2024HRPIWSProgram_2024-01-18_33.pdf

Custom graphics designed by Emily Dung (NASA JPL)
Last updated
1/18/2024

2024 NASA Human Research Program Investigators’ Workshop
February 13-16, 2024
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Last Updated 1/18/2024
About the 2024 NASA HRP IWS graphics
Redefining What’s Possible
The winning graphic was designed by Emily Dung, an intern at NASA’s Jet Propulsion Laboratory. The graphics are used
in this program, the IWS website, mobile app and other tools, and in the presentation templates.
From the Artist:
The graphic is separated into three frames. The bottom frame reflects the research and work HRP has done in allowing
humans to explore space for extended periods of time. There are references to health and research that has been done
like Omics. This frame at the bottom is the foundation (research) for further exploration seen in the next two frames. The
middle frame shows the space launch system (SLS) going past the moon, somewhere we have been before. The top
frame shows the SLS breaking outside of the frame and reaching for Mars, showing where we will be going next.
The HRP IWS Steering Committee would like to thank all the graphic design submitters. There were several outstanding
submissions and it was a challenge to select one winner. The winning graphic, as well as the three (3) honorable
mentions will be on display throughout the workshop venue. Please take a moment to admire these amazing designs.
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NASA Human Research Program
Investigators’ Workshop
Galveston Island Convention Center
Galveston, Texas
Sponsored by:
NASA Human Research Program
Steering Committee
Maneesh Arya, Ph.D. Kris Lehnhardt, M.D.
David Baumann Jay Lemery, M.D.
Becky Brocato, Ph.D. Jancy McPhee, Ph.D.
Lisa Carnell, Ph.D. Lisa Milstead, M.S.
Lynn Clary, Ph.D. Cherie Oubre, Ph.D.
Rachael Dempsey Steven Platts, Ph.D.
Catherine Domingo Janapriya Saha, Ph.D.
Benjamin Easter, M.D. Michael Stenger, Ph.D.
Kristin Fabre, Ph.D. Judy Tate-Brown
Brian Gore, Ph.D. Nina Valverde, M.S.
Madison Hever Brandon Vessey, Ph.D.
Mohi Kumar Sara Whiting, Ph.D.
Charles Lloyd, Pharm.D. Alexandra Whitmire, Ph.D.
Jon McFather Janice Zawaski, Ph.D.
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NASA Human Research Program Investigators’ Workshop
*all times are Central Time*
Tuesday, February 13
9:00 a.m. CT Exhibit Hall B Welcome and Remarks from the Human Research
Program (HRP) Chief Scientist – S Platts
9:10 a.m. Remarks from the HRP Program Director – D Baumann
9:20 a.m. Remarks from the Translational Research Institute for Space
Health (TRISH) Chief Scientific Officer – J Fogarty
9:40 a.m. Remarks from the NASA JSC Director – V Wyche
9:50 a.m. Remarks from the NASA Associate Administrator for the
Exploration Systems Development Mission Directorate –
C Koerner
10:10 a.m. Remarks from the NASA Chief Scientist – K Calvin
10:30 a.m. BREAK
10:45 a.m. Exhibit Hall B Space Radiation Element Welcome and Kick-off
Galleon Data Management
Grand Ballroom A Exploration Medical Capability Element: Overview
Grand Ballroom B Biomarkers: Central, Peripheral or Behavioral After
Exposure to Spaceflight Challenges
Grand Ballroom C Sensorimotor: Space Flight and Ground Analogs
12:15 p.m. Obtain Lunch (available for purchase, pre-function area)
12:45 p.m. Exhibit Hall B Lunch Plenary: International Panel – J McPhee
1:15 p.m. BREAK
1:30 p.m. Exhibit Hall B Plenary: The John B Charles Memorial Lecture – A Huang
2:30 p.m. BREAK
2:45 p.m. Exhibit Hall B Beyond the Mouse (Space Radiation)…
Galleon Commercial Spaceflight and Analogs
Grand Ballroom A Earth Independent Medical Operations (EIMO)
Grand Ballroom B Behavioral Health and Performance: Measures and
Methods
Grand Ballroom C SANS 1: Space Flight
4:15 p.m. BREAK
4:30 p.m. Exhibit Hall A Poster Session A
6:00 p.m. Adjourn
Wednesday, February 14
8:00 a.m. CT Pre-Function Area Morning Coffee Networking
9:00 a.m. Exhibit Hall B Biological Insights into Space Radiation Carcinogenesis
Galleon Miniature Marvels: Exploring Tissue Chips and
Organoids for Use in Space Health Research
Grand Ballroom A Artificial Intelligence Supporting Exploration Spaceflight
Health & Wellness
Grand Ballroom B Behavioral Health and Performance Over Time: Results
from Ground Analogs and Spaceflight
Grand Ballroom C SANS 2: Bed Rest
10:30 a.m. BREAK
10:45 a.m. Exhibit Hall B Plenary: Moon to Mars Program – A Kshatriya
11:45 a.m. Obtain Lunch (available for purchase, pre-function area)
12:15 p.m. Exhibit Hall B Lunch Plenary: Commercial Panel – J McPhee
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12:45 p.m. BREAK
1:00 p.m. Exhibit Hall B Space Radiation Cross Risk Integrations Projects
Introduction
Galleon Joint Panel on the Role of the Vestibular Organs in
Space Exploration
Grand Ballroom A Point of Care Testing Supporting Exploration Spaceflight
Health
Grand Ballroom B Behavioral Health and Performance in Isolation and
Confinement: Outbrief from SIRIUS and HERA Missions
Grand Ballroom C SANS 3: Other Models
2:30 p.m. BREAK
2:45 p.m. Exhibit Hall A Poster Session B
4:15 p.m. BREAK
4:30 p.m. Pre-Function Area Speed Networking
6:00 p.m. Adjourn
Thursday, February 15
8:00 a.m. CT Pre-Function Area Morning Coffee Networking
9:00 a.m. Exhibit Hall B Behavioral Health in Rodent Models After Exposure to
Spaceflight Hazards
Galleon Masters of Metabolism for Long Duration Spaceflight
Grand Ballroom A IMPACT Health Risk Assessment Tool
Grand Ballroom B Characterizing and Mitigating Exploration Mission
Stressors
Grand Ballroom C Sensorimotor: Parabolic Flight
10:30 a.m. BREAK
10:45 a.m. Exhibit Hall B Plenary: In Memorium – M Arya
11:00 a.m. Plenary: Astronaut – K Lindgren
12:00 p.m. Obtain Lunch (available for purchase, pre-function area)
12:30 p.m. Exhibit Hall B Lunch Plenary: Other Government Agencies Panel – K
Fabre
1:00 p.m. BREAK
1:15 p.m. Exhibit Hall B Sex Differences in Biological Effects from Radiation
Exposure
Galleon Flight Research Operations & Integration
Grand Ballroom A Analysis & Risk Approaches To Exploration Spaceflight
Health
Grand Ballroom B Brain and Behavioral Health After Exposure to
Spaceflight Hazards – Results from Ground Analogs and
Spaceflight
Grand Ballroom C Advances in Food Nutrition, Acceptability, and
Microbiology for Spaceflight
2:45 p.m. BREAK
3:00 p.m. Exhibit Hall B Advanced Biological and Mathematical Techniques to
Understanding Space Radiation Damage
Galleon Isolation Analogs
Grand Ballroom A Long Term Health Metrics & Risks for Exploration
Spaceflight Health
Grand Ballroom B Human Capabilities Assessment for Autonomous
Missions: VNSCOR Outbrief
Grand Ballroom C Micro & Immune
4:30 p.m. BREAK
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4:45 p.m. Ex Hall B/Pre-Func Area Career Development
6:00 p.m. Adjourn
Friday, February 16
8:30 a.m. CT Exhibit Hall B Space Radiation Central Nervous System Decrements
Galleon Space Biology: Plants in Space
Grand Ballroom A Pharmacy, Therapeutics & Metabolism in Exploration
Class Missions
Grand Ballroom B Human Factors Considerations for Future Missions
Grand Ballroom C Musculoskeletal Health and EVA Performance
10:00 a.m. BREAK
10:15 a.m. Exhibit Hall B Biological Effects of Combined Stressors
Galleon How We Do Business
Grand Ballroom A Exploration Crew Health and Performance
Grand Ballroom B Measuring and Supporting Resiliency and Adaptation
in Future Long Duration Exploration Missions
Grand Ballroom C Cardiovascular Responses to Varying Gravity
11:45 a.m. BREAK
12:00 p.m. Exhibit Hall B Awards and Closing Remarks – D Baumann, S Platts
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Note: Exhibit Hall A (poster hall) layout is shown on the last page.

