Targovax has two immuno-oncology programs - ONCOS, an oncolytic virus, and TG, a RAS neoantigen vaccine. TG has shown promising results in pancreatic cancer trials, with 20% 10-year survival in previous trials. An ongoing phase I/II trial is validating these results with adjuvant chemotherapy. ONCOS has demonstrated the ability to increase tumor-infiltrating T-cells in early trials. Targovax has a broad clinical program with several upcoming data readouts in 2017-2018 from trials in melanoma, mesothelioma, ovarian/colorectal, prostate, and pancreatic/colorectal cancers.
Targovax is developing immunotherapies to help the immune system fight cancer. They have six ongoing clinical trials combining their oncolytic adenovirus or peptide vaccines with checkpoint inhibitors or chemotherapy. They expect readouts from four of these trials in 2017-2018, which will be important value inflection points. Encouraging survival data was seen in a Phase I/II trial of their peptide vaccine TG01 in resected pancreatic cancer patients.
Targovax presented highlights from Q1 2017, including encouraging survival data from a phase I/II trial of TG01 in pancreatic cancer. 68% of patients were still alive after 2 years, compared to historical rates of 30-53%. Targovax will present further clinical data on TG01 at ASCO in June. The company initiated an exploratory trial of TG01 in colorectal cancer and has six clinical trials ongoing or planned in 2017-2018 across cancer indications. Financially, Targovax has cash of NOK 147M and an operating expenses run rate of NOK 104M annually based on the last four quarters.
Targovax is developing immunotherapies to enable the immune system to kill cancer cells. They have two platforms: oncolytic viruses and peptide vaccines. Their peptide vaccine TG01 showed encouraging 2-year survival data in a Phase I/II trial in pancreatic cancer patients, with a survival rate higher than historical controls. Their oncolytic virus ONCOS-102 is in a Phase I trial in CPI-refractory melanoma patients to see if it can activate the immune system and make those patients responsive to checkpoint inhibitors again. Targovax has multiple clinical readouts expected in 2017 and 2018 that could be value inflection points.
Targovax presented its 3Q 2017 results, highlighting ongoing clinical trials with its two platforms: ONCOS-102, an oncolytic virus in Phase I/II trials in combination with other therapies, and TG01, a neoantigen vaccine showing encouraging survival data in a Phase I/II trial in pancreatic cancer. Targovax has a cash runway into 2019 to fund its clinical programs and is listed on the Oslo Stock Exchange with a market capitalization of around NOK 930 million.
Targovax is developing two immunotherapy platforms - ONCOS-102, an oncolytic virus, and TG01, a peptide vaccine targeting RAS mutations. Early phase clinical trial data shows promise for both platforms. ONCOS-102 increased tumor-infiltrating CD8+ T-cells in 11 of 12 cancer patients and induced systemic anti-tumor immune responses. TG01 shows a median survival of 33.1 months in a phase I/II pancreatic cancer trial compared to historical controls of 27.6 months. Targovax has initiated six new clinical trials to further evaluate these platforms alone and in combination with other therapies.
This document provides an overview of Targovax, a biotechnology company developing immunotherapy treatments for cancer. It summarizes Targovax's two platform technologies: ONCOS-102, an oncolytic virus that selectively infects and lyses cancer cells to trigger an immune response, and TG neoantigen vaccines that target specific cancer mutations to generate T-cells to kill cancer cells. The document outlines Targovax's clinical development plans and timelines across six clinical trials in several cancer indications. It also reviews the company's financial position and shareholder base, noting a strong cash runway into 2019 to complete the planned clinical program.
Targovax presentation december 2017 carnegietargovax2017
Targovax provided an overview of its clinical programs for its two immuno-oncology platforms: ONCOS oncolytic virus and TG mutRAS neoantigen vaccine. For ONCOS, interim data from ongoing phase I/II trials in several solid tumors was highlighted. For TG, encouraging survival data from a phase I/II trial in resected pancreatic cancer was summarized. Upcoming clinical readouts and trial initiations in 2017-2018 were outlined for both platforms.
The document provides an overview of Targovax's clinical programs for ONCOS-102 and TG01. For ONCOS-102, a Phase I/II trial in ovarian and colorectal cancer in combination with durvalumab was initiated in Q3 2017. Encouraging survival and immune response data was reported from the ongoing Phase I/II trial of TG01 in resected pancreatic cancer. Targovax is developing these programs to boost the effectiveness of immunotherapy and has clinical readouts expected in 2017-2019.
Targovax is developing immunotherapies to help the immune system fight cancer. They have six ongoing clinical trials combining their oncolytic adenovirus or peptide vaccines with checkpoint inhibitors or chemotherapy. They expect readouts from four of these trials in 2017-2018, which will be important value inflection points. Encouraging survival data was seen in a Phase I/II trial of their peptide vaccine TG01 in resected pancreatic cancer patients.
Targovax presented highlights from Q1 2017, including encouraging survival data from a phase I/II trial of TG01 in pancreatic cancer. 68% of patients were still alive after 2 years, compared to historical rates of 30-53%. Targovax will present further clinical data on TG01 at ASCO in June. The company initiated an exploratory trial of TG01 in colorectal cancer and has six clinical trials ongoing or planned in 2017-2018 across cancer indications. Financially, Targovax has cash of NOK 147M and an operating expenses run rate of NOK 104M annually based on the last four quarters.
Targovax is developing immunotherapies to enable the immune system to kill cancer cells. They have two platforms: oncolytic viruses and peptide vaccines. Their peptide vaccine TG01 showed encouraging 2-year survival data in a Phase I/II trial in pancreatic cancer patients, with a survival rate higher than historical controls. Their oncolytic virus ONCOS-102 is in a Phase I trial in CPI-refractory melanoma patients to see if it can activate the immune system and make those patients responsive to checkpoint inhibitors again. Targovax has multiple clinical readouts expected in 2017 and 2018 that could be value inflection points.
Targovax presented its 3Q 2017 results, highlighting ongoing clinical trials with its two platforms: ONCOS-102, an oncolytic virus in Phase I/II trials in combination with other therapies, and TG01, a neoantigen vaccine showing encouraging survival data in a Phase I/II trial in pancreatic cancer. Targovax has a cash runway into 2019 to fund its clinical programs and is listed on the Oslo Stock Exchange with a market capitalization of around NOK 930 million.
