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Might-a-Mins® Spectrum Isotonix® Multivitamin provides children with the vitamins and minerals they need for optimal health. Many children do not obtain the necessary amounts of vitamins and minerals due to high consumption of processed foods, poor nutrient absorption and exposure to environmental toxins. Might-a-Mins Spectrum Isotonix Multivitamin provides children in need of neurological, metabolic or digestive support with a strong micronutrient foundation which promotes healthy development and supports optimal immune functions.
1. Isotonix
Might-a-Mins ®
Spectrum Multivitamin
Crystal H. Shelton
Research Associate
Scientific Affairs
2. Isotonix Might-a-Mins ®
Spectrum
Multivitamin
These statements have not been evaluated by the Food
and Drug Administration. This product is not intended to
diagnose, treat, cure or prevent any disease.
3. Important Ingredients for
Neurological, Metabolic and
Digestive Support
Folic Acid Vitamin A
Vitamin B6 (P5P) Zinc
Vitamin B12 Calcium
Vitamin B3 Magnesium
Vitamin C
4. Folinic Acid
Food sources include: Essential for numerous
Leafy green vegetables
processes in the body and
(like spinach and turnip supports the normal
greens), fruits (like citrus
fruits and juices), and development of the nervous
dried beans and peas are system
all natural sources of
folate
Folinic acid (tetrahydrofolic
acid)is the metabolically active
form of folic acid, high
bioavailability
5. Folinic Acid
Supports the conversion of sulfur-containing compounds to
glutathione, studies show low glutathione due to abnormalities
in methionine pathway
Antioxidant
Detoxification
Because of folic acid’s critical role in neurological function, it
can help to maintain healthy sleep quality, and help facilitate
the normal development of communication and social
interaction skills
11:1
6. Vitamin B6 (P5P or
Pyridoxine-5-Phosphate)
Food sources include: B6 is critical for the normal
Beans, meat, poultry, fish, development of language,
attention, alertness, etc.
and some fruits and
vegetables
To be used by the body, B6
must be converted to P5P in
Master vitamin for numerous
the liver
metabolic pathways in the
body
Pyridoxal-5-phosphate is the
active form of vitamin B6
7. B6 and Oxalates
Acts as a cofactor for enzymes that degrade
oxalates
Molecules present in many plants and fruit, all
seeds and nuts, grains
When the gut is leaky higher quantities of
oxalates are absorbed from foods
8. Vitamin B6 (P5P or
Pyridoxine-5-Phosphate)
Vitamin B6 is the most studied nutrient among
children with neuroglogical, metabolic and
digestive issues and is often given in
combination with magnesium.
B6 naturally requires extra magnesium to be
effective
11:1
9. Methylcobalamin (Vitamin
B12)
Food sources include: Promotes normal
Naturally found in foods that conversion of sulfur-
come from animals, including containing compounds to
fish, meat, poultry, eggs, milk, glutathione (antioxidant
and milk products and detox)
A water-soluble vitamin Vitamin B12 deficiency is
that supports normal commonly found in
nerve cell activity, DNA children with neurological,
replication, and metabolic and digestive
production of the mood- needs
affecting substance
SAMe (S-adenosyl-L-
methionine)
10. Methylcobalamin (Vitamin
B12)
Methylated form of B12, The most highly
evidence indicates reduced form of vitamin
methylcobalamin is utilized B12 possible
more efficiently than
cobalamin
Why Methylcobalamin?