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Tuesday, February 13, 2024
Space Radiation Element Welcome and Kick-off
10:45 AM Exhibit Hall B
Chairs: Janice Zawaski and Jason Weeks
10:45 AM Janice Zawaski; Jason Weeks
(1654194) SPACE RADIATION ELEMENT WELCOME AND STATE OF THE ELEMENT
The Space Radiation Element kick-off presentation to IWS 2024
11:10 AM Tony Slaba; Janice Huff; Steve Blattnig; Ryan Norman; Ianik Plante; Floriane Poignant;
Shirin Rahmanian; Charles Werneth; Xiaojing Xu
(1652068) SPACE RADIATION RISK MODELING - THE MULTI-MODEL ENSEMBLE RISK
ASSESSMENT PROJECT
The goal of the Multi‐model Ensemble Risk Assessment (MERA) project at NASA Langley
Research Center is to develop risk projection tools supporting robust and accurate evaluation
of space radiation health risks, including the assessment of medical countermeasures,
individualized risk for health care decisions, and combined spaceflight hazards.
11:25 AM Sigrid Reinsch; S. Robin Elgart; Peter Guida; Gregory Nelson; Janapriya Saha; Sergio Santa
Maria; Brock Sishc; Jason Weeks; Janice Zawaski
(1645749) NASA SPACE HEALTH IMPACTS FOR THE NASA EXPERIENCE (SHINE)
TRAINING PROGRAM: SPACE RADIATION CURRICULUM
In 2023 NASA rolled out its inaugural annual virtual Space Health Impacts for the NASA
Experience (SHINE) Space Radiation Didactic Curriculum which aims to educate participants
not only in the scientific aspects of space radiation but also in the agency’s risk management
strategies
11:33 AM Shelita Augustus; Janice Zawaski; Angela Kubik
(1693071) INTRODUCTION TO THE FUTURE OF THE NEW THREE WEBSITE
Historically the THREE website (https://three.jsc.nasa.gov/) was an encyclopedic site whose
goal is to present a discussion of the space radiation environment and its health risks to
humans. It is our goal in 2024 to update the website to not only be an encyclopedic site but
to increase its scope to include areas such as funding opportunities, grantsmanship, job
opportunities, etc..
11:41 AM Peter Guida; Trevor Olsen
(1643971) NSRL USER GROUP: BIOLOGY, PHYSICS & OPERATIONS
This presentation will serve as the annual NSRL user group forum.
12:06 PM Discussion
12:15 PM Obtain Lunch (available for purchase in the pre-function area)
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Data Management
10:45 AM Galleon
Chairs: Olga Kieschnick and Kathryn Richards
10:45 AM Chair Remarks
10:50 AM Deepak Kulkarni; Susan Steinberg; Greg Eley; Macresia Alibaruho
(1643679) HRP DATA MANAGEMENT PLAN
This presentation will discuss new HRP data management policies and procedures.
11:04 AM Daniel Berrios; Gregory Eley; Ashley Mooney; Deepak Kulkarni
(1645678) ACQUISITION OF AND ACCESS TO RESEARCH OMICS DATA
To assure maximum benefit from omics data, the NASA Human Research Program Data
Management Plan stipulates that human omics data should be archived within and accessed
through the NASA Life Sciences Portal (NLSP).
11:18 AM Kathryn Richards; Byron Smith
(1645482) KNOWLEDGE IS POWER AND DATA STEWARDSHIP IS A SUPERPOWER
With knowledge management, data stewards are the key to implementing governance and
maximizing high value results to ultimately solve some of NASA’s most persistent data
challenges while providing opportunities to close gaps in its ability to make data-backed
decisions.
11:32 AM Jessica Keune; Robert Beaton; Diedre Thomas
(1643787) UPDATES TO THE RESEARCH DATA SUBMISSION AGREEMENT (RDSA)
BLANKBOOK
This presentation will discuss the comprehensive updates that have been made to the
Research Data Submission Agreement (RDSA) Blankbook, a key document in the life cycle
of a Human Research Program (HRP)-funded investigation.
11:46 AM Ryan Scott; Sylvain Costes; Samrawit Gebre; Danielle Lopez; Lauren Sanders; Amanda
Saravia-Butler
(1645895) THE NASA OPEN SCIENCE DATA REPOSITORY: BIOMEDICAL FAIR DATA,
ANALYSIS TOOLS, USER COMMUNITIES, PUBLICATIONS, AND DISCOVERIES FOR
DEEP SPACE MISSIONS
The NASA Open Science Data Repository is FAIR, maximally open access, has data from
>450 studies from model organisms and non-NASA human astronauts, ~600 Analysis
Working Group members data mining, enabled >60 publications, and offers public users the
ability to upload, download, analyze, and visualize data across ‘omics, physiological,
behavioral, bioimaging, video, and environmental telemetry.
12:00 PM Discussion
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Exploration Medical Capability Element: Overview
10:45 AM Grand Ballroom A
Chair: Nancy Fleming
10:45 AM Kris Lehnhardt; Michael Krihak; Jay Lemery; Benjamin Easter
(1651956) THE EXPLORATION CREW HEALTH AND PERFORMANCE SYSTEM OF THE
FUTURE - A SHARED MENTAL MODEL
This presentation will outline the initial work that Exploration Medical Capability is leading on
the development of a prototype design for an exploration Crew Health and Performance
(CHP) system for future NASA human deep space long-duration missions.
11:00 AM Moriah Thompson; Rahul Suresh; Justin Yang
(1646800) AN INTEGRATED ROADMAP FOR ADDRESSING EXPLORATION MEDICAL
CAPABILTY GAPS
An overview of the NASA Exploration Medical Integrated Product Team (XMIPT)'s integrated
roadmap to close human health gaps for exploration missions.
11:15 AM Michael Krihak; John Odina
(1646921) EXMC SYSTEMS ENGINEERING STATUS
This presentation will provide a high-level overview of what the ExMC SE team has
accomplished since the last Investigators’ Workshop, an introduction to upcoming SE talks,
and the ongoing systems engineering work.
11:30 AM Michael Krihak; Christopher Laing; John Odina
(1646946) 2023 ARTEMIS CREW HEALTH AND PERFORMANCE SYSTEM MODEL
DEVELOPMENT
By using a Model-Based Systems Engineering (MBSE) approach, existing requirements,
functions, and concepts of operations were combined to create a single system model
focused on representing CHP from the launch to the return to Earth segments of the Artemis
III and IV missions.
11:45 AM Jordan Blackwelder; Marina Parker; Michael Krihak; John Odina
(1646975) ARCHITECTURAL FRAMEWORK FOR CONCEPTUALIZING EXPLORATION
CLASS MEDICAL OPERATIONS
Development of a System of Systems Architecture (SoSA) utilizing model-based systems
engineering (MBSE) to capture various independent but related efforts into a comprehensive
view associated with the goal of providing progressively Earth-Independent Medical
Operations (EIMO).
12:00 PM Discussion
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February 13-16, 2024 5
Biomarkers: Central, Peripheral or Behavioral After Exposure to Spaceflight Challenges
10:45 AM Grand Ballroom B
Chairs: Catherine Davis and Jimmy Zaid
10:45 AM Catherine Davis; Victoria Elliott; Joan Smith; Sofia Manicka
(1648039) THE EFFECTS OF PROTON RADIATION ON ATTENTION, MEMORY, AND SOCIAL
AND ANXIETY-LIKE BEHAVIOR IN MALE AND FEMALE RATS
Male and female rats were exposed to proton radiation and assessed for changes in sustained
attention, social memory, and social and anxiety-like behaviors at different time points following
exposure, and these results were compared to the effects of exposure to the sim GCR sim on similar
behavioral endpoints.
10:57 AM Gregory Nelson; Tamako Jones; Seta Stanbouly
(1645630) EFFECTS OF RADIATION DOSE RATE ON THE MOUSE NERVOUS SYSTEM
The effect of simulated galactic cosmic rays on the mouse brain was evaluated with a battery of
behavioral, network function and gene expression measures. The effects of dose rate were
determined and two scaling parameters for risk assessment were derived: dose rate effectiveness
factor (DREF) and relative biological effectiveness (RBE). Male and female 6 mo-old C57Bl/6 mice
were the model.
11:09 AM April Ronca; Siddhita Mhatre; Janani Iyer; Steffy Tabares Ruiz; Stephanie Puukila; John Hayes;
Adaline Brekker; Marissa Burke; Maya Semel; Moniece Lowe; Linda Rubinstein; Marianna Sowa;
Yasaman Shirazi-Fard; Candace Tahimic; Joshua Alwood; Amber Paul
(1652029) PLASMA AND BRAIN CYTOKINE RESPONSES TO SINGLE AND COMBINATORIAL
SPACEFLIGHT STRESSORS IN MALE AND FEMALE MICE
Plasma and brain cytokine cytokine profiling of crew age-matched mice exposed to either 5-ion
GCRsim alone or in combination with hindlimb unloading/head down tilt revealed sex-specific, as well
as sex-common, responses with plasma granulocyte colony stimulating factor (GCSF) emerging as a
potential biomarker.
11:21 AM Andrew Wyrobek; I. Bansal; R.A. Britten; J.B. Brown; R.B. Gunier; A.M. Mora; B.M. Rabin; S. Rauch;
L.M. Sanders; A.M. Saravia-Butler; T. Straume; H.E. Witkowska
(1705278) MOLECULAR MODELING OF SUSCEPTIBILITY FOR ANXIETY, MEMORY, AND
CLEVERNESS BEHAVIORS AMONG MALE RATS EXPOSED TO SPACE-RELEVANT RADIATION
Modeling of CNS proteins expression showed quantitative relationships to three distinct radiation-
sensitive behaviors (EPM-anxiety, BM-memory, BM-cleverness) across sham and irradiated outbred
male rats, with similar findings for hippocampal and blood transcripts, with associations to abnormal
brain tissue functions and with concurrence to publicly available datasets for similar behaviors.
11:33 AM Richard Simpson; Kyle Smith; Elizabeth Beattie; Forrest Baker; Grace McKenzie; Alice Lagoy; Brian
Crucian; Judith Gordon; Christopher Connaboy
(1673174) PROMOTING BEHAVIORAL HEALTH, COGNITIVE, SENSORIMOTOR, AND IMMUNE
FUNCTION USING GUIDED IMAGERY TO AUGMENT EXERCISE TRAINING IN AN ISOLATED
AND CONFINED SPACEFLIGHT ANALOG ENVIRONMENT
Promoting behavioral health, cognitive, sensorimotor, and immune function using guided imagery to
augment exercise training in an isolated and confined spaceflight analog environment.
11:45 AM Namni Goel; Lauren Pasetes
(1607258) BIOMARKERS AS PREDICTORS OF RESILIENCY AND SUSCEPTIBILITY TO STRESS
IN SPACE FLIGHT
The aim of this project is to validate biomarkers as predictors of susceptibility or resiliency to the
neurobehavioral effects of stress and sleep deprivation for use in space flight in short-duration and
long-duration analogs.
12:00 PM Discussion
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February 13-16, 2024 5
Sensorimotor: Space Flight and Ground Analogs
10:45 AM Grand Ballroom C
Chairs: Scott Wood and Tim Macaulay
10:45 AM Sarah Moudy; Scott Wood; Brian Peters; Torin Clark; Michael Schubert; Austin Bollinger; Yiri
De Dios
(1646480) VALIDATION OF A SENSORIMOTOR DISORIENTATION GROUND ANALOG
The purpose of this study was to validate a ground-based Sensorimotor Disorientation
Analog (SDA), that was previously developed based on subjective feedback from previously
flown astronauts, by comparing performance in movement tasks that have a wealth of
spaceflight data against task performance while using the SDA.
11:00 AM Michael Schubert; Scott Wood; Colin Grove; Danny Ludwig; Darci Gallimore; Kendra Carter;
Richard Folga; Adam Preston; C. Matthew Stewart
(1650636) SELF-ADMINISTERED REHABILITATION TOOL TO MITIGATE MOTION
SICKNESS AND ENHANCE SENSORIMOTOR RECOVERY
The self-administered SWAN rehabilitation tool appears to offer a quicker recovery than
traditional therapy for some of the common signs and symptoms related to having a
unilateral vestibular deficit.
11:15 AM Torin Clark; Taylor Lonner; Aaron Allred; Aadhit Gopinath; Charles Oman; Ben Lawson; Eric
Groen; Paul DiZio
(1652139) ASSESSMENT OF COUNTERMEASURES TO MITIGATE MOTION SICKNESS
FOR POST-FLIGHT ASTRONAUTS DURING WATER LANDINGS
In ground-based analog experiments, we have evaluated non-pharmacological
countermeasures, including providing visual cues of self-motion in a head mounted display
and engaging postural control mechanisms, to help mitigate motion sickness relevant for
astronauts during water landings.
11:30 AM Olga Kuldavletova; Gilles Clement; Deborah Navarro Morales; Timothy Macaulay; Scott
Wood; Pierre Denise
(1643001) ASTRONAUTS COGNITIVE AND BALANCE FUNCTIONS AFTER
SPACEFLIGHT ARE COMPARABLE TO THOSE OF PATIENTS WITH BILATERAL
VESTIBULAR LOSS
Functional deconditioning of astronauts inflight or after space flight in balance and cognitive
tasks is similar to the performance of patients with bilateral vestibular deficits, which might
indicate the vestibular role in this deconditioning and open the possibility of using vestibular
deficient patients as a model of astronauts for the development of countermeasures and
adaptation strategies.
11:45 AM Aaron Allred; Torin Clark
(1647634) MODELING HUMAN SELF-ORIENTATION PERCEPTION RESTULTING FROM
GALVANIC VESTIBULAR STIMULATION AND PHYSICAL MOTION
We provide a model of spatial orientation perception, based on the observer model, with
neuronal activity encoding canal sensory transduction modulated by GVS currents.
12:00 PM Discussion
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February 13-16, 2024 5
Beyond the Mouse (Space Radiation)…
2:45 PM Exhibit Hall B
Chairs: Steve Blattnig and Janice Zawaski
2:45 PM Christopher Yan; Celine Lai; Sushma Shenoy; Rebecca Yu; Zachary Cook; Julio Guevara;
Yan Zhuge; Joseph Wu; Paul Pang
(1651907) DERIVATION OF LARGE BIOREPOSITORY OF HUMAN IPSC LINES FOR
OPEN ACCESS SHARING AMONG ACADEMIC INVESTIGATORS
We introduce the Greenstone Biosciences iPSC Biobank, a biorepository containing >1,000
human iPSC lines with de-identified patient clinical information and genetic backgrounds.
3:05 PM Afshin Beheshti; Bianca Cerqueira; Holly Chapapas; Giovanni Lorenz; Paul Sherman; Diego
Galeano
(1645464) PREDICTING PREDISPOSED SPACE RADIATION HEALTH RISKS FROM
GRAVITY AND HYPERBARIC ALTERATIONS DETERMINED FROM MINI-PIGS STUDIES
We were able to determine a conserved set of miRNAs between the minipigs and spaceflight
rodents which targeted mitochondrial suppression due to the hypobaric conditions.
3:20 PM Sarah Hay; Timothy Boorady; Rina Eden; Nina Porter
(1626719) TRANSIENT ACUTE LIVER INFLAMMATION DURING FRACTIONATED X-RAY
IRRADIATION WITHIN PARAMETERS OF A LUNAR MISSION: A PORCINE MODEL
We exposed 6 Yucatan minipigs to different doses of an 8- week fractionated x-ray series
totaling 0.1 Gy to the liver then examined the livers s/p necropsy and compared
histopathologic findings to the livers of the 6 control pig.
3:35 PM Lawrence Dauer; Kathryn Held; John Boice
(1643947) THE U.S. MILLION PERSON STUDY OF LOW-DOSE-RATE HEALTH
EFFECTS: INNOVATIONS IN EVALUATING COGNITION AND MULTIPLE STRESSORS
Investigating cognition outcomes in the Million Person Study as well as an epidemiologic
study of 170,000 nuclear submariners for late-occurring neurological and behavioral
disorders and persistent cognitive impairment related to multiple stressors experienced
concurrently with chronic radiation exposure for possible interaction between radiation and
multiple stressors as a focus.
4:05 PM Discussion
4:15 PM Break
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February 13-16, 2024 5
Commercial Spaceflight and Analogs
2:45 PM Galleon
Chairs: Emmanuel Urquieta and Jimmy Wu
2:45 PM Chair Remarks
2:50 PM Nick Downs; Bryan Eleogram; Jason Sylva
(1645264) NEVADA SPACE PROVING GROUNDS AT THE NEVADA NATIONAL
SECURITY SITE: CAPABILITIES, CHALLENGES, AND OPPORTUNITIES WITH A
MISSION-SCALE, HEAVILY CRATERED TESTBED
The Nevada Space Proving Grounds were extensively used by Apollo astronauts to train in a
heavily cratered, volcanic terrain; NSPG's utilization for upcoming Artemis missions is an
important de-risking step for NASA and NASA's commercial, academic, and national lab
partners.
3:02 PM Jeffrey Ayton; John Cherry
(1647988) AUSTRALIAN ANTARCTIC SPACE ANALOG
The Australian Antarctic Program is a hi-fidelity space analogue featuring small, confined,
isolated populations, with real environmental hazards, and a proven medical support model.
Recent collaboration with TRISH provides opportunity to utilise the Australian Antarctic
Space Analog to inform advances in healthcare on long duration exploratory space missions
and translate to terrestrial benefit.
3:14 PM Marc Shepanek
(1645410) A BRIEF EVOLUTION OF GROUND BASED ANALOGS IN SUPPORT OF
SPACED MISSIONS
To better address developing missions to the Moon and Mars, ground based analogs have
and are, providing a range of opportunities for humans to; deal with extreme environments,
adapt to extreme environments, and return to their home environments. Whether for
research or technology development,ground based analogs have been, and are, a critical
element for human space exploration.
3:26 PM Jonathan Bennett; Jeff Ayton; Sandra Iuliano; Nisa Kelly; John Cherry; Michael Wong; Kate
Kloza; Lambert Leong; Bosco Li; Yong Liu; Aenor Sawyer; Aenor Sawyer; John Shepherd
(1618032) EVALUATION OF BODY SHAPE AS A HUMAN BODY COMPOSITION
ASSESSMENT IN ISOLATED CONDITIONS AND REMOTE ENVIRONMENTS
The development and application of optimal configurations of 3-dimensional optical imaging
for body composition assessment allows for the monitoring of changes in fat and fat-free
mass composition in remote space analogs
3:38 PM Doug Ebert; Jeff Ayton; Theodora Bock; John Cherry; Aaron Everson; John Martin; Jaime
Mateus; Victoria Perizes; Marissa Rosenberg; Ashot Sargsyan; Emmanuel Urquieta; Jimmy
Wu
(1647918) SIMULTANEOUS EVALUATION OF SKILL MANAGEMENT METHODS AND
PHYSIOLOGY USING AN INTUITIVE HANDHELD ULTRASOUND SYSTEM IN
SPACEFLIGHT AND AN ANTARCTIC SPACEFLIGHT ANALOG
These projects examine both ultrasound skill management methods and physiology using a
handheld ultrasound device on the Polaris Dawn mission and at Australian Antarctic Division
stations.
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February 13-16, 2024 5
3:50 PM Emmanuel Urquieta; Mathias Basner; Harshavardhan Doddapaneni; Amoy Fraser; Richard
Gibbs; Michal Masternak; Stephen Mayo; Jimmy Wu
(1650313) EXPAND SPACE OMICS SAMPLE COLLECTION: A MULTI-INSTITUTION
CONSORTIUM
The EXPAND Space Omics Program is one-of-a-kind gold-standard sample collection and
processing capability to enable research in commercial spaceflight. Given the complexity of
having different sites for training, launch, and landing of commercial spaceflight participants,
TRISH/EXPAND has developed a consortium of institutions across the United States to
ensure that samples keep their quality.
4:02 PM Discussion
4:15 PM Break
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February 13-16, 2024 5
Earth Independent Medical Operations (EIMO)
2:45 PM Grand Ballroom A
Chair: Jay Lemery
2:45 PM Jay Lemery; Ben Easter; Kris Lehnhardt
(1682243) EARTH INDEPENDENT MEDICAL OPERATIONS
EIMO is the gradual transition of medical care and decision making from terrestrial to space-
based assets, enabling support of astronaut health and performance and reducing overall
mission risk.
3:00 PM Marina Parker; Michael Krihak; Christopher Laing; Jorge Bardina; Arian Anderson
(1646978) EARTH-INDEPENDENT MEDICAL OPERATIONS (EIMO) CONCEPT OF
OPERATIONS
The Human Research Program (HRP) Exploration Medical Capability (ExMC) Element has
developed a model-based Concept of Operations outlining an initial vision for Earth-
Independent Medical Operations Medical System providing illustrative examples of the
various activities (scenarios) for which the system will be employed during Mars missions.
3:15 PM Kurt Berens; Ben Easter; Michael Krihak; Kris Lehnhardt; Jay Lemery
(1661383) EARTH INDEPENDENT MEDICAL OPERATIONS (EIMO) DATASCOPE:
CHALLENGES AND POTENTIAL SOLUTIONS
This abstract summarizes findings from a Technical Interchange Meeting conducted 21
August 2023 surrounding the anticipated data environment necessary to enable
progressively earth independent medical operations.
3:30 PM Behnood Gholami; Negar Ebadi
(1661261) ASTROSIGHT: A REAL-TIME REMOTE CARDIOPULMONARY SENSING
SYSTEM FOR HUMAN EXPLORATION MISSIONS
We present our ongoing work on developing and validating a non-invasive real-time
cardiopulmonary monitoring system.
3:45 PM Lauren Sanders; Sylvain Costes; Ryan Scott
(1650291) BIOLOGICAL RESEARCH AND SPACE HEALTH ENABLED BY MACHINE
LEARNING TO SUPPORT DEEP SPACE MISSIONS
Here we present a decadal view of AI/ML architecture to support deep space mission goals,
developed in concert with leaders in the field.
4:00 PM Discussion
4:15 PM Break
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February 13-16, 2024 5
Behavioral Health and Performance: Measures and Methods
2:45 PM Grand Ballroom B
Chairs: Mathias Basner and Katherine Rahill
2:45 PM Mathias Basner; David Dinges; Adrian Ecker; Ruben Gur; Christopher Jones; Tyler Moore;
David Roalf; Kosha Ruparel
(1648815) NASA'S COGNITION TEST BATTERY FOR SPACEFLIGHT: 10-YEAR REVIEW
AND FUTURE PERSPECTIVES
NASA's Cognition test battery is a widely validated and used neuropsychological test battery
specifically designed for high-performing astronauts. Its 10 test cover a range of cognitive
domains with established brain network recruitment via fMRI. This presentation provides an
overview of Cognition development, key study findings and a perspective on the future of
Cognition.
3:00 PM Jennifer Miller; Suzanne Bell; Lauren Landon
(1647577) DEVELOPMENT AND VALIDATION OF SHORT-FORM EXPLORATION
MEASURE SURVEYS
We describe validation efforts of shorter versions of standard surveys for deployment in
analogs and/or spaceflight.
3:15 PM Alaa Khader; Sheena Dev; Steven Anderson; Suzanne Bell
(1644017) A COMPARISON OF HEART RATE VARIABILITY ON HIGH AND LOW STRESS
TASKS IN ISOLATED, CONFINED AND CONTROLLED SETTINGS
Comparing heart-rate data collection protocols in in the Human Factors and Behavioral
Performance Exploration Measures, and assessing the utility of HRV as an unobtrusive
biomarker of stress adaptability in isolated, confined, and controlled settings.
3:30 PM Theodora Chaspari; Sydney Begerowski; Suzanne Bell; Alaa Khader; Projna Paromita
(1645411) SPEECH-BASED ARTIFICIAL INTELLIGENCE FOR DETECTING MICRO-
BEHAVIORS AND PREDICTING THEIR EFFECT ON TEAM PERFORMANCE
We investigate micro-behaviors in team conversations and their association with
operationally-relevant team performance. The three aims of our work are: 1) Leverage
speech-based data analytics and artificial intelligence to detect microbehaviors in team
interactions; 2) Investigate the impact of microbehaviors on team performance; and 3)
Design machine learning systems to predict team performance.
3:45 PM Suzanne Bell; Aaron Schecter; Alla Vinokhodova; Vadim Gushin; Leslie DeChurch; Noshir
Contractor
(1648245) TEAM COMPOSITION AND INTERPERSONAL RELATIONSHIP FORMATION
IN ISOLATED AND CONFINED ENVIRONMENTS
We collected data from 9, 4-person HERA crews in isolation for up to 45 days, developed
and tested a model of interpersonal relationship formation, and examined the validity of a
method for assessing interpersonal compatibility.
4:00 PM Discussion
4:15 PM Break
15

