When under the care of your dermatologist or doctor, isotretinoin or Accutane is mostly considered safe and one of the most effective treatments for severe acne. Most patients are free of acne after 4 to 6 months of treatment. But can acne come back after Accutane? The unfortunate downside is that some people will have a relapse after taking Accutane and the long term cure rate is actually a lot lower than what people expect. https://banish.com/blogs/article/8-reasons-why-you-may-relapse-after-accutane