Targovax is developing two immunotherapy platforms - ONCOS-102, an oncolytic virus, and TG01, a peptide vaccine targeting RAS mutations. Early phase clinical trial data shows promise for both platforms. ONCOS-102 increased tumor-infiltrating CD8+ T-cells in 11 of 12 cancer patients and induced systemic anti-tumor immune responses. TG01 shows a median survival of 33.1 months in a phase I/II pancreatic cancer trial compared to historical controls of 27.6 months. Targovax has initiated six new clinical trials to further evaluate these platforms alone and in combination with other therapies.
This document provides an overview of Targovax, a biotechnology company developing immunotherapy treatments for cancer. It summarizes Targovax's two platform technologies: ONCOS-102, an oncolytic virus that selectively infects and lyses cancer cells to trigger an immune response, and TG neoantigen vaccines that target specific cancer mutations to generate T-cells to kill cancer cells. The document outlines Targovax's clinical development plans and timelines across six clinical trials in several cancer indications. It also reviews the company's financial position and shareholder base, noting a strong cash runway into 2019 to complete the planned clinical program.
Targovax presentation december 2017 carnegietargovax2017
Targovax provided an overview of its clinical programs for its two immuno-oncology platforms: ONCOS oncolytic virus and TG mutRAS neoantigen vaccine. For ONCOS, interim data from ongoing phase I/II trials in several solid tumors was highlighted. For TG, encouraging survival data from a phase I/II trial in resected pancreatic cancer was summarized. Upcoming clinical readouts and trial initiations in 2017-2018 were outlined for both platforms.
The document provides an overview of Targovax's clinical programs for ONCOS-102 and TG01. For ONCOS-102, a Phase I/II trial in ovarian and colorectal cancer in combination with durvalumab was initiated in Q3 2017. Encouraging survival and immune response data was reported from the ongoing Phase I/II trial of TG01 in resected pancreatic cancer. Targovax is developing these programs to boost the effectiveness of immunotherapy and has clinical readouts expected in 2017-2019.
This document provides an overview of Targovax, a biotech company developing immunotherapies for cancer. It summarizes their two platforms: ONCOS-102, an oncolytic virus, and TG, a neoantigen cancer vaccine targeting RAS mutations. For ONCOS-102, phase 1 data showed it can activate the immune system against tumors. Targovax is conducting multiple clinical trials of ONCOS-102 in combination with other therapies. For TG, earlier phase 1 trials showed a 20% 10-year survival rate in pancreatic cancer patients. A recent phase 1/2 trial in pancreatic cancer showed encouraging survival and safety data. Targovax is seeking a partner to advance TG into a
Targovax is developing two cancer immunotherapy drugs - ONCOS-102, an oncolytic virus, and TG01, a neoantigen vaccine. Data from clinical trials of ONCOS-102 showed it activated patients' immune systems against their tumors. Targovax has an ongoing clinical program testing ONCOS-102 in various cancer types and combinations. TG01 targets RAS mutations in pancreatic cancer and showed encouraging long-term survival rates in previous trials. A recent trial combining TG01 with chemotherapy showed improved median and 2-year survival over historical controls. Targovax is seeking a partner to advance TG01 into a late-stage trial aimed at registration.
1706 ir deck full w_appendix v1_cmd_v6_uten appendixtargovax2017
The document summarizes a capital markets update presentation by Targovax. It discusses Targovax's two immunotherapy platforms - ONCOS-102, an oncolytic virus, and TG01, a peptide cancer vaccine. For ONCOS-102, the virus is injected into tumors where it stimulates an immune response by releasing cancer antigens. TG01 mimics antigens to stimulate "killer" T-cells. Early clinical trial results for ONCOS-102 showed increased tumor-infiltrating T-cells and systemic immune responses in cancer patients. Targovax is pursuing multiple clinical trials to combine its immunotherapies with other treatments.
Arming the patient's immune system to fight cancertargovax2017
This document summarizes a presentation by Targovax CEO Øystein Soug at a healthcare conference on December 15, 2016. Targovax is developing immunotherapies to enable the immune system to kill cancer cells, including oncolytic viruses, peptide vaccines, cell therapies, and checkpoint inhibitors. The presentation outlines Targovax's clinical trial pipeline and strategy, including trials of ONCOS-102 in CPI-refractory melanoma and mesothelioma and TG01 in resected pancreatic and colorectal cancers. Near-term value drivers include TG01 two-year survival data in pancreatic cancer in 1H2017 and ONCOS-102 interim data in melanoma in 2H2017.
1706 ir deck full w_appendix v1_cmd_v12_netttargovax2017
The document discusses Targovax's TG01 peptide vaccine platform. TG01 primes the immune system to recognize and destroy cancer cells with RAS mutations through a cocktail of 7 peptides covering common RAS mutations. Earlier trials in pancreatic cancer showed encouraging median and 1-year survival rates compared to historical controls when TG01 was administered with GM-CSF adjuvant. Long-term survival data also correlated with immune responses detected following vaccination.
Targovax is developing two complementary and highly targeted approaches to cancer immunotherapy: a peptide-based targeted immunotherapy platform for patients with RAS-mutated cancers and a virus-based oncolytic immunotherapy platform based on engineered oncolytic viruses armed with potent immune-stimulating transgenes for patients with solid tumors.
Targovax is developing cancer immunotherapies using their TG technology to arm the immune system to fight RAS mutated cancers. Their lead candidate TG01 is in Phase I/II trials in combination with chemotherapy for resected pancreatic cancer, showing promising early survival data. Targovax has a broad clinical program with upcoming data readouts evaluating TG01 in additional cancer types and TG02 entering Phase I trials. Their therapeutic cancer vaccines target specific RAS mutations found in many cancers, offering a potential new treatment approach.
This document provides an overview of Targovax's clinical programs for their two immuno-oncology platforms: ONCOS oncolytic virus and TG mutRAS neoantigen vaccine. For TG, encouraging survival data was seen in a previous trial in resected pancreatic cancer patients, with 20% 10-year survival. This is now being validated in an ongoing phase I/II trial, with 90% of patients showing immune activation against RAS. For ONCOS, phase I data showed it increased tumor-infiltrating CD8+ T-cells and this correlated with improved survival. In mouse models, ONCOS enhanced the efficacy of checkpoint inhibitors against melanoma. Targovax has an ongoing clinical program with these
- Targovax has developed a peptide vaccine called TG01 that targets RAS mutations found in over 90% of pancreatic cancers.
