5. CATECHOLAMI
NE SYNTHESIS
Tyrosine is produced
from essential amino
acid, Phenylalanine
Stored in synaptic
vesicles
Their release Ca++
dependent
7. Epinephrine and Nor-epinephrine
▪ Epinephrine and nor-epinephrine increase the
blood pressure.
▪ Adrenaline also increases the rate and force of
myocardial contraction.
▪ Epinephrine causes relaxation of smooth muscles
of bronchi.
▪ Adrenaline is anti-insulin in nature, it increases
glycogenolysis and stimulates lipolysis.
▪ Adrenaline is released from adrenal medulla in
response to flight, fight, fright, exercise and
hypoglycemia.
8. DOPAMINE
▪ Plays an essential role in many of our
behaviours.
▪ Reward-seeking behaviours
▪ Too little in Parkinson Disease and Tardive
Dyskinesia
▪ Cocaine is a dopamine agonist
▪ L-dopa – is administered to patients with
Parkinson’s disease, L-dopa is very easily
converted to dopamine.
