Awesome Entertainment hosts an exclusive celebrity party called "What Happens in Vegas" before each MAGIC fashion trade show in Las Vegas. The event attracts hundreds of entertainment, fashion, and music industry executives and celebrities. It features music from celebrity DJs, catering, massages, and is hosted by models. Past celebrity guests have included Russell Simmons, Kimora Lee Simmons, and other notable names. The event capitalizes on the hundreds of millions of dollars of business conducted at MAGIC, the largest global marketplace for fashion.
This document summarizes a study that characterized the heme binding properties of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The key findings include:
1) GAPDH binds heme substoichiometrically, with one heme binding per GAPDH tetramer. The heme forms low-spin complexes with GAPDH that have distinct UV-visible absorption spectra depending on the heme redox state.
2) Kinetic analysis found heme binding to GAPDH is reversible and selective for heme structure. Heme binding affinity ranges from 19-390 nM depending on redox conditions.
3) Spectroscopic analysis indicates the heme in the GAPDH complex is bis-ligated by a histidine residue as the proximal
This study examined the effects of an 8-week resistance training program on quality of life, strength, and functional ability in 10 end-stage renal disease patients undergoing dialysis. Patients were assigned to either a treatment group that performed resistance training during dialysis or a control group. Strength and functional measures improved more for the treatment group compared to controls. Resistance training is a safe and effective way to improve outcomes for dialysis patients.
This study investigated the effects of substituting the native haem group in iNOS with mesohaem, which has a higher electron density. The goals were to dissect the structural and electronic effects on iNOS catalysis. Key findings include:
1) iNOS and the W188H mutant with mesohaem substitution were stable and dimeric, and had similar substrate binding affinities as their native haem counterparts.
2) Single turnover kinetic experiments showed mesohaem substitution triggered higher rates of dioxygen conversion and altered other kinetic parameters.
3) The first crystal structure of iNOS with mesohaem substitution showed essentially identical features to native iNOS, indicating electronic effects primarily influence kinetics rather
This review discusses biomarkers used to diagnose vitamin B12 deficiency. Total serum B12 has limited value as it does not reflect cellular B12 levels. Homocysteine and methylmalonic acid are more specific biomarkers, with elevated levels indicating B12 deficiency, but they can also be influenced by folate or renal status. Holo-transcobalamin is the protein-bound, bioavailable form of B12 and the preferred biomarker. Diagnostic algorithms incorporating two or more biomarkers provide improved detection of vitamin B12 deficiency over single markers. Challenges remain in special populations like the elderly, vegetarians, and those with gastrointestinal or renal disorders.
This document summarizes research on the reduction of manganese porphyrins by flavoenzymes and mitochondrial particles, and how this relates to the catalytic reduction of peroxynitrite. It finds that flavoenzymes like xanthine oxidase and glucose oxidase, as well as mitochondrial Complex I and II, catalyze the reduction of manganese porphyrins using substrates like NADH and succinate. Reduced manganese porphyrins can then rapidly react with peroxynitrite via a two-electron process, producing nitrite and manganese porphyrin radicals. This redox cycle can protect peroxynitrite-sensitive targets in submitochondrial particles.
This document summarizes a study that investigated the role of the MMACHC gene product (cblC protein) in processing alkylcobalamins in mammalian cells. The study found that:
1) Cultured bovine endothelial cells converted [57Co]-adenosylcobalamin to [57Co]-methylcobalamin, suggesting the cells contain machinery to remove alkyl groups from alkylcobalamins.
2) When cultured cells were treated with various [57Co]-labeled straight-chain alkylcobalamins, the cells converted them to both [57Co]-adenosylcobalamin and [57Co]-methylcobalamin, indicating the dealkylation machinery has broad substrate specificity.
External wall insulation (EWI) installed by Halltech provides various benefits such as reduced heating costs up to 40%, reduced CO2 emissions, and improved building aesthetics. EWI insulates walls to reduce heat loss and gain, improving indoor comfort. Homeowners can claim a £4,000 Green Deal voucher toward installation costs, and EWI qualifies for reduced VAT as an energy efficient measure. Halltech aims to train contractors in installing energy efficiency measures like EWI and solar PV through their distribution center and training academy.
This document summarizes a study that characterized the heme binding properties of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The key findings include:
1) GAPDH binds heme substoichiometrically, with one heme binding per GAPDH tetramer. The heme forms low-spin complexes with GAPDH that have distinct UV-visible absorption spectra depending on the heme redox state.