- In clinical trials, TG01 has shown an ability to induce both CD4+ and CD8+ T-cell immune responses against mutant RAS in over 90% of patients. Patients who responded immunologically showed a 3x longer median survival time.
- Interim data from an ongoing Phase I/II trial combining TG01 with chemotherapy in resected pancreatic cancer patients showed 100% 1-year survival for the second cohort and a median survival of 33.1 months, compared to a historical control of 27.6 months.
1708 2 q presentation v6 uten back-upstargovax2017
This document provides a 3-sentence summary of a presentation by Targovax, a biotech company developing immunotherapies to treat cancer:
Targovax is developing two immunotherapy platforms, ONCOS-102 oncolytic virus and TG01 RAS peptide vaccine, to boost immune responses against cancer and has clinical trials ongoing or planned in several cancer types including pancreatic, melanoma, mesothelioma and others.
The presentation highlights interim clinical data from TG01 showing improved survival outcomes compared to historical controls in resected pancreatic cancer patients and outlines the company's clinical development plans and timelines over the next two years with multiple data readouts expected.
Targovax has sufficient cash runway into
The document provides an overview and highlights from Targovax's first quarter 2018 presentation. Some key points:
- Targovax has two immuno-oncology programs in clinical development, ONCOS-102 and ONCOS TG.
- In the mesothelioma trial, the safety lead-in cohort of 6 patients was completed without safety concerns and showed signs of immune activation and early clinical responses in 3 patients.
- Targovax has a sound financial position with cash to fund its planned clinical program into 2019 and is listed on the Oslo Stock Exchange.
1) The document discusses Targovax's clinical programs targeting cancer through immune activation, including their ONCOS oncolytic virus and TG RAS neoantigen vaccine.
2) Early clinical trials of ONCOS-102 demonstrated immune activation and clinical activity in patients with various solid tumors.
3) Targovax is conducting additional trials of ONCOS-102 in combination with checkpoint inhibitors in indications like mesothelioma and peritoneal cancers.
4) The TG vaccine targets mutated RAS neoantigens, which are present in many cancer types, and aims to induce T-cell responses against patient-specific tumors.
Targovax has two immuno-oncology programs in clinical development - ONCOS and TG. For ONCOS, clinical trials are ongoing in melanoma, mesothelioma, and other solid tumors. Data from the melanoma trial showed ONCOS-102 induced immune activation in the first four patients. The mesothelioma trial safety lead-in was completed without concerns. For TG, clinical data in pancreatic cancer showed one-year survival rates and immune activation. Targovax is listed on the Oslo Stock Exchange with a market capitalization of around NOK 900 million and cash reserves to fund the planned clinical program into 2019.
This document summarizes Targovax's approach to activating the immune system to fight cancer. It discusses moving from sequential treatment strategies like surgery, radiation, and chemotherapy to a combination approach harnessing the immune system. Targovax's focus is on immune activators like oncolytic viruses and vaccines to make cancer visible to the immune system. The document outlines Targovax's clinical programs using oncolytic viruses ONCOS and therapeutic cancer vaccine TG, including current and planned trials in cancers like mesothelioma, melanoma, and colorectal cancer. Early data from a phase I/II trial of ONCOS-102 in mesothelioma shows safety and signs of efficacy.
This report discusses Targovax's oncolytic virus and neoantigen vaccine programs for cancer immunotherapy. ONCOS-102, an oncolytic virus, has shown signs of efficacy in early clinical trials and is being studied in combination with chemotherapy for mesothelioma. Targovax is also developing TG, a neoantigen vaccine targeting mutated RAS cancers which accounts for many pancreatic and colorectal cancer cases. Targovax has an ongoing clinical program and aims to become a frontline treatment for mesothelioma with ONCOS-102 based on positive early data.
Targovax is a biotechnology company developing oncolytic viruses and cancer vaccines to activate the immune system and fight cancer. The company has two clinical programs, ONCOS-102, an oncolytic virus, and TG, a neoantigen vaccine targeting mutated RAS cancers. Targovax is conducting clinical trials for both programs and has a strong cash position to complete its planned clinical trials into 2019.
Targovax provides a summary of their company presentation on activating the immune system to fight cancer. They have two clinical programs, ONCOS oncolytic virus and TG neoantigen vaccine. ONCOS has ongoing clinical trials in mesothelioma, melanoma, ovarian and colorectal cancers. Early results show immune activation and clinical activity. Their focus is developing ONCOS as the lead product, with mesothelioma as the potential initial indication due to its orphan drug designation. Financially, Targovax has sufficient cash into the second half of 2019 to complete their planned clinical program.
1) The document discusses Targovax's clinical programs using oncolytic viruses and neoantigen vaccines to activate a patient's immune system to fight cancer.
2) Targovax has two lead programs - ONCOS, an oncolytic virus, and TG, a neoantigen vaccine. ONCOS has several ongoing clinical trials and TG has one ongoing trial in colorectal cancer.
3) Preliminary data from a TG trial in pancreatic cancer showed increased median overall and disease-free survival compared to historical controls, suggesting efficacy.
Targovax is a biotechnology company developing oncolytic viruses and cancer vaccines to activate the immune system and fight cancer. The company has two clinical programs, ONCOS-102, an oncolytic virus, and TG, a neoantigen vaccine targeting mutated RAS cancers. Targovax is conducting clinical trials for both programs and has a strong cash position to complete its planned clinical trials into 2019.
This document discusses Targovax's strategy for outsourcing clinical manufacturing and quality control activities. As a virtual biotech company, Targovax outsources all development, manufacturing, and testing of its three investigational medicinal products - a peptide vaccine (TG), recombinant GM-CSF, and an oncolytic virus (ONCOS-102). The document describes Targovax's current contract manufacturing organizations for clinical supply and its plans to select new partners to support late-stage clinical trials and commercialization. It provides an overview of Targovax's multi-stage process for evaluating and selecting these strategic contract development and manufacturing partners.
Targovax has two immuno-oncology programs, ONCOS and TG, in clinical development. ONCOS is an oncolytic virus that makes cancer antigens visible to the immune system and induces T-cells specific to patients' tumors. TG is a neoantigen vaccine that targets oncogenic RAS mutations and induces T-cells specific to RAS. Targovax has an ongoing clinical program evaluating these programs in several cancer types including melanoma, mesothelioma, ovarian/colorectal, prostate, and pancreatic cancer. Upcoming data readouts are expected in 2018 from ongoing trials in melanoma, pancreatic cancer, and colorectal cancer.
