01

iTEVA Software Manual
Operators Manual

8499 400 30001

210607

© 2007 Thermo Fisher Scientific. All rights reserved.
SOLAAR House, 19 Mercers Row, Cambridge CB5 8BZ.United Kingdom.
Telephone +44 (0) 1223 347400, Fax +44 (0) 1223 347402.
www.thermofisher.com

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iTEVA Software Manual Thermo Fisher Scientific

Contents
Chapter 1 Introduction .................................................................................................1-1
iTEVA Security...................... ......................................................1-3
Opening the Program ..................................................................1-5
ITEVA Security Login ........................................................................1-5
Conventions ................................................................................1-6

Chapter 2 iTEVA Control Center ................................................................................. 2-1
iTEVA Control Center ......................................................................2-3
The Menu Bar .............................................................................2-4
File ..............................................................................................2-4
File, Log On ................................................................................2-4
File, Log Off................................................................................2-4
File, Print Journal ........................................................................2-5
File, Journal Print Preview ...........................................................2-5
File, Print Setup ..........................................................................2-5
File, Page Setup ...........................................................................2-5
File, Exit......................................................................................2-6
View ..............................................................................................2-6
Tools, Options ..................................................................................2-6
Tools, Options, General ..............................................................2-7
Tools, Options, Periodic Table .....................................................2-7
Tools, Options, Journal ...............................................................2-8
Tools, Options, Directories .......................................................2-10
Tools, Options, Print Options ...................................................2-11
Tools, Options, Analyst .............................................................2-11
iTEVA.Security...................... ....................................................2-12
Tools, Options, New Method Parameters ..................................2-12
Tools/Options/Access Rights
- only for iTEVA Security, not present for iTEVA.................2-13
Tools, Options, Application Database .......................................2-16
Database Wizard .............................................................................2-16
Database Info ............................................................................2-18
Create .......................................................................................2-18
Backup ......................................................................................2-18
Detach ......................................................................................2-18
Attach .......................................................................................2-18
Restore ......................................................................................2-19
Users (only for iTEVA, not present for iTEVA Security) ............2-19
iTEVA SQL Databases ....................................................................2-19
iTEVA Security...................... ....................................................2-20
Create New Database ................................................................2-21
Add a New Connection .............................................................2-21
Copy Methods/Results ..............................................................2-24

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Contents

Change Active Connection........................................................2-24
Exporting/Importing/Deleting Databases ........................................2-24
Deleting a Database ..................................................................2-24
Editing/Deleting a Connection .................................................2-25
Exporting/Importing a Database from/to another iCAP ...........2-25
Database Upgrades ....................................................................2-25
Tools, Instrument Options ..............................................................2-26
Autosampler ..............................................................................2-26
Sample Introduction .................................................................2-26
Enable Drain Sensor..................................................................2-27
Accessory...................................................................................2-27
Help ............................................................................................2-27
Help, Help Topics .....................................................................2-27
Feature request / Incident form .................................................2-28
Help, About iTEVA ..................................................................2-28
The Tool Bar....................................................................................2-29
The Workspace ..........................................................................2-29
The Journal ...............................................................................2-30
The Status Bar ...........................................................................2-31
New Firmware dialog box..........................................................2-32

Chapter 3 Analyst ......................................................................................................... 3-1
Analyst Window................................................................................3-3

Chapter 4 Analyst, Method ......................................................................................... 4-1
Analyst, Method ................................................................................4-3
Method Menu Bar.......................................................................4-3
Method .......................................................................................4-3
Create a new Method ........................................................................4-3
Periodic Table, Map Editor ................................................................4-9
Status ............................................................................................4-11
Analysis Preferences .........................................................................4-12
Sample Options ........................................................................4-13
Source .......................................................................................4-13
Analysis Maximum Integration Times .......................................4-14
Calibration Mode ............................................................................4-15
Trailing Fullframe Options ..............................................................4-17
Automated Output..........................................................................4-18
Automated Output, Unknowns.................................................4-19
Automated Output, Standards ..................................................4-21
Report Preferences ...........................................................................4-22
Report Preferences, Unknowns ..................................................4-22
Checks 4-26
Check Type, QC .......................................................................4-29
Check Type, Recovery ...............................................................4-31
Check Type, Limit Check..........................................................4-32
Check Type, Duplicate ..............................................................4-32
Sequence Automation .....................................................................4-33

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Contents

Initial Actions............................................................................4-34
Continuing Actions ...................................................................4-35
End Actions ..............................................................................4-37
Global QC Properties......................................................................4-38
Autosampler ....................................................................................4-39
Source Settings ................................................................................4-42
Internal Standards ...........................................................................4-46
Selecting Internal Standards ......................................................4-47
Standards ..................................................................................4-49
Elements .........................................................................................4-52
Elements, General .....................................................................4-53
Elements, Standards ..................................................................4-56
Elements, Fit .............................................................................4-58
Elements, IEC ...........................................................................4-69
Elements, Subarray ....................................................................4-72
Method Reports ..............................................................................4-75
Method, Open ..........................................................................4-76
iTEVA Security ................................................................................4-80
Select a Method, Sign and Audit Trail .............................................4-80
iTEVA Security ................................................................................4-84
Method, Sign Method .....................................................................4-84
Method, Audit Trail ..................................................................4-85
Toolbar............................................................................................4-85
Tools ............................................................................................4-87
View ............................................................................................4-89
Help ............................................................................................4-90

Chapter 5 Analyst, Analysis ....................................................................................... 5-1
Analyst, Analysis............................................................................... 5-3
Tool Bar ..................................................................................... 5-3
Method ...................................................................................... 5-6
Run ............................................................................................. 5-8
Run Full Frame .......................................................................... 5-8
Time Scan ................................................................................ 5-16
Run, Unknown, QC,Standard, Blank...............................................
5-22
Calibration ............................................................................... 5-29
Method Workspace, Method .......................................................... 5-31
Post-Process Sample ................................................................. 5-37
Results ........................................................................................... 5-44
Instrument ..................................................................................... 5-54
Tools ........................................................................................... 5-60
View ........................................................................................... 5-67
Help ........................................................................................... 5-69

Chapter 6 Analyst, Sequence ..................................................................................... 6-1
Analyst, Sequence ..............................................................................6-3

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Contents

Sequence Menu Bar.........6-3
Auto Session ....................6-4
Auto-Session,New Autosampler...................................................6-4
Auto-Session, New Manual6-7
Run Auto-Session ..........6-10
Signing Autosessions and Autosession Audit Trail ............................6-11
Sequence .............................6-12
Sequence Tool Bar .........6-14
Autosession functions ......................................................................6-15
Manipulating Auto Sessions ......................................................6-23

Chapter 7 Analyst, Publisher ...................................................................................... 7-1
Publisher ...............................7-3 ...........................................................
Publisher Workspace .........................................................................7-3
To obtain a sample report: ...........................................................7-4
Expanded Trend Chart with Data................................................7-6
Trend Chart ................................................................................7-8
Horizontal Table Report ..............................................................7-8
Intensity Report ..........................................................................7-9
Method Detection Limit .............................................................7-9
RSD Trend Chart ......................................................................7-10
Sample Report.................................................................................7-10
Simple Sample Report .....................................................................7-11
Vertical Table Report .......................................................................7-11
File ............................................................................................7-12
View ............................................................................................7-12
Tools ............................................................................................7-12
Window ..........................................................................................7-12
Tool Bar ..........................................................................................7-12

Chapter 8 iTEVA Security ............................................................................................ 8-1
Introduction ......................................................................................8-1
Background .......................................................................................8-3
What is 21 CFR Part 11? ...........................................................8-3
Access Control ............................................................................8-3
User Login and Authentication ...................................................8-3
Electronic Records.......................................................................8-4
Electronic Signatures ..................................................................8-4
Audit Trails..................................................................................8-4
Event Log ....................................................................................8-4
Access Control ..................................................................................8-5
Granting Access Rights ......................................................................8-6
Viewing the current User’s Access Rights ...........................................8-6
User Login and Authentication ...................................................8-7
iTEVA Security Login Process ......................................................8-8
Electronic Records.......................................................................8-8
Electronic Signatures ...................................................................8-9
Audit Trail .......................................................................................8-13

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Event Logs ......................................................................................8-15
Information Events....................................................................8-16
Deleted Samples, Methods and Autosessions .............................8-16
Signing Samples and Sample Audit Trails ........................................8-17
Signing Methods and Method Audit Trail .......................................8-19
Signing Autosessions and Autosession Audit Trail ............................8-20

Thermo Fisher Scientific iTEVA Software Manual vii

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viii Thermo Fisher Scientific

Figures
Chapter 1 Figure 1-1. iTEVA login.............................................................1-5
Figure 1-2. iTEVA Security login ...............................................1-5

Chapter 2 Figure 2-1. The iTEVA Control Center window ........................2-3
Figure 2-2. The Menu Bar ..........................................................2-4
Figure 2-3. The File Menu .........................................................2-4
Figure 2-4. Page Setup Dialog Box .............................................2-5
Figure 2-5. View Menu ..............................................................2-6
Figure 2-6. Tools Menu..............................................................2-6
Figure 2-7. Tools, Options, General ...........................................2-7
Figure 2-8. Tools, Options, Periodic Table .................................2-8
Figure 2-9. Tools, Options, Journal ............................................2-9
Figure 2-10. Tools, Options, Directories ....................................2-10
Figure 2-11. Tools, Options, Print Options................................2-11
Figure 2-12. Tools, Options, Analyst..........................................2-12
Figure 2-13. Tools, Options, New Method Parameters ...............2-13
Figure 2-14. Security Administration program,
Access Control .................................................2-14
Figure 2-15. Tools, Options, Access Rights ................................2-15
Figure 2-16. Tools, Options, Application Database ....................2-16
Figure 2-17. iTEVA Database Wizard for standard (above)
and iTEVA Security (below) .............................2-17
Figure 2-18. Database Wizard ...................................................2-20
Figure 2-19. Database Wizard for iTEVA Security .....................2-21
Figure 2-20. Add a connection icon ..........................................2-21
Figure 2-21. Data Link dialog box ............................................2-22
Figure 2-22. Data link dialog box for iTEVA Security................2-23
Figure 2-23. Data link file name dialog box ..............................2-24
Figure 2-24. Change the Active Connection
dropdown menu ..............................................2-24
Figure 2-25. Edit/Add/Delete a connection icons.......................2-25
Figure 2-26. Database Upgrade dialog box .................................2-25
Figure 2-27. Tools, Instrument Options, Autosampler ...............2-26
Figure 2-28. Tools, Instrument Options,
Sample Introduction ........................................2-26
Figure 2-29. The Help Menu .....................................................2-27
Figure 2-30. The Help Feature Request Incident Form...............2-27
Figure 2-31. About iTEVA .........................................................2-28
Figure 2-32. The Tool Bar ..........................................................2-29
Figure 2-33. Journal window......................................................2-30
Figure 2-34. Status Bar...............................................................2-31
Figure 2-35. New Firmware Window .........................................2-32

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Figures

Chapter 3 Figure 3-1. Analyst - Analysis, Method, Sequence ......................3-3

