2. History
A 45YR old male from Barabanki presented in the
emergency with
Chief complaints- Swelling in the scrotum for about one
and half month
3. History of Present illness- Patient was apparently well one and half month
back .There is a history of sustaining injury from the handle of bicycle in
the scrotum following which swelling and pain started .Initially the swelling
is of mildly enlarge in size and gradually the size is increased . He received
treatment from the local doctor and swelling started to decrease . At
present the swelling is irreducible in standing and supine position.
It is also associated with dull aching pain localized to scrotum and from
past 15 days the nature of pain has became throbbing , continuous, and
relieved on taking medication .
It is also associated with fever which was felt by the patient but not
recorded .It is not associated with chills and rigor and gets relieved on
taking medicine.
History continued
4. After 15 days there was development of multiple abscesses
and crusting for which debridement and dressing is done by
village doctor . There is a history of narrowing of stream of
urine but there is no incomplete sense of evacuation.
Presently he has pain and fever with scrotal swelling
associated wound is present .
There is no history of loss of weight ,loss of appetite ,nausea
,vomiting, haemoptysis ,cough and cold, burning and painful
micturition.
History of present illness continued
5. Past History- There is no history suggestive of Hypertension ,Type 2
Diabetes Mellitus and any respiratory problem .
He was operated for hydrocele (left side) 15yrs back.
Family history- There is no family history suggestive of Hypertension ,Type 2
Diabetes Mellitus ,Tuberculosis .
Personal history-
Mixed diet .
Alcoholic –drinking alcohol from past 20years .
Tobacco chewing from past 20yrs (3-4 packets /day)
Bowel and bladder movement is normal.
Allergy history- There is no known history of allergy to any drug and food .
History continued
6. An average built male person
Weight -65kg
Height-180cm
Basal Metabolic Index-23.1kg/ mt square
Temperature -101.2degree F
Blood Pressure-134/82mm of Hg (left arm )
Pulse Rate-102/min ,regular in rate and rhythm and normal in volume
and character
Respiratory Rate -22/min
SpO2-99% at RA
No pallor , icterus , cyanosis, clubbing , edema , dehydration and
generalized lymphadenopathy (only inguinal lymph nodes are palpable
bilaterally )
General Examination
7. Central Nervous System- conscious ;oriented to time ,place and person.
Chest examination-
Bilateral equal air entry
Normal vesicular breath sound
No added sound
Cardio Vascular System-
S1 S2 heard
No murmur
Per Abdomen-
Soft , non tender ,no distension
No organomegaly
Bowel sound heard
Systemic Examination
8. Local Examination
On Inspection
Penis
Edematous
Meatus is not visible
Skin over the penis is thickened.
Scrotum-
Scotum is enlarged (approx- 12X8cm)
Skin is blackish in color and hardened .
Foul smell present .
Ulcer present which is (approx -10X3cm) with approx 0.5cm depth
Margin irregular
Sloping edge
Floor has yellow slough
Line of demarcation is present.
9. Thigh
Bilateral inner thigh has annular lesion
extending till the mid thigh.
Central is clear and peripherally white scales
are visible.
10. On Palpation
Penis –
Retraction of prepucial skin is difficult
Meatal opening is seen but can’t be exposed fully
Scrotum-
No local rise in temperature.
Swelling (12x10cm) in size .
Consistency –hard .
Non tender.
Skin is blackish and hardened and adherent to the swelling
11. Ulcer is present over the swelling (11x4cm) and
depth of 1cm.
Edge –sloping.
Base –firm .
Floor has yellow slough .
Bleeding is not present.
Bilateral inguinal lymph nodes are palpable
Multiple ,1cm in size,
Round and
Firm in consistency
mobile in both the directions
Non matted ,arranged horizontally
Free from skin
Per Rectal examination- no any significant finding
12. Provisional Diagnosis-
On the basis of the following points –
History of injury and alcoholism
Foul smell
Painless ulcer, discoloration of skin
Do not bleed on touch
Necrotic areas
Fournier’s Gangrene
13. Investigation
Complete blood count
Renal function test
Liver function test
Serum electrolyte
Random blood sugar
Pus culture and sensitivity
Coagulation profile
Chest X ray PA view
Ultrasonography of the scrotum
17. Blood Supply
From superficial external pudendal, deep external
pudendal and internal pudendal arteries.
Nerve Supply
Anterior 1/3rd portion by ilioinguinal nerve and genital
branch of genitofemoral nerve.
Posterior 2/3rd portion by posterior scrotal branch of
pudendal nerve and perineal branch of posterior
femoral cutaneous nerve.
Dartos is supplied by sympathetic nerve.
18. characterised by a polymicrobial infection of
the soft tissues of the perineum, external genitalia and
perianal region. It is a form of necrotising fasciitis.
Fournier’s Gangrene
19. Etiology -an obvious cause is usually absent
Polymicrobial (mixed infection )
Minor injuries or procedures in the perineal area, such as a
bruise, scratch, urethral dilatation
Treatment of haemorrhoids or opening of a periurethral
abscess.
Diabetes mellitus
Alcoholism.
20. Clinical features
sudden pain in the scrotum
associated with prostration, pallor
and pyrexia.
Cellulitis spreads rapidly (within
hours) with small necrotic areas of
skin which, if untreated, coalesce to
involve the entire scrotal and penile
coverings,
which may then slough, leaving the
testes exposed but healthy.
23. Treatment
It is a surgical emergency.
Initial management –
intravenous fluid resuscitation and
Early broad spectrum intravenous antibiotics.
Extensive debridement is needed urgently.
Along with debridement, surgical procedures may include complex
closure, suprapubic tube placement, and fecal diversion.