Targovax Next generation immune activators for solid tumorsRoarFredriksen1
Targovax (OSE:TRVX) is a clinical stage immuno-oncology company developing immune activators to target hard-to-treat solid tumors. Targovax’s focus is to activate the patient’s immune system to fight cancer, and to bring benefit to cancer patients with few available treatment alternatives. Targovax is developing its product candidates in different cancer indications, including melanoma, mesothelioma, and multiple myeloma, and has demonstrated a favorable safety and tolerability profile.
Targovax’s lead clinical candidate, ONCOS-102, is a genetically modified oncolytic adenovirus, which has been engineered to selectively infect cancer cells and activate the immune system against the tumor. Following very encouraging clinical data in several indications, both as monotherapy and in combinations, ONCOS-102 is progressing into a randomized phase 2 trial in melanoma patients resistant to PD-1 checkpoint inhibitor treatment.
Building on successful clinical studies which have provided deep mechanistic insights into the tumor biology and the human immune systems, Targovax is researching circular RNA (circRNA) as novel cancer medicines. In addition, Targovax has a KRAS immunotherapy program, with lead cancer vaccine candidate, TG01, expected to enter the clinic in an enhanced format in the second half of 2022. Together this provides Targovax with a rich pipeline of innovative future immunotherapy product candidates to follow ONCOS-102.
This document provides an overview of Targovax, a biotech company developing immunotherapies for cancer. It summarizes their two platforms: ONCOS-102, an oncolytic virus, and TG, a neoantigen cancer vaccine targeting RAS mutations. For ONCOS-102, phase 1 data showed it can activate the immune system against tumors. Targovax is conducting multiple clinical trials of ONCOS-102 in combination with other therapies. For TG, earlier phase 1 trials showed a 20% 10-year survival rate in pancreatic cancer patients. A recent phase 1/2 trial in pancreatic cancer showed encouraging survival and safety data. Targovax is seeking a partner to advance TG into a
Targovax is developing two cancer immunotherapy drugs - ONCOS-102, an oncolytic virus, and TG01, a neoantigen vaccine. Data from clinical trials of ONCOS-102 showed it activated patients' immune systems against their tumors. Targovax has an ongoing clinical program testing ONCOS-102 in various cancer types and combinations. TG01 targets RAS mutations in pancreatic cancer and showed encouraging long-term survival rates in previous trials. A recent trial combining TG01 with chemotherapy showed improved median and 2-year survival over historical controls. Targovax is seeking a partner to advance TG01 into a late-stage trial aimed at registration.
1706 ir deck full w_appendix v1_cmd_v6_uten appendixtargovax2017
The document summarizes a capital markets update presentation by Targovax. It discusses Targovax's two immunotherapy platforms - ONCOS-102, an oncolytic virus, and TG01, a peptide cancer vaccine. For ONCOS-102, the virus is injected into tumors where it stimulates an immune response by releasing cancer antigens. TG01 mimics antigens to stimulate "killer" T-cells. Early clinical trial results for ONCOS-102 showed increased tumor-infiltrating T-cells and systemic immune responses in cancer patients. Targovax is pursuing multiple clinical trials to combine its immunotherapies with other treatments.
Arming the patient's immune system to fight cancertargovax2017
This document summarizes a presentation by Targovax CEO Øystein Soug at a healthcare conference on December 15, 2016. Targovax is developing immunotherapies to enable the immune system to kill cancer cells, including oncolytic viruses, peptide vaccines, cell therapies, and checkpoint inhibitors. The presentation outlines Targovax's clinical trial pipeline and strategy, including trials of ONCOS-102 in CPI-refractory melanoma and mesothelioma and TG01 in resected pancreatic and colorectal cancers. Near-term value drivers include TG01 two-year survival data in pancreatic cancer in 1H2017 and ONCOS-102 interim data in melanoma in 2H2017.
1706 ir deck full w_appendix v1_cmd_v12_netttargovax2017
The document discusses Targovax's TG01 peptide vaccine platform. TG01 primes the immune system to recognize and destroy cancer cells with RAS mutations through a cocktail of 7 peptides covering common RAS mutations. Earlier trials in pancreatic cancer showed encouraging median and 1-year survival rates compared to historical controls when TG01 was administered with GM-CSF adjuvant. Long-term survival data also correlated with immune responses detected following vaccination.
Targovax is developing two complementary and highly targeted approaches to cancer immunotherapy: a peptide-based targeted immunotherapy platform for patients with RAS-mutated cancers and a virus-based oncolytic immunotherapy platform based on engineered oncolytic viruses armed with potent immune-stimulating transgenes for patients with solid tumors.
Targovax is developing cancer immunotherapies using their TG technology to arm the immune system to fight RAS mutated cancers. Their lead candidate TG01 is in Phase I/II trials in combination with chemotherapy for resected pancreatic cancer, showing promising early survival data. Targovax has a broad clinical program with upcoming data readouts evaluating TG01 in additional cancer types and TG02 entering Phase I trials. Their therapeutic cancer vaccines target specific RAS mutations found in many cancers, offering a potential new treatment approach.
This document provides an overview of Targovax's clinical programs for their two immuno-oncology platforms: ONCOS oncolytic virus and TG mutRAS neoantigen vaccine. For TG, encouraging survival data was seen in a previous trial in resected pancreatic cancer patients, with 20% 10-year survival. This is now being validated in an ongoing phase I/II trial, with 90% of patients showing immune activation against RAS. For ONCOS, phase I data showed it increased tumor-infiltrating CD8+ T-cells and this correlated with improved survival. In mouse models, ONCOS enhanced the efficacy of checkpoint inhibitors against melanoma. Targovax has an ongoing clinical program with these
- Targovax has developed a peptide vaccine called TG01 that targets RAS mutations found in over 90% of pancreatic cancers.
- In clinical trials, TG01 has shown an ability to induce both CD4+ and CD8+ T-cell immune responses against mutant RAS in over 90% of patients. Patients who responded immunologically showed a 3x longer median survival time.
- Interim data from an ongoing Phase I/II trial combining TG01 with chemotherapy in resected pancreatic cancer patients showed 100% 1-year survival for the second cohort and a median survival of 33.1 months, compared to a historical control of 27.6 months.