Already metabolically
Methylcobalamin doesn't active
have to engage the body's
resources to convert it into
Maximally reduced
coenzyme form Less of a strain on our
bodies' antioxidant capacity
Methylcobalmin is closely 4:1
allied with the folic acid
biochemical pathway and
promotes normal
detoxification
11. Vitamin B3
(Niacin/Niacinamide)
Food sources include: A water-soluble vitamin
Beets, brewer's yeast, beef necessary for numerous
liver, beef kidney, pork, metabolic pathways in the
turkey, chicken, veal, fish, body
tuna, peanuts
Involved in pathways that
sustain and renew the
body’s tissues
10:1
12. Vitamin C
Water-soluble vitamin, also Cofactor for dopamine
known as ascorbic acid production, helps maintain
brain health
Food sources include: Vitamin C also promotes
Oranges, green peppers, glutathione levels, another
strawberries, other fruit, important antioxidant in the
tomatoes, broccoli
body
Promotes normal tissue 19:1
repair, bone healing, immune
function among other things
Proven antioxidant
13. Vitamin C
A large study by James et al. confirmed low glutathione levels
in children and associations with abnormalities in their
methionine pathway, i.e. increased oxidative stress
153 children studied for transmethylation and transulfuration
issue and 565 children evaluated for common polymorphic
variants known to modulate these pathways
James et al. Metabolic endophenotype and related genotypes are
associated with oxidative stress in children with autism. American
Journal of Medical Genetics. 141B(8):947-56, 2006.
Vitamin C supported red blood cell glutathione levels in
college students
Johnston et al. Vitamin C elevates red blood cell glutathione in healthy
adults. American Journal of Clinical Nutrition. 58(1):103-5, 1993.
14. Vitamin A (Beta-Carotene)
Essential vitamin – Powerful antioxidant
Beta-Carotene → retinal
form of vitamin A → retinol Vitamin A deficiency is
Food sources include: commonly found in children
Yellow and orange fruits
with neurological, metabolic
(carrots, papaya. mangos), and digestive needs
green leafy veggies (spinach)
19:1
Supports normal cell growth
and differentiation,
especially in tissues of the
gut and brain, helps
maintain vision and immune
functions
15. Zinc
Food sources include: Copper imbalance in children
Oysters, red meat, beans, is also associated with delayed
nuts, certain seafood, whole development, anti-social and
grains hyperactive behavior, learning
difficulties
An essential mineral
Because zinc helps facilitate
When zinc levels are down, the excretion of excess
copper levels are often copper, it is important to make
increased sure a multivitamin has an
adequate amount of zinc
Children who need
neurological or digestive
Avoid copper-containing
support often have an supplements
abnormal zinc to copper ratio
22:1
16. Calcium
Food sources include: Calcium supplementation
Dairy, milk, yogurt, cheese, may help to promote
green leafy vegetables normal oxalate absorption
Bind to dietary calcium and
is removed through the
This mineral promotes digestive tract and not
normal: absorbed
bone health
nerve transmission
It’s especially important to
muscle contraction
vasodilation supplement calcium in
enzyme reactions those on a casein-free
respiration diet
among many others
14:1
17. Magnesium
Food sources include: Combination of B6 and
Green vegetables (spinach), magnesium
legumes (beans and peas),
nuts and seeds
4.6:1 and 11:1
(combination)
Essential mineral
Supports the proper
functioning of many enzymes,
including those responsible
for the production of
neurotransmitters in the brain
18. Recent Multivitamin
Research
A small pilot study found that a strong, balanced multi-
vitamin/mineral supplement resulted in improvements in
sleep and promoted normal gut function in children, and
possibly in other areas
20 children ages 3-8 years old
Given a multivitamin/multimineral supplement for 3 months
Based on parental assessment, there were statistically significant
improvements in sleep and supported GI comfort
Also determined a functional need for more vitamin B6 and vitamin
C
Adams J et al. Pilot study of a moderate dose multivitamin/mineral
supplement for children with autistic spectrum disorder. Journal of
Alternative and Complementary Medicine. 10(6):1033-1039, 2004.
19. Conclusion
• The need for increased support in the areas of
neurology, metabolism and digestion is more prevalent
in our society than ever before, but there are proven
nutritional approaches that may help:
Recap of important ingredients:
Folinic acid
P5P (Vitamin B6)
Methylcobalamin
Vitamin C
Zinc
Calcium
Magnesium
22. Isotonix Might-a-Mins ®
Spectrum
Multivitamin
Helps to promote normal levels of vitamins and
minerals in individuals who need neurological,
digestive or metabolic support
Helps maintain the normal production of
neurotransmitters
Promotes/supports a healthy nervous system
Helps maintain brain health
Promotes a healthy development of sensory and
communication skills.