2) Kinetic analysis found heme binding to GAPDH is reversible and selective for heme structure. Heme binding affinity ranges from 19-390 nM depending on redox conditions.
3) Spectroscopic analysis indicates the heme in the GAPDH complex is bis-ligated by a histidine residue as the proximal
This study examined the effects of an 8-week resistance training program on quality of life, strength, and functional ability in 10 end-stage renal disease patients undergoing dialysis. Patients were assigned to either a treatment group that performed resistance training during dialysis or a control group. Strength and functional measures improved more for the treatment group compared to controls. Resistance training is a safe and effective way to improve outcomes for dialysis patients.
This study investigated the effects of substituting the native haem group in iNOS with mesohaem, which has a higher electron density. The goals were to dissect the structural and electronic effects on iNOS catalysis. Key findings include:
1) iNOS and the W188H mutant with mesohaem substitution were stable and dimeric, and had similar substrate binding affinities as their native haem counterparts.
2) Single turnover kinetic experiments showed mesohaem substitution triggered higher rates of dioxygen conversion and altered other kinetic parameters.
3) The first crystal structure of iNOS with mesohaem substitution showed essentially identical features to native iNOS, indicating electronic effects primarily influence kinetics rather
This review discusses biomarkers used to diagnose vitamin B12 deficiency. Total serum B12 has limited value as it does not reflect cellular B12 levels. Homocysteine and methylmalonic acid are more specific biomarkers, with elevated levels indicating B12 deficiency, but they can also be influenced by folate or renal status. Holo-transcobalamin is the protein-bound, bioavailable form of B12 and the preferred biomarker. Diagnostic algorithms incorporating two or more biomarkers provide improved detection of vitamin B12 deficiency over single markers. Challenges remain in special populations like the elderly, vegetarians, and those with gastrointestinal or renal disorders.
This document summarizes research on the reduction of manganese porphyrins by flavoenzymes and mitochondrial particles, and how this relates to the catalytic reduction of peroxynitrite. It finds that flavoenzymes like xanthine oxidase and glucose oxidase, as well as mitochondrial Complex I and II, catalyze the reduction of manganese porphyrins using substrates like NADH and succinate. Reduced manganese porphyrins can then rapidly react with peroxynitrite via a two-electron process, producing nitrite and manganese porphyrin radicals. This redox cycle can protect peroxynitrite-sensitive targets in submitochondrial particles.
This document summarizes a study that investigated the role of the MMACHC gene product (cblC protein) in processing alkylcobalamins in mammalian cells. The study found that:
1) Cultured bovine endothelial cells converted [57Co]-adenosylcobalamin to [57Co]-methylcobalamin, suggesting the cells contain machinery to remove alkyl groups from alkylcobalamins.
2) When cultured cells were treated with various [57Co]-labeled straight-chain alkylcobalamins, the cells converted them to both [57Co]-adenosylcobalamin and [57Co]-methylcobalamin, indicating the dealkylation machinery has broad substrate specificity.
External wall insulation (EWI) installed by Halltech provides various benefits such as reduced heating costs up to 40%, reduced CO2 emissions, and improved building aesthetics. EWI insulates walls to reduce heat loss and gain, improving indoor comfort. Homeowners can claim a £4,000 Green Deal voucher toward installation costs, and EWI qualifies for reduced VAT as an energy efficient measure. Halltech aims to train contractors in installing energy efficiency measures like EWI and solar PV through their distribution center and training academy.
This document discusses nitric oxide homeostasis and its role in neurodegenerative diseases such as Alzheimer's and Parkinson's. It begins by introducing nitric oxide biosynthesis by nitric oxide synthases and how their expression is altered in Alzheimer's. It then discusses factors that control nitric oxide levels, including endogenous inhibitors, tetrahydrobiopterin levels, and nitric oxide reactivity with superoxide to form peroxynitrite. Overall, the document analyzes how imbalances in nitric oxide signaling can contribute to neurodegeneration through oxidative stress and damage.
External wall insulation (EWI) installed by Halltech provides various benefits such as reduced heating costs up to 40%, reduced CO2 emissions, and improved building aesthetics. EWI insulates walls to reduce heat loss and gain, improving indoor comfort. Homeowners can claim a £4,000 Green Deal voucher toward installation costs, and EWI qualifies for reduced VAT as an energy efficient measure. Halltech aims to train contractors in installing energy efficiency measures like EWI and solar PV through their distribution center and training academy.
This document discusses several studies related to bifunctional air electrodes for metal-air batteries.