February 13-16, 2024 5
SANS 1: Space Flight
2:45 PM Grand Ballroom C
Chairs: Steve Laurie and Tyson Brunstetter
2:45 PM* Steve Laurie; Brandon Macias
(1644808) SPACEFLIGHT ASSOCIATED NEURO-OCULAR SYNDROME (SANS)
RESEARCH UPDATE
Structural changes of the eye and brain are now well-established findings of spaceflight
associated neuro-ocular syndrome (SANS) affecting the majority, but not all, of
crewmembers flying ~4–6-month standard duration missions to the International Space
Station (ISS). We will present advancements in SANS research from both spaceflight and
analog studies, and provide an update on countermeasures.
2:45 PM* Tyson Brunstetter; Sara Mason; Suzi Osborne; C. Robert Gibson; Mary Van Baalen; Ann
Tsung; William Tarver
(1654829) SPACEFLIGHT ASSOCIATED NEURO-OCULAR SYNDROME (SANS): 2024
CLINICAL UPDATE - EYES & VISION
An update will be provided on the latest Spaceflight Associated Neuro-ocular Syndrome
(SANS) clinical analyses and insight.
3:08 PM Mark Christopher; Jalil Jalili; Robert Weinreb; Steven Laurie; Brandon Macias; Alex Huang
(1642467) PREDICTING SANS USING ARTIFICIAL INTELLIGENCE
Deep learning artificial intelligence (AI) models were trained to predict space associated
neuro-ocular syndrome (SANS) risk based on optical coherence tomography (OCT) imaging.
Even with limited OCT data for training, models were able to accurately predict development
of SANS using only OCT data collected pre-flight.
3:21 PM Floris Wuyts; Diana Giraldo; Ben Jeurissen; Steven Jillings; Ekaterina Pechenkova; Viktor
Petrovichev; Ilya Rukavishnikov; Elena Tomilovskaya; Angelique Van Ombergen; Peter zu
Eulenburg
(1646716) WHITE MATTER CHANGES AFTER LONG-DURATION SPACEFLIGHT: NEW
INSIGHTS
This study is the first fixel-based analysis of diffusion MRI data in cosmonauts and it shows
widespread changes in the white matter after spaceflight, which are predominantly
macroscopic artefacts rather than microscopic changes, while in the cerebellum evidence of
new white matter sprouting is elucidated.
3:34 PM Steven Jillings; Chloe Mohanadass; Lauren Church; Chloë De Laet; Inna Nosikova; Elena
Tomilovskaya; Ilya Rukavishnikov; Victor Petrovichev; Ekaterina Pechenkova; Peter zu
Eulenburg; Floris Wuyts
(1650031) VENTRICULAR VOLUME CHANGES ACROSS MULTIPLE SPACEFLIGHTS
Brain ventricular volumes were calculated from cosmonauts' MRI scans before and after at
least two consecutive missions to the ISS, leading to a long follow-up study of ventricular
volume change as a result of spaceflight.
3:47 PM Katherine Warthen; Stuart Sater; Larry Kramer; Khader Hasan; Michael Williams; Brandon
Macias; Steven Laurie; Bryn Martin
(1647025) LONG-DURATION SPACEFLIGHT ALTERS INTRACRANIAL TISSUE AND
FLUID POSITION
Long-duration spaceflight is associated with a consistent and quantifiable whole brain shift
upward, along with corresponding opposite shift in the surrounding CSF.
4:00 PM Discussion
4:15 PM Break
* Single presentation for multiple abstracts
16

February 13-16, 2024 5
Poster Session A: Bone
Poster Hall Location 4:30 PM Exhibit Hall A
165 Margaret Wydotis; Lance Bollinger; John Caruso; Neel Patel; Katherine Maguire
(1621740) EXERCISE-INDUCED STRAIN AND NUTRITIONAL STRATEGIES TO ABATE
IN-FLIGHT BONE LOSS
The abstract describes exercise- and nutritional- based treatments to abate inflight bone
loss.
166 Jean Sibonga; Robert Adler; Chang Gregory; Ashraf Gorgey; Millennia Young; Dimitri Martel
(1636465) MAGNETIC RESONANCE IMAGING (MRI) TO ASSESS CHANGES TO
TRABECULAR MICROARCHITECTURE OF THE HIP
This study validates the sensitivity of 3T MRI to detect irreversible losses of connectivity in
the hip trabecular bone following 12 months of non-weightbearing in newly admitted patients
following spinal cord injury.
167 Richard Perkins; Raj Prabhu; Elisabeth Spector; Jean Sibonga
(1643220) QUANTIFYING FRACTURE PROBABILITIES FOR FUTURE SPACE MISSIONS
USING COMPUTATIONAL METHODOLOGIES
Using computational models and various imaging techniques, bone fracture risk
assessments may be performed for conditions relevant during future Artemis missions to the
Moon and Mars.
168 Anna Wadhwa; Courtney Mazur; Katelyn Strauss; Jennifer Coulombe; Charles Fuller; Satoru
Takahashi; Martha Hotz-Vitaterna; Mary Bouxsein; Marc Wein
(1644405) SINGLE CELL TRANSCRIPTOMICS OF FEMORAL BONE MARROW FROM
RODENTS EXPOSED TO ARTIFICIAL GRAVITY ON THE INTERNATIONAL SPACE
STATION: A NASA-JAXA COLLABORATION
Single-cell transcriptomics of femoral bone marrow revealed significant heterogeneity from
spaceflight (0g) and artificial gravity (1g, using the JAXA Multiple Artificial-gravity Research
System[MARS]), pointing to differential responses in immune function, metabolism,
erythropoiesis, bone matrix mineralization, and more.
169 Anna-Maria Liphardt; Elie-Tino Godonou; Annegret Mundermann; Nadja Djalal; Maren
Dreiner; Frank Zaucke; Wolfgang Wirth; Anna Wisser; Susanne Maschek; Felix Eckstein;
Georg Schett; Anja Niehoff
(1646057) KNEE CARTILAGE QUALITY AND TYPE II COLLAGEN METABOLISM IN
RESPONSE TO 21-DAYS BED REST IMMOBILIZATION
This study aims to investigate the effects of 21 days of head-down-tilt bed rest (HDT) (with
and without exercise and nutrition interventions) on type II collagen metabolism and on knee
cartilage quality in healthy male study participants.
170 Chirayu Patel; Sabrina Vander Wiele; Kaitlyn Reno; Leslie Kim; Jennifer Coulombe; Charles
Fuller; Satoru Takahashi; Martha Vitaterna; Mary Bouxsein; Jeffrey Willey
(1646698) ARTHRITIC REPONSES OF MOUSE KNEE MENISCI TO ARTIFICIAL GRAVITY
ABOARD THE INTERNATIONAL SPACE STATION
1g of artificial gravity aboard the ISS prevented pro-arthritic pathway enrichment and
chondrocyte apoptosis, but exposure to lower g-levels resulted in pro-arthritic transcriptomic
changes similar to those seen at µg.
171 Benjamin Hezrony; Philip Brown
(1648410) A FAST LEVEL SET APPROACH TO MICROSTRUCTURAL INVERSE DESIGN
This novel work presents the first occurrence of a fast structural optimization algorithm with
sub-integration point accuracy, used to print 3D microstructures with equivalent pure linear
elastic anisotropy to targeted human skeletal microstructures derived via GPU accelerated
FEA homogenization.
17

