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This document discusses blood-brain barrier (BBB) permeability and regulation. It describes the cellular components that make up the BBB, including endothelial cells, astrocytes, pericytes, and the mechanisms that control permeability, such as tight junctions between endothelial cells. It also discusses how BBB permeability is altered in various pathological conditions like stroke, trauma, infection, and neurodegenerative diseases.













































































































