Chapter 12 of 'Operating System Concepts' focuses on I/O systems, detailing the complexities and management of I/O hardware, application interfaces, and kernel I/O subsystems. It discusses the mechanisms for device control, including polling, interrupts, and Direct Memory Access (DMA), as well as the characteristics of various I/O devices. The chapter emphasizes I/O performance, error handling, and the importance of efficient management in operating systems.