1. What are the main factors involved in the development of AD in people with DS?
neurodevelopmental alterations general chronic alterations
• structural (e.g., spine pathology, (several genes/aneuploidy)
synaptic alterations, etc) (e.g., ox stress/mitoch dysfunction,
• cognitive (ID) altered immune response/inflammation)
altered expression of
specific genes
(e.g., APP, RCAN1, SOD1, etc)
DS AD
protective factors?