This thesis investigates the role of large conductance calcium and voltage activated potassium (BK) channels in the neurodegenerative process caused by mutations in the cysteine string protein alpha (CSPα). CSPα is a molecular chaperone important for synaptic maintenance. A mutation in the CSPα gene causes adult onset neuronal ceroid lipofuscinosis (ANCL), a fatal neurodegenerative disease characterized by lysosomal accumulation in neurons. Previous studies found increased expression of BK channels in CSPα knockout mice, but the significance is unknown. This study examines BK channel expression levels at various ages in CSPα wild-type and knockout mice, and the effects of lysosome inhibition on BK channel levels, to better
This document discusses the 2012 US presidential election and the Obama campaign's mobile advertising strategy to engage Latino voters. It notes that the Latino population and Latino voters are growing significantly. The Obama campaign partnered with Adsmovil to target mobile ads at Latino voters in key swing states in order to promote the candidate's message, voter registration, and early voting. The objective was to engage Latino voters aged 18+ in strong Hispanic media markets across battleground states.
Liesbet is an HR consultant who works for SD Worx but is assigned to Shell. She works from home 3 days a week to avoid a long commute from Limburg to Brussels. Working from home allows her more flexibility and time to do personal tasks. While she misses the social interaction of working in an office, telecommuting has not negatively impacted her relationships with colleagues or managers. SD Worx is supportive of teleworking as long as work objectives are being met. Liesbet feels strongly aligned with SD Worx's values and sees herself remaining with the company long-term if their values do not change with upcoming leadership transitions.
El documento resume las principales innovaciones tecnológicas desarrolladas por el hombre a lo largo de la historia, desde las primeras herramientas de piedra y el fuego, hasta el desarrollo de la agricultura y la metalurgia en la Edad de los Metales. Más adelante, durante la Revolución Industrial, se inventaron máquinas como la máquina de vapor que permitieron la producción masiva y la organización fabril, así como nuevas fuentes de energía como el carbón. Finalmente, en épocas más recientes se han creado
Market Pulse is a professional market research and consulting firm located in Dhaka, Bangladesh that was founded in 2011. It provides a wide range of market research, social research, and consulting services. It has over 1500 trained field staff and experts in various fields. Market Pulse conducts quantitative and qualitative research studies for clients in various industries including pharmaceuticals, agriculture, and consumer products. Its mission is to provide reliable market intelligence and insights to help clients make important business decisions.
El zócalo del CPU es un dispositivo integrado a la placa base que soporta el procesador y le permite recibir energía e intercambiar información con otros componentes. Hay diferentes tipos de zócalos que son compatibles con ciertos procesadores. El zócalo se identifica al quitar la tapa de la computadora y exponer el procesador fijado en su zócalo correspondiente.
Karan Singh Chauhan is seeking a management role where he can help a company grow. He has over 6 years of experience in roles supporting financial inclusion programs and business development. Currently, he is a senior executive at Vakrangee Limited providing technical support to banking clients. Previously, he worked as a senior executive conducting web research, tender preparation and data entry to support business development. He holds a BSc in Computer Science and has skills in software, hardware, Microsoft Office and programming languages.
This thesis investigates the role of large conductance calcium and voltage activated potassium (BK) channels in the neurodegenerative process caused by mutations in the cysteine string protein alpha (CSPα). CSPα is a molecular chaperone important for synaptic maintenance. A mutation in the CSPα gene causes adult onset neuronal ceroid lipofuscinosis (ANCL), a fatal neurodegenerative disease characterized by lysosomal accumulation in neurons. Previous studies found increased expression of BK channels in CSPα knockout mice, but the significance is unknown. This study examines BK channel expression levels at various ages in CSPα wild-type and knockout mice, and the effects of lysosome inhibition on BK channel levels, to better
This document discusses the 2012 US presidential election and the Obama campaign's mobile advertising strategy to engage Latino voters. It notes that the Latino population and Latino voters are growing significantly. The Obama campaign partnered with Adsmovil to target mobile ads at Latino voters in key swing states in order to promote the candidate's message, voter registration, and early voting. The objective was to engage Latino voters aged 18+ in strong Hispanic media markets across battleground states.
