2. We encourage you to register for the EMR-IBS conference in Tel Aviv
between 22-25 April, 2013.
The conference promises to be very stimulating.
We have an outstanding program lined up, with world-renowned invited speakers.
The topic of the keynote lecture by Prof. Geert Molenberghs is "A flexible modeling framework
for over-dispersed, hierarchical data of a combined nature".
The registration form and other details about the conference and pre-conference short courses
are available on the conference website: https://event.pwizard.com/ims/index.py?p=620
Accommodation is available at a range of prices.
Rooms at the conference venue (Crowne Plaza Tel Aviv) will only be held until 6 March 2013.
Our social program includes a reception, gala dinner in Jaffa preceded by a short guided
walking tour, and a half-day trip to Jerusalem to experience the history, sights, sounds and
flavors of the holy city.
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3. Provisional Program
Monday, April 22nd
08:30-10:00 PRE-CONFERENCE COURSE 1: USING FDR IN PRACTICE: WHERE, WHY AND HOW
Prof. Yoav Benjamini, Tel Aviv University, Israel
Dr. Daniel Yekutieli, Tel Aviv University, Israel
Dr. Ruth Heller, Tel Aviv University, Israel
10:00-10:30 COFFEE BREAK
10:30-12:30 PRE-CONFERENCE COURSE 1: USING FDR IN PRACTICE: WHERE, WHY AND HOW (CONT’D)
12:30-13:30 LUNCH BREAK
13:30-15:30 PRE-CONFERENCE COURSE 2: SURVIVAL ANALYSIS: BEYOND THE COX MODEL
Prof. Malka Gorfine, Technion, Israel
15:30-16:00 COFFEE BREAK
16:00-17:30 PRE-CONFERENCE COURSE 2: SURVIVAL ANALYSIS: BEYOND THE COX MODEL (CONT’D)
19:00-21:30 RECEPTION AT THE HOTEL
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4. Provisional Program
Tuesday, April 23rd
08:30-09:00 OPENING SESSION
Welcome from Gertner Institute
Welcome from EMR
Prof. Stergios Tzortzios, University of Thessaly, Greece
Welcome from IBS
Prof. Clarice Demetrio, Sao Paulo University, Brazil
About the conference
Dr. Havi Murad, The Gertner Institute for Epidemiology and Health Policy Research, Israel
09:00-10:15 PLENARY SESSION: PERSONALIZED MEDICINE / PHARMACOGENETICS
09:00-09:25 Comparative Effectiveness in the Presence of Competing Risks for Multiple Event Time Observations
Prof. LJ Wei, Harvard University, USA
09:25-09:50 Improving Personalized Risk Prediction by Incorporating Short Term Outcomes
Dr. Tianxi Cai, Harvard University, USA
09:50-10:15 Statistical Methods for Dynamic Spatio-Temporal Networks
Prof. Adrian Dobra, University of Washington, USA
10:15-10:45 COFFEE BREAK
PARALLEL SESSIONS
10:45-12:40 Parallel Session 1: Biometrical Applications in Agricultural Research
10:45-11:10 The Ecological Footprint of Taylor's Universal Power Law
Prof. Clarice Demetrio, Sao Paulo University, Brazil
11:10-11:25 On The Use Of a Semi-Parametric Estimator for Censored Data, with Applications in Food Safety Exposure
Assessment
Prof. Marc Aerts, Hasselt University, Belgium
11:25-11:40 On Individual Control Treatments in Designed Genetical and Agricultural Experiments
Prof. Stanislaw Mejza, Poznan University of Life Sciences, Poland
11:40-11:55 Biomarker Quantification Based on New Dynamic Models for Qrt-PCR Efficiency
Dr. Boris Freydin, Jefferson University, USA
11:55-12:10 Direct Estimation of Parameters in Systems Of Ordinary Differential Equations
Dr. Itai Dattner, Eindhoven University, The Netherlands
12:10-12:25 Assessing Cancer Treatment Via Biomathematical Modeling and Nonlinear Mixed Effects Statistical Models
Ms. Mirit Kagarlitsky, Tel Aviv University, Israel
12:25-12:40 The Estimation of the Proportion of Infected People With the Aid of Repeated Quantitative PCR Tests