1708 2 q presentation v6 uten back-upstargovax2017
This document provides a 3-sentence summary of a presentation by Targovax, a biotech company developing immunotherapies to treat cancer:
Targovax is developing two immunotherapy platforms, ONCOS-102 oncolytic virus and TG01 RAS peptide vaccine, to boost immune responses against cancer and has clinical trials ongoing or planned in several cancer types including pancreatic, melanoma, mesothelioma and others.
The presentation highlights interim clinical data from TG01 showing improved survival outcomes compared to historical controls in resected pancreatic cancer patients and outlines the company's clinical development plans and timelines over the next two years with multiple data readouts expected.
Targovax has sufficient cash runway into
The document provides an overview and highlights from Targovax's first quarter 2018 presentation. Some key points:
- Targovax has two immuno-oncology programs in clinical development, ONCOS-102 and ONCOS TG.
- In the mesothelioma trial, the safety lead-in cohort of 6 patients was completed without safety concerns and showed signs of immune activation and early clinical responses in 3 patients.
- Targovax has a sound financial position with cash to fund its planned clinical program into 2019 and is listed on the Oslo Stock Exchange.
1) The document discusses Targovax's clinical programs targeting cancer through immune activation, including their ONCOS oncolytic virus and TG RAS neoantigen vaccine.
2) Early clinical trials of ONCOS-102 demonstrated immune activation and clinical activity in patients with various solid tumors.
3) Targovax is conducting additional trials of ONCOS-102 in combination with checkpoint inhibitors in indications like mesothelioma and peritoneal cancers.
4) The TG vaccine targets mutated RAS neoantigens, which are present in many cancer types, and aims to induce T-cell responses against patient-specific tumors.
Targovax has two immuno-oncology programs in clinical development - ONCOS and TG. For ONCOS, clinical trials are ongoing in melanoma, mesothelioma, and other solid tumors. Data from the melanoma trial showed ONCOS-102 induced immune activation in the first four patients. The mesothelioma trial safety lead-in was completed without concerns. For TG, clinical data in pancreatic cancer showed one-year survival rates and immune activation. Targovax is listed on the Oslo Stock Exchange with a market capitalization of around NOK 900 million and cash reserves to fund the planned clinical program into 2019.
This document summarizes Targovax's approach to activating the immune system to fight cancer. It discusses moving from sequential treatment strategies like surgery, radiation, and chemotherapy to a combination approach harnessing the immune system. Targovax's focus is on immune activators like oncolytic viruses and vaccines to make cancer visible to the immune system. The document outlines Targovax's clinical programs using oncolytic viruses ONCOS and therapeutic cancer vaccine TG, including current and planned trials in cancers like mesothelioma, melanoma, and colorectal cancer. Early data from a phase I/II trial of ONCOS-102 in mesothelioma shows safety and signs of efficacy.
This report discusses Targovax's oncolytic virus and neoantigen vaccine programs for cancer immunotherapy. ONCOS-102, an oncolytic virus, has shown signs of efficacy in early clinical trials and is being studied in combination with chemotherapy for mesothelioma. Targovax is also developing TG, a neoantigen vaccine targeting mutated RAS cancers which accounts for many pancreatic and colorectal cancer cases. Targovax has an ongoing clinical program and aims to become a frontline treatment for mesothelioma with ONCOS-102 based on positive early data.
Targovax is a biotechnology company developing oncolytic viruses and cancer vaccines to activate the immune system and fight cancer. The company has two clinical programs, ONCOS-102, an oncolytic virus, and TG, a neoantigen vaccine targeting mutated RAS cancers. Targovax is conducting clinical trials for both programs and has a strong cash position to complete its planned clinical trials into 2019.
Targovax provides a summary of their company presentation on activating the immune system to fight cancer. They have two clinical programs, ONCOS oncolytic virus and TG neoantigen vaccine. ONCOS has ongoing clinical trials in mesothelioma, melanoma, ovarian and colorectal cancers. Early results show immune activation and clinical activity. Their focus is developing ONCOS as the lead product, with mesothelioma as the potential initial indication due to its orphan drug designation. Financially, Targovax has sufficient cash into the second half of 2019 to complete their planned clinical program.
1) The document discusses Targovax's clinical programs using oncolytic viruses and neoantigen vaccines to activate a patient's immune system to fight cancer.
2) Targovax has two lead programs - ONCOS, an oncolytic virus, and TG, a neoantigen vaccine. ONCOS has several ongoing clinical trials and TG has one ongoing trial in colorectal cancer.
3) Preliminary data from a TG trial in pancreatic cancer showed increased median overall and disease-free survival compared to historical controls, suggesting efficacy.
Targovax is a biotechnology company developing oncolytic viruses and cancer vaccines to activate the immune system and fight cancer. The company has two clinical programs, ONCOS-102, an oncolytic virus, and TG, a neoantigen vaccine targeting mutated RAS cancers. Targovax is conducting clinical trials for both programs and has a strong cash position to complete its planned clinical trials into 2019.
This document discusses Targovax's strategy for outsourcing clinical manufacturing and quality control activities. As a virtual biotech company, Targovax outsources all development, manufacturing, and testing of its three investigational medicinal products - a peptide vaccine (TG), recombinant GM-CSF, and an oncolytic virus (ONCOS-102). The document describes Targovax's current contract manufacturing organizations for clinical supply and its plans to select new partners to support late-stage clinical trials and commercialization. It provides an overview of Targovax's multi-stage process for evaluating and selecting these strategic contract development and manufacturing partners.
Targovax has two immuno-oncology programs, ONCOS and TG, in clinical development. ONCOS is an oncolytic virus that makes cancer antigens visible to the immune system and induces T-cells specific to patients' tumors. TG is a neoantigen vaccine that targets oncogenic RAS mutations and induces T-cells specific to RAS. Targovax has an ongoing clinical program evaluating these programs in several cancer types including melanoma, mesothelioma, ovarian/colorectal, prostate, and pancreatic cancer. Upcoming data readouts are expected in 2018 from ongoing trials in melanoma, pancreatic cancer, and colorectal cancer.
Targovax Next generation immune activators for solid tumorsRoarFredriksen1
Targovax (OSE:TRVX) is a clinical stage immuno-oncology company developing immune activators to target hard-to-treat solid tumors. Targovax’s focus is to activate the patient’s immune system to fight cancer, and to bring benefit to cancer patients with few available treatment alternatives. Targovax is developing its product candidates in different cancer indications, including melanoma, mesothelioma, and multiple myeloma, and has demonstrated a favorable safety and tolerability profile.
