In this webinar on bone health Rousselot explains the role of osteopenia, the pre-stage to osteoporosis, how it can affect our lives and how to prevent it. Dr. Elke de Clerck presents the science behind and importance of Peptan collagen peptides, a pure protein, with specific benefits to support stronger and healthier bones. Rousselot is an official Nutrition Supporter of World Osteoporosis Day in 2015. Watch webinar on https://www.youtube.com/watch?v=daRY5gXd6AQ Presenter: Dr. Elke de Clerck, Technical Support and Development Manager at Rousselot, Elke holds a PhD degree in Biotechnology from Ghent Unviersity and has over 10 years of international experience. She is based in Ghent, Belgium, where Rousselot’s expertise center is located. About Rousselot Rousselot® is the leading manufacturer of gelatine and collagen peptides to the food, pharmaceutical and nutraceutical industries. Rousselot manufactures Peptan, a globally recognized brand, offering a wide range of collagen peptides scientifically proven to improve overall joint health, mobility, bone structure and the natural beauty of skin. http://www.peptan.com

2. Collagen Peptides: Natural
Support to Bone Health
Collagen peptides
for a
healthy lifestyle

3. Title- Date
Presenter
page 3
Dr. Elke de Clerck
Technical Support and Development
Manager Rousselot Europe
Natural Support to Bone Health

4. Name of Presentation - Date page 4
Content
 Global aging population trend
 Quality of life
 Bone health
 Early prevention of osteopenia
 Role of collagen peptides and
bone health
 What is collagen peptide
 How collagen benefits bone
health
 The science behind Peptan®
 Finished products
 Rousselot is WOD Nutrition
Supporter in 2015
Natural Support to Bone Health

5. Title- Date
Bone Health, Quality of Life Indicator
5
Osteoporosis affects both men and women worldwide
 Osteoporosis causes more than 8.9 million fractures annually,
resulting in an osteoporotic fracture every 3 seconds
 1 in 3 women over age 50 will experience osteoporotic fractures, as
will 1 in 5 men aged over 50
Osteoporosis leads to
• Mobility impairments
• Decrease in quality of life
• In many cases fractures
shorten life expectancy
Natural Support to Bone Health
Source: IOF

6. Name of Presentation - Date
Bone health depends on balanced Bone remodeling
page 6
 Osteoblasts – bone formation
 Osteoclasts – bone resorption (breakdown)
 Organic matrix: protein – mostly collagen
 Inorganic matrix (Hydroxylapatite) – Calcium, Phosphor
Natural Support to Bone Health

7. Title- Date
What is Osteoporosis and Osteopenia
page 7
 Osteoporosis has four major
consequences on the bone :
 Bone mineral density
(BMD) is reduced,
- an increased risk of
fractures.
 Imbalance between bone
resorption and bone
formation
 Amount and variety of
proteins in bone is altered
 Bone micro-architecture
is deteriorating
Osteopenia
is the pre-stage to
Osteoporosis
Natural Support to Bone Health

8. Title- Date
An ounce of prevention is worth a pound of cure
page 8
Osteoporosis is a costly disease
 The number of fractures is estimated to reach 6.3 million and the
projected total cost to be $131.5 billion worldwide by 2050
 Government health insurance schemes are under pressure due to aging
population and rising costs, - move towards more private insurance
 Preventing osteopenia is important to avoid or delay limitations of
skeletal functions and therefore minimize the consequential health costs
Natural Support to Bone Health
Source: The Journal of Bone and Joint Surgery

9. Title- Date
Prevention of Osteopenia
page 9
Healthy
diet
• Calcium
• Vitamins
• Protein
Regular
exercise
• Weight bearing
• Muscle-
strengthening
• Balance
Avoid
negative
lifestyle
• Smoking
• Excessive
drinking
• Maintain healthy
weight
Natural Support to Bone Health

10. Title- Date
page 10
Content
 Global aging population trend
 Quality of life
 Bone health
 Early prevention of osteopenia
 Role of collagen peptides and
bone health
 What is collagen peptide
 How collagen benefits bone
health
 The science behind Peptan®
 Finished products
 Rousselot is WOD Nutrition
Supporter in 2015
Natural Support to Bone Health