Liesbet is an HR consultant who works for SD Worx but is assigned to Shell. She works from home 3 days a week to avoid a long commute from Limburg to Brussels. Working from home allows her more flexibility and time to do personal tasks. While she misses the social interaction of working in an office, telecommuting has not negatively impacted her relationships with colleagues or managers. SD Worx is supportive of teleworking as long as work objectives are being met. Liesbet feels strongly aligned with SD Worx's values and sees herself remaining with the company long-term if their values do not change with upcoming leadership transitions.
El documento resume las principales innovaciones tecnológicas desarrolladas por el hombre a lo largo de la historia, desde las primeras herramientas de piedra y el fuego, hasta el desarrollo de la agricultura y la metalurgia en la Edad de los Metales. Más adelante, durante la Revolución Industrial, se inventaron máquinas como la máquina de vapor que permitieron la producción masiva y la organización fabril, así como nuevas fuentes de energía como el carbón. Finalmente, en épocas más recientes se han creado
Market Pulse is a professional market research and consulting firm located in Dhaka, Bangladesh that was founded in 2011. It provides a wide range of market research, social research, and consulting services. It has over 1500 trained field staff and experts in various fields. Market Pulse conducts quantitative and qualitative research studies for clients in various industries including pharmaceuticals, agriculture, and consumer products. Its mission is to provide reliable market intelligence and insights to help clients make important business decisions.
El zócalo del CPU es un dispositivo integrado a la placa base que soporta el procesador y le permite recibir energía e intercambiar información con otros componentes. Hay diferentes tipos de zócalos que son compatibles con ciertos procesadores. El zócalo se identifica al quitar la tapa de la computadora y exponer el procesador fijado en su zócalo correspondiente.
Karan Singh Chauhan is seeking a management role where he can help a company grow. He has over 6 years of experience in roles supporting financial inclusion programs and business development. Currently, he is a senior executive at Vakrangee Limited providing technical support to banking clients. Previously, he worked as a senior executive conducting web research, tender preparation and data entry to support business development. He holds a BSc in Computer Science and has skills in software, hardware, Microsoft Office and programming languages.
The document discusses the organization of the human body. It describes that cells are the smallest living structures that make up tissues like epithelial, connective, nervous and muscular tissues. These tissues come together to form organs which combine into body systems. The key body planes (midsagittal, frontal, transverse) divide the body and directional terms are used to describe locations. The body contains cavities like the cranial cavity that holds the brain and abdominal regions like the epigastric region below the stomach.
NFMNT Chapter 13 Apply Standard Nutrition CareKellyGCDET
The document discusses the steps involved in developing a comprehensive care plan for clients. It explains that the care plan is created by an interdisciplinary team based on a client assessment to identify needs and objectives. The care plan aims to support the client's highest level of functioning and well-being. It also outlines the roles of nutrition professionals like registered dietitians in assessing clients, identifying nutrition problems, setting goals, and communicating as part of the care planning process.
Unveiling the Dynamic Personalities, Key Dates, and Horoscope Insights: Gemin...my Pandit
Explore the fascinating world of the Gemini Zodiac Sign. Discover the unique personality traits, key dates, and horoscope insights of Gemini individuals. Learn how their sociable, communicative nature and boundless curiosity make them the dynamic explorers of the zodiac. Dive into the duality of the Gemini sign and understand their intellectual and adventurous spirit.
B2B payments are rapidly changing. Find out the 5 key questions you need to be asking yourself to be sure you are mastering B2B payments today. Learn more at www.BlueSnap.com.
At Techbox Square, in Singapore, we're not just creative web designers and developers, we're the driving force behind your brand identity. Contact us today.
Implicitly or explicitly all competing businesses employ a strategy to select a mix
of marketing resources. Formulating such competitive strategies fundamentally
involves recognizing relationships between elements of the marketing mix (e.g.,
price and product quality), as well as assessing competitive and market conditions
(i.e., industry structure in the language of economics).
Storytelling is an incredibly valuable tool to share data and information. To get the most impact from stories there are a number of key ingredients. These are based on science and human nature. Using these elements in a story you can deliver information impactfully, ensure action and drive change.