Mr. Ezer Miller, Gertner Institute, Israel
Continued 3
5. Provisional Program
10:45-12:40 Parallel Session 2: Statistical Methods for Diagnostic Medicine, Prediction and Classification
10:45-11:10 Assessing the Impact of Diagnostic Tests and Biomarkers
Prof. Constantine Gatsonis, Brown University, USA
11:10-11:25 Construction of Confidence Regions in the ROC Space After the Estimation of the Optimal Youden
Index-Based Cut-Off Point
Mr. Leonidas Bantis, University of the Aegean, Greece
11:25-11:40 The Use of Time Dependent ROC Curve for Evaluation of the Performance of Apache-Ii and Sofa Scores:
an Application in an Intensive Care Unit
Ms. Eda Karaismailoglu, Hacettepe University, Turkey
11:40-11:55 Statistical Decisions in the Prize4life Data Mining Contest Involving Predicting a Neurologic Score
Prof. David Schoenfeld, Massachusetts General Hospital, USA
11:55-12:10 Centering and the Use of Additional Information When Calibrating in the Presence of Random Effects
Prof. Samuel Oman, The Hebrew University of Jerusalem, Israel
12:10-12:25 Machine Learning Is Utilized for Personalized Medicine; Can It Also Be Used for Detecting Adherence
Problems? HIV Treatments as a Use-Case
Dr. Michal Rozen-Zvi, IBM Research, Israel
12:25-12:40 Comparing Performance Of Support Vector Machines And Relevance Vector Machines For Finding
Promising Molecule
Mr. Selcuk Korkmaz, Hacettepe University, Turkey
10:45-12:40 Parallel Session 3: Statistical Methods for Clinical Trials I
10:45-11:10 Statistical Designs in Planning Randomized Cancer Screening Trials: Application to the Early Detection of
Lung Cancer
Dr. Ping Hu, National Cancer Institute, USA
11:10-11:25 Patient Selection and Sample Size Reassessment in Adaptive Enrichment Designs Using Perfect or
Imperfect Biomarkers
Prof. Meinhard Kieser, University of Heidelberg, Germany
11:25-11:40 Some Observations on the Design of Early Stage Clinical Trials in the Pharmaceutical Industry
Mr. Hans Hockey, BML, New Zeland
11:40-11:55 Hierarchical Weighted Methods which Control the False Discovery Rate Criterion and Their Use in Clinical
Trials
Mr. Rami Cohen, Public Health Association, Israel
11:55-12:10 TBA
12:10-12:25 Comparison of Statistical Tests in Presence of Many Zeros Data: Application in Vaccine Clinical Trial
Mari Kassapian, Frontier Science Foundation-Hellas, Greece
12:25-12:40 Competing Risk Incidence Estimation In Two-Phase Designs
Paola Rebora, University of Milan Bicocca, Italy
12:40-14:00 LUNCH BREAK
Continued 4
6. Provisional Program
PARALLEL SESSIONS
14:00-15:30 Parallel Session 4: Bioinformatics: Contributed Papers
14:00-14:15 Analysis of Dose-Response Microarray Data Using Bayesian Variable Selection (BVS) Methods: Modeling
and Multiplicity Adjustments
Ziv Shkedy, Hasselt University, Belgium
14:15-14:30 Gene-Gene Interaction Analysis of Multiple Phenotypes
Taesung Park, Seoul National University, South Korea
14:30-14:45 Statistical Analysis of Time-Course Tiling Array Data
Dr. Anat Reiner-Benaim, Haifa University, Israel
14:45-15:00 Methods For Association Analysis of a SNP-Set and Multiple Continuous Secondary Outcomes
Dr. Tamar Sofer, Harvard School of Public Health, USA
15:00-15:15 Discovering Findings that Replicate from a Primary Study of High Dimension to a Follow-Up Study
Dr. Marina Bogomolov, Haifa University, Israel
15:15-15:30 High Throughput Genome-Wide Scan for Epistasis with Implementation to Recombinant Inbred Lines (RIL)
Populations
Mr. Pavel Goldstein, Haifa University, Israel
14:00-15:30 Parallel Session 5: Survival: Contributed Papers
