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PAC presentation Anca V2
This document summarizes a study using perturbed angular correlation (PAC) spectroscopy to analyze the stability of polymersomes containing the radionuclide 111In. PAC measurements were taken for 111In in different forms: as a crystal, complexed with DTPA and tropolone, and loaded into polymersomes of varying sizes. The results showed the perturbation was higher for polymersomes in HEPES buffer than PBS buffer, but size did not influence stability. No clear conclusions could be drawn due to technical issues with the detectors and data analysis software. Future work proposed investigating other factors affecting stability and performing in vivo and in vitro studies to analyze polymersome lifetime upon administration.
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PAC presentation Anca V2
This document summarizes a study using perturbed angular correlation (PAC) spectroscopy to analyze the stability of polymersomes containing the radionuclide 111In. PAC measurements were taken for 111In in different forms: as a crystal, complexed with DTPA and tropolone, and loaded into polymersomes of varying sizes. The results showed the perturbation was higher for polymersomes in HEPES buffer than PBS buffer, but size did not influence stability. No clear conclusions could be drawn due to technical issues with the detectors and data analysis software. Future work proposed investigating other factors affecting stability and performing in vivo and in vitro studies to analyze polymersome lifetime upon administration.
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