Chapter 4 Figure 4-1. Method Menu Bar ...................................................4-3
Figure 4-2. Method Menu..........................................................4-3
Figure 4-3. Method Workspace ..................................................4-4
Figure 4-4. Method, Periodic Table ............................................4-5
Figure 4-5. Method, Periodic Table, Cursor information for
specific element ..................................................4-5
Figure 4-6. Method, Periodic Table, Line List display.................4-6
Figure 4-7. Method, Periodic Table, Line List/Interferences
Window .............................................................4-6
Figure 4-8. Method, Periodic Table, Selected element
displayed in aqua ...............................................4-7
Figure 4-9. Method, Periodic Table, Selected Line marked
with asterisk .......................................................4-7
Figure 4-10. Method, Status Window ..........................................4-8
Figure 4-11. Periodic Table, Map Editor ......................................4-9
Figure 4-12. Periodic Tale, Right mouse click, Edit Map,
Add Lines ........................................................4-10
Figure 4-13. Periodic Tale, Right mouse click, Add Lines,
Create ..............................................................4-10
Figure 4-14. Method Workspace, Status .....................................4-11
Figure 4-15. Status Window ......................................................4-11
Figure 4-16. Method, Analysis Preferences .................................4-12
Figure 4-17. Analysis Preferences................................................4-12
Figure 4-18. Analysis Preferences, Sample Options ....................4-13
Figure 4-19. Analysis Preferences, Source ...................................4-14
Figure 4-20. Analysis Preferences, Maximum Integration Times.4-14
Figure 4-21. Analysis Preferences, Calibration Mode ..................4-15
Figure 4-22. Analysis Preferences, Trailing Fullframe Options ....4-17
Figure 4-23. Method, Automated Output ..................................4-18
Figure 4-24. Method, Automated Output dialog .......................4-19
Figure 4-25. Method, Automated Output, Standards .................4-21
Figure 4-26. Method, Automated Output, Standards .................4-21
Figure 4-27. Method, Report Preferences ...................................4-22
Figure 4-28. Report Preferences, Unknowns ..............................4-22
Figure 4-29. Report Preferences, Unknowns, Output
and Default View .............................................4-23
Figure 4-30. Report Preferences, Unknowns,
In Concentration Output Mode, apply ............4-23
Figure 4-31. Report Preferences, Unknowns, Calculate
Correction Factor .............................................4-24
Figure 4-32. Report Preferences, Unknowns, Screen Report,
Print Report and Exported Report ...................4-25
Figure 4-33. Method, Checks.....................................................4-26
Figure 4-34. Checks Window.....................................................4-26
Figure 4-35. Checks, New Check Table......................................4-27
Figure 4-37. Checks, QC Check Type........................................4-29

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Figures

Figure 4-38. Checks, Range Units ..............................................4-29
Figure 4-39. Checks, Standard Normalization type ....................4-30
Figure 4-41. Check Type, Recovery ............................................4-31
Figure 4-42. Check Type, Limit Check ......................................4-32
Figure 4-43. Check Type, Duplicate ...........................................4-32
Figure 4-44. The Method Workspace, Sequence Automation .....4-33
Figure 4-45. Sequence Automation ............................................4-34
Figure 4-46. Method, Sequence Automation, Initial Actions ......4-34
Figure 4-47. Method, Sequence Automation,
Continuing Actions .........................................4-35
Figure 4-48. Method, Sequence Automation, End Actions.........4-37
Autosampler Options .......................................4-39
Check table for Intelligent Rinse ......................4-40
Figure 4-52. Method, Source Settings ........................................4-42
Figure 4-53. Method, Source Settings ........................................4-43
Figure 4-54. Method, Source Settings, Radial Viewing Height ..4-44
Figure 4-55. Method, Source Settings, Additional Gas Flow ......4-44
Figure 4-56. Method, Source Settings,
Laser Sample Introduction ...............................4-45
Figure 4-57 Method, Source Settings,
SSEA Sample Introduction ..............................4-45
Figure 4-58. Method, Internal Standards ...................................4-46
Figure 4-59. Method, Internal Standards,
Periodic Table Selection....................................4-47
Figure 4-60. Method, Change Elements .....................................4-47
Figure 4-61. Method, Internal Standards Selection.....................4-48
Figure 4-62. Method, Standards .................................................4-49
Figure 4-63. Method, Standards Window ..................................4-50
Figure 4-64. Method, Standards, New Standard Dialog Box ......4-50
Figure 4-65. Method, Elements..................................................4-52
Figure 4-66. Method, Elements..................................................4-52
Figure 4-67. Method, Elements, General ...................................4-53
Figure 4-68. Elements, General, Result Labelling ......................4-54
Figure 4-69. Method, Elements, General, Timing ......................4-54
Figure 4-70. Method, Elements, General,
Referenced Internal Standards ..........................4-55
Figure 4-71. Method, Elements, General, Analytical Report ......4-55
Figure 4-72. Method, Elements, Standards.................................4-56
Figure 4-73. Method, Elements, Standards table ........................4-57
Figure 4-74. Method, Elements, Standards, Re-Slope Standards.4-58
Figure 4-75. Method, Elements, Fit ...........................................4-59
Figure 4-76. Method, Elements, Fit, Line Switch
and Print Limits ...............................................4-61
Figure 4-77. Method, Elements, Standards,
Line Switching Arrows .....................................4-61
Figure 4-78. Method, Elements, Standards,
Line Switching for Ca ......................................4-62

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Figures

Figure 4-79. Method, Setting Print Limits .................................4-62
Figure 4-80. Method, Element, Fit, Advanced Options ..............4-63
Figure 4-81. Method, Elements, Fit, Details ..............................4-65
Figure 4-82. Method, Elements, Fit, Std Table ...........................4-67
Figure 4-83. Method, Elements, Fit, Right mouse click .............4-68
Figure 4-84. Method, Elements, Fit, Calibration Plot
Commands, Print (Right mouse click) .............4-68
Figure 4-85. Method, Elements, IEC .........................................4-70
Figure 4-86. Method, Elements, Subarray ..................................4-73
Figure 4-87. Right mouse click on Subarray Plot .......................4-74
Figure 4-88. Method, Method Reports ......................................4-75
Figure 4-89. Method, Method Reports, Common Report ..........4-75
Figure 4-90. Method, Open .......................................................4-76
Figure 4-91. Method Open, Select a Method Dialog Box...........4-77
Figure 4-92. Method Query .......................................................4-77
Figure 4-93. Method Query, Click Ellipsis .................................4-78
Figure 4-94. Method Open, Select a Method Dialog Box -
Show All Revisions ...........................................4-78
Figure 4-95. Select a Method, Copy To, Select a
Destination Database dialog box ......................4-79
Figure 4-96. Method Open, iTEVA Window after
Method is opened ............................................4-79
Figure 4-97. Method Open, Select a Method Dialog
Box for iTEVA Security ....................................4-80
Figure 4-98. Method Open, Sign a Method Dialog Box
for iTEVA Security ..........................................4-80
Figure 4-99. Method Open, Audit Trail for iTEVA Security .......4-81
Figure 4-100. Method, Close .......................................................4-81
Figure 4-101. Method, Save a Method Dialog Box ......................4-82
Figure 4-102. Method, Print Dialog Box......................................4-83
Figure 4-103. Method Menu for iTEVA Security..........................4-84
Figure 4-104. Method, Sign Method............................................4-84
Figure 4-105. Method, Audit Trail ...............................................4-85
Figure 4-106. Method, Tool Bar...................................................4-85
Figure 4-107. Method Tool Bar....................................................4-85
Figure 4-108. Tools Menu............................................................4-87
Figure 4-109. Tools, Options, Change Element Display Order ....4-87
Figure 4-110. Tools, Options, New Method Parameters ...............4-88
Figure 4-111. Help Menu ............................................................4-90
Figure 4-112. Help, About Analyst ..............................................4-90

Chapter 5 Figure 5-1. Analysis Menu Bar ...................................................5-3
Figure 5-2. Method Tool Bar......................................................5-3
Figure 5-3. View, Subarray Plot with multiple samples displayed5-5
Figure 5-4. Method Menu..........................................................5-6
Figure 5-5. Method Menu for iTEVA Security............................5-7
Figure 5-6. Method, Sign Method..............................................5-7
Figure 5-7. Method, Audit Trail .................................................5-8
Figure 5-8. Run Menu ...............................................................5-8

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Figures

Figure 5-9. Run, Run Fullframe .................................................5-9
Figure 5-10. Run, Run Fullframe, Sample ID Information ..........5-9
Figure 5-11. Run, Run Fullframe, Automated Output ...............5-10
Figure 5-12. Run, Run Fullframe, Options ................................5-10
Figure 5-13. Low Wavelength Fullframe Image ..........................5-11
Figure 5-14. High Wavelength Fullframe Image .........................5-12
Figure 5-15. Fullframe Tool Bar .................................................5-12
Figure 5-16. 2d Plot of Fullframe Image Region ........................5-14
Figure 5-17. Line Information ...................................................5-14
Figure 5-18. Analytical Element List ..........................................5-15
Figure 5-19. Line List for Elements in the Method ....................5-15
Figure 5-20. Fullframe Menu .....................................................5-15
Figure 5-21. Run, Run Time Scan..............................................5-16
Figure 5-22. Run, Run Time Scan, Sample ID Information .......5-16
Figure 5-23. Run, Run Time Scan, Automated Output..............5-17
Figure 5-24. Run, Run Time Scan, Acquisition Parameters ........5-17
Figure 5-25. Run, Run Time Scan Options ................................5-18
Figure 5-26. Run, Run Time Scan, Select Lines .........................5-18
Figure 5-27. Time Scan data being acquired...............................5-19
Figure 5-28. Run, Time Scan, (Right mouse click) .....................5-20
Figure 5-29. Time Scan data shown as first derivative.................5-21
Figure 5-30. Time Scan data with defined Gate values ...............5-21
Figure 5-31. Run, Run Unknown ..............................................5-22
Figure 5-32. Run, Run Unknown, Sample ID Information........5-22
Figure 5-33. Run, Run Unknown, Automated Output ..............5-23
Figure 5-34. Run, Run Unknown, Output mode: CONC .........5-23
Figure 5-35. Run, Run Unknown, Preferences ...........................5-24
Figure 5-36. Run, Run Button ...................................................5-24
Figure 5-37. MSA button...........................................................5-25
Figure 5-38. Run, Run Unknown, MSA ....................................5-25
Figure 5-39. Run, Run Unknown, MSA, MSA Setup ................5-26
Figure 5-40. Run, Select Lines Button .......................................5-27
Figure 5-41. Run, Run Unknown, Select Lines ..........................5-28
Figure 5-42. Run, Standardization .............................................5-28
Figure 5-43. Run, Run Calibration ............................................5-29
Figure 5-44. Run, Calibration, Select Lines ................................5-30
Figure 5-45. Run, Start Continuous Run ...................................5-30
Figure 5-46. Method, Right mouse click ....................................5-31
Figure 5-47. Method Workspace, Right mouse click, Export All ......
Samples........................................................5-32
Figure 5-48. Method Workspace, Right mouse click,
Edit Report Option .........................................5-33
Figure 5-49. Method Workspace, Right mouse click
menu for iTEVA Security .................................5-33
Sign Method dialog box ...................................5-34
Method Audit Trail ..........................................5-34

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Figures

on samples ......................................................5-35
Sample Identification .......................................5-36
Recalculate Sample...........................................5-36
Export Sample .................................................5-37
Change Sample Type........................................5-37
menu for iTEVA Security .................................5-38
Sign Sample .....................................................5-38
Audit Trail........................................................5-38
on Fullframe ....................................................5-39
Figure 5-61. Subtract Fullframe .................................................5-40
Figure 5-62. Select the filename for subtraction .........................5-40
Figure 5-63. Select filename for further subtraction....................5-41
Figure 5-64. Resultant-2, Fullframe image .................................5-41
Figure 5-65. Fullframe, Right mouse click,
Produce Sample dialog box ..............................5-42
Figure 5-66. Fullframe, Right mouse click menu for
iTEVA Security .................................................5-42
Figure 5-67. Fullframe, Right mouse click, Sign Sample ............5-43
Figure 5-68. Fullframe, Right mouse, Audit Trail .......................5-43
Figure 5-69. Results Menu .........................................................5-44
Figure 5-70. Results, Typical Screen Report ...............................5-44
Figure 5-71. Results, Print .........................................................5-45
Figure 5-72. Results, Open ........................................................5-45
Figure 5-73. Results, Open, More button ..................................5-46
Figure 5-74. Results, Open, Sample Browser ..............................5-47
Figure 5-75. Results, Save ..........................................................5-47
Figure 5-76. Results, Export Results ...........................................5-48
Figure 5-77. Results, Open Sequence .........................................5-49
Figure 5-78. Results, Delete Repeat............................................5-49
Figure 5-79 Results, Run Recovery............................................5-50
Figure 5-80. Results, Run Recovery, Analytical Report -
Recovery Check ...............................................5-51
Figure 5-81. Results, Run Duplicate ..........................................5-51
Figure 5-82. Results, Run Duplicate, Analytical Report -
Duplicate Check ..............................................5-52
Figure 5-83. Select/Deselect Lines ..............................................5-52
Figure 5-84. Results, QC Actions...............................................5-53
Figure 5-85. Results, QC Actions, Autocalc IECs ......................5-53
Figure 5-86. Calculated KI IEC factor displayed in
Method, Elements, IECs .................................5-54
Figure 5-87. Instrument Menu...................................................5-54
Figure 5-88. Instrument, ICP Control Panel ..............................5-55