February 13-16, 2024 5
Poster Session A: Cardiovascular
039 Hyelim Park; Bokyeong Park; Hyewon Park; Junbeom Park; Kyu-Sung Kim
(1637212) ANTI-ARRHYTHMIA EFFECT OF INTERMITTENT HYPOXIA THROUGH
ATRIAL FIBRILLATION REMODELING
This study aimed to find the relationship of atrial fibrillation in acute Intermittent hypoxia and
investigate its potential as a therapeutic target in AF.
081 Hrudayavani Vellore; Ana Diaz Artiles; Raquel Galvan-Garza
(1641686) USING COMPUTATIONAL PHYSIOLOGICAL MODELING TO DEVELOP A
ROBUST DATASET FOR DEVELOPMENT OF HUMAN ASSESSMENT ALGORITHMS
Using computational physiological modeling of the cardiovascular and respiratory systems to
develop a robust dataset of various gravitational profiles for a large representative population
of individuals for use by future machine learning algorithms.
082 Renee Abbott; Annelise Miller; David Martin; Chris Miller; Jason Lytle; Steven Laurie; Stuart
Lee; Ana Diaz-Artiles; Brandon Macias
(1644331) SEMI-AUTOMATIC EXTRACTION OF INTERNAL JUGULAR VEIN PRESSURE
USING SONOGRAPHY COMPRESSION
A new methodology to extract IJV pressure values frame by frame from video recordings of
compression sonography
040 Sanal Kumar V R
(1646500) ELEVATED BLOOD VAPOR PRESSURE AND THE REDUCED HEAT
CAPACITY OF BLOOD LEAD TO GAS EMBOLISM CAUSING FLOW CHOKING AT A
CRITICAL PRESSURE RATIO IN BOTH GRAVITY AND MICROGRAVITY
ENVIRONMENTS
Maintaining a blood pressure ratio below the critical pressure ratio is crucial to prevent flow
choking in gravity/microgravity environments. Keeping diastolic BP higher than vapor
pressure reduces gas embolism risks. Increasing blood heat capacity lowers vapor pressure,
delaying flow choking and reducing cardiovascular risks. Our discovery significantly
contributes to increasing human longevity.
083 Syeda Zaman; Matteo Fois; Stefania Scarsoglio; Luca Ridolfi; Ana Diaz-Artiles
(1646513) CARDIOVASCULAR AND OCULAR CHANGES OBSERVED DURING 60
MINUTES OF HEAD-DOWN TILT
In this study, we propose to characterize cardiovascular and ocular changes during and after
60 minutes of 6° head-down tilt to simulate altered gravity.
084 Richard Whittle; Ana Diaz-Artiles
(1648651) COMPUTATIONAL MODELING OF CARDIOVASCULAR DOSE-RESPONSE
CURVES IN ALTERED-GRAVITY
In this study, we present data from computational modeling of the cardiovascular system to
augment and extend predictions of dose-response curves derived from experimental data.
085 Stuart Lee; David Martin; Christine Ribeiro; Sondra Perez; Scott Smith; Sara Zwart; Connor
Ferguson; Steven Laurie; Brandon Macias
(1648664) INDICES OF CARDIOVASCULAR DISEASE RISK IN ASTRONAUTS AFTER
LONG-DURATION SPACEFLIGHT IN LOW EARTH ORBIT
The objective was to measure arterial structure and function in these crewmembers for up to
5 years after returning to Earth to determine if long-term negative sequelae develop.
18

February 13-16, 2024 5
086 Kole Lutz; Terry Trevino; Tara Nibhanupudy; Terry Rector
(1649220) EFFECTS OF ELECTROMAGNETIC FIELDS ON RED BLOOD CELLS, FLUID
SHIFT, AND STASIS
Effects of Pulsed Magnetic Field on the RBCs, blood viscosity, and shear rate are outlined.
As too much iron or problems with utilising, storing, or transporting iron is the leading cause
of high blood pressure, PEMF also provides △v to move more ferrous minerals such as
Fe3O4 in red blood cells. A lightweight PEMF wearable is tested to move cells and fluids for
Earth and space.
087 Bokyeong Park; Hyelim Park; Kyu-Sung Kim; Hyewon Park; Junbeom Park
(1649222) THE ROLE OF MICROGRAVITY IN REGULATING AQUAPORIN 4 CHANNELS
RELATED TO ATRIAL REMODELING IN ATRIAL FIBRILLATION.
The aim of this study was to find the relationship between AF and AQP4 expression at the in
vitro level and to investigate the potential of Microgravity and AQP4 as therapeutic targets in
AF.
088 Jason Lytle; Stuart Lee; Steven Laurie; Matthew Poczatek; Annelise Miller; Cambria
O'Grady; Connor Ferguson; Stephanie Melvin; Brandon Macias
(1649835) EVALUATING EFFICACY OF END-OF-MISSION FLUID LOADING
PROTOCOLS
The purpose of this study is to test the efficacy and palatability of the two fluid loading
protocols ingested using the Russian and/or NASA timing protocols.
089 Andrew Blaber; Kouhyar Tavakolian; Da Xu
(1649920) 6-MONTH SPACEFLIGHT IMPAIRS CARDIORESPIRATORY RESPONSES TO
EXERCISE AND ORTHOSTATIC STRESS
Overall reduction of cardiorespiratory controls was observed in four astronauts upon return to
Earth after 6-month spaceflight in response to a supine-to-stand test and cycling exercise
from data collected by the Bio-M garment.
090 Manuel Albornoz-Miranda; Marcela Abde-Celis; Carlos Abarca-Araya
(1650645) MICROGRAVITY AS A RISK FACTOR FOR VENOUS THROMBOEMBOLIC
EVENTS IN ASTRONAUTS: PROPOSED PATHOPHYSIOLOGY
Hypercoagulability, blood stasis, and endothelial stress might occur in a microgravity
environment, leading to thromboembolic events, with inter-individual variability.
091 Mattias Neset; Svetlana Komarova; Anand Narayanan; Ryan Scott
(1650671) CITIZEN SCIENCE APPROACH FOR SEARCHING AND CURATING
LITERATURE ON THE EFFECTS OF SPACEFLIGHT ON CARDIOVASCULAR
OUTCOMES IN RODENTS AND HUMANS
We used a citizen science approach to rapidly compile and analyze large-scale
cardiovascular spaceflight data while promoting spaceflight research in several groups within
the community.
092 Jhan Saavedra Torres; Maira Alejandra Guayambuco Medina
(1652555) CARDIOVASCULAR DECONDITIONING: PROLONGED EXPOSURE TO
MICROGRAVITY REDUCES CARDIAC CONTRACTILITY AND ENHANCES OTHER
MECHANISMS
Simulated microgravity (SMG) causes ROS production in human cardiomyocytes (CMs).
Exposure to outer space microgravity poses a risk for the development of various
pathologies including cardiovascular disease. To study this, we derived cardiomyocytes
(CMs) from human-induced pluripotent stem cells and exposed them to simulated
microgravity (SMG).
19

February 13-16, 2024 5
Poster Session A: Commercial
001 Jeffrey Smith
(1646093) DEEP SPACE LOGISTICS CAPABILITIES AND OPPORTUNITIES TO
SUPPORT FUTURE HUMAN RESEARCH AT THE GATEWAY
NASA's Deep Space Logistics missions will deliver cargo to the Gateway, in orbit around the
Moon, and provide a flexible volume and workspace in deep space to augment Gateway
capabilities for astronaut crews perform the critical human research in deep space that will
extend human exploration from the Moon, on to Mars.
002 Alain Berinstain; Gentry Barnett; Twyman Clements; Shelby Giza; Danielle Rosales
(1646645) R&D AND IN-SPACE PRODUCTION APPLICATIONS: AUTOMATED
CAPABILITIES IN MICROGRAVITY FOR THE NEXT DECADE AND BEYOND
Prioritizing the development of automated technology counters the intimidation of an initially
complex and expensive process, making it possible to build both an infrastructure and a
reliable future for iterative, long-term science and manufacturing applications in microgravity.
003 Dr Jon Sen; Mohammed Ahmed; Christopher Mason; Yvette Gonzalez; Andrew Lee;
Shawna Pandya; Aaron Persad; Bader Shirah
(1649291) THE APPLICATION OF QUANTITATIVE PUPILLOMETRY FOR
NEUROLOGICAL MONITORING IN SHORT DURATION SPACEFLIGHT
Novel automated pupillometry provides rapid quantification of various pupillary parameters
which reflect the structural and functional integrity of wide ranges of intracranial networks
involved in the genesis of pupillary responses. This study investigates the first use of
automated pupillometry in space as a novel neuro-monitoring tool, on the Axiom-2 mission to
the International Space Station
20

February 13-16, 2024 5
Poster Session A: Data Management
004 Judith Peace; Adrienne Hoyt; Kathryn Richards
(1612897) THE HUMAN RESEARCH PROGRAM DATA MANAGEMENT & GRANT
LIFECYCLE INFOGRAPHIC AND TRAINING SHEETS
Due to the size and overlap of information in the HRP Data Management Plan (DMP) and the
NASA & Cooperative Agreements (GCAM), members from the HRP workforce requested
“cheat sheets” containing bite size pieces of information from some of the basic topics and
recurring challenges during the active research and closeout phases.
005 Judith Peace; Mary Kirby; Vanessa Lehman
(1616891) THE HUMAN RESEARCH PROGRAM GRANT LIFECYCLE & DATA
INTEGRATION SCHEDULE: INFOGRAPHIC
The Human Research Program (HRP) Grant Lifecycle infographic poster tells a short story
about a federally awarded grant with emphasis on the HRP Data Integration Schedule and is
intended to help the HRP workforce understand the timeline for this research procurement
and where their specific tasks fall within the 4 phases of the grant lifecycle.
006 Hamed Valizadegan; Michael Von Pohle; Adwait Sahasrabhojanee; Janani Iyer; Sandeep
Shetye; Dan Berrios; Adrienne Hoyt; Truong Le
(1629954) LSKNOWLEDGE: NEXUS FOR TRANSFORMATIVE SCIENTIFIC
DISCOVERIES AND ENHANCED INFORMATION RETRIEVAL IN NASA LIFE SCIENCES
PORTAL
We have launched LSKnowledge, aimed at enhancing the information retrieval capabilities of
NLSP. Our primary goal is to develop a robust semantic search system. This system will
empower HRP (Human Research Program) researchers to navigate NLSP data repositories
more efficiently and precisely, catalyzing the process of hypothesis formation and scientific
breakthroughs.
007 Robert Beaton; Brenna Wheeler; Sara Jorgensen; Jacqueline Charvat; Devan Petersen;
Jessica Keune
(1637953) REDISCOVERING APOLLO BIOMEDICAL DATA TO SUPPORT ARTEMIS: THE
APOLLO RECORDS SYNTHESIS PROJECT
As a joint effort between the Life Sciences Data Archive (LSDA) and the Lifetime
Surveillance of Astronaut Health (LSAH), the Apollo Records Synthesis Project (ARSP)
seeks to expand the available biomedical knowledge base for the Apollo missions and to
develop datasets for buying down risk on the Artemis Program by examining physical
records located across a wide range of collections.
008 Christina Johnson; Richard Barker; Afshin Beheshti; Daniela Bezdan; Gilbert Cauthorn;
Melanie Correll; Sylvain Costes; Rachel Gilbert; Stephen Lantin; Danielle Lopez; Rafael
Loureiro; Gbolaga Olanrewaju; Xavier-Lewis Palmer; Kristen Peach; Sigrid Reinsch; Nitin
Singh; Nathaniel Szewczyk; Chad Vanden Boscht; Sarah Wyatt; Paola Castaño
(1647304) TRACKING COMMUNITY BUILDING IN OPEN SCIENCE
Here, we present greater detail about the makeup and participation metrics of the various
Analysis Working Groups affiliated with the NASA Open Science Data Repository and details
of successful peer-reviewed publication campaigns.
21

February 13-16, 2024 5
009 Amanda Saravia-Butler; Lauren Sanders; Ryan Scott; Danielle Lopez; Samrawit Gebre;
Sylvain Costes
(1647859) ENABLING MODEL ORGANISM AND COMMERCIAL ASTRONAUT DATA
ACCESS THROUGH THE NASA OPEN SCIENCE DATA REPOSITORY
Here we describe the robust privacy and security protocols implemented by the Open
Science Data Repository (OSDR) to safeguard sensitive health data from astronauts while
facilitating metadata and processed data sharing for research purposes. We further provide a
road map for navigating the vast amount of data and associated metadata provided for each
Inspiration 4 study hosted on OSDR.
010 Eliah Overbey; JangKeun Kim; Christopher Mason; Jaime Mateus; Marissa Rosenberg;
Krista Ryon; Bader Shirah; Braden Tierney; Cem Meydan; Jeremy Wain Hirshberg
(1649477) THE CORNELL AEROSPACE MEDICINE BIOBANK (CAMBANK) AND THE
SPACE OMICS AND MEDICAL ATLAS (SOMA)
The Cornell Aerospace Medicine Biobank (CAMbank) has been created to store and
disseminate spaceflight samples to the scientific community and the Space Omics and
Medical Atlas (SOMA) will enable public data visualization of spaceflight biomarker and
omics data.
22

