The document discusses a person's experience listening to someone else's story for 15 paragraphs. In the end, the speaker thanks the listener for taking the time to hear their story.
A product distribution proposal is an important step when trying to attract a potential distributor to your product. It also gives your business partners a clear understanding of what your product entails. This description is used as a selling point for what you're trying to market, emphasizing its benefits, both for your company and the interested distributor. This outline will show you how to construct such a proposal and why it's essential in landing the agreement you're seeking.
Your resume is a vital tool in your job search. We've taken our most important pointers from one of our recent Job Seeker Webinars and we've summarized them for you in this easy-to-use guide.
A product distribution proposal is an important step when trying to attract a potential distributor to your product. It also gives your business partners a clear understanding of what your product entails. This description is used as a selling point for what you're trying to market, emphasizing its benefits, both for your company and the interested distributor. This outline will show you how to construct such a proposal and why it's essential in landing the agreement you're seeking.
Your resume is a vital tool in your job search. We've taken our most important pointers from one of our recent Job Seeker Webinars and we've summarized them for you in this easy-to-use guide.
The Art of the Resume: Your Guide to Writing a Winning Resume in Today's Comp...Molly Sutton
Your resume is a vital tool in your job search but writing the strongest resume is not always intuitive. In this guide: top 5 resume tips from executive career coaches, many rich examples, in-depth explanations, and links to more resume writing and job search resources.
September 22, 2016 - presentation to the Maryland Economic Development Association (MEDA)
The latest headline news includes the announcement of federal funding for the development of the Northeast Maglev, a high speed train, first used in Japan, that will transport users from DC to New York faster than ever before. Hear all the exciting updates on this transformational effort.
Global Food Security including Livestock, based on National Security Plans for poor nations with inadequate food resources. From a lecture to University of Tasmania, May 2015. Based on images from the book "Beliefs that Bias: Questions I'm Often Asked" - see google books, or gutenberg online.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
The Art of the Resume: Your Guide to Writing a Winning Resume in Today's Comp...Molly Sutton
Your resume is a vital tool in your job search but writing the strongest resume is not always intuitive. In this guide: top 5 resume tips from executive career coaches, many rich examples, in-depth explanations, and links to more resume writing and job search resources.
September 22, 2016 - presentation to the Maryland Economic Development Association (MEDA)
The latest headline news includes the announcement of federal funding for the development of the Northeast Maglev, a high speed train, first used in Japan, that will transport users from DC to New York faster than ever before. Hear all the exciting updates on this transformational effort.
Global Food Security including Livestock, based on National Security Plans for poor nations with inadequate food resources. From a lecture to University of Tasmania, May 2015. Based on images from the book "Beliefs that Bias: Questions I'm Often Asked" - see google books, or gutenberg online.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
처음으로 TAPU를 참가하게 되었습니다.
This is the first visit to TAPU.
발표할 기회를 주신 오거나이저분께 감사드립니다.
Thanks to organisers of TAPU for giving this chance to me.
발표를 시작하겠습니다.
Let’s start.
My talk is in terms of counting ideals.
인덱스 n을 갖는 아이디얼 갯수를 세는 것은
자기 자신을 베이스 링으로 갖는 모듈에서 인덱스 n을 갖는 서브모듈을 세는 것과 같습니다.
We easily see that
the number of ideals of given ring Lambda with finite index is the same as the number of submodule of the Lambda-module Lambda with finite index as module.
모듈의 입장에서 다음과 같은 제타함수를 정의할 수 있습니다.
In the module theory, we can define the zeta function of a module.
the zeta function of a Lambda-module L is summand of a_n product n to the -s where a_n is the number of submodules with index n.
여기서 람다와 L이 아이소몰픽하면 a_n 은 아이디얼의 갯수가 됩니다.
If Lambda is isomorphic to L, we can consider a_n is the number of ideals of L with index n.
If Lambda is isomorphic to L, we abbreviate this part.
예를 하나 들어보겠습니다.
L을 정수링을 베이스 링으로 같은 모듈로써 보겠습니다.
For example, let L be the ring of integers.
그러면 모든 서브모듈은 인덱스를 1로 갖기 때문에 다음과 같은 제타함수를 수할 수 있습니다.
Then for each n, a_n is 1.
The zeta function of L is that.
이 제타함수는 리만제타함수와 같고 우리는 이것을 제타 에스라고 디노트 하겠습니다.
Actually, this is the Riemann zeta function.
We will denote this by zeta s.
다른 정의 하나를 더 소개하겠습니다.
See another definition.
정수 다항식 링의 쿼션트 링으로 정의됩니다.