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Figures

Figure 5-89. Instrument, ICP Control Panel and
Instrument Status.............................................5-55
Figure 5-90. Instrument, Perform Auto Peak..............................5-57
Figure 5-91. Auto Peak Warning dialog box ...............................5-58
Figure 5-92. Instrument, Torch Alignment ................................5-59
Figure 5-93. Instrument, Optimise Source .................................5-59
Figure 5-95. Tools, Example of a Wavelength Line Library ........5-61
Figure 5-96. Tools, Line Library, Right-click ..............................5-62
Figure 5-97. Tools, Wavelength Line Library,
Edit BEC and Detection Limit ........................5-63
Figure 5-98. Tools, Archive Fullframe Data................................5-63
Figure 5-99. Tools, Archive Fullframe Data, Sample Browser .....5-64
Figure 5-100. Tools, Archive Fullframe Data, insert
media window .................................................5-64
Figure 5-101. Tools, Archive Fullframe Data, Select Drive
and Volume Label ............................................5-65
Figure 5-102. Tools, Archive Fullframe Data, finish .....................5-65
Figure 5-103. Tools, Options .......................................................5-66
Figure 5-104. View Menu ............................................................5-67
Figure 5-105. View, Single Sample view .......................................5-67
Figure 5-106. View, Multiple Sample Presentation .......................5-68
Figure 5-107. Help, About Analyst ..............................................5-69
Figure 5-108. View, Subarray Plot with multiple
samples displayed .............................................5-70

Figure 6-1. Sequence Menu Bar .................................................6-3
Chapter 6 Figure 6-2. Auto-Session Menu ..................................................6-4
Figure 6-3. Auto-Session, New Autosampler ..............................6-4
Figure 6-4. Auto-Session, New Autosampler dialog box .............6-5
Figure 6-5. New Autosampler, New Sequence dialog box ...........6-5
Figure 6-6. Auto Session, New Autosampler dialog box .............6-6
Figure 6-7. Auto-session Menu ..................................................6-7
Figure 6-8. Auto-Session, New Manual Dialog box ....................6-8
Figure 6-9. Auto-Session, New Manual prompt .........................6-8
Figure 6-10. The iTEVA Window Sequence Tab ........................6-10
Figure 6-11. Sample List ............................................................6-11
Figure 6-12. Auto-Session menu for iTEVA Security ..................6-11
Figure 6-13. Auto-Session, Sign .................................................6-12
Figure 6-14. Auto-Session, Audit Trail .......................................6-12
Figure 6-15. Sequence Menu......................................................6-12
Figure 6-16. Sequence, Add .......................................................6-13
Figure 6-17. Sequence, New Sequence .......................................6-13
Figure 6-18. Sequence, Remove ...............................................6-14
Figure 6-19. The Sequence Tool Bar ...........................................6-14
Figure 6-20. Halt Auto-Session dialog box .................................6-15
Figure 6-21. Assigning Sample Positions (Right mouse click) .....6-16
Figure 6-22. Auto-Locate Sample Positions ................................6-17
Figure 6-23. Unlocate, Right mouse click ..................................6-18

Thermo Fisher Scientific iTEVA Software Manual xv

Figures

Figure 6-24. Sample U:1 position empty....................................6-18
Figure 6-25. Sample relocated to position 42 .............................6-19
Figure 6-26. Sample List showing relocation of sample
position 42.......................................................6-19
Figure 6-27. The Add Samples Dialog Box .................................6-20
Figure 6-28. Sample List ............................................................6-20
Figure 6-29. Sample List, Calculate Correction Factor ...............6-21
Figure 6-30. Import Warning Dialog Box ..................................6-22

Figure 7-1. The Publisher Window.............................................7-3
Figure 7-2. Publisher, Sample Query ..........................................7-4
Chapter 7 Figure 7-3. Workspace selection .................................................7-4
Figure 7-5. Publisher, Sample report display window .................7-5
Figure 7-4. Publisher, Sample Browser dialog box ......................7-5
Figure 7-6. Publisher, Export Dialog Box ...................................7-6
Figure 7-7. Publisher, Trend Chart Parameters ...........................7-6
Figure 7-8. Publisher, Expanded Trend Chart with Data ............7-7
Figure 7-9. Publisher, Trend Chart .............................................7-8
Figure 7-10. Publisher, Horizontal Table ......................................7-8
Figure 7-11. Publisher, Intensity Report .......................................7-9
Figure 7-12. Publisher, Method Detection Limit Report ..............7-9
Figure 7-13. Publisher, RSD Trend Chart ..................................7-10
Figure 7-14. Publisher, Sample Report .......................................7-10
Figure 7-15. Publisher, Simple Sample Report ...........................7-11
Figure 7-16. Publisher, Vertical Table Report..............................7-11
Figure 7-17. File Menu ..............................................................7-12
Figure 7-18. View Menu ............................................................7-12
Figure 7-20. Window Menu ......................................................7-13
Figure 7-21. Tool Bar .................................................................7-13

Figure 8-1. iTEVA Access Control Window ...............................8-5
Figure 8-2. iTEVA Access Rights Window .................................8-7
Chapter 8 Figure 8-3. New Users Window ...............................................8-10
Figure 8-4. Default Signatures..................................................8-10
Figure 8-5. Sign Sample Window .............................................8-12
Figure 8-6. Sign Method Window............................................8-12
Figure 8-7. Sign Autosession Window .....................................8-13
Figure 8-8. Audit Trail Window ...............................................8-13
Figure 8-9. Event Viewer Window ...........................................8-15
Figure 8-10. Event Properties Window.......................................8-15
Figure 8-11. Security Administration Window ...........................8-16
Figure 8-12. Sign Sample Window .............................................8-17
Figure 8-13. Sign Audit Trail Window .......................................8-18
Figure 8-14. Sign Method Window............................................8-19
Figure 8-15. Sign Method, Audit Trail Window .........................8-19
Figure 8-16. Auto-Session menu for iTEVA.Security ..................8-20

xvi iTEVA Software Manual Thermo Fisher Scientific

Figures

Figure 8-17. Auto-Session, Sign .................................................8-20
Figure 8-18. Auto-Session, Audit Trail .......................................8-21

Thermo Fisher Scientific iTEVA Software Manual xvii

Figures


xviii Thermo Fisher Scientific

Chapter 1 Introduction

iTEVA is a powerful and flexible Windows®- based application that is
used to acquire, process, store and report analytical data from Thermo
Scientific’s iCAP ICP spectrometers.

This manual describes the features of the program and explains how
the analyst can generate analytical methods and data processing
routines to determine the concentration of elements in complex
samples. The program includes a broad variety of features to allow the
analyst to configure methods and sequences to obtain manual and
automated analytical results.

Thermo Fisher Scientific iTEVA Software Manual 1-1

Introduction


1 - 2 iTEVA Software Manual Thermo Fisher Scientific

Introduction
iTEVA Security

iTEVA Security iTEVA Security is a separate iTEVA software package designed with
FDA, title 21 of the Code of Federal Regulations, part 11 (21 CFR, 11
pertains to electronic records and electronic signatures) in mind and
is thus constructed to keep visible audit trails of all actions that occur
within iTEVA and impact data integrity. Whilst the vast majority
of iTEVA.Security uses the same functionality as iTEVA, where it is
different, the iTEVA.Security.settings will be indicated at the end of the
page, or on a stand alone page where applicable.


Introduction


1 - 4 iTEVA Software Manual Thermo Fisher Scientific

Introduction
Opening the Program

Opening the Program To open iTEVA:
1. Click on the iTEVA control center icon on the Windows desktop
to present the iTEVA login dialog box.

Figure 1-1. iTEVA login
2. Enter your User name in the dialog box, or select it from the list,
and click OK to start iTEVA Control Center.
To Add a new User to iTEVA, simply type in the name and it will
be stored.
The Remove User button is used to delete analyst logins from the
system, select the user you wish to delete from the User Name
dropdown list. A prompt will appear to confirm this deletion.

ITEVA Security Login iTEVA Security requires a user name and password to gain access,
according to 21 CFR, 11.200(a)(1) that user identification should:
Employ at least two distinct identification components such as
an identification code and password

Figure 1-2. iTEVA Security login


Introduction
Conventions

This is the same user name and password that is used to log onto
Windows. New users are added using windows user manager,
they are then granted access rights to iTEVA in the Security
Administration program.

After logging in, the iTEVA Control Center window will open. This
is used to setup the instrument, the application database, the default
method values, plasma ignition settings, etc.

It is used to access:

● The Analyst window for data acquisition.
● The.Publisher.window for report generation.
● The Journal.(a listing of major activities).
● The Plasma.and.interlock.icons for instrument settings.
This dialog is also shown when logging in after having logged out with
the File/ Log Off / Log On menu item.

Conventions In general, iTEVA follows the general conventions of Microsoft
WindowsTM and it is expected that the analyst has a good understanding
of this operating system.
For the sake of brevity:
1. We will not describe functions and commands that are common to
Windows application programs (unless the command leads to an
operation that is unique to iTEVA).
2. It is assumed that buttons such as OK and Apply are to be selected
when the analyst has completed the selection of the options in
a dialog box or window, so we will not mention the use of these
buttons. Similarly, the Cancel button closes a dialog box or window
and erases any data entry or alteration.
3. In many cases, there are two or more acceptable ways to perform
a task, access a window, etc. As an example, you can access the list
of methods by selecting Open on the Method menu of the iTEVA
Analyst window or by selecting Ctrl + O keys simultaneously.
When two (or more) options are available, we will only indicate
one.
Note: Menus provide dropdown lists of appropriate operations
available in each application. Often-used operations may also be
provided on the tool bar. Clicking on a menu item produces the
dropdown list. Clicking on a highlighted option selects it. 

Note: The Tool bar and Menu bar can be relocated by depressing the
LEFT mouse button when the cursor is on the double vertical bar at
the left of each tool bar. With the mouse button depressed, move the
cursor to the desired location and release the button to deposit. 

1-6 iTEVA Software Manual Thermo Fisher Scientific

Chapter 2 iTEVA Control Center


iTEVA Control Center



iTEVA Control Center

iTEVA Control Center The general, day-to-day operation of iTEVA involves the use of two
main options : Analyst and Publisher. When the program is opened, the
iTEVA Control Center is displayed. This window gives access to:

● Analyst window: Used to develop methods, analyze samples and
set up the auto sampler. The Analyst window is accessed via the
Analyst icon in the Control Center workspace.

● Publisher window: Used to generate analytical reports using
analyst selected formats. The Publisher window is accessed via
the Publisher icon in the Control Center workspace.

Figure 2-1. The iTEVA Control Center window

The iTEVA Control Center window consists of:

● Menu Bar - Accesses general System commands, such as default
values for methods, application database, periodic table, journal,
etc.

● Tool Bar - Provides shortcuts to commonly used commands.

● Workspace - Icons to open Analyst and Publisher windows. It
provides access to the various applications and navigation tools
within an application.

● Journal - Listing of major activities of the system, for review or
printing. The journal parameters are set in Tools, Options, Journal.


File

● Status Bar - Indicates the status of the system and provides brief
information about a command when the cursor is placed over it.
The status bar provides detail on the current operation selected and
instrument conditions such as plasma, interlocks, autosampler and
communications.

The Menu Bar The menu bar accesses functions that are active when the Control
Center window is open.

Figure 2-2. The Menu Bar

File The File menu is used to log an analyst on or off and to edit parameters
that relate to the journal.

Figure 2-3. The File Menu

File, Log On The Log.On command on the File menu allows an individual to access
the system by presenting the iTEVA.Login dialog box which is used
to enter the analyst name. For iTEVA Security, a valid username and
password is required. If the system is being used when the Log.On
command is selected, the present analyst’s authority will be terminated.

The use of the system by an active analyst can be ended via the Log.Off.
command on the File menu (e.g. if another analyst wanted to use the
system). When a analyst is logged off, the present instrument conditions
are maintained and the User.Name dialog box will be presented to allow
a new analyst to Log.On.