Targovax’s lead clinical candidate, ONCOS-102, is a genetically modified oncolytic adenovirus, which has been engineered to selectively infect cancer cells and activate the immune system against the tumor. Following very encouraging clinical data in several indications, both as monotherapy and in combinations, ONCOS-102 is progressing into a randomized phase 2 trial in melanoma patients resistant to PD-1 checkpoint inhibitor treatment.
Building on successful clinical studies which have provided deep mechanistic insights into the tumor biology and the human immune systems, Targovax is researching circular RNA (circRNA) as novel cancer medicines. In addition, Targovax has a KRAS immunotherapy program, with lead cancer vaccine candidate, TG01, expected to enter the clinic in an enhanced format in the second half of 2022. Together this provides Targovax with a rich pipeline of innovative future immunotherapy product candidates to follow ONCOS-102.
An oncology-focused immunotherapy company is conducting a Phase 3 clinical trial of its lead product, NeuVax, for the prevention of breast cancer recurrence in early-stage, node-positive patients. The trial is fully enrolled with 758 participants and is evaluating NeuVax compared to placebo on disease-free survival. NeuVax targets the HER2 protein and consists of an HLA-A2/A3-restricted peptide that elicits CD8+ T-cell responses. Previous clinical trials demonstrated NeuVax has a positive safety profile and signals of efficacy in reducing recurrence rates. An interim analysis is upcoming in mid-2016, with final results expected in 2018.
This investor presentation summarizes the development of Oncolytics Biotech's lead product REOLYSIN, a therapeutic reovirus. Key points include:
1) REOLYSIN has demonstrated statistically significant improvements in overall survival for metastatic breast cancer and doubled two-year survival for metastatic pancreatic cancer.
2) The clinical development plan focuses on combination therapies with chemotherapy, immunotherapy agents like pembrolizumab, and targeted therapies/IMiDs to boost REOLYSIN's mechanism of action.
3) Over 1,100 patients have been treated with REOLYSIN which has shown a good safety profile with no maximum tolerated dose reached and mostly mild side effects.
This investor presentation summarizes Oncolytics Biotech's REOLYSIN viral therapy program. It highlights statistically significant increases in overall survival seen in phase 2 trials in metastatic breast cancer and pancreatic cancer. The clinical development plan focuses on three pathways: chemotherapy combinations as the first registration pathway, immunotherapy combinations with agents like pembrolizumab, and targeted therapy combinations using agents like pomalidomide. Safety data from over 1,100 patients shows a good toxicity profile. Manufacturing is established at commercial scale and the company has a strong patent portfolio. The leadership team has extensive experience in oncology drug development.
This document discusses Targovax's focus on immune activators to treat cancer. It summarizes:
1) Targovax's approach of using oncolytic viruses and vaccines to activate T-cells to target tumors, rather than directly targeting cancer through surgery, radiation, or chemotherapy.
2) Targovax's two programs - ONCOS, an oncolytic virus, and TG, a therapeutic cancer vaccine - and their clinical development strategies.
3) Early positive results from a Phase I/II trial of ONCOS-102 for malignant pleural mesothelioma, with the drug showing safety, innate and adaptive immune activation, and early signs of clinical activity.
This corporate presentation provides an overview of Oncolytics Biotech and their lead product REOLYSIN. Key points include:
- REOLYSIN is a proprietary reovirus being studied in five randomized phase 2 clinical trials for various cancers.
- Preclinical research shows REOLYSIN selectively replicates in cancer cells with Ras pathway activation. Over 1,000 patients have been treated safely.
- The company has a strong patent portfolio with over 370 patents worldwide and manufacturing capacity at commercial scale.
- Ongoing studies are evaluating REOLYSIN alone or in combination with chemotherapy to show improved survival outcomes and tumor response rates.
REOLYSIN® shows promise as a cancer therapeutic through two mechanisms of action. It acts as a directed cytotoxin against cancer cells with Ras pathway mutations, reducing tumor burden in clinical trials. It also stimulates anti-tumor immune responses, improving overall survival in some studies compared to chemotherapy alone. Oncolytic Biotech is conducting additional registration trials with tumor reduction and overall survival endpoints to confirm these findings and seek approvals.
This presentation provides an overview of Oncolytics Biotech Inc. and its lead product REOLYSIN®, a novel cancer therapy. Key points include:
- REOLYSIN® is a proprietary reovirus being studied in five randomized Phase II clinical trials for various cancer indications. Interim data has shown increased progression-free and overall survival compared to controls.
- Preclinical research demonstrates REOLYSIN®'s ability to directly kill tumor cells and stimulate anti-tumor immune responses. Combinations with immunotherapies are being explored.
- Over 1,100 patients have been treated with REOLYSIN® to date, which has shown a favorable safety profile both as monotherapy and in
Oncolytics Biotech presented their investor presentation which included the following key points:
1) Oncolytics is developing REOLYSIN, a novel immuno-oncology viral agent for systemic administration that exploits cancer cell lysis and anti-tumor immunity.
2) Additional randomized phase 2 clinical trials in 2017 are expected to generate overall survival data in breast cancer, ovarian cancer, non-small cell lung cancer, and colorectal cancer.
3) The clinical development plan focuses on combining REOLYSIN with chemotherapy for late-stage development and establishing it as a backbone agent combined with immunotherapy.
4) Over 900 patients have been treated with REOLYSIN intravenously with no drug
Co-Chairs and Presenter Jessica Donington, MD, Jonathan D. Spicer, MD, PhD, FRCSC, and Patrick M. Forde, MD, prepared useful Practice Aids pertaining to NSCLC for this CME/MOC/CC/AAPA activity titled “A Practical Guide for Making Multidisciplinary Decisions About Neoadjuvant and/or Adjuvant Immunotherapy in Resectable NSCLC.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CC/AAPA information, and to apply for credit, please visit us at https://bit.ly/3MQVu5l. CME/MOC/CC/AAPA credit will be available until February 27, 2025.
