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Paracetamol
Paracetamol is related to a category of medicines which is known as
painkillers or analgesics. It is used to get relieve from pain and fever
(high temperature) in children and adults. Paracetamol is easily available
in all retail medicine shops because it is a common painkiller.
A recent review published in UK magazine has revealed that now
doctors have strong medical proof to recommend paracetmol as the
finest treatments for patients suffering from acute pain which may be
triggered by inflammation from surgery, tissue damage and dental
exertion or any other injury. The study has shown that no other drug
gave all patients a high relief from pain except paracetamol. It was the
most efficient drug which aided more than 70% of patients where as the
other painkillers only gave 14 % relief.
Paracetamol powder is white crystalline in nature which has been
available in chemist shops in sachets. Chemical suppliers supply
acetaminophen powder to pharmaceutical scientists, chemistry students,
educational institutions, biochemists, medical institutions,
pharmacologists, toxicologists and medical students.
Paracetamol drug is produced by numerous pharmaceutical
manufacturers with a unique brand name of their product. In few
countries, paracetamol is recognized as acetaminophen. It is available in
tablet, capsule, soluble tablets, suppositories, powder form and oral
suspension. Paracetamol is also available in liquid form which is
particularly aimed for children treatment. It is available in the form of
tablets, capsules, injection and syrup. You can buy Paracetamol
powder available in sachet.
Acetaminophen is the
common name for
paracetamol easily
available over-the-counter
and prescription
medications. It is
advisable that one must
check product labels to
make sure that he/she
takes only single dose of paracetamol. One should avoid paracetamol if
he/she consumes more than three drinks of alcohol because
acetaminophen lowers your body’s tolerance which can result into
further harm to your liver.
Many companies
manufacture the
medicines containing
Paracetamol and these
medicines mostly used for
cold and flu remedies. It
is also used to alleviate
headache, body ache,
tooth pain, muscle pain,
backache, arthritis etc.
Before taking the Paracetamol always keep in mind that an overdose of
Paracetamol can cause serious harm. The highest quantity of
Paracetamol for adults is 1 gram per dose and per day its amount should
not exceed from 4 grams. If you are medicating a child, never use
Paracetamol tablet. You must use paracetamol in the form of syrup or
drops. You must carefully follow the instruction and dosage directions
given by the paediatrician. If your child younger than 5 years, you must
consult a doctor before giving any medicine otherwise it can harm your
child. You can also buy Paracetamol powder which can also be used
for the same purpose.
You should keep Paracetamol away from moisture and heat in order to
preserve it. You keep it normal room temperature but away from the
reach of children. The syrup or drop can be stored in the refrigerator.
The chemical analysis related with paracetamol may vary depending on
the quantity and also accurate treatment procedure. In most of the cases,
significant hepatic necrosis induces intensity hepatic failure by means of
difficulties like hypoglycaemia, sepsis, hepatic encephalopathy, internal
bleeding, renal disaster, cerebral oedema, various other malfunction,
plus death within few months.
To avoid Paracetamol poisoning or any other side effect, before
consuming it, carefully read the manufacturer's printed detail on the
leaflet. The manufacturer's leaflet provides you exact information related
to paracetamol and it also contains a complete list of the side-effects
which you may get after taking it. Take Paracetamol exactly as you have
been suggested by your doctors or pharmacist. To know the exact
dosage, you can also read the label of the bottle.
It is an effective analgesic alone or in combination. It is also an
antipyretic which is usually found as a 500 mg tablet, but it is often
mixed with other chemical ingredients in numerous preparations.
After about 10-60 minutes of oral administration of paracetamol, it gets
absorbed in the gastrointestinal tract together with peak plasma
concentrations. Paracetamol gets circulated into body tissues
immediately. Plasma protein is negligible at normal remedial doses but it
starts increasing as the doses increase. Paracetamol is metabolized
(organic process essential for life) comprehensively in the liver and
emitted out in the urine majorly as waste sulfate conjugates and
glucuronide.