File, Log Off The Log.Off command removes the permission of the present analyst to
access the system. The Log.On command will remain active so that some
other analyst can access the system. The Log.Off selection is enabled
only when a valid analyst is currently logged on.

The File menu includes a number of commands for the Journal:


File

File, Print Journal Print.Journal - Presents a dialog box to set printer parameters (standard
Windows printer dialog box for the printer).

File, Journal Print Preview Journal.Print.Preview - Presents the journal in the format in which it
will be printed.

File, Print Setup Print.Setup - Presents a dialog box to set printer parameters (standard
Windows printer dialog box, which is dependent on the printer).

File, Page Setup The general format of the journal can be established via the Page.Setup
dialog box, which can be accessed via the File menu.

Figure 2-4. Page Setup Dialog Box

The dialog box provides margin selection for the Journal Table.
Checkboxes provide for the selection of titles and gridlines. In addition,
journal contents can be printed in black and white only if desired.
Should the table exceed the page size the page order can be prioritized
on either row or column.

● Margins - (entered in inches) - Define spacing in four
directions.
● Preview - Shows the configuration of the finished report.
● Titles and Gridlines - Offers checkboxes for header inclusion,
partition lines and color options.
● Page Order - Panel customizes the report of tables that extend
beyond the page margins.
● Center on Page - Can position the table in the center of either
or both page dimensions.
The table can be centered in vertical and/or horizontal directions


File

automatically. When satisfied with the journal page setup, check the
Save settings to profile button to re-use the page format.

Note: When tables exceed the page size, the table dimensions may
change from page to page. 

File, Exit There are two ways to exit the iTEVA operating software.

● From the Menu bar, select Exit. Exit appears under File on the
Home Page.

● On Home Page select the `X’ button found at the top right
corner of the window.

View The View menu is used to select the items that should appear on the
iTEVA Control Center window.

Figure 2-5. View Menu
Each item is a toggle to place or remove the indicated item on the
window. A check mark adjacent to Tool.Bar or Status.Bar indicates that
the item is present. The Hide.Workspace command is used to remove the
workspace. When the workspace has been removed, the command is
Show.Workspace.

Tools, Options Tools
The Tools menu is used to access a variety of commands that relate to
system operation.

Figure 2-6. Tools Menu
Options is the main area where the software is customized. There
are several Options windows, which are used to enter a variety of
instrument-specific parameters and conditions. All of the options are
explained in the following pages.


Tools

Tools, Options, General General - The analyst can enter an instrument name. The software will
automatically associate the acquired data with the instrument name in
the database.

Figure 2-7. Tools, Options, General
When the Demonstration.Mode,.Desktop is selected, the software will run
from a remote computer and expects no instrument input.

Note: The status bar displays a monitor image when the software is
run in desktop mode and an instrument when communicating with the
spectrometer. 

The Language Translation is analyst selectable to display iTEVA in
different languages.

Tools, Options, Periodic Table Periodic.Table.- The color scheme can be set for the symbol name as well
as for the Unselected,.Selected or Non.Selectable status conditions. The
interfering elements can be selected to be either Shown or Hidden.

The default Periodic Table colors may be changed globally. Note
however, that any changes you make will not be reflected in the on-line
help.


Tools

Figure 2-8. Tools, Options, Periodic Table
Preview - Shows the selected colors for the three types of element;
Unselected,.Selected and Non.Selectable.

Clicking on the color rectangle right of the element type provides a
color palette to chose from.

Interfering.elements - Fields with Shown and Hidden.IE’s appear. The
default is that all interfering elements appear in the Shown.IE’s field.
However, if the Apply.all.IE’s.checkbox is disabled, element symbols
can be transferred to the hidden IE’s field by highlighting the element
symbol and clicking the arrows right button. Hiding rare elements
simplifies the interfering element list during line selection.

Apply.all.IE’s - When checkbox is selected, all IE’s are displayed at line
selection regardless of Shown/Hidden current status.

Tools, Options, Journal Journal.- The analyst can select which type of journal messages should
be displayed. The journal messages can be selected for display for a
range of applications, each of them is analyst selectable. The length of
time for the messages to be displayed can be selected as number of days
in the history display.


Tools

Figure 2-9. Tools, Options, Journal
Display.Journal.Messages.for.Applications - The Journal options page has
check boxes for eight different areas of software. When checkmarks
appear in these boxes all journal messages associated with the checked
application will appear. The eight specified applications are iTEVA.
Control.Center,.Analyst,.Sequence,.Publisher,.Fullframe.Imaging,.
Wavelength.Calibration,.Diagnostics.and.Unknown.

Display.Journal.Message.of.Type - There are five types of message that are
included in the journal when the associated checkbox is marked. They
are Error,.Alerts,.Warning,.Information.and.Debug. Debug is left off as
default as this option is only used by Thermo personnel for diagnostics
purposes.

History - Authorized users may define the number of days to include in
the journal display and to maintain in the journal, and also there is the
option to export the journal.

Show.Message.Description - When checked, a brief statement explaining
the message appears in the journal display.

Clear.History - Active when the journal contents exceed the limit
entered to the left of the button.


Tools

Export - To export the journal (this may be required when logging
a service call with Thermo). On clicking Export, the journal is
automatically exported as a text file to

C:Program FilesThermoiTEVAExport.

Tools, Options, Directories iTEVA uses a number of directories to store its data. If you wish you
can change the location this data is stored using this option page:

Figure 2-10. Tools, Options, Directories
Analytical.data: When you create a new database, the files will be
stored here. If you archive Fullframes then they will also be put here by
default. This directory also stores the files which hold information on
the database links listed in the Application Database options page.
Autosampler: This holds the user-editable autosampler .xml files. See the
section on editing your own autosampler layouts: Editing Sample Racks
and Layouts in Chapter 6.
Export: Any exported files are stored here. Exported samples, methods
and journal.
Reports:.This holds the report templates used by Publisher.


Tools

Tools, Options, Print Options Print.Options - Enables the customization of the report. A default
company and client name can be entered, which will be printed as a
header for each report.

The four additional buttons Journal,.Method,.Result and.Sequence.List.
(this.applies.to.automated.sequences.using.an.autosampler) allow the
analyst to customize each of these in an individual layout, e.g. the result
printout can be set up in a different layout to the method printout. To
define any of these text strings, move the cursor to the appropriate field,
click to select and type.

Figure 2-11. Tools, Options, Print Options
Tools, Options, Analyst Analyst.- Allows the analyst to specify parameters that control the
behaviour of the Analyst application.
Plasma.Stabilisation.Time is the time that the software will delay after
changing plasma parameters, e.g. if the plasma RF power or nebuliser
flow is different from one method to the next, then the analyst selected
Plasma.Stabilisation.Time will be employed after this change has taken
place.
Min.Number.of.Repeats.for.Variance.Weighting.defines the amount of
analytical repeats that are required before this is employed, it is analyst
selectable between 1 and 9 although 3 is the industry standard.


Tools

When Corrected.Print.Limits is selected, the software reports only the
defined print limits (if any) for the method.

Full.Frame.Gray.Scale.as.Default.Display.Mode enables either grayscale
when selected, or colour if not.

Sample.Customer.ID.Defaults are analyst definable to add labels for
additional identification to all samples during analysis.

Figure 2-12. Tools, Options, Analyst

iTEVA Security Note: If an analyst does not have access right “Edit System Settings”
granted, then this dialog is read only and not editable. 

Tools, Options, New Method This will open the New.Method.Parameters dialog box. These are
Parameters settings which supply defaults to a method when it is created, and can
be adjusted by the analyst.

Plasma.parameters - The plasma parameters (Flush.Pump.Rate,.Analysis.
Pump.Rate,.RF.Power,.Nebulizer.Gas.Flow,.Coolant.Gas.Flow,.Auxiliary.
Gas.Flow) can be adjusted from the default values.


Tools

Print.Units.-.Print Units can be specified (typically ppm).

Calibration.Conc.Weighting.Zero.Factor,.Calibration.Var.Weighting.Zero.
Factor - Values can be entered.

Figure 2-13. Tools, Options, New Method Parameters

Note: Any parameters changed here will be reflected in Analyst/
Tools/Options as they perform the same function. 

Tools, Options, Access Rights - The access rights that are displayed in Control Center/Tools/Options
(only for iTEVA Security) reflect an accumulation of rights that exist for the current user, resulting
from the rights that have been explicitly granted to that user’s own
log in account and the rights that the user has inherited through
membership of Windows groups. This section is not editable from
iTEVA Security and is provided for information only. Any changes to
access rights must be made by an administrator or equivalent in the
separate program Security Administration.

Access Rights are assigned in the Security Administration program and
allow iTEVA Security users to perform various functions as described
overleaf.


Tools - Access Rights

Figure 2-14. Security Administration program, Access Control

Run iTEVA Security
Allows the user to login to iTEVA Security..

Edit System Settings
This allows the analyst to edit the plasma parameters, change the new
method parameters, perform auto peak, torch alignment and source
optimisation.
Edit Map Database
Allows the analyst to add new elements to the line library, edit existing
wavelengths and make them available for analysis.

Edit Methods
Allows the analyst to edit, delete, create methods.

Edit Samples
Allows the analyst to edit samples e.g. change background points, delete
repeats etc.

Edit Sequences
Allows the analyst to edit, delete and create sequences.

Create Reports
Allows the analyst to access Publisher.

Override Method Parameters on Run
Allows the analyst to change the number of repeats, flush time,
correction factor, check table use, collection and storage of full frame
and export options from sample to sample, rather than using the
method parameters.


Tools - Access Rights

Figure 2-15. Tools, Options, Access Rights


Tools - Application Database

Tools, Options, Application This contains the information regarding what database is in use for data
Database storage and also, the tools to create new databases etc. Run.database.
wizard can be used to verify databases, attach/detach, create and backup
databases.

A new database can be created or an existing database can be either
attached or detached or a backup can be created or restored.

Figure 2-16. Tools, Options, Application Database

Database Wizard Database.Wizard - Is accessed via the Run database wizard button on
the Application.Database tab of the iTEVA options dialog box (which
is accessed via the Options command on the Tools menu of the.iTEVA.
Control.Center.window).

The Server Name denotes the name of the server that stores the iTEVA
databases, if this is a local server (on the same PC, usual practice for
standalone PCs) then the Server Name is “.iTEVA”. The Server Type
and Version are verified before each task is completed.

The analyst must indicate the User.name (default “sa”) and the Password.
(default “teva”). For iTEVA Security, there are no fields for username or
password as we are using Windows integrated security.


Tools - Database Wizard

Figure 2-17. iTEVA Database Wizard for standard (above) and
iTEVA Security (below)



Database Info Database.Info - Is used to access information about each of the various
databases that are present on the server. To obtain information about
a specific database, select the database via the dropdown menu under
Database.Name. The parameters that are displayed cannot be edited.

Create This is used to generate a new database. When the wizard is opened, the
Database.Wizard is presented to enter the User.name and Password.

1. Enter the User.name and Password.

2. Enter the desired name of the new database (it should be unique, as
iTEVA will not allow the creation of new databases which name is
already in use).

Detach This function is used to detach an active database and will take it offline
from the server. This function needs to be performed if you intend to
copy a database and send it to another iTEVA analyst, or delete the
database from the PC.

1. Enter the User.name and Password. Choose Detach.

2. The iTEVA.Database field is used to indicate the database to be
removed. After you have selected the database to be removed, the
Database.properties fields will describe the database. These fields
cannot be edited.

3. Click OK to detach the database.

Attach This function is used to attach a previously detached database or to
attach a database from an external source, i.e. to share/read results and
data from another iCAP instrument running iTEVA.

1. Enter the User.name and Password in the Database.Wizard box.

2. Choose Attach, and click on the ellipsis to the right of the filename
to browse for database .mdf file to be attached.

3. The database name will automatically be filled in to match the
database file you have selected.

Backup 1. Enter the User name and Password in the Database Wizard box.

2. Select the Database to be backed up via the dropdown menu. The
Database properties fields will describe the selected database.



3. Click OK.to present the backup location dialog box, which is
used to select the path for the backup. Click OK and a prompt is
displayed asking for confirmation before proceeding. Select Yes if
you want to continue with the backup and a full backup will be
performed. It is recommended that the selected backup path is not
on the local disk.

