1. TriPore ® : a Platform Technology A New Class of Bioactive Synthetic Bone Graft “ Meeting the Challenge of Autograft” September 2010 Copyright Orthogem September 2010 Confidential not for Distribution Prepared by Dr Wei-Jen Lo

2. September 2010 Copyright Orthogem September 2010 Confidential not for Distribution Orthogem is a Medical Device Manufacturing company based in Biocity Nottingham. Our current CE marked and FDA approved Medical Device is TriPore synthetic bone graft. TriPore has been widely used around the world and we are now seeking new clinical application for TriPore synthetic bone graft.

3. TriPore Synthetic Bone Graft Copyright Orthogem September 2010 Confidential not for Distribution 3 months 6 months 12 months

4. TriPore ® Block for Limb Reconstruction Application A New Solution for Real Problem “ Meeting the Challenge of Autograft” September 2010 Copyright Orthogem September 2010 Confidential not for Distribution Prepared by Dr Wei-Jen Lo Title of the project

5. Copyright Orthogem September 2010 Confidential not for Distribution What is the limb reconstruction ? Limb reconstruction is a term that covers all sorts of treatments for injured or deformed limbs, many of them using external fixators. Limb reconstruction is a long, drawn out process that can last over a year and it can be another year before you start to feel the real benefits. However, it can heal fractures that have stubbornly refused to respond to other treatment and help limb deformities, so vastly improving your mobility. King's College Hospital Limb Reconstruction Trust http://www.med.wayne.edu/wayne medicine

6. Copyright Orthogem September 2010 Confidential not for Distribution Orthogem Solution for limb reconstruction Traditional external metal cage for limb reconstruction. The process could take up to two year to complete. Bespoke TriPore block synthetic bone graft was design to fit into the gap and induce bone fusion in 3 to 6 months times. TriPore block bone graft insert to bridge the gap