Paracetamol includes
metabolites which are
negligible
hydroxylated
transitional which
have hepatotoxic
action. This
transitional
metabolite is
detoxified by
combination with glutathione, though it can gather more than 150mg/kg
or 10g total paracetamol consumed (overdose), but if left untreated, it
can result into permanent liver damage. Premature infants, infants,
newborns, and young children compared with adults, paracetamol gets
metabolized differently, and the sulfate conjugate remains significant.
As per mechanism process of paracetamol, it is a p-aminophenol product
that shows antipyretic and analgesic action. It does not have anti-
inflammatory action. It is considered to generate analgesia via a middle
prostaglandin synthesis inhibition.
Paracetamol side effects are uncommon and normally mild, however
haematological reaction (related with blood producing organs) have
been reported. Hypersensitivity and skin reactions are observed rarely. If
the overdose of paracetamol is not treated in time, it can cause severe
and sometimes serious liver damage and occasionally, delicate renal
tubular necrosis.
Overdose of Paracetamol could damage your liver. If you have liver
disease or you take over three alcoholic drinks per day, you must consult
your doctor before taking Paracetamol. Make sure that you are not
consuming more than one medicine containing Paracetamol. If you are
prescribed to take this medicine (Paracetamol), avoid drinking alcohol as
it may induce the chances of liver damage. If you are allergic to
Acetaminophen or Paracetamol, you should not take any medicine
containing Paracetamol. Also, If you are pregnant and do not want to
harm your unborn child, you must ask your doctor before taking
Paracetamol.
Overdose of paracetamol may cause liver malfunction. This can also
result into
 Vomiting and nausea that may last for around 24 hours.
 Hypoglycaemia (low blood sugar level)
 Haemorrhage (bleeding)
 Cerebral Oedema (fluid on the brain)
 Encephalopathy (related with brain function)
You should stop taking Paracetamol and consult your doctor in the
following cases-
 If you noticing some skin rashes, swelling, redness, inflammation
or ongoing headache.
 If you still have fever (high temperature) after the use of
Paracetamol for continuously three days.
 If your pain is not alleviated even after the use of Paracetamol for
seven days. (5 days in case of child).

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Things to know about Paracetamol

  • 1. Paracetamol Paracetamol is related to a category of medicines which is known as painkillers or analgesics. It is used to get relieve from pain and fever (high temperature) in children and adults. Paracetamol is easily available in all retail medicine shops because it is a common painkiller. A recent review published in UK magazine has revealed that now doctors have strong medical proof to recommend paracetmol as the finest treatments for patients suffering from acute pain which may be triggered by inflammation from surgery, tissue damage and dental exertion or any other injury. The study has shown that no other drug gave all patients a high relief from pain except paracetamol. It was the most efficient drug which aided more than 70% of patients where as the other painkillers only gave 14 % relief. Paracetamol powder is white crystalline in nature which has been available in chemist shops in sachets. Chemical suppliers supply acetaminophen powder to pharmaceutical scientists, chemistry students, educational institutions, biochemists, medical institutions, pharmacologists, toxicologists and medical students. Paracetamol drug is produced by numerous pharmaceutical manufacturers with a unique brand name of their product. In few countries, paracetamol is recognized as acetaminophen. It is available in tablet, capsule, soluble tablets, suppositories, powder form and oral suspension. Paracetamol is also available in liquid form which is particularly aimed for children treatment. It is available in the form of tablets, capsules, injection and syrup. You can buy Paracetamol powder available in sachet.