23. Isotonix Might-a-Mins ®
Spectrum
Multivitamin
Provides strong antioxidant defense
Combats free radicals
Promotes normal tissue and cell growth
Provides nutrients essential for numerous processes
in the body
Supports optimal immune functions
Supports skeletal health and growth
Supports healthy teeth and gums
Supports growth and strength of teeth and bones
Supports cognitive health and development
Supports healthy vision and eyes
Supports a healthy heart
24. References
Kidd P. Autism, an extreme challenge to integrative medicine. Part II: medical
management. Alternative Medicine Review. 7(6):472-499, 2002.
Adams J. Summary of Biomedical Treatments for Autism. Autism Research
Institute Publication. 40 (April), 2007.
Adams J et al. Pilot study of a moderate dose multivitamin/mineral supplement for
children with autistic spectrum disorder. Journal of Alternative and Complementary
Medicine. 10(6):1033-1039, 2004.
Megson M. Is autism a G-alpha protein defect reversible with natural vitamin A?
Medical Hypotheses. 54(6):979-983, 2000.
Lelord G et al. Effects of pyridoxine and magnesium on autistic symptoms: initial
observations. Journal of Autism Developmental Disorders. 11(2):219-229, 1981.
Martineau J et al. Effects of vitamin B6 on averaged evoked potential in infantile
autism. Biological Psychiatry. 16(7):627-641, 1981.
Martineau J et al. Vitamin B6, magnesium, and combined B6-Mg: therapeutic
effects in childhood autism. Biological Psychiatry. 20(5):467-478, 1985.
Lonsdale D et al. Treatment of autism spectrum children with thiamine
tetrahydrofurfuryl disulfide: A pilot study. Neuroendocrinology Letters. 23(4):303-
308, 2002.
Rimland B et al. The effect of high doses of vitamin B6 on autistic children: a
double-blind cross-over study. American Journal of Psychiatry. 135(4):472, 1978.
Rimland B. Vitamin B6 (and magnesium) in the treatment of autism. Autism
Research Review International. 1(4), 1987.
25. References
Dolske M. et al. A preliminary trial of ascorbic acid as supplemental therapy for autism.
Progress in Neuropsycho-pharmacology and Biological Psychiatry. 17(2):765-774, 1993.
Rimland B. Vitamin C in the Prevention and Treatment of Autism. Autism Research Review
International. 12:3, 1998.
Martineau J et al. Brief report: an open middle-term study of combined vitamin B6-
magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.
Journal of Autism and Developmental Disorders. 18:435-447, 1988.
Martineau J et al. Electrophysiological effects of fenfluramine or combined vitamin B6 and
magnesium on children with autistic behavior. Developmental Medicine and Child
Neurology. 31:728-736, 1989.
Audhya T. (2002, October). Laboratory indices of vitamin and mineral deficiency in autism.
Paper presented at the Defeat Autism Now! Conference, San Diego, California.
Angley M et al. Children and autism--Part 2--management with complementary medicines
and dietary interventions. Australian Family Physician. 36(10):827-30, 2007.
Levy S et al. Novel treatments for autistic spectrum disorders. Mental Retardation and
Developmental Disabilities Research Reviews. 11(2):131-42, 2005. Review.
Rimland B. Controversies in the treatment of autistic children: vitamin and drug therapy.
Journal of Child Neurology. 3 Suppl:S68-72, 1988.
Pfeiffer S et al. Efficacy of vitamin B6 and magnesium in the treatment of autism: a
methodology review and summary of outcomes. Journal of Autism and Developmental
Disorders. 25(5):481-93, 1995.
Kleijnen J and Knipschild P. Niacin and vitamin B6 in mental functioning: a review of
controlled trials in humans. Biological Psychiatry. 29(9):931-41, 1991.