14:00-14:15 A Sup-Score Test for the Cure Proportion in Mixture Models for Long-Term Survivors
Prof. Kyungmann Kim, University of Wisconsin, USA
14:15-14:30 Cross-Sectional Sampling, Bias, Dependence, and Composite Likelihood
Dr. Micha Mandel, The Hebrew University of Jerusalem, Israel
14:30-14:45 Nonparametric Adjustment for Measurement Error in Time to Event Data
Ms. Danielle Braun, Harvard University, USA
14:45-15:00 Cox Model With Intermittent and Error-Prone Covariate Observation
Mr. Yury Gubman, The Hebrew University of Jerusalem, Israel
15:00-15:15 An R Package for the Estimation of the Transition Probabilities in 3-State Models
Dr. Luis Machado, University of Minho, Portugal
15:15-15:30 On Properties of Measures of Explained Variation in Survival Analysis
Prof. Janez Stare, University of Ljubljana, Slovenia
14:00-15:30 Parallel Session 6: Longitudinal Analysis and Time Series: Contributed Papers
14:00-14:15 Application of a Random Partition Model with Regression on Covariates for Inference in a Longitudinal Study
Prof. Gary Rosner, Sidney Kimmel Comprehensive Cancer Institute, USA
14:15-14:30 Extended Cox Regression Model for the Analysis of Dental Implant Failure in Periodontal Patients
Dr. Ronen Ofec, Ofec Private Dental Practice, Israel
14:30-14:45 Robust Estimation for Count Time Series
Prof. Kostantinos Fokianos, University of Cyprus, Cyprus
14:45-15:00 Approaches to the Analysis of Unbalanced Repeated Measure and Longitudinal Data
Prof. Refik Burgut, Cukurova University, Turkey
15:00-15:15 Joint Modelling of Longitudinal Ordinal and Time-To-Event Data
Mr. Carles Forne, University of Lleida, Spain
15:15-15:30 Missing Data in Geriatric Cohort Studies Continued
Ms. Dikla Geva, Ben- Gurion University of the Negev, Israel 5
7. Provisional Program
15:30-15:50 COFFEE BREAK
15:50-16:50 PLENARY SESSION: BIOINFORMATICS AND STATISTICS FOR MICORARRAYS
15:50-16:15 Removing Unwanted Variation from High-Dimensional Data Using Negative Controls
Prof. Terry Speed, University of Berkeley, USA
16:15-16:40 Bayesian False Discovery Rate Controlling Procedures
Dr. Daniel Yekutieli, Tel Aviv University, Israel
16:40-16:50 Discussion
16:50-17:50 KEYNOTE LECTURE: A FLEXIBLE MODELLING FRAMEWORK FOR OVERDISPERSED, HIERARCHICAL
DATA OF A COMBINED NATURE
Prof. Geert Molenberghs, Hasselt University, Belgium
17:50-18:35 EMR BUSINESS MEETING AND STUDENT COMPETITION AWARDS
19:15 LEAVE FOR JAFFA AND GALA DINNER
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8. Provisional Program
Wednesday, April 24th
PARALLEL SESSIONS
08:30-10:35 Parallel Session 7: Statistical Methods for Image Analysis
08:30-08:50 Surfaces, Shapes and Anatomy
Prof. Adrian Bowman, University of Glasgow, Scotland
08:50-09:10 Multi-Scale Multiple Testing for Detection of Regions of Genomic Copy Number Change in Population Analyses
Dr. Armin Schwartzmann, Harvard University, USA
09:10-09:30 Wavelet-Domain Methods for Scalar-on-Image Regression
Prof. Phil Reiss, New York University, USA
09:30-09:50 A Life-Table Approach to The Kinetic Analysis of Time-Course Data from Molecular Imaging Studies with PET
in Cancer
Prof. Finbarr O'Sullivan, University College Cork, Ireland
09:50-10:05 A Spatial Factor Model for Summarizing Area-Level Townsend-Like Index
Dr. Demetris Lamnisos, Cyprus University of Technology, Cyprus
10:05-10:20 Comparison of PNN and SVM in Determining the Disease in Diabetes
Ms. Duygu Aydin, Hacettepe University, Turkey
10:20-10:35 Contributed Paper - TBA
08:30-10:35 Parallel Session 8: Statistical Issues in Monitoring Institution Performance