The Evolution and Impact of OTT Platforms: A Deep Dive into the Future of Ent...ABHILASH DUTTA
This presentation provides a thorough examination of Over-the-Top (OTT) platforms, focusing on their development and substantial influence on the entertainment industry, with a particular emphasis on the Indian market.We begin with an introduction to OTT platforms, defining them as streaming services that deliver content directly over the internet, bypassing traditional broadcast channels. These platforms offer a variety of content, including movies, TV shows, and original productions, allowing users to access content on-demand across multiple devices.The historical context covers the early days of streaming, starting with Netflix's inception in 1997 as a DVD rental service and its transition to streaming in 2007. The presentation also highlights India's television journey, from the launch of Doordarshan in 1959 to the introduction of Direct-to-Home (DTH) satellite television in 2000, which expanded viewing choices and set the stage for the rise of OTT platforms like Big Flix, Ditto TV, Sony LIV, Hotstar, and Netflix. The business models of OTT platforms are explored in detail. Subscription Video on Demand (SVOD) models, exemplified by Netflix and Amazon Prime Video, offer unlimited content access for a monthly fee. Transactional Video on Demand (TVOD) models, like iTunes and Sky Box Office, allow users to pay for individual pieces of content. Advertising-Based Video on Demand (AVOD) models, such as YouTube and Facebook Watch, provide free content supported by advertisements. Hybrid models combine elements of SVOD and AVOD, offering flexibility to cater to diverse audience preferences.
Content acquisition strategies are also discussed, highlighting the dual approach of purchasing broadcasting rights for existing films and TV shows and investing in original content production. This section underscores the importance of a robust content library in attracting and retaining subscribers.The presentation addresses the challenges faced by OTT platforms, including the unpredictability of content acquisition and audience preferences. It emphasizes the difficulty of balancing content investment with returns in a competitive market, the high costs associated with marketing, and the need for continuous innovation and adaptation to stay relevant.
The impact of OTT platforms on the Bollywood film industry is significant. The competition for viewers has led to a decrease in cinema ticket sales, affecting the revenue of Bollywood films that traditionally rely on theatrical releases. Additionally, OTT platforms now pay less for film rights due to the uncertain success of films in cinemas.
Looking ahead, the future of OTT in India appears promising. The market is expected to grow by 20% annually, reaching a value of ₹1200 billion by the end of the decade. The increasing availability of affordable smartphones and internet access will drive this growth, making OTT platforms a primary source of entertainment for many viewers.
Taurus Zodiac Sign: Unveiling the Traits, Dates, and Horoscope Insights of th...my Pandit
Dive into the steadfast world of the Taurus Zodiac Sign. Discover the grounded, stable, and logical nature of Taurus individuals, and explore their key personality traits, important dates, and horoscope insights. Learn how the determination and patience of the Taurus sign make them the rock-steady achievers and anchors of the zodiac.
How MJ Global Leads the Packaging Industry.pdfMJ Global
MJ Global's success in staying ahead of the curve in the packaging industry is a testament to its dedication to innovation, sustainability, and customer-centricity. By embracing technological advancements, leading in eco-friendly solutions, collaborating with industry leaders, and adapting to evolving consumer preferences, MJ Global continues to set new standards in the packaging sector.
The document discusses the organization of the human body. It describes that cells are the smallest living structures that make up tissues like epithelial, connective, nervous and muscular tissues. These tissues come together to form organs which combine into body systems. The key body planes (midsagittal, frontal, transverse) divide the body and directional terms are used to describe locations. The body contains cavities like the cranial cavity that holds the brain and abdominal regions like the epigastric region below the stomach.
NFMNT Chapter 13 Apply Standard Nutrition CareKellyGCDET
The document discusses the steps involved in developing a comprehensive care plan for clients. It explains that the care plan is created by an interdisciplinary team based on a client assessment to identify needs and objectives. The care plan aims to support the client's highest level of functioning and well-being. It also outlines the roles of nutrition professionals like registered dietitians in assessing clients, identifying nutrition problems, setting goals, and communicating as part of the care planning process.
Unveiling the Dynamic Personalities, Key Dates, and Horoscope Insights: Gemin...my Pandit
Explore the fascinating world of the Gemini Zodiac Sign. Discover the unique personality traits, key dates, and horoscope insights of Gemini individuals. Learn how their sociable, communicative nature and boundless curiosity make them the dynamic explorers of the zodiac. Dive into the duality of the Gemini sign and understand their intellectual and adventurous spirit.