Key findings include:
1) Potential distribution measurements showed that electrode potential depends on electrolyte penetration patterns, with nonplanar penetration resulting in larger potential variations.
2) Testing of different teflon loadings and agglomerate sizes found that oxygen reduction performance was best with lower teflon loading and smaller agglomerate size.
3) Hot pressing studies indicated that higher pressing temperature, pressure and time generally improved electrode performance, up to certain limits.
This document summarizes the design and performance of an iron-air battery for electric vehicle applications. Key points include:
- The battery uses an iron electrode and bifunctional air electrode with a potassium hydroxide electrolyte. Near-term technology could provide over 100 miles of range for a 1900 lb vehicle with power comparable to alternative advanced systems.
- Cell-level performance targets are outlined for the iron and air electrodes, as well as full cells and modules. Battery-level targets include over 100 Wh/kg energy density and 90 $/kWh cost.
- A mission analysis models two vehicle types over urban and highway driving cycles to size the battery for the performance requirements using the cell-level models
This document provides information about three public library case studies:
1) The Daegu Gosan Public Library in South Korea, which uses an open floor plan and children/adult zones to promote interaction.
2) The Bibliotheca Alexandrina in Egypt, located on the historic harbor, with spaces like a planetarium, digital lab, and rare books collection.
3) The Sharjah Public Library in the UAE reflects Islamic architectural styles with domes and arches, and provides activities for learners of all ages.
Standard space requirements and functions for different library areas are also outlined.
This document discusses nitric oxide homeostasis and its role in neurodegenerative diseases such as Alzheimer's and Parkinson's. It begins by introducing nitric oxide biosynthesis by nitric oxide synthases and how their expression is altered in Alzheimer's. It then discusses factors that control nitric oxide levels, including endogenous inhibitors, tetrahydrobiopterin levels, and nitric oxide reactivity with superoxide to form peroxynitrite. Overall, the document analyzes how imbalances in nitric oxide signaling can contribute to neurodegeneration through oxidative stress and damage.
External wall insulation (EWI) installed by Halltech provides various benefits such as reduced heating costs up to 40%, reduced CO2 emissions, and improved building aesthetics. EWI insulates walls to reduce heat loss and gain, improving indoor comfort. Homeowners can claim a £4,000 Green Deal voucher toward installation costs, and EWI qualifies for reduced VAT as an energy efficient measure. Halltech aims to train contractors in installing energy efficiency measures like EWI and solar PV through their distribution center and training academy.
This document discusses several studies related to bifunctional air electrodes for metal-air batteries.
Key findings include:
1) Potential distribution measurements showed that electrode potential depends on electrolyte penetration patterns, with nonplanar penetration resulting in larger potential variations.
2) Testing of different teflon loadings and agglomerate sizes found that oxygen reduction performance was best with lower teflon loading and smaller agglomerate size.
3) Hot pressing studies indicated that higher pressing temperature, pressure and time generally improved electrode performance, up to certain limits.
This document summarizes the design and performance of an iron-air battery for electric vehicle applications. Key points include:
- The battery uses an iron electrode and bifunctional air electrode with a potassium hydroxide electrolyte. Near-term technology could provide over 100 miles of range for a 1900 lb vehicle with power comparable to alternative advanced systems.
- Cell-level performance targets are outlined for the iron and air electrodes, as well as full cells and modules. Battery-level targets include over 100 Wh/kg energy density and 90 $/kWh cost.
- A mission analysis models two vehicle types over urban and highway driving cycles to size the battery for the performance requirements using the cell-level models
This document provides information about three public library case studies:
1) The Daegu Gosan Public Library in South Korea, which uses an open floor plan and children/adult zones to promote interaction.
2) The Bibliotheca Alexandrina in Egypt, located on the historic harbor, with spaces like a planetarium, digital lab, and rare books collection.
3) The Sharjah Public Library in the UAE reflects Islamic architectural styles with domes and arches, and provides activities for learners of all ages.
Standard space requirements and functions for different library areas are also outlined.
2.
What
Happens
In
Vegas…
At
each
MAGIC
fashion
trade
show
week,
Awesome
Entertainment
host
an
exclusive
private
celebrity
lifestyle
party!
Invited
guests
get
to
mingle,
relax,
and
network
just
before
the
main
MAGIC
festivities
begin!
Previous
“What
Happens
in
Vegas”
events
have
attracted
capacity
crowds
of
up
to
300.
