Early leukemia diagnostics startup called Immunoslide is developing a new device that can detect leukemia at an earlier stage through a simple blood test. The Immunoslide analyzes both the appearance and surface antigens of blood cells to identify abnormal cells 10 times more accurately than standard methods. This allows leukemia to be diagnosed when it is still at a preventable and treatable stage. Immunoslide tests will cost $6 each, compared to $10-30 for other methods, and the disposable devices require minimal equipment to operate. Clinical trials of the prototype show promise and the founders plan to partner with hospitals and laboratories for production and distribution.

1. Early leukemia diagnostics
Startup Village 14-05-2013
Andrey Senyut senyut@immunoslide.com

2. Leukemia
Leading cause of death among children under 15
250 000 deaths per year
350 000 new cases
per year

3. The disease is detected TOO LATE
Common methods of leukemia diagnostics are
NOT SENSITIVE ENOUGH
ONLY 4% are diagnosed at the stage of
preventive inspection
Problem

4. ImmunoSlide Affordable price
High accuracy

5. Immunoslide
Abnormal blood cells appear in a person’s blood stream when he has leukemia.
Pathological cells differ from normal ones by:
External appearance
(morphology)
Antigens on their surface
(immunophenotype)
There must be no cells with
“CD11C-”
antigen (special protein)
on their surface when a person is
healthy.
Common methods of leukemia diagnostics (blood smear) don’t deliver the data
about cell’s surface antigens.
Immunoslide allows doctor to receive data both on the external
appearance of blood cells and on the surface antigens of blood cells.
EXAMPLE
Pathological cells
EXAMPLE

6. Immunoslide
(disposable)
Device for an automated
analysis of immunoslide
+
Product
73% margin
200 000 rubles
15% margin
300 rubles per test

7. Immuno
Slide
Flow
cytometry
Immunocito
chemistry
Blood
smear
Morphological
analysis
(Cell
outlook
analysis)
++
-­‐-­‐
-­‐
+
Immunophenotyping
(Cell
surface
an?gens
analysis)
+
++
+
-­‐-­‐
Cost
of
one
test
6$
10
–
30$
20
–
40$
3$
Cost
of
equipment
7
000$
100
000$
-­‐
-­‐
Dura?on
of
analysis
1,5
hour
0,5
hour
3
hours
0,5
hour
Simplicity
of
exploita?on
+
-­‐-­‐
-­‐-­‐
+
Competitors

8. Overall market volume - 0.5 bln $
Russian market
PRIVATE MARKET
GOVERNMENTAL MARKET
revenue in 5 years – 30 mln $
Required investments 2 mln $

10. Fazly
Ataullakhanov,
Member
of
the
Na?onal
Biochemical
Society
of
Russia
(1975)
and
Member
of
the
Biophysical
Society
of
USA
(1997),
Editorial
board
of
“Biologicheskie
Membrany”
(1989),
Member
of
the
Science
Council
of
Ins?tute
for
Chemical
Biophysics
(1997),
Editorial
Board
of
Open
Journal
of
Structural
Biology,
Bentham
Pub,
USA
and
Journal
of
Biophysics
(open
access)
(2007),
Member
of
Academy
of
the
Natural
Sciences.
Igor
Pivovarov,
Member
of
execu?ve
boards
of
several
innova?ve
companies.
CEO
of
LLC
“HemaCore”,
the
joint
project
with
RUSNANO
venture
fund.
HemaCore
develops
the
unique
medical
equipment
for
precise
diagnos?cs
of
coagula?on
disorders.
Igor
has
5
year
work
experience
in
biotech
as
CTO,
CMO,
CEO.
Raised
about
660
mln.
rubles
of
investments.
Mentors

11. – winner of the grant START 2012

12. We are Skolkovo residents

13. Thank you for your attention!
mail@immunoslide.com
Q&A?

14. Sensi?ve
Y Y Y Y
An6gen
Immobilized
an6body
Blood
cell
Immunoslide
gives
10
TIMES
HIGHER
CHANCE
of
finding
leukemia
at
it’s
early
stage
Devise
for
early
leukemia
diagnos?cs.
Affordable
CD
4
CD
4
CD
8
CD
8
Immunoslide

15. 0
20,000
40,000
60,000
80,000
100,000
120,000
140,000
1
2
3
4
5
6
7
8
9
-­‐40000
-­‐20000
0
20000
40000
60000
80000
100000
120000
140000
1
2
3
4
5
6
7
8
9
-­‐20000
0
20000
40000
60000
80000
100000
120000
140000
160000
1
2
3
4
5
6
7
8
9
Thousands of rubles
half year
NPV = 41 mln rubles, r = 40%
IRR = 69%
PBP = 3.8 years
Required investments
54 mln rub
CF
CF without bringing in
investmnets
EBITDA
Financial forecast
Thousands of rubles
Thousands of rubles
half year
half year

16. Ready by 80%
Prototype
No manual labor required

17. D. Rogachev’s children’s hematological center
Governmental clinical and diagnostic laboratories
Private clinical and diagnostic laboratories
Morozov children’s hospital
Partners
Hematological science center