B2B payments are rapidly changing. Find out the 5 key questions you need to be asking yourself to be sure you are mastering B2B payments today. Learn more at www.BlueSnap.com.
At Techbox Square, in Singapore, we're not just creative web designers and developers, we're the driving force behind your brand identity. Contact us today.
Implicitly or explicitly all competing businesses employ a strategy to select a mix
of marketing resources. Formulating such competitive strategies fundamentally
involves recognizing relationships between elements of the marketing mix (e.g.,
price and product quality), as well as assessing competitive and market conditions
(i.e., industry structure in the language of economics).
Storytelling is an incredibly valuable tool to share data and information. To get the most impact from stories there are a number of key ingredients. These are based on science and human nature. Using these elements in a story you can deliver information impactfully, ensure action and drive change.
The Evolution and Impact of OTT Platforms: A Deep Dive into the Future of Ent...ABHILASH DUTTA
This presentation provides a thorough examination of Over-the-Top (OTT) platforms, focusing on their development and substantial influence on the entertainment industry, with a particular emphasis on the Indian market.We begin with an introduction to OTT platforms, defining them as streaming services that deliver content directly over the internet, bypassing traditional broadcast channels. These platforms offer a variety of content, including movies, TV shows, and original productions, allowing users to access content on-demand across multiple devices.The historical context covers the early days of streaming, starting with Netflix's inception in 1997 as a DVD rental service and its transition to streaming in 2007. The presentation also highlights India's television journey, from the launch of Doordarshan in 1959 to the introduction of Direct-to-Home (DTH) satellite television in 2000, which expanded viewing choices and set the stage for the rise of OTT platforms like Big Flix, Ditto TV, Sony LIV, Hotstar, and Netflix. The business models of OTT platforms are explored in detail. Subscription Video on Demand (SVOD) models, exemplified by Netflix and Amazon Prime Video, offer unlimited content access for a monthly fee. Transactional Video on Demand (TVOD) models, like iTunes and Sky Box Office, allow users to pay for individual pieces of content. Advertising-Based Video on Demand (AVOD) models, such as YouTube and Facebook Watch, provide free content supported by advertisements. Hybrid models combine elements of SVOD and AVOD, offering flexibility to cater to diverse audience preferences.
Content acquisition strategies are also discussed, highlighting the dual approach of purchasing broadcasting rights for existing films and TV shows and investing in original content production. This section underscores the importance of a robust content library in attracting and retaining subscribers.The presentation addresses the challenges faced by OTT platforms, including the unpredictability of content acquisition and audience preferences. It emphasizes the difficulty of balancing content investment with returns in a competitive market, the high costs associated with marketing, and the need for continuous innovation and adaptation to stay relevant.
The impact of OTT platforms on the Bollywood film industry is significant. The competition for viewers has led to a decrease in cinema ticket sales, affecting the revenue of Bollywood films that traditionally rely on theatrical releases. Additionally, OTT platforms now pay less for film rights due to the uncertain success of films in cinemas.
Looking ahead, the future of OTT in India appears promising. The market is expected to grow by 20% annually, reaching a value of ₹1200 billion by the end of the decade. The increasing availability of affordable smartphones and internet access will drive this growth, making OTT platforms a primary source of entertainment for many viewers.
Taurus Zodiac Sign: Unveiling the Traits, Dates, and Horoscope Insights of th...my Pandit
Dive into the steadfast world of the Taurus Zodiac Sign. Discover the grounded, stable, and logical nature of Taurus individuals, and explore their key personality traits, important dates, and horoscope insights. Learn how the determination and patience of the Taurus sign make them the rock-steady achievers and anchors of the zodiac.
How MJ Global Leads the Packaging Industry.pdfMJ Global
MJ Global's success in staying ahead of the curve in the packaging industry is a testament to its dedication to innovation, sustainability, and customer-centricity. By embracing technological advancements, leading in eco-friendly solutions, collaborating with industry leaders, and adapting to evolving consumer preferences, MJ Global continues to set new standards in the packaging sector.
Company Valuation webinar series - Tuesday, 4 June 2024FelixPerez547899
This session provided an update as to the latest valuation data in the UK and then delved into a discussion on the upcoming election and the impacts on valuation. We finished, as always with a Q&A
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