Due
to
the
popularity,
our
Summer
2015
festivities
will
feature
even
more
specially
invited
entertainment
and
fashion
industry
executives,
recording
artists,
celebrities
and
key
tastemakers.
EVENT
HIGHLIGHTS
Music
by
high
profile
celebrity
DJs
Catered
food
and
open
bar
all
night
Private
Swedish
and
exotic
massages
Video
gaming
consoles
Hosted
by
some
of
Las
Vegas'
most
beautiful
models
3.
Past
celebrity
attendees
include
Russell
Simmons,
Kimora
Lee
Simmons,
Jalen
Rose,
Michael
Rappaport,
Laila
Ali,
Tracy
Morgan,
Busta
Rhymes,
Kool
Herc,
Angela
and
Vanessa
Simmons,
Bun
B,
Ice-‐T,
Mr.
FAB,
DJ
Whoo
Kid
and
more.
Attending
media
has
included
representatives
from
SiriusXM,
The
Source
Magazine,
AllHipHop.com,
DrJays.com,
2DopeBoyz.com,
HipHopDX.com,
and
more.
4.
Magic
Fashion
-‐
Las
Vegas
MAGIC
is
the
largest
global
marketplace
for
contemporary
men’s
and
women’s
apparel,
footwear,
accessories
and
sourcing
resources
—
and
the
world’s
most
comprehensive
forum
for
fashion
buyers
and
brands.
Every
February
and
August,
the
industry
convenes
in
Las
Vegas
for
connection,
inspiration
and
to
shop
a
portfolio
of
ten
expertly
merchandised
and
curated
shows
across
every
category,
trend
and
price
point.
MAGIC
fuels
the
business
of
fashion.
In
addition
to
the
MAGIC
show,
ROJECT,
WWDMAGIC,
FN
PLATFORM,
SOURCING
at
MAGIC,
ENK
VEGAS,MEN’S,
POOLTRADESHOW,
WSA@MAGIC,
THE
TENTS
and
Playground,
which
are
all
part
of
the
MAGIC
community
will
be
simultaneously
taking
place.
These
shows
boost
over
$200
million
in
revenue
from
the
tradeshows
alone.
This
does
not
include
what
is
generated
during
the
pre
and
post
parties.
5.
6.
7.
What
Happens
in
Vegas
August,
2015
Palm’s
Place
-‐
Las
Vegas
4321
W
Flamingo
Rd
Las
Vegas,
NV
89103
8.
The
elegant
and
stylish
aesthetic
of
the
Palms
Place
is
a
luxurious
escape.
Every
dwelling
is
an
unforgettable
experience
unto
itself.
From
the
incredible
themed
suites
to
the
gorgeous
villas
and
penthouses,
to
the
bars
and
nightclubs,
these
accommodations
sit
at
the
pinnacle
of
luxury.
9.
Palm’s
Place
Penthouse
This
3,120-‐square-‐foot
penthouse
has
amazing
views
and
the
amenities
to
match.
The
Penthouse
features
floor-‐to-‐ceiling
windows
running
the
length
of
the
suite,
a
gourmet
kitchen,
spacious
living
room,
elegant
bedrooms
and
spa-‐inspired
bathrooms.
With
amenities
like
these,
it’s
not
just
the
views
that
are
breathtaking,
it’s
the
experience
that
creates
the
everlasting
memory.
10.
Some
of
our
Product
and
Media
Sponsors
have
included:
11.
12.
13. WHAT
HAPPENS
IN
VEGAS
2015
Some
Sponsorship
Amenities
Include:
• Marketing
on
Step-‐and-‐Repeat
banner
• Placement
on
Awesome
Entertainment’s
and
Writings
of
the
Goddess’
Facebook,
Twitter,
and
Instagram
pages
• On-‐Air
Mentions
by
Sirius
Radio
Personalities
• Logo
included
on
all
promotional
collateral
(flyers,
e-‐vites,
t-‐shirts,
etc.)
• Gift
bags
• E-‐Mail
Blasts
to
Awesome
Entertainment’s
database
of
33,000
DJs,
celebrities
and
tastemakers.