February 13-16, 2024 5
Poster Session A: Exploration Medical Capability (ExMC)
093 Avinav Sahoo
(1609330) R2-D2 ASTRO-MED: ARTIFICIAL INTELLIGENCE GENERATED MEDICAL
HISTORY TAKING CHATBOT FOR SPACE MEDICINE.
This is chatbot user interface to take medical history of astronauts who are having inflight
medical conditions or emergencies. This chatbot will collect data and transmit it to the ground
control system for doctors to analyse the conditions and plan the management accordingly .It
is named R2-D2 Astro-Med after the Star Wars character R2-D2.
094 Nicholas Antonino; Brent Feldt; Sarah Maginnis; George Pantalos; Robert Rigor
(1630997) APPENDECTOMY USING A HERMETIC SURGICAL SYSTEM (HESS): A
PROTOTYPE FOR SURGERY IN SPACE AND AUSTERE ENVIRONMENTS
Endoscopic surgery using a Hermetic Surgical System (HeSS) as a prototype for surgery in
space and austere environments.
095 Sheyna Gifford; Rose Jardine; Tyler Pugeda; Luke Brane; Erik Viirre
(1631772) MEDICAL OPERATIONS CONSIDERATIONS FOR ASTRONAUTS WITH
DISABILITIES
This observational study explores the development of protocols informing medical
operational considerations for people with disabilities and shows that, with carefully
conducted health and safety reviews, and in some cases with individualized flight plans,
researchers with disabilities can participate safely in, and successfully conduct research
during, altered gravity parabolic flights.
096 Philippe Arbeille
(1633210) LIVER TISSUE CHANGES DURING 6-MONTH SPACE FLIGHT MEASURED BY
ULTRASOUND RF SIGNAL PROCESSING.
The objective of the present research was to check using the ultrasound RF signal
processing if the Liver tissue response to ultrasound changed during the spaceflight.
097 Clara Gasiewski; Lauren McIntyre; Drayton Munster; Jerry Myers; Sean Bostic
(1637542) NOVEL APPROACH TO SIMULATING DIAGNOSTIC CAPABILITIES IN
MEDICAL RESOURCE RISK ASSESSMENT
This analysis presents an alternative means of representing diagnostic resources within the
medical risk domain for spaceflight through simulating the effect in risk, resource
consumption, and competition for resources of a missing or depleted diagnostic.
098 Drayton Munster; Sean Bostic
(1637668) ENABLING RAPID AND REPRODUCIBLE MODELING VIA SOFTWARE
DEVELOPMENT BEST PRACTICES
Adopting best practices from software engineering enables research that is reproducible and
sharable with full provenance in the code and data.
099 Sean Bostic; Drayton Munster
(1637676) WEB-BASED APPLICATION FOR THE DISTRIBUTION OF COMPUTATIONAL
ANALYSIS RESULTS
A web application was created to allow the information in an analysis result to be distributed
in a more streamlined, interactive, and accessible manner.
100 Sylwia Kaduk; Janina Post; Gabriel Huber; Lara Dietlein; Carla Tamai; Raphael Kneffel;
David Cyrol; Stefan Sammito
(1638312) LESSONS FOR ULTRASOUND USE IN SPACE- FAST ULTRASOUND
SCANNING BY MEDICALLY INEXPERIENCED INDIVIDUALS
A study investigating the usability, feasibility, and quality of conducting FAST ultrasound
scans by medically inexperienced individuals relying solely on the in-built instructions of
TEMPUS PRO vital signs monitor.
23

February 13-16, 2024 5
101 Julia Scarpa; Gary Strangman
(1641955) THE PERIOPERATIVE PERIOD: AN UNDERAPPRECIATED TESTING
GROUND FOR AEROSPACE MEDICAL TECHNOLOGY
Collaboration with perioperative practitioners to test aerospace medical technology can
provide gold-standard validation across a broader physiologic spectrum and in a more
accessible, cheaper, rapid fashion than traditional pipelines.
102 Allison Porter; Aleksandra Stankovic; Katya Arquilla
(1643590) NATURALISTIC APPROACH TO CAPTURING KEY SITUATION AWARENESS
CUES IN EMERGENCY POINT-OF-CARE ULTRASOUND FOR USE IN EARTH-
INDEPENDENT SURFACE OPERATIONS
This paper discusses the process of identifying situation awareness cues via direct
observations of urgent medical care in a well-equipped hospital setting (Emergency
Department), findings from those observations, and the characterization of differences
between the wilderness medicine and hospital settings to begin bridging this work to the
surface exploration paradigm.
103 Brita Mittal; Amran Asadi; Marissa Rosenberg
(1643687) ASSESSMENT OF ACUTE UPPER AIRWAY CHANGES DURING
SPACEFLIGHT USING ENDOSCOPIC AIRWAY EXAMINATION AND ULTRASOUND
This prospective, observational pilot study aims to characterize changes to human upper
airway anatomy induced by sustained microgravity exposure using a novel combination of
transnasal endoscopic airway examination and ultrasound performed during a commercial
spaceflight mission.
104 Kendall Farnham; Ryan Halter; Ethan Murphy
(1650622) INTEGRATED ULTRASOUND AND ELECTRICAL IMPEDANCE TOMOGRAPHY
FOR IMPROVED KIDNEY STONE DETECTION
We are integrating ultrasound and EIT to increase sensitivity to kidney stones with high-
contrast, dual-modality imaging for improving treatment outcomes of astronauts on deep
space and long-duration missions.
105 Alamelu Sundaresan; Vivek Mann
(1646463) ENVIRONMENTAL DUST EXPOSURE - LUNAR DUST AND THE HUMAN
CHALLENGE FOR MOON MISSIONS
This study will explore and explain the effects of lunar simulant on skin fibroblasts, immune
cells and lung epithelial cells. Preliminary results show evidence of mutagenesis in the lung
cells, increase in inflammatory mediators in immune cells and dysregulation of focal
adhesion kinases in the fibroblasts.
106 Luke Apisa; Yann Wendu-Foyet; Tovy Haber Kamine; Erik Antonsen; Lauren McIntyre; Jerry
Meyers; Dana Levin
(1647238) USE OF PREDICTIVE ANALYTICS TO DETERMINE THE NECESSARY TIME
HORIZON OF SURGICAL CAPABILITIES FOR SPACE MISSIONS
To begin to bound the problems posed by specialty-specific causes of return to definitive
care, this study implemented MEDPRAT in conjunction with the IMPACT Evidence Library to
estimate the number of person years before the risk of surgical pathology might justify the
need for on-board surgical capabilities in long-duration human spaceflight.
107 Megan Waldock; Carly O'Rourke; Alex Roberts
(1647618) LONG TERM HEALTH METRICS - YET2 EXPERT SEARCH
Beginning July 2023 and expected to complete in November 2023, yet2, a technology
scouting and open innovation consulting company, is working with NASA HRP to identify
experts to critically evaluate existing long-term health (LTH) metrics and provide guidance on
their applicability to astronauts.
24

February 13-16, 2024 5
108 Megan Waldock; Roddy MacCallum; Carly O'Rourke
(1647646) CLINICAL DECISION SUPPORT TECHNOLOGY - YET2 TECHNICAL SURVEY
From September 2023 to November 2023, yet2, a technology scouting and open innovation
consulting company, worked with NASA XMIPT to conduct a landscape analysis of
partners/technologies for diagnosis, monitoring, and treatment of medical conditions on
future deep-space missions.
109 Ryan Lacinski; Jonathan Steller; Arian Anderson; Dana Levin; Ariana Nelson
(1647670) HARNESSING ARTIFICIAL INTELLIGENCE FOR MEDICAL DIAGNOSIS AND
TREATMENT DURING SPACE EXPLORATION MISSIONS
The purpose of this study was to identify Artificial Intelligence (AI) tools currently available or
in development for the assistive diagnosis and care of medical conditions predicted for an
extended duration Lunar mission.
110 Ariana Nelson; Tovy Kamine; Jonathan Steller; Arian Anderson; Dana Levin
(1647678) EXTRATERRESTRIAL PRE-HOSPITAL ORBITAL NETWORK EVACUATION
Examination of five potential methods for medical evacuation from orbital habitats: 1)
Ground-launched ambulance and medical crew (emergency medical services [EMS] model),
2) Prepositioned lifeboat (ISS model), 3) Orbital ambulance (U.S. Coast Guard model), 4)
Ground launch lifeboat (near-peer conflict evacuation model), 5) Space based hospital (U.S.
Navy model).
111 Craig Kutz; Amit Mistry; Charles Dukes
(1647806) KETAMINE - AN ALTERNATIVE FOR ACUTE SUICIDALITY IN SPACEFLIGHT
The goal of this study was to review current literature and collate the understanding of
ketamine as a safe, effective pharmacological adjunct for acute suicidality in spaceflight.
112 Aristée Thevenon; Philippe Arbeille; Didier Chaput; Orphée Faucoz
(1648600) ECHOFINDER: EVALUATION OF AN EARTH-INDEPENDANT ULTRASOUND
ACQUISITION PROTOCOL ON THE INTERNATIONAL SPACE STATION
To allow earth-independent ultrasound imaging sessions, we propose an innovative solution
based on augmented reality (AR) and artificial intelligence (AI) which will be tested during
Axiom 3 mission.
113 Katie Harris; David Lerner; Michael Pohlen
(1648913) UTILITY OF WHOLE BODY MAGNETIC RESONANCE IMAGING FOR PRE-
FLIGHT MEDICAL MISSION RISK REDUCTION
Whole body magnetic resonance imaging pre-flight may be useful to buy down mission risk
for approximately 10% of the conditions on the ExMC ICL, and could contribute greatly to
spaceflight physiology research when combined with post-flight studies.
114 Abhilash Chandra; Esther Ko; Christopher Markovic; Edward Palmar; Steve Cook
(1649285) THE ROLE OF IMMERSIVE TECHNOLOGIES FOR HUMAN FACTOR
OPTIMISATION AND PREPARATION FOR EXTRA-TERRESTRIAL MEDICAL AND
SURGICAL EMERGENCIES.
This abstract demonstrates how SABRN is working towards utilising VR technologies to
prepare non-clinical personnel to perform clinical procedures prior to deployment to hostile
environments, and then using AR technologies to support these non-clinical personnel
perform clinical procedures after deployment to hostile environments.
115 Shawna Pandya; Mike Wesolowski
(1650042) MIXED REALITY, COLLABORATIVE POINT-OF-CARE ULTRASOUND FOR
AUSTERE AND RESOURCE LIMITED ENVIRONMENTS
In this study, we review our experiences with testing and deploying a mixed-reality,
collaborative, point-of-care SiEVRt ultrasound system developed to address gaps in care in
both rural and remote environments, as well as in exploration-class missions.to aid with
diagnosis and clinical decision-making.
25

February 13-16, 2024 5
116 Michael Marge; Tina Beard
(1650073) IAASS/AEROSPACE CORPORATION HUMAN RESEARCH PROGRAM FOR
CIVILIANS IN SPACEFLIGHT AND SPACE HABITATION
The International Association for the Advancement of Space Safety/the Aerospace
Corporation co-sponsored the development of a Human Research Program for Civilians in
Space Travel and Space Habitation that identifies the types of data collection and scientific
research required to make space accessible, healthy, and safe for everyone, even for those
with chronic health problems and disabilities.
117 Kenny Chao; Atandra Burman; Jitto Tittus; W. Frank Peacock; Amit Padaki; Dana Levin
(1650315) NON-INVASIVE PROTEIN MEASUREMENT BY TRANSCUTANEOUS SENSOR
Remote Cardiac Enablement (RCE) has developed a transcutaneous sensor capable of
detecting cardiac biomarkers such as troponin as a proof-of-concept of reusable, point-of-
care sensing technology that allows for the potential detection of innumerable proteins -
providing an expanded scope of diagnostic testing for spaceflight while reducing the mass,
volume, and power footprint.
118 Dora Babocs; Matthew Melin; Gustavo Oderich; Rowena Christiansen
(1650598) SURGICAL CONCERNS FROM ACCELERATED ATHEROSCLEROSIS
DURING LONG-DURATION SPACEFLIGHT
Many studies have investigated cardiovascular aspects, fluid shifts, space radiation effects
on crew health, and vascular surgical aspects in space; however, a notable gap exists with
no dedicated research on atherosclerosis from a surgeon's perspective, making
endovascular surgery an enticing prospect.
119 Dora Babocs; Gustavo Oderich; Matthew Melin; Rowena Christiansen
(1643994) TRADITIONAL SURGICAL METHODS AND CUTTING-EDGE TECHNIQUES:
PIONEERING ENDOVASCULAR SURGERY IN LONG-DURATION HUMAN SPACE
EXPLORATION
As we extend our reach beyond our planet, understanding the implications of space travel on
human health and developing appropriate medical responses becomes paramount. The
synergy between traditional surgical methods and cutting-edge techniques could shape the
future of space medicine, ensuring the health and well-being of astronauts as they journey
into the cosmos.
120 Dora Babocs; Matthew Melin; Gustavo Oderich; Rowena Christiansen
(1650650) FROM A SURGEON'S PERSPECTIVE: FACTORS INFLUENCING WOUND
HEALING DURING LONG-DURATION HUMAN DEEP SPACE EXPLORATION
Understanding challenges like potential wound healing delays and the effects of microgravity
on surgical outcomes is pivotal for successful long-duration space missions, necessitating
advancements in surgical techniques, wound care strategies, and preventative measures to
ensure astronauts' health and safety as humanity explores deeper into space.
161 Donghyeon Ryu
(1652586) PHYSICAL DIGITAL TWIN BUILT USING IN-PLANE STRAINS ON BODY
SURFACE FOR HEALTH MONITORING DURING A LONG-TERM SPACE TRAVEL
This presentation is to propose a novel way to create a physical digital twin using an in-plane
strain on human body surface for health monitoring in space.
26