26. References
Kotsanis C et al. Autism – A multidisciplinary approach to treatment. Study
Profile, DFW Ear, Nose & Throat Associates. Grapevine TX. No date given.
Levy A and Hyman S. Use of complementary and alternative treatments for
children with autistic spectrum disorders is increasing. Pediatric Annals. 32:685-
91, 2003.
Werbach M. Nutritional treatments for autism - nutritional influences on illness.
Townsend Letter for Doctors and Patients. October 2003.
Autism Research Institute. http://www.autism.com/ari/. Accessed May and June
2008.
Osendarp S et al. Effect of a 12-mo micronutrient intervention on learning and
memory in well-nourished and marginally nourished school-aged children: 2
parallel, randomized, placebo-controlled studies in Australia and Indonesia.
American Journal of Clinical Nutrition. 86(4):1082-93, 2007.
Mousain-Bosc M et al. Improvement of neurobehavioral disorders in children
supplemented with magnesium-vitamin B6. Magnesium Research. 19(1):53-62,
2006.
Moretti P et al. Cerebral folate deficiency with developmental delay, autism, and
response to folinic acid. Neurology. 64(6):1088-90, 2005.
Marlow M et al. Decreased magnesium in the hair of autistic children. Journal of
Orthomolecular Psychiatry. 13(2):117-122, 1984.
Editor's Notes
Thank you, Tanya. Various ingredients that have shown a role in helping those with neurological and digestive health issues. To date, there have been countless studies documenting these effects and, because it is such a hot topic, I am sure new studies are on the horizon. Some of those ingredients include (but are certainly not limited to), Read lists.
I’m sure many of you have heard of folic acid, an important B vitamin. The big question is does your child get enough folic acid…leafy greens, like spinach or turnip greens in his diet? Folic acid is a very important vitamin for many processes in the body, specifically for the nervous system. (give some specific examples)Folinic acid is the metabolically active form of folic acid, meaning one less step is required for it’s conversion in the body. Folic acid has to be activated but by using folinic acid, it’s more readily available. Folinic acid aids in the conversion of sulfur-containing compounds to glutathione, and glutathione is an antioxidant found in the body. Studies on folinic acid have shown improvements in sleep, communication, social interaction in those with neurological, metabolic and digestive needs . The Better-Worse ratio is 11:1, meaning supplementation with folic acid caused 11 children to get better for every one that got worse.
Another extremely important vitamin is vitamin B6. Food sources include beans, meat, poultry, fish, and some fruits and vegetables . Pyridoxal-5-phosphate is the active form of vitamin B6 and it has been shown that the conversion to P5P is problematic in some children. Some studies have shown a low activity of pyridoxal kinase, which is the enzyme required for the conversion to P5P . For this reason, it is best to only supplement with the P5P form. B6 is involved in the synthesis of neurotransmitters in the brain and peripheral nerve cells, which are critical for the development of language, attention, alertness, etc.
B6 also acts as a cofactor for enzymes that degrade oxalates. Oxalates are molecules that are present in many plants and fruits and almost every seed and nut. Becomes more of a problem when the gut is leaky, because higher quantities of oxalates will be absorbed from foods. B6 helps degrade oxalates so they are not absorbed. High oxalates can cause frequent urination, GI pain. Why is this important to this discussion? Because oxalates appear increased in the urine in certain individuals with impaired neurological function.