08:30-08:55 Provider Comparisons: Identifying and Meeting Goals
Prof. Tom Louis, Johns Hopkins University, USA
08:55-09:20 The National Program for Quality Indicators in Community Healthcare in Israel: Methodological Challenges
Prof. Orly Manor, Hebrew University, Israel
09:20-09:35 Using Classification Trees Modeling to Investigate Drug
Mr. Dan Kajungu, Indepth Network, Uganda
09:35-09:50 Genome-Wide Association Interaction Analysis for Complex Diseases: an Example on Alzheimer Disease
Dr. Elena Gusareva, University of Liege, Belgium
09:50-10:05 Optimal Sequential Designs for Microarray Experiments
Dr. Legesse K. Debusho, University of Pretoria, South Africa
10:05-10:20 A Sharper Meinshausen's Procedure
Dr. Aldo Solari, Unviersity of Milan Bicocca, Italy
10:20-10:35 Rotation-Based Multiple Testing in the Multivariate Linear Model
Dr. Livio Finos, University of Padua, Italy
10:35-10:55 COFFEE BREAK
Continued 7
9. Provisional Program
10:55-12:40 PLENARY SESSION: STATISTICAL ISSUES IN CLINICAL TRIALS
10:55-11:15 Statistical Issues in Clinical Trial Reporting:
Prof. David DeMets, University of Wisconsin, USA
11:15-11:35 Adaptive Designs for Clinical Trials
Dr. Frank Bretz, Novartis, Switzerland
11:35-11:55 Statistical Considerations in Studies of Medical Devices
Prof. Sharon-Lise Normand, Harvard University, USA
11:55-12:40 Floor Discussion
12:40-13:40 LUNCH BREAK
14:00 VISIT TO JERUSALEM
8
10. Provisional Program
Thursday, April 25th
08:30-10:20 PLENARY SESSION: CAUSAL INFERENCE
08:30-08:55 Adjusting for Time-Varying Confounding in Survival Analysis Using Structural Nested Cumulative Failure
Time Models
Prof. Stijn van Steelandt, University Ghent, Belgium
08:55-09:15 Selective and Future Ignorability in Causal Inference
Dr. Marshall Joffe, University of Pennsylvania, USA
09:15-09:35 Robust Estimation of Causal Effects of Erythropoiesis-Stimulating Agents on Mortality
Dr. Roee Gutman, Brown University, USA
09:35-10:20 A Discussion of Estimators of the Odds Ratio
Prof. Christiana Drake, University of California, USA
09:35-09:50 Reconsidering Definitions of Direct and Indirect Effects in Mediation Analysis
Dr. Ilya Novikov, Gertner Institute, Israel
09:50-10:05 Assessment of Outcomes in Mental Health Research
Dr. Amita Manatunga, Emory University, USA
10:20-10:45 COFFEE BREAK
PARALLEL SESSIONS
10:45-12:20 Parallel Session 9: Machine Learning Methods in Biostatistics
10:45-11:10 Advances in Sequential Multiple Assignment Randomized Trials and Treatment Policies
Prof. Susan Murphy, University of Michigan, USA
11:10-11:30 Support Vector Regression for Right Censored Data
Dr. Yair Goldberg, Haifa University, Israel
11:30-11:50 Identifying Subgroups in Large Observational Data Sets
Dr. Marianthi Markatou, TJ Watson Research Center, IBM, USA
11.50-12.05 Confidence Interval for Test Error of Support Vector Machine Classifiers
Mr. Jonathan Yefenof, The Hebrew University of Jerusalem, Israel
12.05-12.20 Genetic Algorithm in L∞-Space For Holistic Face Recognition
Dr. Carlos Villegas-Quezada, Universidad Iberoamericana, Mexico
10:45-12:20 Parallel Session 10: Spanish-Italian Session
10:45-11:05 P-Splines Mixed Models: A Flexible Approach for Spatio-Temporal Data
Prof. Maria Durban, Universidad Carlos III de Madrid, Spain
11:05-11:25 Smoothing Survival Estimates Through Pseudo Values
Dr. Federico Ambrogi, Universita degli Studi di Milano, Italy
11:25-11:45 A New Method for Choosing the Best Model: "Farms"
Ms. Susana Perez-Alvarez, IrsiCaixa Foundation, Spain
11:45-12:05 Comparative Randomized Inverse Sampling