여기서 에프는 어드잭센시 매트릭스의 미니멀 폴리노미얼입니다.
For given graph G, the adjacency algebra of G is the quotient ring of the polynomial ring with integral coefficients where F is the minimal polynomial of the adjacency matrix of G.
그렇다면 어드잭센시 알제브라의 제타함수는 무엇일까요?
OK. Then.
What is the zeta function of the adjacency algebra?
This question is extremely general.
물론 일반적인 경우는 매우 어렵습니다.
그래서 저는 특별한 그래프의 종류를 제한해서 접근해 보았습니다.
We are concentrated on graphs have some conditions.
바로 커넥티드 레귤러 그래프에 대해서 입니다.
The connected regular graph.
(We thought this kind graphs looks properly difficult.)
레귤러 그래프는 모든 점이 같은 갯수의 엣지와 연결되어있는 그래프 입니다.
The regular graph means every vertices have the same number of adjacent edges.
우선 점의 갯수가 적은 레귤러 그래프에 대한 어드잭센시 알제브라의 제타함수를 살펴보겠습니다.
At first, we see the zeta functions of small regular graphs.
점의 갯수가 하나일 경우는 리만제타함수가 됩니다.
one point. zero regular graph.
Then minimal polynomial is x.
the zeta function of that is the same as the Riemann zeta function.
점의 갯수가 두개인 경우는 원 패스가 되고 이때 어드잭센시 알제브라는 오드 2를 갖는 시클릭 그룹에 대한 그룹링과 아이소몰픽합니다.
two point. one regular graph. that is a path.
minimal polynomial is square of x minus 1.
This adjacency algebra is isomorphic to the group ring of a cyclic group with order 2 as rings.
이 경우는 프람임 오더를 갖는 시클릭 그룹의 그룹링에 대한 솔로몬의 결과를 이용해서 제타함수를 구할 수 있습니다.
There is a theorem to help us.
1977 Solomon proved that result.
For a group ring of a cyclic group with prime order, we can get zeta function like that where this is the Dedekind zeta function of number field.
Using the result of Solomon, we can get this zeta function.
솔로몬이 증명한 방법과 유사하게 다음 결과를 얻을 수 있습니다.
three point. two regular graph.
minimal polynomial is x^2-x-2.
we quite easily get this zeta function by same method for the next graph.
The method is similar to Solomon’s but we have to calculate more concretely.
제 발표제목에 나와있는 대상은 사각형의 어드잭센시 알제브라 입니다.
the next graph is the quadrangle.
In the title, the equation is the adjacency algebra of the quadrangle.
In this talk, our goal is to get the zeta function of that.
제타함수를 구하기 위해서 몇가지를 준비하겠습니다.
We need some settings for obtaining the zeta function of the quadrangle.
A는 유리계수의 폴리노미얼 링의 쿼션트 링입니다.
이 링은 심플 알제브라의 디렉섬으로 세미심플 알제브라입니다.
Lambda는 A에 속하는 정수 오더입니다.
오더는 서브링이면서 전체를 제네레이팅하는 정수 래티스를 말합니다.
Gamma는 Lambda를 포함하는 맥시멀 정수 오더입니니다.
전체 알제브라를 스팬하는 오쏘고날 아이뎀포턴터들의 셋을 포함하는 정수 오더는 맥시멀이라는 렘마를 사용하면 Gamma의 맥시멀리티를 증명할 수 있습니다.
B는 모든 Gamma의 원소를 몇배를 했을 때 Lambda에 속하게 만드는 정수의 프라임 디바이져의 모임입니다. 여기서는 그 숫자가 2밖에 없습니다.
L은 사각형의 어드젝센시 알제브라입니다.
Z_(2)은 정수의 로컬라이제이션
L_(2)와 Lambda_(2)는 모듈 로써의 로컬라이제이션입니다.
이렇게 준비하면 다음 정리를 사용할 수 있습니다.
유리수 필드 자체를 1x1의 매트릭스 알제브라로 볼 수 있기 때문에 우리는 이 정리를 사용할 수 있습니다.
저희가 관심있어하는 부분은 여기 제타함수부분입니다.
이 부분을 구하기 위해서는 세가지 제타함수를 구해야 합니다.
A에 대한 제타함수를 솔로몬의 방법을 따라서 구합니다.
그러면 L의 제타함수는 분수표현에 리만제타함수의 3승을 곱한 형태가 됩니다.
이제 남은 부분은 분자 부분에 대해서 계산을 하면 우리는 원하는 결과를 얻게 됩니다.
우선 L의 로컬라이제이션의 몇가지 성질에 대해서 알아보겠습니다.
