calm an overactive bladder )
Antidepressant, pelvic floor exercise , bladder training. kegel exercise

URINARY RETENTION
DEFINITION
• Inability to void even when the urge to void is present.
CAUSES:-
• Tumor, interference with the sphincter muscles during surgery, side effect
of medications
SYMPTOMS:-
• Frequency of urination, voiding small amounts, pain, palpation of a
distended bladder above the symphysis pubis
TREATMENT:-
Analgesic, colinergic medication, urinary catheter, surgery may be
performed to remove any obstruction .

URINARY TRACT INFECTIONS (UTI)
DEFINITION
• UTI is a bacterial infection in part of a urinary tract. When it
affects the lower urinary track it is known as simple cystits
(bladder infection).when it affects the upper urinary tract it is
known as pyelonephritis(kidney infection).
CAUSES:
• Urine is excellent medium for microorganism growth
• Escherichia coli.
• Females more anatomically vulnerable
• Older males with prostatic hypertrophy and retention of urine prone to
UTI

UTI
CYSTITIS—signs and symptoms
• Pain in lower abdomen, dysuria, frequency, urgency, inflammation of
bladder wall irritated by urine, systemic signs of infection
PYELONEPHRITIS—signs and symptoms
• Signs of cystitis, Dull aching pain in lower back that results from renal
capsule stretching, cloudy urine with unusual odor
DIAGNOSTIC EVALUATION:-
• History collection, physical examination,
• Urinalysis indicates bacteria (+100,000/ml), pyuria, microscopic
hematuria
TREATMENT
• Antibiotics (Bactrim),Increase fluid intake, Especially cranberry juice.

URINARY TRACT OBSTRUCTIONS: UROLITHIASIS
DEFINITION:
• Urolithiasis refers to stones (calculi) in the
urinary tract stones are formed in the urinary
tract when urinary concentrations of substance
such as calcium oxalate, calcium phosphate,
and uric acid increase.
CAUSES:-
• Chronic dehydration, poor fluid intake,
infection, urinary stasis, inflammatory bowel
disease, medication- antacids, acetazolamide
vitamin-d.

URINARY TRACT OBSTRUCTIONS: UROLITHIASIS
SIGN AND SYMPTOMS:-
• Pain : “renal colic” it consists of intense spasms in back and groin, hematuria,
edema, dysuria, nausea, vomiting, diarrhea, abdominal discomfort, chills and
fever.
DIAGNOSTIC EVALUATION:
• History taking, physical examination, urinalysis, blood studies, stone chemistry
radiographic studies
TREATMENT
• Small stones eventually passed out
• Larger stones: Extracorporeal shock-wave lithotripsy (ESWL)
• Some drugs can partially dissolve

NEPHROTIC SYNDROME
DEFINITION
• Nephrotic syndrome is a clinical disorder
characterized by marked increase of protein in the
urine (proteinuria),decrease in albumin in blood
(hypo-albuminemia), edema, and excess lipids in the
blood (hyperlipidemia).
ETIOLOGY
• Physiologic changes of the glomeruli interfere with
selective permeability,
CLINICAL MANIFESTATIONS
• Proteinuria; hypo-albuminemia, Generalized edema,
Anorexia, Fatigue, Oliguria

NEPHROTIC SYNDROME
DIAGNOSTIC EVALUATION
• History taking, physical examination, urinalysis, blood studies.
TREATMENT
• Treatment of causative glomerular disease, diuretics and angiotensin
converting enzymes inhibitors to control proteinuria, corticosteroids and
immunosuppressant's.
• General management of edema: sodium and fluid restriction.

ACUTE RENAL FAILURE
DEFINITION
• Acute renal failure is a sudden and almost
complete loss of kidney function caused by
failure of renal circulation or by glomerular or
tubular dysfunction.
ETIOLOGY
• Pre renal: hemorrhage, renal loses, anaphylaxis.
• Intra renal: prolonged renal ischemia,
nephrotoxic agent, heavy metals.
• Post renal: renal calculi, tumors, blood clots

ACUTE RENAL FAILURE
SYMPTOMS
• Nausea, weight loss, pale urine, hematuria, nocturnal urination, pain back
and side, Poor skin turgor, Urine output less than 400 mL/24 hours
TREATMENT
• Pharmacological management: Diuretics, Antibiotics
• Administer fluids, Dialysis
• Diet: High in carbohydrates; low in protein, potassium, and sodium

CHRONIC RENAL FAILURE
DEFINITION
• Chronic renal failure also known as chronic kidney disease, this is present
when GFR has fallen to around 20% of normal.
ETIOLOGY
• Hemorrhage, renal loses, anaphylaxis, prolonged renal ischemia, nephrotoxic
agent, heavy metals.

CHRONIC RENAL FAILURE
SYMPTOMS
• Headache, Lethargy, Anorexia, Pruritus, Anuria, Muscle cramps or
twitching, Dusky yellow-tan or gray skin color, Disorientation and mental
lapses, Anemia
TREATMENT:
• Dialysis, Renal transplant, Medications to treat symptoms
• Diet: High in calories; restricted protein, potassium, and sodium, Restricted
fluids

ASSIGNMENT
• Draw a diagram of kidney
• Draw a diagram of bladder
• Write the process of Urine formation
• Write a note on micturition

SUMMARY
• The organs of the urinary system include the kidneys, ureters, bladder, and
urethra.
• The kidneys remove metabolic waste products from the blood and secret
erythropoietin and renin.
• Urine travel through the ureters to bladder
• Stretching of the bladder triggers micturition reflex.
• Urine travels from the bladder through the urethra to outside world.

CONCLUSION
• Urinary system is helps to extract excess mineral or vitamins.
• Urinary system is maintain the acid base (pH) balance.
• Remove waste products and drugs from the body.
• Balance the body’s fluids.
• Control production of red blood cells.
• The urinary system filters waste and extra fluid from the blood stream.

RECAPTUALIZATION
Question. Define kidney
Answer. The kidneys are a pair of excretory organs situated on the
posterior abdominal wall, one on the vertebral column, behind the
peritoneum.
Question. What is the functional unit of kidney?
Answer. Nephron

RECAPTUALIZATION
Question. Explain the composition of urine?
Answer . Water (96 %),urea (2 %), uric acid, creatinine,
ammonia, sodium, potassium, chlorides, phosphates, sulphates
and oxalates (2 %).

RECAPTUALIZATION
Question. What is nephrotic syndrome?
Answer. Nephrotic syndrome is a clinical disorder characterized by marked
increase of protein in the urine (proteinuria),decrease in albumin in blood
(hypoalbuminemia), edema, and excess lipids in the blood (hyperlipidemia).

BIBLIOGRAPHY
BOOK REFERENCE:-
Wilson and Ross. Anatomy and Physiology in Health and Illness
12th
edition (International Edition) Anne Waugh Allison Grant.
ELSEVIER
INTERNET REFERENCE:
https://www.healthengine.com
https://www.donatingplasma.org
https://www.slideshare.net
https://en.m.Wikipedia.org

Genitourinary system Anatomy and Physiology.

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