Restore This function is used to restore backups of a database for use.

1. Select the database from the dropdown menu.

2. Click OK and select the location of the backup file that you wish to
restore.

3. A warning will be displayed to advise you that the restored backup
version of the database will be used and will only contain data up to
the date that it was backed up. Click Yes.to proceed.

Users Users.wizard - Is used to enter a new password for a analyst.
(only for iTEVA,
not present for iTEVA Security) 1. Select the name of the analyst for whom you want to modify the
password.

2. Enter the old password and new password; then verify the new
password.

iTEVA SQL Databases iTEVA analytical data and methods are stored in a user-selected
database. This allows the analyst to save and recall data according
to a number of criteria that have been setup in the formation of the
database. iTEVA databases may be managed either using Microsoft SQL
Server Express (provided with your iTEVA installation), or by Microsoft
SQL Server (a fully featured database management application).
iTEVA allows data storage up to the capacity of the available storage
space. However, SQL Express databases have a limited database file
size of 4GB (approximately 70,000 sample records, or 3,000 Sample
Records with associated Fullframe images), so it may be necessary to
create new databases from time to time and to establish a connection to
each database. iTEVA will give a warning at 0.5GB (500MB) before the
database size limit is reached. SQL Server databases have no such size
limitation.
Data that is stored in an iTEVA database includes the method, sample
results and the sequence used to collect the data. The database can be
established on the workstation that is used to control the spectrometer
or on a separate workstation. You can conserve database space by not
storing Fullframe images with each sample.



iTEVA Security When running iTEVA Security, the database contains a secure audit
trail for all samples (of all types), methods and autosessions. When
installed and configured correctly (as per the IQ process) the database
is protected from access by unauthorized users and from all users using
applications other than iTEVA Security. Any changes made to the contents
of the that are not made via iTEVA Security.are detected by the software,
an error is reported and the data is marked as unavailable for use.

Note: iTEVA will not connect to an iTEVA Security database or vice
versa and it is not possible to upgrade or convert a database from
iTEVA to iTEVA Security or vice versa. 

Creating a new database involves the following steps (each step is
discussed in detail below).
● Creating new database.
● Adding a connection to the new database in iTEVA.
● Making the new connection active.
● Copying methods/results.
● Change active connection.

Figure 2-18. Database Wizard



Create New Database Open database wizard, type in user name “sa” and password “teva”,
choose Create, enter a new database name. Close the database wizard.

For iTEVA Security.(as shown below), there is no user name and
password field, simply select Create and enter the name of the new
database. Close the Database Wizard.

Figure 2-19. Database Wizard for iTEVA Security

Add a New Connection

Figure 2-20. Add a connection icon

On the Application database page click on the Add.a.connection.(middle
icon) as shown above.



Enter the server name as “.iTEVA” if connecting to a local server, or
select the network server from the dropdown menu.

The user name is “sa”and the password “teva”.

Figure 2-21. Data Link dialog box



In iTEVA.Security.(as shown below), the data link properties dialog
should be filled in with the server name .iTEVASECURITY if
attempting to connect to a database hosted locally by SQL Server
Express on the same computer as iTEVA Security is running. Otherwise
the name of the network server should be selected from the list.

Figure 2-22. Data link dialog box for iTEVA Security
For iTEVA Security (as shown above) should select ‘Use Windows NT
Integrated Security’ as opposed to ‘Use a specific name and password’.
Select the newly created database from the dropdown menu.
A prompt then appears for a Data link file name (connection) name,
[see Figure 2-23 overleaf ] for ease of use it should relate to the database
name. Click.OK to accept new connection name.



Figure 2-23. Data link file name dialog box

Copy Methods/Results To copy existing methods into a new database (which will be empty of
results and methods), open Analyst. This will open up the methods page
automatically, and from here, highlight the method to copy, choose the
Copy to button and select the new database name from the dropdown
menu.

To copy results into a new database (or any database), use Results/
Open and select the required data, choose Copy to and select the
required database name from the dropdown menu. When all methods/
results have been copied you require, close Analyst and return to Tools,
Options, Application Database.

Note: When results are copied, a copy of the method that they were
stored with is automatically copied. 

Change Active Connection This option is used when the analyst is changing from one database to
another, e.g. when looking back at some old data on a different database
or attaching a newly created database.

Figure 2-24. Change the Active Connection dropdown menu

On the application database page, use the dropdown menu on the
active connection to choose the new connection.
Click Apply - The new database and connection will now store all new
results/methods generated.

Deleting/Exporting/Importing/ Deleting a Database
Databases Deletion of databases may be required in order to free up space on the
PC. This is done by Detaching the database as described above and
deleting the associated .ldf, .mdf and .udl files from
C:/Program files/Thermo/iTEVA/Andata.
The connections for those databases may then be deleted as described
overleaf.



Editing/Deleting a Connection

Figure 2-25. Edit/Add/Delete a connection icons
To edit a connection, highlight it from the Available Connections
and select the Edit.the.Connection icon (first icon above) and edit the
parameters from the Data Link Properties dialog box. To delete an
unused connection, select it from the Available Connections and choose
the Delete.the.Connection icon (third icon above) and confirm the
deletion.

Exporting/Importing a Database from/to another iCAP
iTEVA and iTEVA Security databases may be detached and attached
to any instance of iTEVA or iTEVA Security. Please note that only
iTEVA databases are compatible with iTEVA and only iTEVA Security
databases are compatible with iTEVA Security. This feature is very
useful for transferring data from site to site or for examining data off
line.

Database Upgrades If the database you are trying to connect to was created with a previous
version of iTEVA, you will see the following dialog. Users are advised
to check the Backup.before.upgrading box and specify a valid backup
pathway before upgrading any database. When the upgrade progress bar
is complete and the database upgraded, it is available for use.

Figure 2-26. Database Upgrade dialog box


Tools - Instrument Options

Tools, Instrument Options Presents a dialog box to allowing the analyst to change the Autosampler.
Autosampler Type.and COM.Port. There are options for the AIM1250, various CE-
TAC models and Gilson autosamplers. When the autosampler is con-
nected, the analyst must choose the correct model from the dropdown
menu and verify the COM port being used.
In Desktop mode, the Auto.Sampler.Emulation is used to simulate the
autosampler actions.

Figure 2-27. Tools, Instrument Options, Autosampler

Sample Introduction If you have a 6500 Series ICAP then the Sample Introduction feature
will be available. The settings can be edited on this page:

Figure 2-28. Tools, Instrument Options, Sample Introduction


Tools - Help

Enable Drain Sensor This option allows the analyst to enable/disable the drain sensor for
accessories that do not require it, e.g. laser, SSEA, ultrasonic nebuliser
or hydride accessory (any accessory that does not have a drain actively
pumping liquid waste via the instrument peristaltic pump).

Accessory The analyst must specify the Accessory being used, such as SSEA and
Laser. If an external accessory that is not listed is connected, the analyst
must choose the Custom Device option which will enable the Input and
Output Trigger options. From here the analyst can choose the options
specific to that device.
If an SSEA is specified then the COM port will need to be selected
so that iTEVA can communicate with it to send it the frequency and
power settings ( See Method,.Source.Settings.).

Note: Please note that this feature is only available for iCAP 6500
Series ICP Emission Spectrometers. 

Help The Help menu provides access to useful information for the analyst.

Figure 2-29. The Help Menu

Help, Help Topics Help.Topics - This provides on-line help, where all aspects of the iTEVA
software is described.

Figure 2-30. The Help Feature Request Incident Form


Tools - Help

Feature request / Incident form Feature.request/incident.form - This automatically recalls all the variables
of the instrument, for example the software version, instrument type,
firmware, etc.

Using this will enable Thermo to obtain all relevant information about
your type of instrument to process the feature request or incident form
correctly.

Help, About iTEVA About.iTEVA - This will display the software and firmware version
currently installed on the system. This information can be useful when
discussing issues with Thermo personnel.

The GUID number is a unique number, which is generated during the
software installation.

The purpose of this GUID is to allow the generation of a new
ThermoService password for service engineers to access diagnostic
software installed with iTEVA. The engineer will contact Thermo
who will request the value of the GUID and use it to generate a new
password for them.

Figure 2-31. About iTEVA

Note: On-line Help for a given topic can be accessed via the F1 key. 


Tools - The Tool Bar

The Tool Bar The Tool Bar includes a series of icons to rapidly access various
functions.

Figure 2-32. The Tool Bar

Home.Page - Not active on this page (this is the home page)

Back - Not active on this page (this is the home page)

Next.Page - Not active on this page (use the workspace)

Print.Journal

Show.(Hide).Journal

About.iTEVA

The Workspace The Workspace presents two icons:

Analyst - Used to access the iTEVA Analyst window and the Select a
Method dialog box. To collect, process and report data.

Publisher.- Used to generate reports using the analytical data.


Tools - The Journal

In each application, the workspace provides a navigational tool between
methods, samples, method parameters and other applications.

The Journal The Journal is a listing of major activities of the system and is presented
at the bottom of the iTEVA.Control.Center window. It can also be
viewed via the Journal.Print.Preview command and printed via the Print.
Journal command on the File.menu. The complete journal captures the
Date/Time, an informational message about the activity, User.Name,.
Application,.Sequence.Name and a short description of the activity.

Figure 2-33. Journal window

The symbol before each entry has the following meaning:

Information icon

Error icon

Alert icon

Debug icon
Typical information presented in the journal includes information,
error messages, warnings and alerts. The analyst can select the types of
information to be indicated in the Journal via the Options window.

The components of the journal are:

● Date/Time - When the event occurred
● Message - A short description of the activity that occurred
● User Name


Tools - The Status Bar

● Application
● Sequence Name
● Description - Additional information about the activity (e.g.
when a sequence is started, this field will indicate the number
of samples and standards in the sequence)

To Export the Journal entries, which may be required by Thermo
Personnel during a service call, open Control.Center/Tools/Options/
Journal and choose Export as in above figure.

The Status Bar The Status Bar presents information about the status of the system and
provides access to commonly used features.
The fields on the right side of the status bar are:

Figure 2-34. Status Bar

When the plasma is ignited, this will display the nebulizer back pressure
(only for iCAP 6500). this can be used as a guideline to indicate if the
nebulizer is becoming blocked during analysis.

Name of individual presently using the system.

Accesses the Plasma.Status.window to ignite/extinguish the plasma, and
view/edit plasma parameters.

Indicates connection of computer to spectrometer. If you are in desktop
mode, this will appear as a PC icon (as above in Figure 2-34).

Accesses the Interlock Status window to view Interlock and Plasma
status.

Indicates presence of autosampler.


Tools - New Firmware

Indicates that the system is connected to the instrument. It displays `X’
if not communicating.

Indicates the completion status of samples being run - green is busy
analyzing, blue is analysis complete/ready.

New Firmware dialog box If the software detects that the instrument has firmware that is a
different version to that shipped with the iTEVA software, the New.
Firmware window will be displayed. This window allows new firmware
to be downloaded to the instrument.

Figure 2-35. New Firmware Window

iTEVA Security:

Note: A user must have ‘Edit System Settings’ rights to be able to
download firmware to the instrument. 


Chapter 3 Analyst


Analyst



Analyst
Analyst Window

Analyst Window The Analyst window is opened by clicking the Analyst button in iTEVA.
Control.Center.

The iTEVA Analyst window is used to establish and perform methods
and sequences. All parameters for the analytical tasks are created in the
Analyst window. The Analyst window consists of three tabs, Analysis,.
Method.and.Sequence. Each of the three tabs has its own program
structure as shown in the Figure below.

Figure 3-1. Analyst - Analysis, Method, Sequence


Analyst
Method

Three tabs are presented in the workspace:

Analysis - Displays the analyses to be performed and those which are
yet to be performed in the present session. A detailed discussion of the
Analysis tab is presented in Chapter 5.

Method - Enables the analyst to either create new methods or edit
existing ones. It is used to access the various components of the
analytical method that is to be used to analyze samples, process data
and report data. A detailed discussion of the Method tab is presented in
Chapter 4.