11. Title- Date
What is collagen ?
page 11
Collagen is a triple helix of alpha-chains of amino-acids, which builds strong
fibers used for the body structure.
 Most abundant protein of the body (25% of
the total protein content)
 It is the major constituent of connective
tissues (skin, tendon, cartilage, bones)
 Synthesized by fibroblasts, chondrocytes
and osteoblasts
 1000 amino-acid residues per chain
 There are 23 different types of collagen,
 Type 1 Collagen: bones and skin
 Type 2 Collagen: cartilage
 Type 3 Collagen: skin
Natural Support to Bone Health

12. Title- Date
Why protein and collagen is important for bone health
page 12
Protein intake influences bone health. The effect of dietary protein is:
These mechanisms leads to improved bone density and strength
(adapted from Gaffney-Stomberg et al., 2009)
Collagen is the main protein in bone
representing ~ 90% of organic bone mass,
Collagen provides the structural framework for
Calcium and other minerals
Collagen works together with Calcium &
Vitamins (D, K) to promote stronger, healthier bones
Intake of 10g/day of protein such as Collagen Peptides can increase bone
mineral density
Calcium
Collagen
Vitamin
Natural Support to Bone Health

13. Title- Date
Rousselot® technology
based on a specific enzymatic hydrolysis process
Excellent organoleptic profile
 Product consistency
Peptan® Collagen Peptides
page 13
 2000 – 5000 Da
Highly digestible
 Soluble in cold water
Peptan® is a natural and bioactive
protein characterized by a unique
amino acid composition and
high bioavailability
Collagen type 1 peptides
high in the AA’s Glycine,
Hydroxyproline, Proline and
Glutamic acid
Natural Support to Bone Health

14. Title- Date
Rousselot research publications
page 14
Research studies conducted at INRA-AgroParisTech laboratory
(France) confirm Peptan benefits on bone health
1st Publication in
peer-reviewed
journal of the
International Bone
and Mineral Society
‘Bone’
2nd Publication in
the peer-reviewed
journal of
‘Osteoporosis
International’
Peptan is scientifically proven to support bone health in
in-vitro and in-vivo studies:
Stimulates osteoblasts (bone forming cells) and bone health markers
Increase bone strength and bone mineral density
Natural Support to Bone Health

15. Title- Date
page 15
Test with Peptan
1mg.ml -1 for 14 days.
Standard with
BSA protein 1mg.ml -1 for 14 days.
Osteoblasts
(bone resorption
cells)
Star-shaped cells
Osteoclasts
(bone forming
cells)
Round black
cells
Pictures of osteoblast cultures with Peptan or BSA
In vitro studies - Results
Natural Support to Bone Health
Peptan increases the differentiation of osteoblasts

16. Title- Date
page 16
 Peptan modulates bone formation and
mineralization of the bone matrix by
stimulating osteoblast growth and
differentiation while reducing osteoclast
activity.
 Peptan restores the bone mineral
density and improves bone health by
increasing the bone size and strength
Conclusion
Rousselot studies have demonstrated in vitro and in vivo:
Natural Support to Bone Health
Peptan & bone health- The science behind

17. Title- Date
Peptan, the key to healthy aging
page 17
 Peptan not only
supports bone health,
it is:
 Scientifically
proven to also
promote joint
health and as a
pure protein, it
supports muscle
mass
 Peptan helps to reduce
the impact of common
mobility-limiting, age-
related conditions.

18. Title- Date
Peptan, a bioactive ingredient
The right ingredient to enhance bone health in any
finished products
 Excellent organoleptic
properties
 Neutral taste and odor
 Allows high dosage
 Instant solubility and easy
dispersal
 Used all over the world in
supplements, functional foods and
drinks
Easy
to use
powder
Confec-
tionneries
Dietary
Supple-
ments
Drinks
Functional
Foods
Nutritional
Bars
Tablets
Natural Support to Bone Health
For more information please visit www.peptan.com

19. Title- Date
Nutrition Supporter of World Osteoporosis Day in 2015
page 19
 Rousselot is an official Nutrition Supporter of World Osteoporosis Day
(WOD) in 2015.
 WOD is an annual event led by International Osteoporosis Foundation. The
event takes places on 20th October each year, and serves to raise
awareness of the prevention, diagnosis and treatment of
osteoporosis.
Rousselot as WOD Nutrition Supporter

20. www.peptan.com