February 13-16, 2024 5
Poster Session A: Extravehicular Activity (EVA)
172 Katherine Maguire; John Caruso; Jennifer Daily; Neel Patel; Margaret Wydotis
(1622915) CONTINUOUS PALM COOLING ON HEART RATE AND AUDITORY CANAL
TEMPERATURE VALUES
The abstract describes palm cooling's ability to reduce heat rate and auditory canal
temperatures.
173 Neel Patel; John Caruso; Jennifer Daily; Frances Maguire; Pete Quesada; Margaret Wydotis
(1624020) CONTINUOUS PALM COOLING'S EFFECT ON HEAT TRANSFER AND HAND
TEMPERATURES
The abstract describes the cooling effects of palm cooling on palmar skin temperatures and
heat transfer across the palm.
174 Maddie Haas; Kristin Moeller; Pascaline Tausend; Jack Calhoun; Darren Hartl
(1648716) DESIGN AND OPTIMIZATION OF LIQUID COOLING AND VENTILATION
GARMENT PERFORMANCE VIA THERMAL FINITE ELEMENT ANALYSIS
This research describes a thermal finite element analysis model of a cooling tube layout of a
LCVG developed using the Abaqus Unified FEA suite, focused on maximizing metabolic heat
removal by defining the layout of cooling tubes within the garment through topological
optimization.
175 Derek Nusbaum; Andrew Abercromby; Tony Babb; Mathias Basner; Alexander Baughman;
Benjamin Levine; James Pawelczyk; Robert Scully
(1652313) EFFECT OF CARBON DIOXIDE EXPOSURE ON PHYSICAL AND COGNITIVE
PERFORMANCE IN A SIMULATED SPACEFLIGHT CONTINGENCY SCENARIO
This study will provide valuable information regarding how various partial pressures of CO2
exposure impact acute health, as well as cognitive and physical performance during
simulated contingency lunar EVA.
27

February 13-16, 2024 5
Poster Session A: Food
035 Jess Bunchek; Mary Hummerick; LaShelle Spencer; Matthew Romeyn; Millennia Young;
Robert Morrow; Cary Mitchell; Grace Douglas; Raymond Wheeler; Gioia Massa
(1644672) PICK-AND-EAT SPACE CROP PRODUCTION FLIGHT TESTING ON THE
INTERNATIONAL SPACE STATION
The VEG-04 study with Mizuna mustard has found that yield, organoleptic acceptability,
microbial load and food safety, nutritional content, and the resources required to grow fresh
produce in the Veggie vegetable production chamber on the ISS can be influenced by the
selected lighting recipe, duration and method of cultivation and harvesting, and microgravity
environment.
036 Alain Maillet; Davis Moreeuw; Jean-Loup Cartier; Florence Clement; Thierry Varlet; Marc
Della-Siega; Philippe Chancerel; Elisabeth Araujo; Marie Chancerel; Tristan Hermel; Florian
Roselli; Anne-Dominique Malinge; Nicolas Guignard; Remi Canton
(1648379) FOOD PROCESSOR: A FIRST RECIPE COOKED ON BOARD THE ISS
We would like to present this abstract as a poster, it will describe the Food Processor project
(CNES) and the first recipe cooked on board the space station
037 Grace Douglas; Holly Dlouhy; Audrie Colorado; Douglass Diak; Norberto Gonzalez-Juarbe;
Cody Gutierrez; Satish Mehta; Sara Whiting; Hernan Lorenzi; Brian Crucian; Scott Smith;
Millennia Young; Sara Zwart
(1652468) THE INTEGRATED IMPACT OF DIET ON HUMAN IMMUNE RESPONSE,
THE GUT MICROBIOTA, AND NUTRITIONAL STATUS DURING ADAPTATION TO
SPACEFLIGHT
We expect this study to provide evidence of beneficial impact of this enhanced diet on crew
health and adaptation to spaceflight. These data will aid in evidence-based mass-risk trades
for food system design and development of targeted dietary interventions for future
exploration-class space missions.
038 Michael Dzakovich
(1652494) NOTHING TO BE SALTY ABOUT: MODEST SALINITY STRESS IMPROVES
CAROTENOID BIOACCESSIBILITY FROM SPINACH
Mild salinity stress can improve delivery potential of fat-soluble phytochemicals from spinach
without negatively impacting yield.
28

February 13-16, 2024 5
Poster Session A: Immune
021 Cassian Yee; Paul Hung; Jamie Lin; Shialbala Singh
(1634730) THE EFFECT OF MICROGRAVITY ON HUMAN T CELL DIFFERENTIATION
AND MEMORY
T cells require a well-orchestrated series of biochemical, structural and kinetic events for
activation and differentiation into functional memory T cells. Understanding the effects of
microgravity on these pathways can modulate T cell memory and exhaustion-resistance can
have broad and immediate implications for immunosurveillance, vaccine, and T cell therapies
for cancer and other diseases
022 Maria Moreno-Villanueva; Stephanie Krieger; Ye Zhang; Brian Crucian; Honglu Wu
(1644824) GENE EXPRESSION OF PERIPHERAL BLOOD MONONUCLEAR CELLS OF
CREW MEMBERS DURING LONG-DURATION SPACE MISSIONS INDICATE
DYSREGULATION OF IMMUNOLOGICAL AND CELL SURVIVAL MECHANISMS
PCR analysis were performed in peripheral mononuclear cells from the ISS crew members.
A list of 62 genes were carefully selected addressing immunological and cell survival
pathways. Differentially expressed genes indicated changes in chemokine receptor activity,
chemokine binding, toll-like receptors, adhesion molecules and cellular response to DNA
damage.
023 Bikash Konda; Minon Ishizuka; Hasan Nisar; Jessica Kronenberg; Claudia Schmitz;
Sebastian Diegeler; Edwin Mulder; Maria Bohmeier; Irmtrud Schrage-Knoll; Jens Jordan;
Christine Hellweg
(1646059) INFLUENCE OF HEAD-DOWN TILT BEDREST ON DNA REPAIR CAPACITY
Physical deconditioning by head-down tilt bedrest did not alter DNA repair capacity in
peripheral blood mononuclear cells which was investigated by immunofluorescence staining
of gamma H2AX quantified by flow cytometry.
024 Nathalie Pineda
(1647588) CONCURRENT EXPOSURE TO CHRONIC IRRADIATION AND/OR
SIMULATED MICROGRAVITY ALTERS SPLENIC IMMUNE CELLS PHENOTYPE AND
FUNCTION
To enhance mission safety, female C57BL/6 mice were subjected to chronic γ-irradiation
(CIR) and hind-limb unloading (HLU) for 29 days, revealing that the combined exposure to
microgravity and CIR significantly disrupted immune cell properties, CD4+/CD8+ and B cell
functions, and cellular structure, underscoring the importance of developing
countermeasures for deep-space missions.
025 Honglu Wu; Brian Crucian; Stephanie Krieger; Maria Moreno-Villanueva; Nathaniel Stucky;
Ye Zhang
(1649410) ROLE OF PIEZO1 IN T CELL ACTIVATION UNDER SIMULATED
MICROGRAVITY
Piezo1 is a known mechanosensing gene and has been shown to be critically involved in
human T cell activation. The role of the Piezo1 gene in T cell activation under simulated
microgravity was investigated.
026 Patrick Rydzak; Christian Castro; Hang Nguyen; Audrey Almengor; Sarah Stahl-Rommel;
Satish Mehta; Douglass Diak; Miten Jain; Stephen Tyring; Brian Crucian; Sarah Castro-
Wallace
(1649732) SPACEFLIGHT-COMPATIBLE METHOD FOR THE IN-SITU, REAL-TIME
DETECTION OF HERPESVIRUS REACTIVATION IN OVERWINTER CREW AT PALMER
STATION USING NANOPORE SEQUENCING
Optimized previously developed method for the detection of herpesviruses from saliva to
allow the method to be spaceflight compatible.
29

February 13-16, 2024 5
027 Daniel Tavakol; Ivana Matkovic; Danielle Mendonca; Gerarda Cappuccio; Keith Yeager;
Ilaria Baldassarri; Francois Chesnais; Roberta Lock; Diogo Teles; Connie Chen; Pamela
Graney; Griffin Daly; Mirjana Maletic-Savatic; Gordana Vunjak-Novakovic
(1650071) EXTENDING THE LIFETIME OF SYSTEMIC, MULTI-ORGAN BIOENGINEERED
HUMAN TISSUE MODELS WITH INTEGRATED IMMUNE COMPONENTS
In this work, we are developing bioengineering platforms of the heart-bone marrow-
vasculature (at Columbia University) and brain-bone marrow-vasculature tissues (at Baylor
College of Medicine), to enable immune cell-tissue interactions over long durations of culture
(up to 6 months).
028 Dagan Loisel; Mackenzie Costello; Brian Crucian; Colby Fane-Cushing; Elizabeth Marini;
Jordyn Morey; Mayra Nelman-Gonzalez; Madeline Van Winkle; Melissa VanderKaay
Tomasulo
(1650311) VR MEDITATION COUNTERMEASURE HAS POSITIVE EFFECTS ON
AUTONOMIC, MOOD, AND IMMUNE INDICATORS OF THE STRESS RESPONSE IN A
LAB SETTING
Our results indicate that VR-delivered guided meditation was associated with a decrease in
systolic blood pressure and negative affect, an increase in positive affect, and positive
changes in salivary biomarkers of stress.
029 Christopher Mason
(1650592) SINGLE-CELL MULTI-OME AND IMMUNE PROFILES OF THE INSPIRATION4
CREW REVEAL CELL-TYPE, SEX, AND MICROBIOME-SPECIFIC RESPONSES AND
RECOVERY
We report here findings on the SpaceX Inspiration4 (i4) mission, an all civilian-crewed
commercial orbital spaceflight, including multi-omic, in-depth immune system profiling at the
single-cell level for the four-member crew with a broad age range (29-50 years old at launch
date) and biomedical background.
030 Mayra Nelman-Gonzalez; Forrest Baker; Alexander Chouker; Brian Crucian; Douglass Diak;
Cody Gutierrez; Grace McKenzie; Satish Mehta; Rickie Simpson; Scott Smith; Sara Zwart
(1652100) DRY SALIVA DEVELOPMENT - ARTEMIS
Deployment of prolonged deep space missions carry increased crew health risks. Transition
to Gateway and Artemis will limit the available up mass and biosample return capability
resulting in challenges to monitor crew health. The goal of this study is the development of
dried biosampling as a technology that enables sample collection and tracking of crew health
during exploration class missions.
031 Douglass Diak
(1652228) HERPES VIRAL SHEDDING DECREASES IN ANTARCTIC EXPEDITIONERS
WITH PROPHYLACTIC ANTIVIRAL (VALACYCLOVIR) TREATMENT: A CLOSER LOOK
AT IMMUNE STRESS
This study will provide an analysis of additional salivary inflammatory and immune
biomarkers to further solidify the claim that Antarctic expeditioners under prophylactic
antiviral treatment experience not only less viral stress, but also reduced inflammation and
immune stress than those taking a placebo.
032 Cody Gutierrez; Alexander Chouker; Brian Crucian; Douglass Diak; Dagan Loisel; Satish
Mehta; Mayra Nelman-Gonzalez; Sergey Ponomarev; Rickie Simpson; Scott Smith;
Raymond Stowe; Melissa Tomasulo; Sara Wallace; Sara Zwart
(1652232) VALIDATION OF MULTISYSTEM COUNTERMEASURES PROTOCOL FOR
SPACEFLIGHT DURING ANTARCTICA WINTER-OVER AT PALMER STATION (PALMER
COUNTERMEASURES)
Countermeasure development and validation at Plamer Station in Antartica.
30

February 13-16, 2024 5
033 Sara Bustos Lopez; Douglass Diak
(1652305) INFLUENCE OF MICROGRAVITY ON BACTERIAL PATHOGENS VIRULENCE
AND IMMUNE CELL FUNCTION RELEVANCE FOR INFECTIOUS DISEASE RISK DURING
SPACE FLIGHT
This study examines the impact of the pathogens Pseudomonas aeruginosa, Salmonella
enterica, and Burkholderia cepacia pre-exposed to microgravity or ground based simulated
microgravity on human PBMCs recovered from astronauts and ground based control
subjects. Data shows an altered impact of microgravity on immune cell activation, cytokine
profile, and immune cell behavior by imaging analysis.
034 Elizabeth Beattie; Kyle Smith; Grace McKenzie; Brian Crucian; Christopher Connaboy;
Emmanuel Katsanis; Richard J. Simpson
(1673128) ASSOCIATIONS BETWEEN VOLUNTARY EXERCISE TRAINING, STRESS
BIOMARKERS AND IMMUNE DYSREGULATION DURING A 45-DAY HUMAN
EXPLORATION RESEARCH ANALOG (HERA) MISSION
ASSOCIATIONS BETWEEN VOLUNTARY EXERCISE TRAINING, STRESS BIOMARKERS
AND IMMUNE DYSREGULATION DURING A 45-DAY HUMAN EXPLORATION
RESEARCH ANALOG (HERA) MISSION
31

