1) Before implementing Microsoft Defender for Endpoint, experts recommend learning how the tool works by creating a lab environment and testing it with attack simulations.
2) When first deploying the tool, start with a baseline configuration and one test machine to familiarize yourself with all settings and configurations.
3) Ongoing monitoring and responding to alerts is important for the tool's machine learning capabilities to improve over time at detecting threats in the environment. User buy-in is also important as some initial false positives may occur.