Read Slide - The combination of B6 and magnesium has been described by many as a “breakthrough intervention” for children with increased needs in brain and digestive health. Significant improvements in behavior, better eye contact, fewer tantrums, improved sleep patterns, better speech, etc., have been consistently reported using vitamin B6 and magnesium. You may wonder why does the combination of Vitamin B6 and magnesium have such an effect? B6 improves and supports nerve impulse conduction and blood flow in the brain. By the same token, magnesium, acts as a vasodilator, allowing for better circulation of oxygen and nutrients to the brain. These nutrient almost always lead back to brain health. B6 and magnesium combination has 11:1 B:W ratio
Vitamin B12 is naturally found in foods that come from animals, including fish, meat, poultry. It’s vitamin needed for many processes, including nerve cell activity, DNA replication. It’s best to use methylcobalamin, rather than cobalamin, as evidence indicates this form is utilized much more efficiently. Again, this vitamin is necessary for glutathione production. A vitamin B12 deficiency is common in children with neurological, metabolic and digestive needs. evidence for transmethylation defects
It’s best to use methylcobalamin, rather than cobalamin, as evidence indicates this form is utilized much more efficiently, especially in children with methylation defects . Every cell in the body expresses the folate/methionine cycle, defects in transmethylation can affect vital biochemical reactions at many places in metabolism. This is important, as some children do have methylation defects. So it makes sense to consume B12 in a form in which it's already metabolically active and maximally reduced, and thereby put less of a strain on our bodies' antioxidative capacity.
You’re all familiar with vitamin C, also known as ascorbic acid. Food sources include many fruits and vegetables. The vitamin is essential for tissue repair, wound and bone healing, immune function among it’s antioxidant capabilities. Vitamin C is also a cofactor for dopamine production which helps to maintain brain health, as dopamine has important roles in behavior and cognition, motivation and reward, sleep, mood, attention, and learning. It’s also helps elevate glutathione production. B:W Ratio – 19.1!!!
Vitamin C supported red blood cell glutathione levels by 50% in college students
Zinc is a mineral that can be found in the following food sources…oysters, red meat, beans, nuts and grains etc. is an essential mineral that is a component of more than 300 enzymes needed to repair wounds, synthesize proteins, aid in the development and maintenance of the brain, help cells reproduce, preserve vision, boost immunity, and protect against free radicals, among many other functions. It is a known fact that when zinc levels are down, copper levels are often increased. 90% of children with neurological and digestive needs have this abnormal zinc to copper ratio. Excess copper can lead to copper imbalance in the body and organs and copper imbalance in children is associated with delayed development, anti-social and hyperactive behavior, and learning difficulties. Because zinc helps facilitate the excretion of excess copper, it is important to make sure a multivitamin has an adequate amount of zinc. You should avoid copper-containing supplements for these children. Also, the B:W ratio for zinc is 22:1, even higher than that of vitamin C!
I know you’re all familiar with calcium and the many important functions it has in the body. Calcium sources are easy, milk cheese, green leafy veggies. We know calcium is good for everyone as it is an essential component of many processes in the body. Specifically, calcium has been shown to reduce oxalate absorption (oxalates are much higher in people with impaired neurological function). When calcium is taken with foods high in oxalates, the oxalic acid combines with the calcium to form calcium oxalate crystals which can be eliminated in the stool. This excretion through the stool prevents the oxalic acid from being absorbed into the body, binding with the calcium within the blood, forming calcium oxalate crystals there, resulting in urinary problems and pain . Also, calcium deficiency is common among these types children. Many of these individuals are on a casein-free (no milk) diet, so it’s especially important to supplement with calcium. The Better:Worse ratio for calcium is 14:1.
Magnesium is another mineral that you’re probably familiar with. Food sources include green vegetables, like spinach and beans and peas, among others. How many of you or your kids eat healthy amounts of spinach? Probably not very many. Magnesium is an essential mineral required by many enzymes to function properly, specifically those enzymes responsible for the production of neurotransmitters in the brain. As mentioned before, magnesium in combination with vitamin B6 has shown remarkable results among certain children, including improved communication and better social interaction. Magnesium in combination with B6 has been described as breakthrough intervention for children with neurological, metabolic and digestive needs.
In support of the use of these ingredients for certain children, Adams and others conducted a small pilot study using a strong, balanced multivitamin/multimineral formulation. 20 children ages 3-8 years old with neurological and digestive issues. This formulation included the P5P form of vitamin B6, magnesium, zinc, vitamin C, vitamin B12, calcium, among others. The results clearly indicated statistically significant improvements in sleep and GI health. They also determined a functional need for more B6 and vitamin C in these individuals.