This document lists 20 research publications from 2008 to 1999 by authors Sidi A, Muehlschlegel JD, Kirby DS, and Lobato EB studying treatments for pulmonary hypertension, myocardial ischemia, and cardiac dysfunction in pig models. The publications examine drugs like sildenafil, milrinone, dobutamine, hypertonic saline, and amyl nitrite administered before, during, or after events like coronary occlusion or ischemia to evaluate effects on pulmonary pressure, cardiac function, and metabolic impairment. Measurement methods compared in some studies include thermodilution, noninvasive partial CO2 rebreathing, and direct aortic flow.

1. Sidi A, Naik B, Muehlschlegel JD, Kirby DS, Lobato EB.
Ethanol-induced acute pulmonary hypertension and right ventricular dysfunction in pigs.
Br J Anaesth.2008 Apr;100(4):568-9. No abstract available.
PMID: 18344581 [PubMed - indexed for MEDLINE]
Sidi A, Naik B, Urdaneta F, Muehlschlegel JD, Kirby DS, Lobato EB
Treatment of ethanol-induced acute pulmonary hypertension and right ventricular dysfunction in pigs, by sildenafil
analogue (UK343-664) or nitroglycerin. Ann Card Anaesth.2008 Jul-Dec;11(2):97-104.
PMID: 18603749
Sidi A, Muehlschlegel JD, Kirby DS, Lobato EB.
Administration of milrinone before ischemia, in the presence of beta-blockade, to treat metabolic impairment and
myocardial stunning in pigs. Acta AnaesthesiolScand.2008 Mar;52(3):397-405.
PMID: 18269389 [PubMed - indexed for MEDLINE]
Sidi A, Muehlschlegel JD, Kirby DS, Kirby RR, Lobato EB
Treating ischemic left ventricular dysfunction with hypertonic saline administered after coronary occlusion in pigs. J
Cardiothorac Vasc Anesth.2007 Jun;21(3):400-5. Epub 2007 Apr 5.
PMID: 17544894 [PubMed - indexed for MEDLINE]
Sidi A, Muehlschlegel JD, Kirby DS, Lobato EB
Treating metabolic impairment and myocardial stunning with phosphodiesterase inhibitor type III, milrinone,
administered prior to coronary artery occlusion in the presence of calcium channel blockade in pigs. Ann Card
Anaesth.2007 Jan;10(1):34-41. Erratum in: Ann Card Anaesth.2008 Jan-Jun;11(1):69. Muehschlegel,Jochen D
[corrected to Muehlschlegel, Jochen D].
PMID: 17455406 [PubMed - indexed for MEDLINE
Muehlschlegal JD, Lobato EB, Kirby DS, Arnaoutakis G, Sidi A.
Inhaled amyl nitrite effectively reverses acute catastrophic thromboxane-mediated pulmonary hypertension in pigs.
Annalsof Cardiac Anaesthesia 2007 July; 10(2): 113-120
Sidi A, Muehlschlegel JD, Kirby DS, Lobato EB. Treatment of ischaemic left ventricular dysfunction with
milrinone or dobutamine administered during coronary artery stenosis in the presence of beta blockade in pigs.
British Journal of Anaesthesia 2006; 97: 799-807
Lobato EB, Beaver T, Muelschlegel J, Kirby DS, Klodell C, Sidi A.
Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination
during thromboxane-induced acute pulmonary hypertension. British Journal of Anaesthesia 2006 March; 96(3):
317-22
Botero M, Kirby D, Lobato EB, Staples ED, Gravenstein N
Measurement of cardiac output before and after cardiopulmonary bypass:Comparison among aortic transit-time
ultrasound,thermodilution, and noninvasive partial CO2 rebreathing. J Cardiothorac Vasc Anesth.2004
Oct;18(5):563-72. PMID: 15578466 [PubMed - indexed for MEDLINE]
Bonnell MR, Urdaneta F, Kirby DS, Valdez NR, Beaver TM, Lobato EB
Effects of sildenafil analogue UK 343-664 on a porcine model of acute pulmonary hypertension.Ann Thorac Surg.
