PARA EL CURSO DE SANGRE

1. CUESTIONARIO DE FUNCIÓN SANGUINEA
GRUPO: _________ FECHA: ______________ EQUIPO: _________________
NOMBRES: _____________________________________________________________
________________________________________________________________________
DESARROLLAR LOS SIGUIENTES PUNTOS DE LA FUNCIÓNSANGUINEA:
PLATELET PRODUCTION (THROMBOPOIESIS) ISAFFECTEDBY MORE THAN ONE CYTOKINE.WHICH
OF THE FOLLOWINGSETS SEEMS TO BE THE MOST IMPORTANTIN PLATELET DEVELOPMENT?
a. IL-3, granulocyte colony-stimulatingfactor(G-CSF),andgranulocytemacrophage colony-
stimulatingfactor(GM-CSF)
b. IL-4, IL-6,and thrombopoietin
c. Erythropoietin,thrombopoietin,andIL-6
d. IL-6 and thrombopoietin
e.IL-3, IL-4, and IL-6
WHICH OF THE FOLLOWINGFACTORSCOMPLEXES WITH FACTORVIII,WHICH IS ACTIVATEDTO
FACTORVIIIA WHEN RELEASED FROMTHE COMPLEX?
a. Factor XIII
b. Highmolecularweightkininogen
c. VonWillebrandfactor(vWF)
d. Thromboplastin
e.Plasminogen
WHICH OF THE FOLLOWINGFACTORSDEPENDSON PLATELETS FOR SYNTHESIS?
a. Factor II (prothrombin)
b. Factor VII(proconvertin)
c. ProteinS
d. Factor XIII(fibrin-stabilizingfactor)
e.Factor X (Stuart-Prowerfactor)
WHICH OF THE FOLLOWINGCAUSES OF ANEMIA ISASSOCIATEDWITH MICROCYTOSIS?
a. Folicaciddeficiency
b. Therapywithzidovudine (AZT)
c. Hypothyroidism
d. Alcohol
e.Thalassemia

2. WHICH OF THE FOLLOWINGCAUSES OF AN ELEVATED HEMOGLOBIN CONCENTRATION IN THE
BLOOD IS CHARACTERIZEDBY A LOW LEVEL OFERYTHROPOIETIN IN THE BLOOD?
a. Chronictobacco smoking
b. Dwellingathighaltitudes,suchasinthe Andes
c. Erythrocytosisassociatedwithrenal tumors
d. Primarypolycythemia(polycythemiavera)
e.Erythrocytosissecondarytochronicpulmonaryinsufficiency
WHICH OF THE FOLLOWINGCAUSES A LEUKOCYTOSISWITHOUT AN INCREASEIN THE NUMBER OF
CIRCULATINGPOLYMORPHONUCLEARNEUTROPHIL LEUKOCYTES?
a. Acute infection
b. Release of epinephrine
c. Tissue necrosis
d. Myelocyticleukemia
e.Collagenvasculardisease
IN A TYPICAL CASEOF IRON DEFICIENCY,WHICH OF THE FOLLOWINGMOLECULAR FORMS THAT
CONTAINSORCAN BINDTO IRON INCREASESIN THE PATIENT’SSERUM?
a. Hemoglobin
b. Ferritin
c. Hemosiderin
d. Myoglobin
e.Transferrin
WHICH OF THE FOLLOWINGDISORDERSIS ASSOCIATEDWITH THROMBOCYTOSIS?
a. Disseminatedintravascularcoagulation
b. A plasticanemia
c. Postsplenectomy
d. Hypersplenism
e.Prostheticvalves
A 47-YEAR-OLD MAN WALKS INTOTHE EMERGENCY ROOMBECAUSE OF FEELING VERY WEAK,
TIRED, SHORT OF BREATH, ANDDIZZY. HE HAS NUMBNESS ANDTINGLING OFHIS FINGERS.HE
APPEARSPALEANDSALLOW. ON EXAMINATION,HISHEART RATE IS 132. HIS SCLERAE AND
NAILBEDSARE PALE.HIS HEART ISENLARGED AND HE HAS DEPENDENT EDEMA OF HIS ANKLES.
LABORATORYFINDINGSINCLUDE A NEGATIVECOOMBS’ TEST ANDA HEMOGLOBIN OF 4 G/DL.
THE LIKELY DIAGNOSISIS
a. Traumatic hemolyticanemia
b. Autoimmuneanemia

3. c. Bloodloss
d. Perniciousanemia
e.Iron-deficiencyanemia
MOST DRUGS INDUCE THROMBOCYTOPENIA BY WHICH MECHANISM?
a. Marrow-depressingeffect
b. Directlycytotoxicof platelets
c. Depressmegakaryoctye production
d. Immune response inwhichthe plateletisdamagedbycomplementactivation
e.Impairmegakaryoctye production
WHICH OF THE FOLLOWINGSTATEMENTS RELATED TO CIRCULATINGERYTHROCYTES (RED CELLS)
IS UNTRUE?
a. The nuclei of the precursorcellstoerythrocytesare extrudedfromtheircellsshortlybeforethe
redcellsleave the bone marrow.Consequently,the presence of nucleated redcellsinthe
peripheral bloodshouldbe regardedasabnormal andmayindicate anunderlyingdiseasestate.
b. Ina thinbloodsmearstainedwithRomanowsky’sstain(suchasWright’sstain),the youngest
cells(reticulocytes) canbe recognizedbyablue coloration(basophilia) asdifferentfrommostof
the red cellspresent.
c. The average diameterof erythrocytesisabout8 µm; consequently,theycannotflow through
the smallercapillariesthathave adiameterof 2 to 4 µm.
d. The proteinof hemoglobin,whichisthe principal constituentof the redcell contents,isin
tetramericform,withtwoα and twoβ subunits.
e.The ironatom of the hemoglobinmolecule,whichisessential toitsfunctionof carryingoxygen,
isan intrinsicpartof the heme complex attachedtoeachsubunitof protein.
WHICH OF THE FOLLOWINGSTATEMENTS CONCERNINGTHE RELATIONSHIPOFTHE NEUTROPHIL
POLYMORPHONUCLEARLEUKOCYTE (PMN) TO INFECTION WITHBACTERIAL PATHOGENSIS
INCORRECT?
a. The principal functionsof the PMN are expressedinthe tissuesandnotusuallyinthe
bloodstream,whichissimplythe transportpathof the cellstotheirrequiredsite of action.
b. The cytoplasmicgranulesof PMN are essentiallyinert,butmetabolicallyhave onlyavegetative
role inmaintainingcell viability.
c. Whenthe cell numbersof PMN are reducedsignificantly,the probabilityof severebacterial
infectioncanbe greatlyincreased.
d. The average durationof the periodof circulationof PMN afterenteringthe bloodstreamis
about6 to 8 h.
e.An increasingneedforPMN producedbyinfectionismetinpartby large numbersof immature
cells(especiallybandcells)beingreleasedfromthe marrow pool intothe bloodstream.