This presentation provides an overview of Oncolytics Biotech Inc. and its lead product REOLYSIN®. REOLYSIN® is a first-in-class immuno-oncology viral therapy for solid tumors and blood cancers. Recent clinical trials showed REOLYSIN® statistically significantly increased overall survival when combined with chemotherapy for metastatic breast cancer. The company has defined a clinical development plan targeting registration in metastatic breast cancer and is pursuing combination trials to further develop REOLYSIN®'s mechanism of action. Oncolytics Biotech has strengthened its leadership team and secured manufacturing agreements to support late-stage trials and early commercialization.
Oncolytics Biotech presented an investor presentation that summarized their progress with REOLYSIN, a therapeutic reovirus for treating cancer. Key points included:
- REOLYSIN showed statistically significant increased overall survival in a phase 2 trial for metastatic breast cancer.
- The FDA granted REOLYSIN Fast Track designation and the clinical development plan focuses on combinations with chemotherapy, immunotherapy, and targeted therapies.
- Safety data has shown REOLYSIN to be well-tolerated with no maximum tolerated dose reached. Manufacturing is established at commercial scale.
- The patent portfolio and leadership team provide a strong foundation to further develop REOLYSIN as a potential treatment for multiple cancer types.
Methanex is the world's largest producer and supplier of methanol. We create value through our leadership in the global production, marketing and delivery of methanol to customers. View our latest Investor Presentation for more details.
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Cleades Robinson, a respected leader in Philadelphia's police force, is known for his diplomatic and tactful approach, fostering a strong community rapport.
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June 12, 2024 UnityNet International (#UNI) World Environment Day Abraham Project 2024 Press Release from Markham / Mississauga, Ontario in the, Greater Tkaronto Bioregion, Canada in the North American Great Lakes Watersheds of North America (Turtle Island).
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2. www.targovax.com
Important notice and disclaimer
This report contains certain forward-looking statements based on uncertainty, since they relate to events and
depend on circumstances that will occur in future and which, by their nature, will have an impact on the results of
operations and the financial condition of Targovax. Such forward-looking statements reflect the current views of
Targovax and are based on the information currently available to the company. Targovax cannot give any assurance
as to the correctness of such statements.
There are a number of factors that could cause actual results and developments to differ materially from those
expressed or implied in these forward-looking statements. These factors include, among other things, risks or
uncertainties associated with the success of future clinical trials; risks relating to personal injury or death in
connection with clinical trials or following commercialization of the company’s products, and liability in connection
therewith; risks relating to the company’s freedom to operate (competitors patents) in respect of the products it
develops; risks of non-approval of patents not yet granted and the company’s ability to adequately protect its
intellectual property and know-how; risks relating to obtaining regulatory approval and other regulatory risks relating
to the development and future commercialization of the company’s products; risks that research and development
will not yield new products that achieve commercial success; risks relating to the company’s ability to successfully
commercialize and gain market acceptance for Targovax’s products; risks relating to the future development of the
pricing environment and/or regulations for pharmaceutical products; risks relating to the company’s ability to secure
additional financing in the future, which may not be available on favorable terms or at all; risks relating to currency
fluctuations; risks associated with technological development, growth management, general economic and
business conditions; risks relating to the company’s ability to retain key personnel; and risks relating to the impact of
competition.
2
3. www.targovax.com
Immunotherapy has the potential to cure cancer
3
1 year afterPrior to Yervoy®
Patient example – Yervoy® checkpoint inhibitor trial
IMMUNOTHERAPY
4. www.targovax.com 4
Response rate to checkpoint inhibitors (CPIs)
Boosting T-cells in
tumors may make
checkpoint inhibitors
effective in more
patients
~80%
~84%
~80%
~70%
~70%-80%
~40%
Head and Neck
Lung Carcinoma (NSCLC)
Triple Negative Breast
Renal Cell carcinoma
Bladder
Most patients do not respond to currently available
immunotherapies
Non-respondersResponders
Melanoma
IMMUNOTHERAPY
5. www.targovax.com
Targovax has two immuno-oncology programs in
clinical development
5
ONCOS
Oncolytic virus
TG
RAS neoantigen
vaccine
o Cocktail of synthetic peptides
o Mimics cancer causing RAS neoantigens
o Induces T-cells specific to RAS mutations
o Genetically designed adenovirus
o Makes cancer antigens visible to immune system
o Induces T-cells specific to patients’ tumor
ONCOS TG
8. www.targovax.com 8
Fold-changefrombaseline
Ranki et al., Journal for Immunotherapy of Cancer 2016, 4(17)
ONCOS TG
The T-cell increase correlates with survival
Phase I trial data: Fold-change CD8+ T-cell count vs. survival
r = 0.75
p = 0.005
Overall survival (months)
Pre-treatment Post-treatment
CD8+ T-cell staining
0 25
0.1
10,000
1
1,000
100
10
5 10 15 20
9. www.targovax.com
Clinical trial program overview
9
Phase I trial
7 Solid tumors
12 patients
o Correlation between
immune activation
and survival
Mesothelioma
Phase Ib/II
30 patients
Melanoma
Phase I
12 patients
Prostate
Phase I
10 patients
Ovarian / colorectal
Phase I/II
up to 78 patients
o Combination with PD-1
CPI in refractory patients
o Memorial Sloan Kettering
o 1st line combination with chemo
o Randomized controlled trial
o Collaboration with Ludwig, CRI
and MedImmune (AstraZeneca)
o Intraperitoneal administration
o Partnered with Sotio
o Combination with DC therapy
ONCOS TG
Compassionate
use program
Finland
115 patients
o Individual clinical
responses