14. WHAT
HAPPENS
IN
VEGAS
2015
Sponsorship
Opportunities
Platinum
Package
$10,000
Presenting
Rights
/
Exclusivity
• Event
presenting
sponsor
• Category
exclusivity
• Exclusive
branding
of
main
event
room
15. WHAT
HAPPENS
IN
VEGAS
2015
• Branding
on
all
print
and
digital
promotion
and
flyers
Sponsor
Logo
Featured
On
• Event
invitations
and
fliers:
quantity
500
• Marketing
and
on-‐site
collateral
• Printed
Materials
• Logo
inclusion
on
Step-‐and-‐Repeat
• Premium
positioning
throughout
venue
(provided
by
sponsor)
• Brand
mentions
by
DJ
throughout
the
duration
of
event
Measurement
/
Sampling
• On-‐site
sampling
opportunities
or
product
included
in
event
gift
bags:
quantity
300
• Sponsor
on-‐site
surveying
opportunities
for
benefit
(conducted
by
sponsor)
Hospitality
• Guaranteed
admission
for
20
representatives
to
event
16. WHAT
HAPPENS
IN
VEGAS
2015
Gold
Package
$7,500
Presenting
Rights
/
Exclusivity
• Event
presenting
sponsor
• Category
exclusivity
• Exclusive
branding
of
main
event
room
• Branding
on
all
print
and
digital
promotion
and
flyers
Sponsor
Logo
Featured
On
• Event
invitations
and
fliers:
quantity
500
• Printed
Materials
• Logo
inclusion
on
Step-‐and-‐Repeat
• Premium
positioning
throughout
venue
(provided
by
sponsor)
• Brand
mentions
by
DJ
throughout
the
duration
of
event
Measurement/
Sampling
• On-‐site
sampling
opportunities
or
product
included
in
event
gift
bags:
quantity
300
Hospitality
• Guaranteed
admission
for
8
representatives
to
event
17. WHAT
HAPPENS
IN
VEGAS
2015
Silver
Package-‐
$5,000
Presenting
Rights
• Table
/space
for
sponsor
to
present
goods
to
attendees,
outside
of
main
room
Sponsor
Logo
Featured
On
• Printed
materials,
press
release,
event
invitations
and
flyers:
quantity
500
• Logo
inclusion
on
step
and
repeat
• Signage
and
premium
placement
in
venue,
with
exception
of
main
room
(provided
by
sponsor)
• Sponsor
name
mentions
by
DJ
throughout
the
duration
of
the
event
Hospitality
• 4
invitations
to
event
Measurement
/
Sampling
• Product
sampling
opportunities
on-‐site
• Product
included
in
event
gift
bags:
quantity
300
19. WHAT
HAPPENS
IN
VEGAS
2015
Social
Media
Marketing
Campaign
An
additional
social
media
campaign
will
be
run
alongside
the
event
itself,
with
Platinum
&
Gold
sponsors.
Creating
a
buzz
and
awareness
using
mass
media
outreach,
the
campaign
can
be
tailored
to
a
client’s
specific
branding,
message,
and
existing
marketing
materials
if
need
be.
With
a
heavy
emphasis
on
live
interaction
with
the
social
media
audience,
the
goal
is
to
get
the
event
hashtag
to
trend
and
explode
via
various
social
media
platforms
and
online
as
a
whole.
Phase
1
The
Facebook
campaign
will
be
branded
around
a
specific
client,
packaged
to
advertise
their
brand
and
their
inclusion
in
our
event
in
Las
Vegas.
Through
an
online
video
/
photo
submission
contest,
users
will
be
able
to
submit
their
fashion
profile
and
best
looks,
and
the
winners
can
be
selected
to
get
free
tickets
to
the
event
itself.
The
contest
will
be
supported
with
Facebook
ads,
Tweets
and
online
ads
on
fashion
related
websites.
Phase
2
Before
the
event,
ads
for
campaign
will
start
to
show
up
online,
inviting
people
to
submit
their
own
Vegas
fashion
look
via
the
Facebook
app,
Instagram
and
Twitter
hashtags,
etc.
20. WHAT
HAPPENS
IN
VEGAS
2015
Measurement
/
Sampling
• Attendance
at
the
event
(including
media
and
media
coverage
pre
and
post
event)
-‐
Facebook
likes,
comments,
mentions
and
shares.
• Number
of
pictures
shared
from
the
Facebook
page
after
the
event-‐
Twitter
and
Instagram
mentions,
retweets,
favorites
and
followers.
• Number
of
pictures
tagged
on
Instagram,
likes
and
shares.
• CPC
click
through
on
Facebook
ads
and
online
ads.
• Number
of
unique
visitors
and
amount
of
time
spent
on
the
microsite
21. WHAT
HAPPENS
IN
VEGAS
2015
Contact
Information
Tedd Whiting
teddwhiting@msn.com
201-954-1523
Qiana Williams
writingsofthegoddess@gmail.com
347-520-3133