Sequence - Controls the functions of the autosampler and the setup of
the automated sessions. It displays the sequence(s) to be performed in
the present automated session. A detailed discussion of the Sequence.tab
is presented in Chapter 6.

When Analyst.opens, it displays the method directory to allow the
analyst to open a method.
The commands on the menu bar, the general format of the workspace
and the data space are different for each of the tabs and are discussed in
detail in the referenced chapters. The buttons and menus are active or
inactive depending on the current status within the Analyst.

Analysis

Method

Sequence


Chapter 4 Analyst, Method


Analyst, Method



Analyst, Method
Method

Analyst, Method A method contains the parameters that define the specific protocol for
a given quantitative analysis (e.g. the lines to be used, instrumental
parameters, information about the standards to be used, etc.). Sequence
actions are incorporated into the method to determine how a series of
samples are analyzed using an autosampler.

In addition to the analysis parameters, the method enables various
storage options for data, print options and report preferences.

Method Menu Bar Once the Method tab has been clicked, the Menu bar will be displayed,
showing further options for Method,.Tools,.View.and.Help.

Figure 4-1. Method Menu Bar

Method

Figure 4-2. Method Menu

Create a new Method The initial step in establishing a new method is to select the elements
that will be used in the analysis method. When you select New on
the Method menu of the iTEVA.Analyst window, a periodic table is
presented so that the elements/lines can be selected.

The Method.Workspace.is provided to assist the analyst in establishing/
editing a method. The contents of the Data Display Area changes
depending on which entry in the method Workspace has been selected.
A description of each entry is described in the section Method.Reports.


Analyst, Method
Method New

Figure 4-3. Method Workspace

Each entry on the Method tab leads to one (or more) options, used
to describe a discrete aspect of the overall analytical procedure. For
Automated.Output.and.Report.Preferences, an option is provided for each
sample type.(Unknowns,.QC.Standards,.Blanks,.Standards,.Recoveries,.
Spikes.and.Time.Scans).

Note: Although the method is changed as soon as you change a
parameter, we suggest that you save the method before using it. If
you attempt to close an edited method, a dialog box will be presented
asking if you want to save the changes. 


Analyst, Method
Method New

Note: All elements shown in a gray box can be selected for analyses.
The elements in the red boxes cannot be analyzed. 

Figure 4-4. Method, Periodic Table

1. Move the cursor to the first element to be selected (elements with a
light gray field can be selected). As you move the cursor, a pop-up
box will be presented. It displays the wavelength and order of each
line currently available for the element beneath the cursor. Any
current method lines are indicated with an asterisk *.

Figure 4-5. Method, Periodic Table, Cursor information for
specific element

2. Click on the element to select the lines to be used for the analysis of
this element.


Analyst, Method
Method New

Figure 4-6. Method, Periodic Table, Line List display

For some elements, several analytical wavelengths are displayed
in descending order of relative intensity. Usually, one of the
wavelengths is more sensitive, and performs better (improved
precision and detection limits) than the others for particular
applications.

If a green tick appears on the wavelength symbol , this means
that the wavelength has been finely adjusted during an Auto Peak
Adjust.

3. Click on the analytical line that you want to use. A table of nearby
interferences for the selected line will be presented.

Figure 4-7. Method, Periodic Table, Line List/Interferences
Window

4. Use the list of interferences to decide whether to use the selected
wavelength.
5. Double click on the analytical line. The checkbox will be activated
(a checkmark will also be placed over the selected icon).


Analyst, Method
Method New

6. Click OK to accept the line. The periodic table will be reactivated
to select another element. The color of the selected element will be
indicated in aqua.

Figure 4-8. Method, Periodic Table, Selected element
displayed in aqua

The selected line will be indicated by an asterisk (if the cursor is
placed on the element).

Figure 4-9. Method, Periodic Table, Selected Line marked
with asterisk

Note: It is possible to select more than one analytical line for an
element by double clicking on them, for example to check for
interferences. 


Analyst, Method
Method New

After all elements have been selected, click OK. The Method tab will be
presented in the workspace and the Status window will be presented.
The method could now be used for an analytical run.

Note: The analyst can add further wavelengths to each element using
the right click Edit Map function. This is explained in Periodic Table,
Map Editor [overleaf]. Initially, only the default wavelength selection
is displayed. 

Figure 4-10. Method, Status Window

If you want to remove an element from a method:

1. Click on the Periodic.Table.icon to present the table .

2. Click on the element to be removed to present the Line.List/
Interferences window.

3. Remove the checkmark by double clicking from the Select.Element.
field and press OK or uncheck the Select.Element box to deselect all
wavelengths for the element.


Analyst, Method
Method New

Periodic Table, Map Editor Right mouse clicking on an element in the periodic table opens the
following menu. The example below displays the Map Editor for
Strontium (Sr)...

Figure 4-11. Periodic Table, Map Editor

Edit.map.for.Sr... - Opens the map editor, where the Wavelength.&.
Order,.Wavelength.Range,.Column,.Row,.Peak.Status,.Relative.Intensity are
displayed. The analyst can select the elements which should be Available.
for.Analysis or to Auto.Select.for.New.Method.


Analyst, Method
Method New

Add.Lines.- Clicking on Add.Lines opens a dialog box to add an available
line from the Element.Line.Library.to the selected lines.

Figure 4-12. Periodic Tale, Right mouse click, Edit Map, Add Lines

Create - Clicking on.Create.opens a dialog box to add a new line to the
element line library, Edit map.

Figure 4-13. Periodic Tale, Right mouse click, Add Lines, Create

Properties - Opens the Periodic.Table properties dialog box. See Chapter
2,.Tools,.Periodic.Table for more details.


Analyst, Method
Method New

Status Provides the Method.Name,.Revision.and.Instrument names as well
as the Current.Status, the dates the method was created,.modified.and
standardized,.the.Number.of.Elements.and Wavelengths selected for the
method. Specific comments can be added to the Notes section.

Figure 4-14. Method Workspace, Status

Figure 4-15. Status Window


Analyst, Method
Method New

Analysis Preferences The Analysis.Preferences option is used to define all of the analytical
parameters for the method.

Figure 4-16. Method, Analysis Preferences

Figure 4-17. Analysis Preferences


Analyst, Method
Method New

Sample Options

Figure 4-18. Analysis Preferences, Sample Options
Number.of.Repeats - The number of times that a given sample should be
analyzed (range = 1 to 99), typically 3 repeats.

Delay.Time - Additional delay time between sample insertion and
acquisition of data (range 0-1000 sec). The delay time is generally only
used for solid sample introduction systems, such as spark emission or
laser ablation. The delay time is in addition to the uptake (flush) time.
It is only enabled when a different sample introduction is selected in the
Control.Center.at Instrument.Options/Sample.Introduction.

Sample.Flush.Time.- Period of time that the sample flush solution
should be used (range 0-1000 sec). It defines the uptake time for the
solution to reach the plasma.

Analysis.Mode.- Can be toggled between Speed.and Precision. Speed.mode
is a unique mode of analysis which analyzes all radial/high wavelength
elements for all replicates, then all axial/low wavelength elements for all
replicates e.g. for a 3 replicate method with Ca393 and Al167 they are
analyzed as follows: Ca393 replicate 1,2,3. Al167 replicate 1,2,3. Speed
mode of analysis saves time as it removes the need for settle times when
switching from one plasma view to the other, and time savings of up to
30% can be achieved. Precision mode is the traditional analysis mode,
which is per replicate, so for the same method the analysis sequence
would be: Ca 393 replicate 1, Al167 replicate 1, Ca 393 replicate 2,
Al167 replicate 2, Ca 393 replicate 3, Al167 replicate 3.

Note: These two options are only available for iCAP 6500 Series
Emission Spectrometers, the 6300 Series uses the traditional
Precision mode for analysis. 

Source Sample.Introduction - The menu lists the sample introduction options
that are available. On systems with an external accessory such as a Laser
connected, the drop down menu will include this option. (To enable
accessories, the analyst must ensure that they are correctly set up on
Control.Center/Tools/Instrument.Options/Sample.Introduction).


Analyst, Method
Method New

Figure 4-19. Analysis Preferences, Source

Plasma View - Auto View, Axial, Radial and Line Selection are the
available options. On a Duo system, the default is Axial. Autoview
allows the software to decide which wavelengths to run on what view,
(it defaults to all lines below 234nm are analyzed Axial and all lines
above are analyzed Radial). When using a Radial iCAP, only Radial will
be available. If Line.Selection is chosen, the analyst must then click Set..
This displays the method wavelengths and the default view. The analyst
may then use the Move key to change wavelengths from one view to
another.
Auto-Increment.Sample.Names - If this option is selected, the Sample.
Name for consecutive samples will be automatically incremented
(e.g.Soil1, Soil2, Soil3, etc.).

Use.Sample.Weight.Corrections - Enables sample weights to be entered
and the correction factor applied.

Analysis Maximum
Integration Times

Figure 4-20. Analysis Preferences, Maximum Integration Times

The maximum analysis integration time is the longest period in seconds
that the signal will be collected prior to processing. Depending on
instrument configuration and analytical wavelengths selected in the
method, up to four separate maximum integration periods may be
required.

Analysis.Maximum.Integration.Times.(Seconds) - range 0.1 to 1000, can
be set for Axial.and.Radial.view.


Analyst, Method
Calibration Mode

Low.Wavelength.Range - range 1 to 120.

High.Wavelength.Range - range 1 to 120.

For typical applications, a reasonable starting point is 15 seconds for the
low wavelength range, and 5 seconds for the high wavelength range.

Calibration Mode

Figure 4-21. Analysis Preferences, Calibration Mode

The Calibration.Mode field is used to select the desired type of
calibration that should be used in the method.

Concentration.mode compares instrument response to standards of
known concentration. Instrument response typically is corrected
for background and may additionally be corrected using an internal
standard or inter-element correction. In addition, there are two
special calibration modes.

These are called Concentration.Ratio.and.Summation.to.100%. These
may be used to analyze samples for ALL elements present. The results
must always add up to 100 percent. In essence, the whole sample
becomes its own internal standard.

Typically, when these methods are used, only one line for each
element will be used, as the concentrations are reasonably well known.
If a wide concentration range is expected, line switching can be used.
Multiple lines can also be used and, in some special circumstances,
this can provide improved accuracy. iTEVA uses a special algorithm
which rejects any lines reporting errors, then averages the valid lines if
multiple lines are reported in either of these two modes.

The calibration mode is selected in the method within the Analysis.
Preference.Window. The selected calibration mode appears in the field
to the left of the options bar. Using the dropdown menu displays the
options. Moving the cursor to each option will highlight that option
and a left-click will insert the option as the selected calibration mode.

Concentration.- The concentration of each element in the calibration
standards is entered.


Analyst, Method
Concentration Ratio

Concentration.Ratio.- The concentration of each element is indicated
with reference to the internal standard. The base element is the sole
internal standard for the method and the sum of all of the element
concentrations must be 100%. If this requirement is not met, the
method will default to Concentration Mode.

To use the Concentration.Ratio mode, a Standards.Table is created which
uses a Base.Concentration. This appears with a value of 100 percent. The
major element in the material is omitted from the list of elements in the
standard. This major element is designated as the Internal.Standard.

When inserting the concentrations of the various elements, the
value for the Base is reduced, so that the total always adds to
100%. After inserting all element concentrations (other than the
major constituent), the Base.Concentration should equal the major
constituent concentration. If not, there may be a small concentration
of undetermined species present. These undetermined elements should
constitute less than 1% of total composition (preferably less than
0.1%). Provision is made for the inclusion of a “residual concentration”;
this residual is an approximation of the concentration of undetermined
species.
Thus:
C[is] + C[a] + C[b] + ... = 100% - C[r]

Where: C[is] is the concentration of the Internal Standard element
C[a], C[b], ... are concentrations of elements a, b, ...
C[r] is the residual concentration (if any)
If both sides of the equation are now divided by C(is), the result is:
1 + CR[a] + CR[b] + ... = 100 - C[r]C[is]

Where CR[a], CR[b], ... are Concentration Ratios of elements a, b, ...

