Mechanism of action of digoxin is one intriguing explanation each medico had to struggle to understand in pharmacology. This presentation contains a simple self-explanatory animation.

1. MECHANISM OF ACTION OF
DIGOXIN
Dr. Deepak Anand. R.

2. CONTRACTION OF MUSCLE
Na-K ATPase
Ca-Na
pump
Na-K ATPase pumps Na out & K in
This causes high Na outside, high K inside
Ca causes contraction of muscle
The calcium is pumped out by Ca-Na pump that
depends on HIGH Na OUTSIDE
DIGOXIN blocks Na-K ATPase
HIGH Na gradient outside diminishes
Progressive Ca accumulation
Inceased force of contraction
Ca-Na pump fails