Prof. Mauro Gasparini, Politecnico di Torino, Italy
12:05-12:20 A General Class of Models in Continuous Time Capture-Recapture, with Application to Drug Users in Italy
Dr. Alessio Farcomeni, La Sapienza University, Italy
Continued 9
11. Provisional Program
12:20-13:30 LUNCH BREAK
PARALLEL SESSIONS
13:30-14:35 Parallel Session 11: Modeling Infectious Disease
13:30-13:55 Hope-Simpson's Progressive Immunity Hypothesis Explains Herpes Zoster Incidence Data
Dr. Piero Manfredi, University of Pisa, Italy
13:55-14:20 The Impact of Misspecified Disease Dynamics on Modeling Individual Heterogeneity in The Acquisition of
Infectious Diseases
Dr. Niel Hens, Hasselt University, Belgium
14:20-14:35 Modeling and Statistical Analysis of the Spatio-Temporal Patterns of Seasonal Influenza in Israel
Dr. Amit Huppert, Gertner Institute, Israel
13:30-14:30 Parallel Session 12: Student Competition
13:30-13:50 Revisiting Random Effects Analysis in Group FMRI Studies
Mr. Jonathan Rosenblatt, Tel Aviv University, Israel
13:50-14:10 Quasi-Likelihood Inference and Prediction for Count Time Series
Mr. Vasiliki Christou, University of Cyprus
14:10-14:30 Causal Mediation Analysis to Study The Relation Between Physical Activity and Prostate Cancer Incidence
Ms. Alessandra Grotta, University of Milano Bicocca, Italy
14:35-14:45 BREAK
14:45-16:30 Parallel Session 13: Survival and Longitudinal Analysis
14:45-15:10 Statistical Measures to Evaluate Biomarkers as Predictors of Incident Cases
Prof. Patrick Heagerty, University of Washington, USA
15:10-15:35 Combining Joint Models with Different Association Structures Using Bayesian Model Averaging
Dr. Dimitris Rizopoulos, Erasmus University, Netherlands
15:35-15:55 Estimating a Survival Distribution in the Presence of Dependent Left Truncation
Prof. Rebecca Betensky, Harvard University, USA
15:55-16:15 Clustering Longitudinal Count Data
Dr. Dimitris Karlis, Athens University, Greece
16:15-16:30 Joint Modeling Of Two Longitudinal Outcomes And Competing Risk Data
Ms. Eleni-Rosalina Andrinopoulou, Erasmus MC Rotterdam, The Netherlands
Continued 10
12. Provisional Program
14:45-16:30 Parallel Session 14: Statistical Methods for Clinical Trials 2
14:45-15:10 Observational Studies in Healthcare: Are They Any Good?
Prof. David Madigan, Columbia University, USA
15:10-15:30 Resolving Inference Issues in Mixed Models
Dr. Samaradasa Weerahandi, Pfizer, USA
15:30-15:45 Randomization: To Block or Not To Block
Prof. Urania Dafni, University of Athens, Greece
15:45-16:00 Examining the Reliability and Usefulness of Interim Analysis Data: Case of Antipsychotic Drug Trials
Prof. Jonathan Rabinovitz, Bar- Ilan University, Israel
16:00-16:15 Cost Effectiveness Evaluation for Promoting HIV Treatment Adherence: Cohort Simulation Using a Pilot
Study Data
Ms. Nuria Perez-Alvarez, Fight against AIDS Foundation, Spain
16:15-16:30 Effect of the Choice of Copulas in the Asymptotic Relative Efficiency of the Logrank Test Based on a
Composite Endpoint
Mr. Oleguer Plana-Ripoll, Aarhus University, Denmark
16:30-16:55 COFFEE BREAK
16:55-18:25 PLENARY SESSION: REPLICABILITY OF RESEARCH RESULTS IN EPIDEMIOLOGY AND LIFE SCIENCES
16:55-17:25 Empirical Studies of Repeatability, Replication, and Reproducibility
Prof. John Ioannidis, Stanford University, USA
17:25-17:55 Replicability and Selective Inference
Prof. Yoav Benjamini, Tel Aviv University, Israel
17:55-18:15 Replicability Analysis for Genome-Wide Association Studies
Dr. Ruth Heller, Tel Aviv University, Israel
18:15-18:25 Discussion
18:25-18:35 CLOSING REMARKS
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