파이나이트 인덱스를 갖는 람다 투의 모든 서브모듈의 셋을 델타라 하겠습니다.
그러면 델타의 모든 서브모듈의 인덱스가 2의 지수로 표현된다는 사실과
모든 서브모듈의 맥시멀 서브모듈의 델타안에 들어간다는 사실을 증명할 수 있습니다.
이 결과는 일반적인 p에서도 성립합니다.
또한 제가 얻은 다음 결과도 성립합니다.
델타에 속하는 모든 서브모듈에 대해서 아이소몰피즘 클래스는 모두 10개입니다.
이 사실은 컴퓨터 알고리즘을 통한 계산결과입니다.
알고리즘은 다음과 같은 구성을 하고있습니다.
첫번째 레프리젠터티브를 L_(2)로 가져와서 인덱스를 키워가며 하나씩 비교를 해주었습니다.
그럼 다음과 같은 Hasse Diagram을 얻을 수 있습니다.
동그라미 친 부분이 처음으로 다른 레프리젠터티브들을 얻었던 부분이구요.
마지막 단계에서는 새로 발견되는 레프리젠터티브들이 하나도 없음을 알 수 있습니다.
결국 10개의 아이소몰피즘 클래스들의 대표원소를 찾은것이죠.
첫번째 레프리젠터티브가 L_(2)라는 것을 기억해주십시오.
일반적으로 람다모듈 L 이 세가지 조건을 만족하면 다음 솔로몬의 렘마를 사용할 수 있습니다.
유한개의 아이소몰픽 클래스를 갖고
유한인덱스의 서브모듈이 적당한 프라임넘버 q의 파워로 나타나고
유한인덱스 서브모듈의 맥시멀 서브모듈이 모두 델타엘에 포함된다는 조건입니다.
이 렘마를 L_(2)에 적용시키기 전에 렘마를 조금 살펴보겠습니다.
파이나이트 레프리젠터티브가 h개라 하겠습니다.
파이 아이제이를 정의하는데 엘 아이의 서브모듈 중 L_i의 레디컬을 포함하고 엘제이와 아이소몰픽한 모든 서브모듈을 가져옵니다. 여기서 레디컬을 제이콥슨레디컬을 의미합니다.
그리고 누 펑션을 정의하는데 누 엔 엠은 엠의 맥시멀 서브모듈을 인터섹션한 인덱스의 갯수만큼 -1을 거듭제곱한 숫자들을 모두 더합니다.
서브모듈 엔의 인덱스가 적당한 프라임넘버 q의 n승으로 표현될때 우리는 가 괄호 를 인디털미네이트 t의 n승으로 적겠습니다.
A_ij는 파이 ij에 포함되는 모든 엔에 대해서 누 N L_i 값과 L_i에서 N의 인덱스에 대응하는 t의 지수승을 곱한항을 모두 더한 다항식입니다.
Z_ij는 L_i의 서브모듈 중 L_j와 아이소몰픽한 N에 대해서 L_i에서 N의 인덱스에 대응하는 t의 지수승을 더한 다항식입니다.
렘마의 결론에서 A행렬과 Z행렬은 역행렬 관계이 있다는 사실을 알 수 있습니다.
렘마를 L_(2)에 적용하면 우리는 10개의 레프리젠터티브중 첫번째가 L_(2) 자신이라는 사실을 알고 있기 때문에 L_(2)의 제타함수를 Z_1j 다항식에 2^(-s)를 입한 식의 합이라는 사실을 알 수 있습니다.
요약하면 A의 역행렬의 첫행이 합에 2^(-s)를 대입하면 L_(2)의 제타함수를 구할 수 있다는 말이죠.
A를 구하기 위해서는 파이 ij 를 계산해야합니다. 우리는 각 모듈의 포함관계 그리고 레디컬을 알고리즘을 통해서 계산했고, 그 결과는 다음 다이어그램과 같습니다.
이 다이어그램을 통한 행렬 A는 다음과 같이 구해지고
결과적으로 L_(2)의 제타함수를 구할 수 있습니다.
마지막으로 우리는 L의 제타함수를 구하면 되는데 바로 이 분자 부분에 대입을 하면 되죠. 그래서 메인 정리를 말씀드리면 이것입니다.
앞으로 더 연구 하고 싶은 부분은 더 큰 커넥티드 레귤러 그래프의 제타함수를 구하는 방법 작은 그래프의 제타함수와의 연관성 그리고 다른 유형의 그래프에 대한 제타함수는 어떨 것인가 입니다.
이상입니다. 감사합니다.