If the patient survives the acute episode, skin grafting is often
necessary.
24. Once the infection is eradicated,
healthy granulation tissue develops;
this signifies the time to proceed to
reconstruction.
Options for reconstruction include the
following:
•Primary closure of the skin, if possible
•Local skin flap coverage
•Split-thickness skin grafts
•Muscular flaps, which are used to fill a
cavity (eg, ischiorectal space)
Shameful exposure of testis
25.
26. Summary
Fournier’s gangrene requires early and aggressive treatment
if the patient is to survive .
Treatment involves urgent surgical debridement of necrotic
tissue in combination with early use of intravenous broad
spectrum antibiotics
Sympathetic nerve from superior hypogastric plexus
Genitofemoral nerve L1
Post scrtal branch of pudendal nerve and perineal branch of post femoral cut –S3 AND S4
Fournier gangrene was first identified in 1883, when the French venereologist Jean Alfred Fournier described a series in which 5 previously healthy young men suffered from a rapidly progressive gangrene of the penis and scrotum without apparent cause. This condition, which came to be known as Fournier gangrene, is defined as a polymicrobial necrotizing fasciitis of the perineal, perianal, or genital areas
Vascular disease of infective origin.
There is a mixed infection of aerobic and anaerobic bacte-
ria in a fulminating inflammation of the subcutaneous tissues,
which results in an obliterative arteritis of the arterioles to the
scrotal skin that in turn results in gangrene. The condition
can spread rapidly to involve the fascia and skin of the penis,
perineum and abdominal wall.
There is rapid onset of gangrene leading to exposure of the scrotal contents.
Although it can occur in conjunction with sepsis of the tes-
tis, epididymis or perianal region,
Wound cultures from patients with Fournier gangrene reveal that it is a polymicrobial infection with an average of 4 isolates per case. Escherichia coli is the predominant aerobe, and Bacteroides is the predominant anaerobe.
Other common microflora include the following:
Proteus
Staphylococcus
Enterococcus
Streptococcus (aerobic and anaerobic)
Pseudomonas
Klebsiella
Clostridium [25]
Rarely, Candida albicans has been reported as the pathogen in cases of Fournier gangrene. [26, 27, 28]
Predisposition to disease
Any condition that depresses cellular immunity may predispose a patient to the development of Fournier gangrene. Examples include the following:
Diabetes mellitus (present in as many as 60% of cases) [29, 25]
Morbid obesity
Alcoholism
Cirrhosis
Extremes of age
Vascular disease of the pelvis
Malignancy (eg, acute leukemia) [30, 31]
Systemic lupus erythematosus [32]
Crohn disease
HIV infection [33] ref34}
Malnutrition
Iatrogenic immunosuppression (eg, from long-term corticosteroid therapy or chemotherapy [34] )
Facultative organism lower the oxidation reduction potential of the wound micro environment and promotes favourable condition for the growth of the anaerobes .anaerobes interfere the host phagocyte function and thereby facilitate the proliferation of aerobic bacteria.
The infectious process activates the coagulation system that in turn produces lacal vascular thrombosis and infarction .
Fournier gangrene in patients with type 2 diabetes mellitus treated with sodium-glucose cotransporter-2 (SGLT2) inhibitors.
Sglt2 inhibitors- canagliflozin,dapagliflozin,empagliflozin (jardiance)
Fulminant inflammation of subcutaneous tissue cause obliterative arteritis of arterioles of skin causing gangrene .
thickened scrotal wall with multiple hyperechoic foci possibly air
Urinary and
faecal diversion may be necessary.
Early review of the wounds is helpful to confirm that all
dead tissue has been removed, and when the infection has
been controlled, vacuum-assisted dressing is helpful, if it is
Despite best therapy, mortality rates as
high as 50% are often reported.
Hyperbaric oxygen therapy (HBO) has been used as an adjuvant to surgical and antimicrobial therapy. Indications include failure of conventional treatment, documented clostridial involvement, or myonecrosis or deep tissue involvement. HBO is postulated to reduce systemic toxicity, prevent extension of necrotizing infection, and inhibit growth of anaerobic bacteria.
n 1995, Laor and colleagues introduced the Fournier Gangrene Severity Index (FGSI). [43] The FGSI is based on deviation from reference ranges of the following clinical parameters:
Temperature
Heart rate
Respiratory rate
White blood cell count (WBC)
Hematocrit
Serum sodium
Serum potassium
Serum creatinine
Serum bicarbonate
Each parameter is assigned a score between 0 and 4, with the higher values indicating greater deviation from normal. The FGSI represents the sum of all the parameters’ values.
Laor and colleagues determined that an FGSI greater than 9 correlated with increased mortality. [43] The FGSI has been validated in several retrospective studies. [44, 45, 46] In a retrospective review of 20 patients with Fournier gangrene, the average FGSI was 9 overall and 14 for fatal cases. An increased FGSI was predictive of having an increased mortality rate or hospital stay longer than the median (>25 days) (P=0.0194). [47]
This study also developed a novel scoring system, the Combined Urology and Plastics Index (CUPI), designed to predict length of stay in Fournier gangrene patients. CUPI parameters include the following:
Age at admission
Hematocrit
Plasma CO 2 (serum bicarbonate)
Blood urea nitrogen
Serum calcium
Alkaline phosphatase
Albumin
International normalized ratio (INR)
Lactate
Total bilirubin
The CUPI scoring system has a minimum score of 0 and a maximum score of 15. Patients with CUPI scores ≤5 had an average length of stay of 25 days (standard deviation [SD], 15.6), while those with CUPI scores >5 had an average length of stay of 71 days (SD 49.8). [53]