Remember that the calibration curve is now relating SIR to
concentration ratio; i.e., the value obtained in each case when the
concentration of each element in the Standard is divided by the Base.
Concentration, or the concentration of the Internal.Standard element:
CR [a] = C[a]/C[is]
During analysis, the instrument determines intensity ratio values, which
are then related to concentration ratios calculated from a calibration
curve which has been established in concentration ratio mode. The
equation above may then be solved for C[is], the Internal.Standard.
Concentration.
Once this is known, The equation may be solved for all the individual
element concentrations.


Analyst, Method
Trailing Fullframe Options

Summation.to.100% - The standard concentrations for all elements add
up to 100% including the base element. If this requirement is not met,
the method will default to Concentration.mode.

Note: The Summation to 100% is generally used in the metals industry
where the major elements have to be measured as well as the minors
and traces. 

Trailing Fullframe Options

Figure 4-22. Analysis Preferences, Trailing Fullframe Options

A Fullframe image determines all elements in your sample, from
this you can produce semi-quantitative analysis on major and minor
components. Fullframe can also be used to determine the presence of
contaminants or to look for unexpected constituents in your sample.

When the elements to be determined are identified, you can simply
create a new method using suitable lines. The line selection process is
important, to eliminate possible spectral interferences and to match
concentration to instrument dynamic range. For each line selected, one
or two background correction points should be established.

Intelli-Frame - Selecting Intelli-Frame will enable automated integration
time calculation which intelligently integrates all element signals
to ensure that they are read/analyzed correctly and will yield semi-
quantitative results within 20% of the fully quantitative analyses.

Note: In the Method, Analysis Preferences the analyst only decides
to either set the integration times for the Fullframe automatically via
Intelli-Frame or manually. In order to perform and save the Fullframe,
the analyst MUST select Acquire and save Trailing Fullframe to
Database, from Automated Output. 

Maximum.Integration.Time - Period of time to integrate data using the
Fullframe (Range 0.1 to 1000 sec).

WL.Range - Indicates if low, high or both ranges should be used. To
gain the complete spectral picture of your sample, both a High and a
Low Wavelength Fullframe is required.


Analyst, Method
Automated Output

Automated Output The formats of the Automated.Output tabs are identical for each sample
type except for standards. The tab for each sample type includes an
Apply.to.all.Sample.Types button to copy a template from one sample
type to another.

Note: If desired, the settings can be overridden using the Run dialog
box, which is presented when a sample is to be run. This is not
applicable for iTEVA Security unless the user has been granted the
Access Right “Override Method Parameters on Run”. 

Figure 4-23. Method, Automated Output

There are different types of samples which can be run:

Unknowns - These are the samples to be analyzed.

QC.Standards.- Quality control check samples.

Blanks - These are blank samples, not the calibration blanks. Every
time a sample blank is analyzed, all following unknowns will have this
value subtracted from them until the next sample blank is analyzed. To
enable this function, the Blank.Subtraction must be ticked in Method/
Report.Preferences. This can be applied post run via right click on the
samples and selecting Edit.Report.Options.


Analyst, Method
Automated Output

Standards - Calibration standards to generate the calibration graphs.

Recoveries - Recoveries are samples analyzed and checked against stored
values.

Spikes - Spikes can be used for Standard Addition.

TimeScans.- TimeScans are used for transient signals and often with
accessories like the Laser.

If you want to use the same output format for all sample types, click the
Apply.to.All.Sample.Types button. For each of the solutions the analyst
can set up a different template.

Automated Output, Unknowns The Automated.Output.for.Unknowns tab is accessed via the Automated.
Output command on the Method menu. It is used to indicate the
location(s) to which the data is to be sent. A window is presented for
each type of sample, as different output formats might be used for each
sample type.

Figure 4-24. Method, Automated Output dialog
Print.results - Prints results automatically after each analysis. If Print.
results is not selected, the analyst can print the results at any time after
the analysis. Data will be printed using the format selected in the
Method, Report Preferences window and the general print format for
the Print.Options tab of the iTEVA.Options dialog box.
Acquire.and.save.trailing.Fullframe.to.database - If this option is selected,
the Fullframe will be performed and the data will be stored. First, the


Analyst, Method
Automated Output

selected wavelength(s) will be analyzed and afterwards the Fullframe will
be taken.
Export.results.to.comma-delimited.text.file - Automatic export function.
The data will be exported after each sample. As soon as Export.results is
activated, the analyst can type in a Filename in the Export.Information.
There are two options available for the files, Append or Overwrite.
The data will be exported to a file using the name Append/Overwrite
selection described below.
Export.Filename.- This field is used to indicate the filename to be used
to store the data as a text file. The file will be stored in the directory
indicated in the Options tab of the iTEVA.Options dialog box. Sample
results can be converted to comma delimited information and sent to
remote destinations and the contents viewed using text or spreadsheet
software. Such exported results are convenient for transmission to
laboratory information management systems (LIMS).
A checkmark in the box next to “Export.Results.to.a.Comma.Delimited.
Text.File” will automatically convert each result to a text file, with each
field separated by commas. The data is then inserted into the export
filename displayed in the field at the bottom of the Automated.Output.
Screen.
The default storage mode for Export.Results is Append.
Append - If the Append selection is chosen, the data will be added to the
existing file.
Overwrite - If the Overwrite option is selected, data presently in the file
will be overwritten.
Note: At time of analysis, each Run dialog box provides a checkbox
for immediate selection of the auto-export feature. Run time selection
of the auto-export feature is limited to append mode only. The
filename found in the current method’s Automated Output will be
used. 
Save.results.to.database.- This field is used to indicate if you would like to
store the data from the method. You can indicate the library you would
like to save results to by creating a new one or using an existing library.
To create a new library, type the name in the field; to select an existing
library, access the dropdown menu.

Apply.to.all.Sample.Types - Is used if you want to copy what you have
selected for a given sample type to all sample types.

Note: An Intelli-Frame image requires more than 1 MB of disk space.
This option is not normally used for the analysis of routine samples,
because of storage limitations. 
Note: The analyst can set up different templates for each sample
type. The data for each individual sample type can be stored in a
different Library. New libraries are created by simply typing the new
name in the Library text field. 


Analyst, Method
Automated Output

Automated Output, Standards The template is only slightly different for Calibration.Standards, where
a Report can be automatically created after the calibration graphs have
been generated.

Figure 4-25. Method, Automated Output, Standards

Figure 4-26. Method, Automated Output, Standards
After.calibration,.automatically.print.a.calibration.plot.report?.- Check
this box for automatic print.
Include.standards.read.back - To include standards read back values, click
the box.

Note: The analyst can always print the report afterwards via the
Method, Print Options, if the option was not selected. 


Analyst, Method
Report Preferences

Report Preferences The Report.Preferences selection includes a tab for each sample type
(Unknowns,.QC.Standards,.Blanks,.Standards,.Recoveries and Spikes).
Each tab is used to indicate the type of information that should be
reported/stored for that sample type. The format for each sample type is
identical, but not all options are available for all sample types.

Figure 4-27. Method, Report Preferences
The Report.Preferences tabs are used for indicating the type of
information to be presented for each type of sample. As described
below, there are small differences for each sample type.

Report Preferences, Unknowns The Report.Preferences for.Unknowns tab is used to select the type of

Figure 4-28. Report Preferences, Unknowns


Analyst, Method
Report Preferences

information to be presented on the screen, on the written report and to
be exported.

Output Mode

Figure 4-29. Report Preferences, Unknowns, Output and Default View

Output.Mode - Used to indicate the nature of the data output as
Intensity,.Intensity.Ratio,.Standardized.Intensity.Ratio.and.Concentration.

Default.View - Used to indicate what data should be output Results.for.
all.Lines.or.Element.Averages.

In Concentration Output Mode, apply

Figure 4-30. Report Preferences, Unknowns, In Concentration Output
Mode, apply
The In.Concentration.Mode.Output, apply fields are used to indicate how
data should be treated when Concentration is selected as the Output.
Mode. In Concentration.Output.Mode, the following options can be
applied:

Print.Limits,.Significant.Figures,.Blank.Subtraction,.Line.Switching
and IECS.

Note: The various options that are required should be indicated with
a checkmark. If Limit Checking is selected, the dropdown menu will
list the Limit Checks that are incorporated in the method. This field is
not active if an output mode other than concentration is selected. 

Correction.Factor - If the correction factor is not a known or exact factor,
e.g. Factor 10, the analyst can click on the Question.Mark button, which
will open a new dialog box to calculate the correction factor.


Analyst, Method
Report Preferences

Figure 4-31. Report Preferences, Unknowns, Calculate Correction
Factor
Correction.Factor.Components.- Values can be entered, such as the
Sample.Weight, Nominal.Weight, Initial.Volume, Final.Volume and
Adjustment.Factor. This is particularly useful when working with oxides,
carbonates, etc., to display a final/total concentration.

Limit.Checking - If the analyst would like to carry out limit checking,
the box must be checked and the appropriate Limit.Check table selected.

Note: The Limit Check table is created in Method, Checks. 


Analyst, Method
Report Preferences

Screen Report, Print Report and Exported Report.

Figure 4-32. Report Preferences, Unknowns, Screen Report, Print
Report and Exported Report
The Screen.Report, Printed.Report and Exported.Report fields are used to
indicate the information to be included in the various reports.

The analyst can select which of the following options should be
included:
Average,.Statistics,.Repeats,.Errors,.Wavelength,.Int.Std..ref,.Print.units and
Checks.

Report Preferences, QC Standards
The Report.Preferences.for.QC.Standards tab is similar to that for
Unknowns except that the only Output.Mode selection is Concentration.
The Limit.Checking feature in the In.Concentration.Mode.Output, apply
field is disabled.

Report Preferences, Blanks
The Report.Preferences for.Blanks tab is similar to that for unknowns
except that the only Output.Mode selection is Concentration.

Report Preferences, Standards
The Report.Preferences.for.Standards tab is similar to that for Unknowns
except that the only Output.Mode selection is Intensity.Ratio and the
In.Concentration.Output Mode field selections are not active. The Print.
Units and Checks options are not available in the Report.Options fields.

Report Preferences, Recoveries
The Report.Preferences.for.Recoveries tab is similar to that for Unknowns
except that the only Output.Mode selection is Concentration.

Report Preferences, Spikes
The Report.Preferences for Spikes tab is similar to that for Unknowns
except that the only Output.Mode selection is Intensity.Ratio and the
In.Concentration.Mode.Output field selections are not active. The print
units field is required and the Checks are not available in the Report.
Options fields.


Analyst, Method
Checks

Checks The Checks window is used to create Quality.Control.Check tables,
Recoveries tables, Limit Check tables and Duplicate.Check tables, which
can be incorporated into the method.

Figure 4-33. Method, Checks
These tables are used to set limits for various activities. As an example, a
Quality.Control.Limit table is used to indicate the acceptable range for a
QC sample, and to indicate the limits for a warning or failure.

The general protocol for entering parameters for the various check types
is similar for each of the four protocols. The Checks window, is used to
select the check type to be established and to enter the parameters. This
window is opened by selecting Checks on the Method Workspace.

Figure 4-34. Checks Window

Checks window - Supplies three buttons for creating new checks,
duplicating checks and deleting existing checks.

New - To establish a new check protocol, click New to present the New.
Check.Table dialog box. The default Check.Type is QC and the default
Check.Name is QC-1.


Analyst, Method
Report Preferences

Figure 4-35. Checks, New Check Table

Duplicate - Allows an existing checks table to be duplicated. Enter the
New.Check.name in the dialog box.

Delete - Deletes an existing check table.

Check.Type field - Supplies a dropdown list of allowed check types
including QC,.Recovery, Limit.Check and Duplicates.


Analyst
Report Preferences

To change the check type, click the down arrow in the Check.Type field
to present a menu containing the four check types. When you select the
desired check type, some of the fields in the dialog box will change, as
described below.

Check.Name - This is an identifier that correlates the solution, values
and failure actions.

Range.Units field - This field is a dropdown list. Selection may be
Relative (+/-),.Relative.(%) or Absolute.

Default.Check.Ranges - Define upper and lower.limits for warning and
failure.

Where the check sample has a known value such as a QC or Recovery,
the known value is included.

Standard.Normalization.type - This is a dropdown list of provided failure
actions.

OK - When the entries are complete, clicking on OK will enter the
defined values into the method Check window for all analytical lines in
the method. A new table will be opened, which summarizes the Check
values that you have just entered.

