Frontotemporal dementia (FTD).

1.  I want to talk about the frontotemporal
dementia that actor Bruce Willis has and all
because some days ago I saw the movie 12
monkeys and I was so sad for me to know that
he got retired from acting.

2.  Is defined as a neurodegenerative disease
characterized by a progressive change in
personality and behavior and/or an early and
progressive evolution of language.
 FTD there are always
emotional and behavioural
changes that prevail over
the cognitive deficits.

3.  The patient shows difficulty in giving and
receiving information when conversing,
abnormal behavior due to the involvement of
the right anterior temporal lobe and its
connections with the orbitofrontal cortex.
 If the posterior temporal region and visual
association areas are affected, visual agnosia
and aprosopagnosia (inability to recognize
faces) may develop.

4.  The affectation in the frontal reflexes can be
appreciated later.
 The characteristic finding of FTD on neuroimaging
studies is atrophy or hypometabolism of the right
anterior temporal or frontal lobe.
 In the behavioral variant, reduced connectivity
between different parts of the brain has been
described, including the frontal lobe, anterior
cingulate, insula, amygdala, medial thalamus, and
ventral striatum; all these regions are involved in
emotions

5.  In FTD the anatomical areas involved are affected
with specific phenotypes.
 Recognizing abnormal connections in the structural
white matter is of particular interest in
understanding the spread of neurodegeneration.
 In FTD, an autosomal dominant pattern can be
found, in which there are affected first-degree
relatives (40% of cases). There are at least eight genes
involved, of which three are the main similarities
(50%): the microtubule-associated protein tau
(MAPT) gene on chromosome 17, the proglanulin
gene (PGRN), also related to at least chromosome 17,
and the C9orf72 gene, associated with chromosome
910.
 In DFT effects of GRN and MAPT mutations are
expressed in partially overlapping but distinct
anatomical networks that link specific molecular
dysfunction with clinical .

6.  I belive this course have had me a lot of
important information aboud who the brain
works and that information have let me
understand, or al least, ask me aboud what
happened when people get problems, mental,
psiquiatric, neurodegenerative or fisical. This
course have really helped me to wake up more
my curiosity for know more about the brain
and how can we explain the behavior.

7.  Rodríguez-Leyva, I., Oliva-Barrios, J. E., Cueli-Barcena, S., Carrizales-Rodríguez, J.,
Chi-Ahumada, E., & Jiménez-Capdeville, M. E. (2018). Demencia frontotemporal:
revisión y nuestro punto de vista. Revista Mexicana de Neurociencia, 19(6), 27-38.
 Rohrer, J. D., Ridgway, G. R., Modat, M., Ourselin, S., Mead, S., Fox, N. C., ... &
Warren, J. D. (2010). Distinct profiles of brain atrophy in frontotemporal lobar
degeneration caused by progranulin and tau mutations. Neuroimage, 53(3), 1070-
1076.