2004 Jan;77(1):238-42.
PMID: 14726068 [PubMed - indexed for MEDLINE]
Urdaneta F, Kirby D, Lobato EB.
“Effects of ascorbic acid vs ketorolac on myocardial ischemia-reperfusion during propofol anesthesia,” abstracted.
Anesthesia Analgesia 94:S34, 2002.
Urdaneta F, Kirby D, Lobato EB.

2. “Myocardial stunning following transient coronary occlusion in pigs: comparison of propofol vs isoflurane,”
abstracted. Anesthesia Analgesia 94:S36, 2002.
Lobato EB, Botero M, Kirby DS, Browd CR, Sidi A, Kirby RR.
“Effects of beta-blockade and PDEIII inhibition on myocardial ischemia and function during temporary coronary
occlusion,” abstracted. Anesthesia Analgesia 92:S28, 2001.
Lobato EB, Sulek CA, Hollis S, Kirby D, Kirby RR.
“Hypertonic saline improves stunned myocardium following transient coronary occlusion in pigs,” abstracted.
Anesthesia Analgesia 92:S29, 2001.
Lobato EB ,Botero M, Kirby DS, Browd CR, Sidi A.
“Effect of milrinone on myocardial ischemia and stunning in the presence of calcium channel blockade in pigs,”
abstracted.Anesthesia Analgesia 92:SCA104, 2001.
Lobato EB ,Botero M, Kirby DS, Browd CR, Sidi A.
“Effects of combined PDEIII and PDEV inhibition on a porcine model of acute pulmonary hypertension,”
abstracted. Anesthesia Analgesia 92:SCA125, 2001.
Botero M, Briesacher K, Kirby D, Gravenstein N, Hess P, Lobato EB.
“Comparison of noninvasive cardiac output using a partial CO2 rebreathing systemwith direct aortic flow
measurements during cardiac surgery,” abstracted. Anesthesia Analgesia 90:S31, 2000.
Botero M, Bresacher K, Kirby D, Gravenstein N, Hess P, Lobato EB.
“Comparison of noninvasive determination of cardiac output (CO) using a partial CO2 rebreathing
systemwith thermodilution during cardiac surgery,” abstracted. Anesthesia Analgesia 90:S32, 2000.
Botero M, Hess P, Kirby D, Briesacher K, Gravenstein N.
“Cardiac output measurement during off pump coronary artery bypass grafting (OPCABG): comparison of four
methods,” abstracted. Anesthesia Analgesia 90:SCA44, 2000.
Botero M, Hess P, Kirby D, Briesacher K, Gravenstein N.
“Measurement of cardiac output during coronary artery bypass grafting (CABG): comparison of pulmonary
artery catheter, noninvasive CO2 rebreathing, and direct aortic flow,” abstracted. Anesthesia Analgesia 90:SCA87,
2000.
Botero M, Khansarinia S, Kirby D, Gravenstein N, Lobato EB.
“Noninvasive cardiac output using partial CO2 rebreathing vs direct aortic flow measurements during
off pump coronary artery bypass grafting,” abstracted. Anesthesiology 93:A323, 2000.
Botero M, Khansarinia S, Kirby D, Gravenstein N, Lobato EB.
“Measurement of cardiac output in the intensive care unit after coronary artery bypass grafting (CABG):
comparison of pulmonary artery catheterand noninvasive partial CO2 rebreathing,” abstracted. Anesthesiology
93:A590, 2000.
Botero M, Gravenstein N, Briesacher KS, Kirby D, Hess P, Lobato EB. “Thermodilution cardiac output monitoring
vs direct measurement of aortic flow during coronary artery bypass grafting,” abstracted. Critical Care Medicine
27:193, 1999.