Individual values for each line can be modified if desired.

Note: Only a QC check can initiate actions to be taken such as, Re-
calibrate, Repeat Sample Analyses, etc. Any other check type, such
as Recovery, Limit check or Duplicate can only pass or fail. 


Analyst, Method
Report Preferences

Check Type, QC Uses a check sample to determine that the concentrations of elements
in a specific sample are within the limits prescribed by the analyst. The
sample should be one that is well defined (i.e. the concentration of the
elements of interest is known with a high degree of accuracy) but it
need not be a standard.

Figure 4-37. Checks, QC Check Type
Warning.and.Failure.Limits.- When QC.Check is selected, the analyst
can select the Failure.limits, the Warning.limits and the expected value
for the parameter. The values entered via this dialog box refer to all
elements in the method.

Figure 4-38. Checks, Range Units
Range.Units.- The Range.Units can be set to Relative.+/-,.Relative.%, or
Absolute.


Analyst, Method
Report Preferences

Figure 4-39. Checks, Standard Normalization type
There are three options for normalization.

The global actions are set in Standard.Normalization type to either Slope,
None or Offset.

To change the normalization action for a particular element, click
on the cell in the Norm column and desired element row to view the
dropdown list shown in the figure above. Move the cursor to the desired
normalization function and click to accept.

None - This option will do nothing.

Slope - Will adjust the calibration curve re-slope value as displayed
in Method, Element, Fit, so that the instrument response for the
highlighted QC sample corresponds to its known concentration.

Offset - Will adjust the Y-intercept so that the instrument response for
the highlighted QC sample corresponds to its known concentration.

In the example shown in the figure below, the expected value of all
elements is 10.00. A warning will be issued if the reported value is
< 9.90 or > 10.10 and a failure will be issued if the reported value
is <9.80 or > 10.20. Since we have selected the Absolute.Range.Units
option, this could refer to a concentration range of 10.00 ppm +/- 0.10
for the warning and 10.00 +/- 0.20 for failure. At this stage, only one
value for each warning/failure can be entered.



Analyst, Method
Report Preferences

Note: This window is used to set specific values for each element
or remove an element from the test. You can click in the table matrix
itself and the values can be edited for each individual element. 

Note: Within the Method Checks, the analyst sets up the criteria
for passing or failing. Please note that the Actions to be taken if a
QC sample fails during an automated run are chosen in the Method,
Sequence Automation. 

To remove an element from the check, remove the checkmark from the
first column.

To change the Failure, Warning or Value fields, click the field and enter
the desired value.

Check Type, Recovery This is a type of quality control check in which an unknown sample
is spiked (an additional concentration of the element(s) of interest is
added and then reanalyzed). The analytical result should be the original
result plus the concentration of the added spike (the spike is then said
to be “100 % recovered”). In theory, any interference of a spectral or
chemical nature will cause the recovery of the spike to deviate (either
positively or negatively) from the ideal of 100 %.

Figure 4-41. Check Type, Recovery
When Recovery is selected on the New.Check.Table dialog box, the
Default.Check.Range fields are Low.Failure,.Low.Warning,.Spike,.High.
Warning and High.Failure. The range units are the same as for a QC
check. Selection of parameters in the Checks dialog box is identical to
that for QC.check, except for the Std.Normalization type. The Spike.
value is the concentration of the element(s) of interest that was added to
the sample.
To use the recovery function, you must first analyze an unknown, then
select Results/Run.Recovery and select the appropriate recovery check
table from the dropdown menu.


Analyst, Method
Report Preferences

Check Type, Limit Check These are applied to unknown samples. A limit check table contains a
list of elements along with a high and low acceptable result for each. A
result which falls above its high limit check, or below its low limit check
will be flagged. For example, if the high limit is set at the High.Standard
concentration, then a decision to dilute the sample can be made based
upon high results.

Figure 4-42. Check Type, Limit Check

When Limit.Check is selected on the New.Check.Table dialog box, the
Default.Check.Range fields are Low.Failure,.Low.Warning,.High.Warning
and High.Failure. The Range units are the same as for a QC.check.

Selection of parameters in the Checks dialog box is identical to that for
QC check.

Note: The Limit Check table can be activated for use in Method,
Report Preferences. 

Check Type, Duplicate This is used to determine if two (or more) analyses of a given sample
provide the same analytical result within a user-specified tolerance.

Figure 4-43. Check Type, Duplicate


Analyst, Method
Report Preferences

When Duplicate is selected on the New.Check.Table dialog box, the
Default.Check.Range fields are Low.Failure,.Low.Warning,.High.Warning
and High.Failure. The Range units are the same as for a QC check.
Selection of parameters in the Checks dialog box is identical to that for
QC check.

Note: To use the duplicate function, you must first analyze an
unknown, then select Results, Run Duplicate and select the
appropriate duplicate check table from the dropdown menu. 

Sequence Automation Sequence.Automation refers to the addition of a series of steps before,
during or after an analysis.

Figure 4-44. The Method Workspace, Sequence Automation

The Sequence.Automation feature is used to indicate the checks that
should be performed during an automated analysis and to indicate
the desired action if the test is not passed. A check can be performed
before, during or after a sequence is performed. The general protocol for
selecting Initial.Actions, Continuing.Actions and End.Actions is identical
(but the activities differ).

Operations which qualify the sample preparation, standards, method
and instrument may be required for every sequence of samples run and,
if so, should be completed under Initial.Actions operations. Blanks,
calibration checks, and recoveries are continuing actions that need to be
run frequently throughout the entire sequence of samples to ensure the
instrument is operating constantly within control.


Analyst, Method
Sequence Automation

Figure 4-45. Sequence Automation

Initial Actions

Figure 4-46. Method, Sequence Automation, Initial Actions


Analyst, Method
Sequence Automation

To establish an Initial.Action:

1. Click Add.Action to activate the next open line of the Initial.Actions
field.
Clicking on the Add button will add another entry into the
Continuing.Actions table.

2. Click on the Operation field to present a menu that includes the
available operations (Calibrate,.Standardize) and select the desired
operation.
3. Click on the Failure.Action field to present a menu that includes the
available options (None and Halt) and select the desired option.

Remove.Action - When one of the actions in a panel is highlighted
(click to select), the Remove.Action button becomes active. Clicking
on the Remove.Action button will remove the highlighted action from
the associated panel only. Placing the cursor on the number column
changes the cursor to a black arrow. The black arrow can be used with
Control and Shift keys to remove multiple actions.

Note: If the operation fails (e.g. the system cannot be calibrated
within defined limits) during the execution of the sequence and the
selected Failure Action is Halt, the sequence will stop. 

Continuing Actions

Figure 4-47. Method, Sequence Automation, Continuing Actions
Continuing.Actions - The Continuing.Actions field is used to enter
operations to be performed during the sequence. Continuing.Actions
have an application frequency that appears in the column labelled


Analyst, Method
Sequence Automation

Frequency. In the example displayed above QC-1 would be analyzed
after the 10th, 20th, 30th, etc. samples. Additionally, QC-1 would be
analyzed once after the last sample, regardless of the total number of
samples in the sequence.

QC samples are defined for each method in Method,.Checks. To change
an operation, click on it under Operation, move the cursor to the
desired action in the dropdown list, and click to select it.

The roles of the Operation and Failure.Action fields are similar to that for
Initial. The Frequency column is used to indicate the interval between
the each performance of the operation. As an example, if 10 is chosen,
the system will perform the desired operation after every 10 samples.

Note: Frequency defines how many samples are analyzed between
the QC samples. As a default, the frequency is set to 10, therefore the
QC sample will be run after every 10 samples. 

The only check operations that can be performed during a sequence are
QC.methods and the failure options are None and Normalize.

In case of a QC failure, the analyst can select one of the following
actions:

None - The sequence will continue operating. It flags the results but
otherwise ignores the failure, continuing the sequence.

Normalize - Normalizes as per the options set in the check table. The
system will change the report for samples that were run since the last
QC sample and continue. As an example, if the QC value for Fe was
increased by 0.13% since the last QC sample, the concentration of Fe
for all unknowns since the last QC check will be multiplied by 1.0013.

Note: Normalize has three options: none, offset and slope. This
function is defined separately for each analytical line in Method,
Checks. 

Note: During normalization, the concentrations from a QC standard
may be used to make a correction to one of the standardization
coefficients. A correction may be made to the standardization slope
or intercept, but not to both. This procedure may be viewed as a
single point re-standardization. Any time that a normalization is
performed, the coefficients are first reset to 1 (slope) and 0 (intercept)
before the new normalization factor is applied. That is, factors are
not repeatedly applied on top of previous factors. The normalization
method to use may be selected on an element-specific basis. 

Normalize,.Re-run.samples - Re-run all samples that were run since the
last acceptable QC check was run.


Analyst, Method
Sequence Automation

Standardize - Re-run the standard and generate a revised concentration/
system response curve. Standardize will run the re-slope standards, if
defined in Method,.Elements,.Standards. When the method has no re-
slope standards defined, the full calibration standards will be re-run.

Standardize,.Recheck.QC - Re-run the standard to generate a revised
concentration/system response curve and then run the QC sample.

Standardize,.Recheck.QC,.Re-run.Samples - Re-run the standard,
generate a revised concentration/system response curve, then run the
QC sample and then re-run all samples that were analyzed since the last
QC sample.

Halt - Stops sequence after failure occurs.

Note: Where the selection contains more than one failure action,
each action will be performed in the displayed order. 

End Actions

Figure 4-48. Method, Sequence Automation, End Actions
End.Actions - These are identical to the Initial.Actions field and the only
operations that can be performed are QC methods. The failure options
are:

None - There is no further action and the sequence is closed.

Invalidate.all.Results - Will invalidate the affected analytical results for
the samples in the sequence.

Halt - Stops sequence after failure occurs.


Analyst, Method
QC Properties

Global QC Properties

Figure 4-49. Method, Sequence Automation, Global QC Properties

Global.QC.Properties - The Global.QC.Properties field is used to indicate
what constitutes a failure and what the system should do when a failure
is observed.

Number.of.Failed.Lines.to.Fail.a.QC.Sample - If the analytical protocol
is such that the failure of one (or more) lines is acceptable, enter the
number of lines that must fail before a failure is reported. For example,
the analyst can define that a QC failure is only reported when four lines
fail. In this case, the run would continue if less than four wavelengths
have failed.

Maximum.QC.visits.per.tube location- During operation of a sequence,
this is the maximum number of times that a QC standard can be
withdrawn from the tube. The allowed number of QC visits per tube
avoids running out of QC solution during an automated run.

Restandardize.QC.failed.lines.only - The QC sample should be run again,
but only data for the lines that originally failed should be reported. It
will perform the failure actions on the subset of failed lines only. For the


Analyst, Method
Autosampler

same subset of lines, failed samples will be re-run, following successful
QC checks.

Continue.on.2nd.QC.Failure - Instructs the system to ignore the failure
if the system fails the QC test twice. It will then proceed with the
analysis sequence.

Sound.Alarm.on.1st.failure.(2nd.failure).5.sec - Used to indicate that the
alarm should be sounded for the indicated period of time. Sound.Alarm
provides audio support for operators working away from the computer
display. Selection and duration of alarms for first and second QC
failures are independent.

Autosampler The analyst can set the Standard.Rinse.Time for the system, select
Intelligent.Rinse and Sipper.Step.Ahead.

Figure 4-50. Method, Sequence Automation, Autosampler Options

Standard.Rinse.Time - A fixed rinse time can be set, e.g. 5 sec. The
autosampler will run a sample, then go to the rinse station for 5 seconds
before continuing to the next sample.
Intelligent.Rinse - The rinse time needed for a sample analysis is
usually based on the minimum time needed to rinse out the highest
concentration of an analyte that might be present in a sample. Many
sequences may never contain analytes at this level or may only contain
a few samples in that region. A long rinse time would be needed and
add extra time to the sample run even if it were not always necessary.
The ability to monitor samples and use only an appropriate rinse time
increases sample throughput. By monitoring the rinse station for carry
over, IRINSE can ensure that contamination from one sample to the
next does not occur.
The Intelligent.Rinse option is always grayed out initially. In order to
activate it, an IRINSE.Limit.table must be specified.


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