February 13-16, 2024 5
Poster Session A: MicroHost
016 Kristyn Hoffman; Adriana Babiak-Vazquez; Mark Ott
(1643722) HISTORICAL MICROBIAL POPULATION OF THE ISS AND ITS CLINICAL
RELEVANCE
The historical microbial population was analyzed with clinical symptom incidence from crew
health records with random forest machine learning assessment to uncover potential host
pathogen relationships on ISS.
017 Ralf Moeller; Alena Warkentin; Laura de Boni; Petra Frings-Meuthen; Katharina Siems;
Christine Hellweg
(1646252) GUT MICROBIOME DYNAMICS UNDER SIMULATED MICROGRAVITY - FIRST
INFORMATION FROM THE SPACEFLIGHT-ASSOCIATED NEURO-OCULAR SYNDROME
(SANS) -COUNTERMEASURES STUDIES
In the area of space exploration, numerous factors are able to decrease the quality of health
and recovery of space travelers. Among those, weightlessness comes with significant
challenges. Besides the negative effect it has on bone density, muscle mass, and risk for
space-associated neuro-ocular syndrome, it also has the ability to influence the composition
of the gut microbiome.
018 Frances Donovan; Natalie Ball; Sadie Downing; Ami Hannon; Hiromi Kagawa; Jing Li; Hami
Ray; Oscar Roque; Andrew Settles; Kevin Sims; Sandra Vu
(1649533) STRATEGIES FOR DETERMINING SAFETY OF FERMENTED FOODS
PRODUCED IN SPACE
An evaluation and comparison of various pathogen detection methods and the challenges for
use with high microbial content products.
019 Mark Ott; Jennifer Barrila; Sandhya Gangaraju; Laura Banken; Jiseon Yang; Richard Davis;
Audrie Medina-Colorado; Ji Sun Park; Eleanor Blakely; Phillip Stafford; Cheryl Nickerson
(1649639) EFFECTS OF LOW DOSE RADIATION AND RADIATION
COUNTERMEASURES ON INFECTION BY SPACEFLIGHT ANALOGUE CULTURED
SALMONELLA USING 3-D BIOMIMETIC HUMAN TISSUE MODELS
This study investigates whether the already enhanced infection potential of spaceflight
analogue cultured S. Typhimurium will be further exacerbated when used to infect human
cells exposed to low dose radiation and if this enhanced pathogenicity can be mitigated by a
radioprotective compound.
020 Polina Shtern; Charlotte Pouwels; Margot Issertine; Gauravam Majmudar; Rowan Moorkens
O’Reilly; Alexandra Lissouba
(1650155) UV LIGHT FOR SPACE LAUNDRY: MITIGATING MICROBIAL RISKS ON
LONG-DURATION CREWED MARS MISSIONS
This research project aims to mitigate the impact of long-duration spaceflight on the human
skin microbiome by testing the effectiveness of a portable UV-C device on astronaut clothing
during an analog mission, with the goal of reducing microbial counts, minimizing infection
and allergic response risks, and supporting a balanced skin microbiome for long-term Mars
missions.
32

February 13-16, 2024 5
Poster Session A: Mixed Topics
351 Steven Rader
(1610070) OPEN INNOVATION SUCCESS STORIES IN HEALTH RELATED
GOVERNMENT RESEARCH
This presentation will highlight a number of successful open innovation projects run through
the NASA Tournament Lab for NASA, CDC, HHS, NIH, NSF, and VA to demonstrate the
power of open innovation (available to IWS attendees via NASA CoECI) to enhance and
accelerate health related research.
352 Helen Schell
(1622823) THE HUMAN SPACESHIP, UPON THE MOON
The Human Spaceship: New 21st century space endeavors have resulted in the need for
extensive research into altered gravity’s impact on visual physiology and perception, so how
do artists represent the need for creative thinking, which transcends academic barriers,
promoting cross-disciplinary skills to achieve long-term human spaceflight goals and living,
(Moon, Mars and space stations)?
353 Sandeep Kamat; Ivan D'souza
(1641789) PUBLICATION TRENDS ANALYSIS: A NEW PERSPECTIVE ON ASSESSING
RESEARCH OUTPUT
We present a new approach to assessing research output through a quantitative analysis of
volume of peer-reviewed journal articles indexed in the NASA Task Book bibliography, which
will help monitor overall publication activity and identify publication trends for specific
subsystems related to countermeasures against spaceflight hazards.
354 Vanessa Farsadaki
(1642159) SPACE PREGNANCY BIOETHICS
Exploring ethics of space pregnancy: Risks, benefits, and societal impact.
355 Vanessa Farsadaki
(1642174) THE DEMOCRATIZATION OF SPACE MEDICINE
Democratizing space medicine is imperative as space travel becomes more accessible,
necessitating education, innovation, and collaboration for comprehensive healthcare
provision beyond Earth.
356 Alyssa Adcock; Allison Caherty; Jennifer Buss
(1643066) WHY IT MATTERS: STRATEGICALLY COMMUNICATING YOUR SCIENCE
To support both HRP's mission to mitigate the risks of human spaceflight and strategic goal
to communicate impact, the Potomac Institute for Policy Studies presents a science
communication framework to help communicate science more effectively to relevant
stakeholder groups across academia, industry, and government, including policy makers.
357 Meena M. C. Shekar; John Hansen
(1649466) THE UNSUNG HEROES OF APOLLO 11: ANALYZING MISSION-CRITICAL
CONVERSATIONS THROUGH SPEAKER DIARIZATION ON FEARLESS STEPS APOLLO
we implement a novel framework based on dynamic Graph Attention Network for speaker
diarization and clustering. Further, we also identify, track, analyze key speakers of interest
throughout the complete Apollo 11 mission. One of the first initiatives to to identify and
extract meta-labels for speakers serving as a lasting tribute to the unsung heroes of the
Apollo mission.
33

February 13-16, 2024 5
358 Aditya Joglekar; Iván López-Espejo; John H.L. Hansen
(1650171) FEARLESS STEPS APOLLO: IDENTIFYING CONVERSATIONAL MISSION-
CRITICAL TOPICS IN NASA APOLLO MISSIONS AUDIO BASED ON KEYWORD
SPOTTING
In this study, we focus on customizing keyword spotting (KWS) and topic detection
mechanisms, laying the foundational groundwork for advanced conversational
comprehension.
359 Chloe Tuck; Ursula Koniges; Wanessa Priesmeyer
(1650180) LEVERAGING SUBORBITAL FLIGHT TESTING TO ADVANCE SCIENCE AND
TECHNOLOGY IN THE EXPANDING SPACE ECONOMY
Presenters from two NASA programs – Flight Opportunities and the Biological and Physical
Science (BPS) Division’s Commercially Enabled Rapid Space Science (CERISS) initiative –
will discuss ways of accessing flight tests to advance technologies that meet U.S. space
exploration priorities and support the expanding space economy, including those that support
sustained human presence in space.
360 Xi Liu; John Hansen
(1650663) A CEPSTRUM AND SPECTRUM FUSION BASED NETWORK FOR MONAURAL
SPEECH ENHANCEMENT IN NASA MISSION BASED TEAM COMMUNICATION
Many NASA communications such as audio recordings from the Apollo missions contain
sever communications-based noise level, which pose substantial challenges for effective
human engagement as well as research tasks for subsequent team dynamics based
analysis.In this study, we propose an advanced denoising approach that combines both
signal processing expertise with deep learning algorithms.
34

February 13-16, 2024 5
Poster Session A: Muscle & Aerobic
176 Igor Mekjavic; Riccardo Sorrentino; Jack Fortune; Urša Ciuha; Lydia Tsoutsoubi; Leonidas
Ioannou; Jason Fisher; Sara Podgornik; Matija Šatej; Adam McDonnell
(1617099) RESISTANCE VIBRATION EXERCISE: A POTENTIAL COUNTERMEASURE
A 2-week training program of squat exercise and heel raises conducted on a vibration
platform during the application of artificial gravity on a short arm human centrifuge (SAHC)
bestowed significant benefits in lower leg muscle strength, when compared to a similar
training programme conducted in the upright position (ground reaction force was similar in
both exercise protocols).
177 Sandra Faragalla; Kaitlin Lostroscio; Leslie Quiocho; Charlotte Bell; Fouad Matari
(1640649) KINEMATIC SENSORS EVALUATION FOR SPACEFLIGHT EXERCISE DATA
COLLECTIONS
A kinematic accuracy evaluation of three motion tracking sensors to inform the most feasible
ISS exercise data collection method in the future and aid in understanding the sensors and
developing end-to-end processing.
178 Timo Frett; Leopold Lecheler; Michael Arz; Willi Pustowalow; Guido Petrat; Florian
Mommsen; Jan Breuer; Marie-Therese Schmitz; David Adrew Green; Jens Jordan
(1643501) ROWING IN ARTIFICIAL AND IN TERRESTRIAL GRAVITY: TOLERABILITY,
PERFORMANCE, AND PHYSIOLOGICAL RESPONSES
Rowing combined with artificial gravity via short-arm centrifugation was found to be feasible,
well-tolerated, and a potential strategy to mitigate cardiovascular and muscular
deconditioning during extended spaceflight, with certain differences in muscle activation and
ground reaction forces compared to terrestrial gravity rowing.
179 Cuiping Zhang; Peng Huang; Jeffrey Richards; Ye Zhang; Abba Zubair
(1643659) IMPACT OF SIMULATED MICROGRAVITY ON MESENCHYMAL STEM CELL
PROLIFERATION
Type of microgravity simulator and duration of culture significantly affect MSC proliferation.
180 Mariam Othman; Khaled Kamal; Joo Kim; Rachel Rauth; Lauren Wesolowski; Jessica
Simons; Pier Semanchik; Sarah White-Springer; Mariana Gomez; John Lawler
(1643843) THE SIRTUIN-1 AGONIST SRT2104 MITIGATES UNLOADING-INDUCED
SKELETAL MUSCLE ATROPHY AND INFLAMMATION
This study investigates whether the SIRT1 agonist SRT2104 mitigates inflammatory
signaling and mitochondrial dysfunction, thus reducing muscle atrophy induced by hindlimb
unloading.
181 Bergita Ganse; Danjana Teves
(1644101) IMMOBILIZED PATIENTS WITH (MULTIPLE) INJURIES AS A SPACEFLIGHT
ANALOGUE FOR MUSCLE ATROPHY - HIGH VARIABILITY, BUT GREAT AVAILABILTY
AND CLINICAL RELEVANCE
Immobilised patients with (multiple) injuries can serve as an analogue for studying muscle
atrophy if a large effect is expected, but due to the high variability compared to normal bed
rest studies with healthy participants, a much higher number of participants is required
35

February 13-16, 2024 5
182 Yoshinobu Ohira; Che Show Chen; Reggie Edgerton; Takuya Goto; Alan Hargens; Hisashi
Naito; Toshio Ohhata; Takashi Ohira; Masaki Takeda
(1644654) ESTIMATION OF WALKING PATTERNS AND METABOLIC RATES OF HUMAN
IN PARTIAL GRAVITY ENVIRONMENTS USING PARABOLIC FLIGHT AND ALTER-G
TREADMILL
Whole body oxygen consumption and electromyogram activities in soleus and lateral portion
of gastrocnemius during standing rest, stepping, and/or walking were recorded using
compact devices during the exposure to 1-G, 3/8-G, 1/5-G, or 1/6-G. The EMG activities of
both muscles during standing rest and stepping were decreased with reduction of gravity
level.
183 Nicole Strock; Brian Prejean; Alyssa Varanoske; Jason Norcross; Taylor Schlotman; Karina
Marshall-Goebel
(1645391) TEMPORAL CHANGES IN ASTRONAUTS' MUSCLE AND
CARDIORESPIRATORY PHYSIOLOGY BEFORE, DURING, AND AFTER SPACEFLIGHT
This flight study will provide valuable information for determining time course of change and
the interindividual variability of spaceflight-induced deconditioning of aerobic capacity and
muscle strength and endurance over the course of spaceflight missions up to and beyond 1
year.
184 Jonas Böcker; Guillaume Fau; Thomas Krüger; Jörn Rittweger; Torsten Siedel; Jochen
Zange
(1646104) ATHLETIC: AN EXOSKELETON COUNTERMEASURE DEVICE FOR
RESISTIVE AND PLYOMETRIC EXERCISE
The exoskeleton ATHLETIC device is a novel exercise device counteracting muscle and
bone loss for upcoming deep-space missions. Clinical tests showed the functionality and
efficacy of the device and first results comparing reference results with exercising on
ATHLETIC.
185 Jonas Böcker; Guillaume Fau; Jörn Rittweger; Arnaud Runge; Torsten Siedel; Jochen Zange
(1646113) NEX4EX - NOVEL APPROACH ENABLING RESISTANCE, SENSORIMOTOR
AND PLYOMETRIC TRAINING FOR DEEP-SPACE MISSIONS
Novel Exercise Hardware for Exploration (NEX4EX) is a countermeasure device enabling
sensorimotor training, resistive and plyometric training. The clinical tests evaluated the
efficacy and comparability of this novel approach and control measurements.
186 Alyssa Varanoske; Brian Prejean; Nicole Strock; Danielle Conly; Brian Peters; Erin Morant;
Jean Sibonga; Scott Smith; Sara Zwart; Elisabeth Spector; Renita Fincke; Millennia Young;
Karina Marshall-Goebel
(1646734) EFFECTS OF REPLACING TREADMILL RUNNING WITH ALTERNATIVE
EXERCISE COUNTERMEASURES DURING LONG-DURATION SPACEFLIGHT
This study will assess the efficacy of exploration exercise modalities, including the effects of
removing the treadmill exercise capability or of exclusively using the European Enhanced
Exploration Exercise Device (E4D), compared to nominal ISS exercise across an entire
mission on bone, muscle, aerobic, and sensorimotor health and performance.
187 Erik LeRoy; Brett Bennett; David Wassell
(1646759) AEROBIC TESTING LOGISTICS AS A PRE-FLIGHT COUNTERMEASURE FOR
MICROGRAVITY-RELATED VASCULAR DEGRADATION: A REVIEW
Optimizing maximal aerobic capacity closer to launch date will allow for less degradation of
aerobic fitness between test and launch date and subsequently during flight, as well as
getting ahead of the elastin degradation that takes place in microgravity during long duration
missions.
36

