HBase is a distributed column-oriented database built on top of Hadoop that provides quick random access to large amounts of structured data. It uses a key-value structure to store table data by row key, column family, column, and timestamp. Tables consist of rows, column families, and columns, with a version dimension to store multiple values over time. HBase is well-suited for applications requiring real-time read/write access and is commonly used to store web crawler results or search indexes.