o Reassuring safety
data
Completed trials
Ongoing trials
Starting trials
10. www.targovax.com
ONCOS TG
70% reduction in tumor volume with CPI combination
in mouse melanoma model
Effect of ONCOS-102 and Keytruda in humanized mouse melanoma model, change in tumor volume
20 30 40
0
100
200
300
400
Days after tumor cells engraftment
Volume(mm3)
(R+L)
Vehicle
OV
Keytruda 200
Keytruda 400
OV+Keytruda 200
OV+Keytruda 400
ONCOS-102
Neg. control
10
Tumor volume reduction vs. vehicle control
% change by Day 40:
Keytruda only No change
ONCOS-102 only 52% reduction p<0.05
ONCOS-102 + Keytruda (200) 61% reduction p<0.05
ONCOS-102+ Keytruda (400) 69% reduction p<0.05
12. www.targovax.com
The five year survival rate for pancreatic cancer
patients has not improved since the 1970s
12
SOURCE: Cancer Research UK, graphic adapted from The Economist September 16 2017
No improvement in long-
term survival over the
past 45 years
ONCOS TG
13. www.targovax.com
The RAS gene is mutated in 90% of pancreatic
cancer patients, making it an ideal target
13
RAS mutations result in
uncontrolled cell
division
There are no existing
therapies targeting RAS
Targovax has developed a
unique vaccine against
mutant RAS
Frequency of RAS mutations
ONCOS TG
14. www.targovax.com
In previous trials in resected pancreatic cancer,
TG vaccination has shown 20% 10 year survival
14
1 Wedén et al., 2011 3 Oettle H et al., JAMA 2013, vol 310, no 14
0
10
20
30
40
50
60
70
80
90
100
0 6 12 18 24 30 36 42 48 54 60 66 72 78 84 90 96 102 108 114 120
o 4/20 (20%) of treated patients
alive after 10 years
o 0/87 untreated patients alive in
a similar cohort from the same
period, at the same hospitals
Survival(%)
Months from resection
10 year survival in historical TG trials in resected pancreatic cancer (n=20, TG monotherapy)
Historical control:
7.7% 10 year survival2
ONCOS TG
15. www.targovax.com
These promising results are now being validated in an
ongoing phase I/II trial with adjuvant chemotherapy
15
2nd cohort
(13 patients)
13 of 13 patients (100%) alive 1 year after surgery
mutRAS immune
response (1 yr)
90% of patients (29/32) had RAS-specific immune activation
Safety
TG01 and gemcitabine combination treatment is well-tolerated
Four allergic reactions reported in 1st cohort, none in 2nd
cohort (up to 1 year)
1st cohort
(19 patients)
Median survival 33.1 months vs. 27.6 for historical control
13 of 19 patients (68%) alive 2 years after surgery,
vs. 30-53% in historical controls
ONCOS TG
16. www.targovax.com
TG01 data in context
As presented by TG01 PI Prof. Daniel Palmer, London, June 2017
ONCOS TG
Comparative survival rates across trials in resected pancreatic cancer
16
Emerging trend from
TG01 + Gemcitabine
19 patients Phase I/II
NOTE: Relative survival curves across studies (ESPAC), meant for indicative comparisons only. No Kaplan Meier analysis has been done of the TG01 study
data. Instead 1 and 2 year survival as well as median OS have been plotted.
17. www.targovax.com
Why TG may succeed where others have failed
Target often poorly defined and not
cancer specific
Mutated RAS is a well-defined neo-
antigen, and a driving cause of cancer
Lessons Learned The TG approach
Most clinical trials have been done in
advanced disease
✓
Insufficient immune activation of
CD4+ helper and CD8+ killer T-cells
Initial focus on resected patients,
with stronger immune system
TG peptides are proven to induce both
CD4+ and CD8+ mutRAS T-cells✓
✓
17
ONCOS TG
18. www.targovax.com
Clinical trial program overview
18
Resected pancreas
Phase I/II
32 patients
o 10 year survival data
o Correlation between
immune response
and survival
Colorectal
TG02 - Phase I
20 patients
Resected pancreas
TG01 - Phase IIb/III
n = tbd
o TG02, targets 8 mutations
o Combination w/KEYTRUDA®
Currently recruiting patients
o Ph IIb-III adaptive design
o Aimed to reach registration
o Possible CPI combination arm
ONCOS TG
Pancreas, resected
& non-resected
Phase I
>200 patients
o Encouraging
median survival
o 90% immune
response
Completed trials
Ongoing trials
Planned trials
19. www.targovax.com
Resected pancreatic cancer is the lead indication,
but all RAS mutated cancers are potential TG targets
19
1 2 3 4
Pancreatic
cancer (resected)
Colorectal
cancer
Lung cancer
(NSCLC)
All mutRAS
cancers
TG01 lead indication
Completing phase I/II
Planning phase IIb/III
TG02 lead indication
Phase I trial recruiting
50% RAS mutated
Up to 500.000
patients
40.000 patients
TG02 potential
future indication
30% RAS mutated
Up to 500.000
patients
TG02 + TG03 ultimate
long-term potential
30% of all cancers
Up to 30% of all
cancer patients
Source: Global data, Riva et al. Plos One 2017 Estimated total addressable patient number with RAS mutations in US, EU and China
ONCOS TG
21. www.targovax.com
Overview of Targovax’ full clinical program
21
Cancer indication
ONCOS-102
Melanoma
Mesothelioma
Ovarian & Colorectal
Partnered w/CRI & MedImmune
Prostate
Partnered w/ Sotio
TG
Resected Pancreas
Colorectal
4 readouts
2017
5 readouts
2018
2017 2018
H1 H2 H1 H2
2019
H1
Phase l
Interim data
Clinical, immune
and safety data
ONCOS TG
Phase lb/II
Phase l/II
Phase l
Phase l/II
Phase lb
Interim data,
partnered trials
22. www.targovax.com
Strong upcoming news flow, with multiple near
term value inflection points
22
2015 2016 2017 2018H1 H2
phase ll initiated
TG01
Immune activation
and MoA demo
ONCOS-102
Interim data
pancreas
TG01 (1st cohort)
Immune activation
pancreas
TG01 (2nd cohort)
2-year survival
pancreas
TG01 (1st cohort)
2-year survival
pancreas
TG01 (2nd cohort)
Initiate phase l/ll
mesothelioma
ONCOS-102
Initiate phase l
prostate
ONCOS-102
Initiate phase l/ll
melanoma
ONCOS-102
Interim data
ovarian /colorectal
ONCOS-102
phase l/ll data
melanoma
ONCOS-102
Interim data
melanoma
ONCOS-102
Interim data
mesothelioma
ONCOS-102
Initiate phase Ib in
colorectal
TG02
Interim data
colorectal
TG02 (mono)
Initiate phase l
Ovarian/colorectal
ONCOS-102
Interim data
prostate
ONCOS-102
phase I data/
colorectal
TG02 (combo)
H1 H2
Listing on OSE main
list
Oslo Stock Exchange
ONCOS TG
23. www.targovax.com 23
Broad clinical
program
TG
ONCOS
✓ Six shots on goal
✓ Several upcoming data points
✓ Unique approach for targeting RAS mutations
✓ Potential to benefit up to 1/3 of all cancer patients
✓ Demonstrated ability to increase T-cell count
✓ Potential to make CPIs effective in more indications
Arming the patient’s immune system to fight cancer
ONCOS TG