  • 2. Acetaminophen is the common name for paracetamol easily available over-the-counter and prescription medications. It is advisable that one must check product labels to make sure that he/she takes only single dose of paracetamol. One should avoid paracetamol if he/she consumes more than three drinks of alcohol because acetaminophen lowers your body’s tolerance which can result into further harm to your liver. Many companies manufacture the medicines containing Paracetamol and these medicines mostly used for cold and flu remedies. It is also used to alleviate headache, body ache, tooth pain, muscle pain, backache, arthritis etc. Before taking the Paracetamol always keep in mind that an overdose of Paracetamol can cause serious harm. The highest quantity of Paracetamol for adults is 1 gram per dose and per day its amount should not exceed from 4 grams. If you are medicating a child, never use Paracetamol tablet. You must use paracetamol in the form of syrup or
  • 3. drops. You must carefully follow the instruction and dosage directions given by the paediatrician. If your child younger than 5 years, you must consult a doctor before giving any medicine otherwise it can harm your child. You can also buy Paracetamol powder which can also be used for the same purpose. You should keep Paracetamol away from moisture and heat in order to preserve it. You keep it normal room temperature but away from the reach of children. The syrup or drop can be stored in the refrigerator. The chemical analysis related with paracetamol may vary depending on the quantity and also accurate treatment procedure. In most of the cases, significant hepatic necrosis induces intensity hepatic failure by means of difficulties like hypoglycaemia, sepsis, hepatic encephalopathy, internal bleeding, renal disaster, cerebral oedema, various other malfunction, plus death within few months. To avoid Paracetamol poisoning or any other side effect, before consuming it, carefully read the manufacturer's printed detail on the leaflet. The manufacturer's leaflet provides you exact information related to paracetamol and it also contains a complete list of the side-effects which you may get after taking it. Take Paracetamol exactly as you have been suggested by your doctors or pharmacist. To know the exact dosage, you can also read the label of the bottle. It is an effective analgesic alone or in combination. It is also an antipyretic which is usually found as a 500 mg tablet, but it is often mixed with other chemical ingredients in numerous preparations. After about 10-60 minutes of oral administration of paracetamol, it gets absorbed in the gastrointestinal tract together with peak plasma concentrations. Paracetamol gets circulated into body tissues immediately. Plasma protein is negligible at normal remedial doses but it
  • 4. starts increasing as the doses increase. Paracetamol is metabolized (organic process essential for life) comprehensively in the liver and emitted out in the urine majorly as waste sulfate conjugates and glucuronide. Paracetamol includes metabolites which are negligible hydroxylated transitional which have hepatotoxic action. This transitional metabolite is detoxified by combination with glutathione, though it can gather more than 150mg/kg or 10g total paracetamol consumed (overdose), but if left untreated, it can result into permanent liver damage. Premature infants, infants, newborns, and young children compared with adults, paracetamol gets metabolized differently, and the sulfate conjugate remains significant. As per mechanism process of paracetamol, it is a p-aminophenol product that shows antipyretic and analgesic action. It does not have anti- inflammatory action. It is considered to generate analgesia via a middle prostaglandin synthesis inhibition. Paracetamol side effects are uncommon and normally mild, however haematological reaction (related with blood producing organs) have been reported. Hypersensitivity and skin reactions are observed rarely. If the overdose of paracetamol is not treated in time, it can cause severe and sometimes serious liver damage and occasionally, delicate renal tubular necrosis.
  • 5. Overdose of Paracetamol could damage your liver. If you have liver disease or you take over three alcoholic drinks per day, you must consult your doctor before taking Paracetamol. Make sure that you are not consuming more than one medicine containing Paracetamol. If you are prescribed to take this medicine (Paracetamol), avoid drinking alcohol as it may induce the chances of liver damage. If you are allergic to Acetaminophen or Paracetamol, you should not take any medicine containing Paracetamol. Also, If you are pregnant and do not want to harm your unborn child, you must ask your doctor before taking Paracetamol. Overdose of paracetamol may cause liver malfunction. This can also result into  Vomiting and nausea that may last for around 24 hours.  Hypoglycaemia (low blood sugar level)  Haemorrhage (bleeding)  Cerebral Oedema (fluid on the brain)  Encephalopathy (related with brain function) You should stop taking Paracetamol and consult your doctor in the following cases-  If you noticing some skin rashes, swelling, redness, inflammation or ongoing headache.  If you still have fever (high temperature) after the use of Paracetamol for continuously three days.  If your pain is not alleviated even after the use of Paracetamol for seven days. (5 days in case of child).