February 13-16, 2024 5
188 Evagelia Laiakis; Afshin Beheshti; Elizabeth Blaber; Emma Kosowski; Tytus Mak; Jeffrey
Willey
(1646976) ALTERATIONS IN ENERGY METABOLISM PATHWAYS IN SKELETAL
MUSCLE IN RELATION TO MICROGRAVITY ANALOG AND SPACE RADIATION
Metabolomics of muscles from combined injuries (radiation + hindlimb unloading) at 24 hours
after exposure suggest that radiation (acute exposures) leads to a higher metabolic
detriment, while hindlimb unloading either does not exacerbate the responses or the
responses reach a plateau.
189 Rachel Bellisle; Katya Arquilla; Lonnie Petersen; Andrea Webb; Dava Newman
(1647496) QUALITATIVE EVALUATION OF THE GRAVITY LOADING
COUNTERMEASURE SKINSUIT DURING EXERCISE AND FUNCTIONAL ACTIVITY IN
LOW EARTH ORBIT AND 1G
The abstract and poster discuss the qualitative evaluation of the Gravity Loading
Countermeasure Skinsuit, a proposed wearable musculoskeletal and sensorimotor
countermeasure, with one participant on a 10-day ISS mission, supplemented by a
participant study (n≥3) in 1G.
190 Eve Elmore; Lance Bollinger; John Caruso; Stuart Best; Timothy Butterfield
(1648838) EFFECTS OF UNILATERAL LOWER LIMB SUSPENSION OF THE
QUADRICEPS STRUCTURE AND FUNCTION
Muscle unloading during space flight decreases strength and cross-sectional area of anti-
gravitational muscles, such as the quadriceps. Purpose is to assess changes in quadriceps’
size, anisotropy, and function following unilateral limb suspension (ULLS), where one limb is
unloaded and the contralateral limb acts as an internal (loaded) control.
191 Khaled Kamal; Mariam Othman; Joo-Hyun Kim; Jacob Kendra; Shadi Golpasandi; Rachel
Rauth; Aaron Morton; John Lawler
(1650211) ENHANCING SKELETAL MUSCLE RECOVERY AND MITIGATING ATROPHY
IN DISUSE: A NOVEL APPROACH USING TIME RELEASE ION MATRIX (TRIM)
APPLICATION
A biocompatible ceramic called TRIM has potential to mitigate spaceflight induced muscle
atrophy, enhance growth factors, and reduce oxidative stress and inflammation, ultimately
increasing muscle size and accelerating recovery after unloading.
192 John Lawler; Joo-Hyun Kim; Khaled Kamal; Mariam Othman; John Ford; Yuxiang Sun;
Rachel Rauth; James Fluckey
(1650458) WE HAVE IGNITION: REDOX REGULATION OF MECHANOTRANSDUCTION
WITH SPACEFLIGHT AND TRANSLATION TO MYOPATHIES ON EARTH
The redox biology of mechanotransduction during spaceflight is regulated by positive
feedback loops, that include RANKL and effectors of oxidative stress and inflammation,
amplifying pathology with spaceflight, aging, and Duchenne muscular dystrophy.
193 Matthew McDonnell; Cody Burkhart; Nathaniel Jenkins; Jeevan Perera
(1650878) QUANTIFYING CALORIC EXPENDITURE DURING ZERO-G EXERCISE
This study aims to develop a user-friendly predictive model to measure calories burned
during exercise aboard the International Space Station, using spirometry, heart rate, forces
and more, with the goal of improving health and wellness for astronauts on extended space
missions.
194 Kelly Crowe; Brianna Mackey; Nate Mazza; Robert Cullen; Marie Mortreux
(1652522) SKELETAL MUSCLE SIALYLATION IN SIMULATED MICROGRAVITY
This preliminary data shows alterations in the extracellular glycans of rat skeletal muscle
after exposure to hindlimb unloading, which could represent a novel target for
pharmacological and nutraceutical interventions to address skeletal muscle atrophy in
spaceflight conditions.
37

February 13-16, 2024 5
Poster Session A: Research Operations & Integration (ROI)
162 Meredith Russell; Lauren Secino; Sami Anjum
(1647595) NASA ROI PROSPECTIVE DATA SHARING PROCESS OVERVIEW OF
SPACEFLIGHT STUDIES
Learn how to navigate the new Research Operations and Integration (ROI) data sharing
process from the perspective of a researcher including best practices and frequently asked
questions.
163 Oscar Ojeda; Samuel Cadavid; Yael Méndez; Camilo Zorro
(1650455) DEVELOPMENT OF A HUMAN SPACEFLIGHT ANALOG RESEARCH
PROGRAM IN A NON SPACE-FARING NATION
This work presents the development of an analog research program in Colombia, centered
around the HAdEES-C station, built north of Bogotá, which allows analog missions to be
undertaken. A description of the facilities, the activities developed, and the importance for
non-space-faring nations to develop these activities is presented, as well as the undergoing
projects and cooperation opportunities.
164 Katherine Rahill; Alexandra Whitmire; Ajitkumar Mulavara
(1691331) REVIEW OF SCIENTIFIC REQUIREMENTS FOR HIGH-FIDELITY LUNAR AND
MARTIAN RESEARCH ANALOGS
This presentation highlights the importance of analog research for human spaceflight,
emphasizing analogs’ critical role in preparing for Artemis and Mars missions, particularly in
regard to buying down behavioral health and performance risks.
38

February 13-16, 2024 5
Poster Session A: Sensorimotor
195 Caroline Austin; Beth Lewandowski; Jerry Myers; Hunter Rehm; Scott Wood
(1627322) CHP-PRA: SENSORIMOTOR COUNTERMEASURES PROOF OF CONCEPT
This effort demonstrates the use of countermeasure data to inform performance risk using
sensorimotor data as an example.
196 Faye Tan; Jeffrey Strakowski; Han Zhang; Millard Reschke
(1629141) HIGH FREQUENCY ULTRASOUND IMAGING OF CADAVERIC INNER EAR
STRUCTURES
The study demonstrates that pertinent anatomic structures of the inner ear as well as their
positional relationships can be reliably identified with high frequency ultrasound to facilitate
appropriate beam positioning toward the targets of interest with dissected windows in
cadaveric specimens.
197 Caroline Austin; Torin Clark
(1641986) SIMULATING POSTFLIGHT VESTIBULAR ILLUSIONS WITH GALVANIC
VESTIBULAR STIMULATION
This project investigates the effect of Galvanic Vestibular Stimulation on orientation
perception and how it may be optimized to mimic astronaut post-flight vestibular illusions and
functional mobility performance.
198 Torin Clark; Taylor Lonner; Caroline Dixon; Sherrie Holder; Jordan Dixon; Tristan Endsley
(1642031) DETECTING PILOT SPATIAL DISORIENTATION TO TRIGGER ACTIVE
COUNTERMEASURES DURING LUNAR LANDING
We aim to develop a pilot aiding system to detect spatial disorientation in real-time during
lunar landing and trigger a countermeasure to maintain performance and safety.
199 Taylor Lonner; Aaron Allred; Aadhit Gopinath; Luca Bonarrigo; Torin Clark
(1643095) ACTIVE POSTURAL CONTROL AND ANTICIPATORY CUEING AS
COUNTERMEASURES FOR ASTRONAUT MOTION SICKNESS DURING WATER
LANDINGS
Two novel, non-pharmacological countermeasures are evaluated for efficacy in reducing the
incidence and severity of astronaut motion sickness and sensorimotor degradation following
a water-landing analog.
200 Timothy Macaulay; Scott Wood; Millard Reschke; Yiri De Dios; Joseph Dervay; Tomoko
Makishima; Michael Schubert; Mark Shelhamer; Amir Kheradmand; Gilles Clement
(1644351) NEURO-VESTIBULAR EXAMINATION DURING AND FOLLOWING
SPACEFLIGHT (VESTIBULAR HEALTH)
This study represents the Sensorimotor arm of the Complement of Integrated Protocols for
Human Exploration Research (CIPHER) and aims to characterize the severity of vestibular
syndromes experienced by astronauts as a function of spaceflight duration and examine
whether the effects are caused by changes at the peripheral end organs, midbrain,
cerebellum, or vestibular cortex.
241 Timothy Macaulay; Seward Rutkove; Brian Peters; Lars Oddsson; Scott Wood; Leah Bent;
Francisco Valero-Cuevas; Emily Lawrence; Nicole Strock; Millennia Young; Jacob
Bloomberg; Marie Mortreux; Mary Bouxsein; Afshin Beheshti; Thomas Abitante; Dava
Newman
(1644498) COUNTERMEASURES FOR MITIGATION OF SENSORIMOTOR
DECREMENTS FOLLOWING HEAD-DOWN BED REST
This study will evaluate the efficacy of sensorimotor countermeasures (proprioceptive
training and electrical muscle stimulation) performed during head down bed rest (HDBR) for
protecting functional task performance, sensorimotor function, and other key physiological
measures following 60 days of 6° HDBR.
39

February 13-16, 2024 5
242 Hannah Weiss; Sarah Moudy; Scott Wood
(1644918) DEVELOPMENT OF HEAD-TRUNK COORDINATION MEASURES FOR
MONITORING POSTFLIGHT SENSORIMOTOR READAPTATION STRATEGIES
To better characterize microgravity-induced sensorimotor adaptations, we investigated head-
trunk coordination measures that are sensitive enough to detect coupling changes by
comparing sensitivity of these measures with and without vestibular disorientation via
Galvanic Vestibular Stimulation (GVS) and physical restriction via a neck brace during short
duration testing.
243 Victoria Kravets; Aadhit Gopinath; Torin Clark
(1645212) QUANTIFYING TEMPORAL DYNAMICS OF NEUROVESTIBULAR
ADAPTATION TO ALTERED GRAVITY
This research investigates how humans adapt to changes in the magnitude of gravity,
specifically focusing on neurovestibular impairment during the first hour after transitioning
from normal Earth gravity to a higher gravity environment, using centrifugation and subjective
perception measurements.
244 Austin Bollinger; Kevin Duda; Steven Moore; Douglas Wheelock; Scott Wood
(1645216) MANUAL CREW OVERRIDE OF VEHICLE LANDINGS FOLLOWING G-
TRANSITIONS
In this study, we will examine operational piloting tasks following International Space Station
(ISS) missions in a simulated lunar landing using a six-degree-of-freedom (6DOF) motion
base.
245 Olivier Etard; Olga Kuldavletova; Mikael Naveau; Gaëlle Quarck; Antoine Langeard; Marion
Hay; Adela Kola; Michel Toupet; Christian van Nechel; Charlotte Hautefort; Pierre Denise;
Gilles Clément
(1646168) CAN IDIOPATHIC BILATERAL VESTIBULOPATHY BE A GROUND-BASED
MODEL FOR LONG DURATION SPACEFLIGHT?
Patients with bilateral vestibular deficits could be a model of the effects of long-duration
space travel, and would thus facilitate understanding of the mechanisms involved, in
particular by exploring the role of the hippocampus in the link between vestibular perception
and impaired postural control.
246 Grant Tays; Bianca Arocha; Rachael Seidler; Scott Wood
(1646949) THE EFFECTS OF SENSORY BIAS AND TRANSCRANIAL DIRECT CURRENT
STIMULATION ON FUNCTIONAL MOBILITY TEST ADAPTATION AS A POST-FLIGHT
COUNTERMEASURE
We investigate the use of transcranial direct current stimulation over the human vestibular
cortex, as vestibular mediated performance deficits are common following spaceflight, on
functional mobility test performance as a post-flight countermeasure.
247 Grant Tays; Tyler Fettrow; Heather McGregor; Kathleen Hupfeld; Yiri De Dios; Nichole
Beltran; Scott Wood; Patricia Reuter-Lorenz; Jacob Bloomberg; Rachael Seidler
(1647230) FUNCTIONAL BRAIN NETWORK SEGREGATION PREDICTS POST-FLIGHT
BALANCE IMPAIRMENTS
We assessed pre-flight vestibular and visual functional brain network segregations ability to
serve as predictor of post-flight balance impairment and found that visual segregation
predicts post-flight balance perform 1 day after returning to Earth, where vestibular pre-flight
segregation predicted balance performance 4 days after returning to Earth; both networks
had high test-retest reliability.
248 Matthew Carey; Matthew Ehrenburg; Tim Macaulay; Scott Wood
(1647946) COMPARISON OF ACTIVE AND PASSIVE HEAD IMPULSE TESTING OF THE
HORIZONTAL VESTIBULO-OCULAR REFLEX: EXPLORING THE FEASIBILITY OF
DIFFERENT APPROACHES FOR SPACEFLIGHT
As a part of the CIPHER Vestibular Health project, this study aimed to test the reliability of
Head Impulse Testing (HIT) between different operators and to compare passive (pHIT) vs
active (aHIT) administration, gaining a better understanding of HIT efficiency and reliability in
quantifying vestibular function before, during, and after human spaceflight.
40

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