1 edwin j. alvarado 3 jose a. cruz arzon phages report revised
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This document compares and contrasts the Guánica State Forest and Caribbean National Forest in Puerto Rico. It discusses how the biodiversity, flora, fauna, and climate differ between the two ecosystems. The Guánica State Forest has higher biodiversity and is more diverse overall due to its location near the coast and exposure to varying temperatures and precipitation, while the Caribbean National Forest has adapted to harsher and more arid conditions inland. The conclusion is that the Guánica State Forest is the more diverse of the two forests compared.
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This document discusses using an extract from the plant Petiveria alliacea L. to treat gastroesophageal reflux disease (GERD). It reports on a study with 20 patients who had symptoms of GERD and were given capsules containing P. alliacea extract or a placebo over 4 weeks. The results showed that the patients taking the P. alliacea extract had a reduction in GERD symptoms and episodes compared to the placebo group, suggesting this plant extract may be an effective natural treatment for GERD.
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This document reports on genetic alterations and clinical findings related to GM1 gangliosidosis and Morquio B disease, which are rare lysosomal storage disorders caused by beta-galactosidase deficiency. Molecular analysis identified 27 mutations in 25 GM1 gangliosidosis patients, including 9 new mutations. Three remarkable cases were described, including a patient with GM1 gangliosidosis and triple X syndrome. Clinical features of patients were collected and compared. Homology modeling was used to analyze the structural effects of new missense mutations. The findings provide insights into classifying late-onset GM1 gangliosidosis and Morquio B disease.
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1) Galsulfase is a recombinant form of human N-acetylgalactosamine 4-sulfatase enzyme replacement therapy approved in 2005 for MPS VI, a rare lysosomal storage disorder caused by deficiency of this enzyme.
2) Clinical trials showed galsulfase improved patients' walking and stair-climbing abilities compared to placebo.
3) While enzyme replacement therapies have been developed for several lysosomal storage disorders, challenges remain in fully treating all disease sites due to limitations in enzyme distribution and determining when irre
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A document discusses the challenges faced in protein crystallography and graduate school. Specifically, it mentions lysosomal storage diseases which are disorders caused by the absence or malfunctioning of certain enzymes. It also notes an upcoming seminar on October 18th, 2012 from 10:30-11:20 in the Science Seminar Room 106 MMM where refreshments will be provided by the Biology Honor Society.
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These two alumni from the 2012 summer program will describe their research experiences as part of the seminar. Their research involved incorporating unnatural amino acids into proteins to enable new functions, which has potential for advancing biomedical research. The technique allows adding a wide range of functional groups beyond the 20 common amino acids to study biological processes using reporter tags.
Genetically encoded norbornene directs
This document describes a new method for site-specifically labeling proteins using genetically encoded norbornene and tetrazine probes. Specifically:
- A norbornene-containing amino acid was genetically encoded in E. coli and mammalian cells using the pyrrolysyl tRNA synthetase system.
- A series of tetrazine probes were developed that react rapidly and specifically with norbornenes via a Diels-Alder reaction.
- The labeling of encoded norbornene was shown to be specific and much faster than other bioorthogonal reactions, demonstrating advantages for protein labeling in vitro and on cells.
- Rapid and site-specific labeling of a cell surface protein was demonstrated,
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The document proposes extracting Petiveria alliacea L. to test its ability to treat gastroesophageal reflux disease (GERD). It outlines experiments to determine if the extract can increase stomach pH levels and reduce acid irrigation over time. Mice will receive diets with or without the extract, with and without acid promoters, to analyze pH and acid levels in the stomach over 4 weeks. The goal is to provide an alternative GERD treatment that relieves pain and controls the disease through neutralizing stomach acid.
Research proposal 804 12-0165
This document proposes an experiment to test whether Petiveria alliacea extract can treat gastroesophageal reflux disease (GERD) by altering stomach pH levels. The experiment would divide rats into four groups: one exposed to the extract without acid promoters, one with both extract and promoters, one with just promoters, and a control group with neither. The stomach contents of rats in each group would be examined weekly over four weeks to measure pH, acids, and other substances. If the extract raises pH levels or inhibits acid production long-term, it could provide an alternative GERD treatment to existing options by targeting the underlying causes beyond just relieving symptoms.
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This pilot study examined the effectiveness of high-dose zidovudine plus valganciclovir for treating Kaposi sarcoma herpesvirus-associated multicentric Castleman disease (KSHV-MCD) in 14 HIV-infected patients. The drugs target two KSHV lytic genes, ORF36 and ORF21, whose proteins activate ganciclovir and zidovudine. A total of 86% of patients achieved a major clinical response and 50% achieved a major biochemical response, with a median progression-free survival of 6 months and overall survival of 86% at 12 months. The treatment was generally well-tolerated with hematologic toxicities being most common. The
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This document summarizes a research article from Blood about targeting Kaposi's sarcoma-associated herpesvirus (KSHV) in multicentric Castleman disease (MCD) with antiviral drugs. It discusses how:
1) Uldrick et al conducted a pilot study using valganciclovir and zidovudine to target two KSHV enzymes involved in viral DNA synthesis, representing the first antiviral chemotherapy targeting KSHV.
2) MCD has an unusual pathoetiology that allows antiviral drugs to work by targeting KSHV-infected cells amid uninfected cells driven to multiply by viral cytokines.
3) The study provides hope that targeting latent viral proteins
Petiveria Alliacea
This document proposes an experiment to test whether Petiveria alliacea extract can treat gastroesophageal reflux disease (GERD) by altering stomach pH levels. The experiment would divide rats into four groups: one exposed to the extract without acid promoters, one with both extract and promoters, one with just promoters, and a control group with neither. The stomach contents of rats in each group would be examined weekly over four weeks to measure pH, acids, and other substances. If the extract raises pH levels or inhibits acid production long-term, it could provide an alternative GERD treatment to existing options by targeting the underlying causes beyond just relieving symptoms.
petiveria alliacea l
This document discusses using an extract from the plant Petiveria alliacea L. to treat gastroesophageal reflux disease (GERD). It reports on a study with 20 patients who had symptoms of GERD and were given capsules containing P. alliacea extract or a placebo over 4 weeks. The results showed that the patients taking the P. alliacea extract had a reduction in GERD symptoms and episodes compared to the placebo group, suggesting this plant extract may be an effective natural treatment for GERD.
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Herpesviruses like KSHV have the ability to establish lifelong latent infections and periodically reactivate from latency. During reactivation, the viruses undergo full gene expression and produce new virus particles. Reactivation is a key step in disease development for many herpesviruses, including KSHV which is associated with Kaposi's sarcoma cancer. The research lab focuses on understanding the molecular mechanisms that drive KSHV reactivation in order to develop new therapies and diagnostics for KSHV infection.
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Nanoparticles that communicate in vivo to amplify tumour targeting
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High dose zidovudine plus valganciclovir for kaposi sarcoma
High dose zidovudine plus valganciclovir for kaposi sarcoma