3. Outperforms Traditional Ultra-High Performance,
p.27 Fully Porous Columns p.02 Low Backpressure
Replace 3 µm
p.20 Wide Applicability p.04 and 5 µm Columns
PERFORMANCE
Advanced in Every Way
1
Complementary and Increase Resolution
p.16 Orthogonal Selectivities p.06 and Maximize Throughput
p.14 Solvent Savings p.08 Easier Method Transfer
p.12 Long Column Lifetime p.10 Increase Sensitivity
PHENOMENEX | WEB: www.phenomenex.com
4. Ultra-High Backpressure,
Low Backpressure Not Required
sub-2 µm Efficiency
™
With the efficiency of a sub-2 µm column and typical operating backpressure less
than 400 bar†, you can achieve the promise of UHPLC on any LC system.
18165 18166
Sub-2 µm N = 272,080 p/m Kinetex™ N = 267,720 p/m
> 400 bar! < 300 bar!
PERFORMANCE
mV mV
1 1
400 Method cannot transfer to 400 Easier method transfer
a non-UHPLC instrument to ANY system
2 4
4 2
2 3
200 3 200
App ID 18165
App ID 18166
0 0
0 1 2 min 0 1 2 min
Conditions for both columns
Column: Kinetex 2.6 µm C18
Traditional 1.7 µm C18
Dimensions: 50 x 2.1 mm
Mobile Phase: Acetonitrile / Water (50:50)
Flow Rate: 0.6 mL/min
Temperature: 25 °C
Detection: UV @ 254 nm
Instrument: *Waters® ACQUITY® UPLC®
Sample: 0.5 µL test mixture
1. Acetophenone
2. Benzene
3. Toluene
4. Naphthalene
†
Kinetex 2.6 µm columns are pressure rated to 600 bar use on both HPLC and UHPLC instrumentation.
* ACQUITY and UPLC are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation.
Comparative separations may not be representative of all applications.
PHENOMENEX | WEB: www.phenomenex.com
5. 2x Efficiency
of Traditional 3 µm Columns
Replace traditional 3 µm or 5 µm analytical columns with Kinetex™ 2.6 µm core-
shell columns for immediate performance improvements in efficiency, speed,
resolution, and sensitivity. Optimize methods for UHPLC performance and transfer
them to any system.
18628
3 µm N = 166,502 p/m 18539
Kinetex™
N = 295,343 p/m
PERFORMANCE
mV mV
240 240
210 210 4
180 180
3
150 150
3
120 4 App ID 18628 120
App ID 18539
2
90 3 90
2
60 60
1
30 1 30
0 0
0 2 4 min 0 2 4 min
Conditions for both columns
Column: Kinetex 2.6 µm C18
Traditional 3 µm C18
Dimensions: 150 x 4.6 mm
Mobile Phase: Acetonitrile / Water (70:30)
Flow Rate: 1.8 mL/min
Temperature: 25 °C
Backpressure: 380 bar (Kinetex)
250 bar (Traditional 3 µm)
Detection: UV @ 254 nm
Instrument: Agilent 1200SL
Sample: 1. Uracil
2. Acetophenone
3. Toluene
4. Naphthalene
Comparative separations may not be representative of all applications.
PHENOMENEX | WEB: www.phenomenex.com
6. Replace 3 µm and 5 µm Columns 18514
For Improved Speed, Resolution, and Sensitivity
Unlike traditionally fully porous particles, higher-pressure capable instru- mAU 1
ments are not required with Kinetex 2.6 µm core-shell technology to
™
achieve ultra-high performance chromatography. Generating much 6
lower backpressure (< 400 bar) at optimal linear velocities, you can now 3
achieve 2-3x the column efficiencies of traditional fully porous 3 µm and
5 µm columns on any LC instrument. Use that extra efficiency to improve
5
the resolution of a critical pair or consider decreasing your column length
for higher throughput. 4
PERFORMANCE
2
18514
Optimization of Atenolol EP Method EP Specified 5 µm C18 Column
3
This EP (European Pharmacopoeia [Ph. Eur.]) monograph is an impurity
1
4
profile that uses an isocratic method. As shown to the right, Kinetex™
mAU
*Waters® Symmetry® 4
4
core-shell technology columns allow you to shorten the run time to less
6
3 25 µm C18
than 11 minutes and still maintain the resolution of all impurities. 5
4
2 1
3
5
4
0
App ID 18514
2
6
1
5 8
7
0
0 5 10
0 5 10 15 20 25 30 35 40 min
Dimensions: 150 x 3.9 mm
Mobile Phase: 12.5 mM Phosphoric acid in Water, pH 3.0 + 2.0 g Sodium
Octanesulfonate + 0.8 g Tetrabutyl Ammonium Hydrogen
Sulfate / Methanol / THF (80:18:2)
Flow Rate: 0.6 mL/min
Temperature: 22 ºC
Detection: UV @ 226 nm
Sample: Atenolol Related Substance
1. Impurity B 5. Impurities D and E
2. Impurity A 6. Impurity F
3. Impurity J 7. Impurity G
4. Impurity I 8. Impurity H
* Waters and Symmetry are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters
Corporation.Comparative separations may not be representative of all applications.
PHENOMENEX | WEB: www.phenomenex.com
7. mAU 1 3
6
2
5
4
4 ™
18516 Substitute* with Kinetex C18 4
mAU 1 3
3
6
2 18517 Improved Resolution
5
4
4
2 6
and Higher Sensitivity
3 8
mAU 1 6 5
Column: Kinetex 2.6 µm C18
7
App ID 18516
2 Dimensions: 150 x 4.6 mm
8 Part No.: 00F-4462-E0
5
1
6 7
Flow Rate: 0.6 mL/min
0
0
0 5 10 5 20
15 25 30 35 min
Increase Flow Rate
4 0 5 10 15 20 25 30 35 min
PERFORMANCE
18517 4
mAU
3
30 %
6
5 Conditions are same except as noted
2
Kinetex™
Mobile Phase: 12.5 mM Phosphoric acid in Water, pH 3.0 + 2.0 g Sodium
4 Faster Analysis
6
18519
3
Octanesulfonate + 0.8 g Tetrabutyl Ammonium Hydrogen
Sulfate / Methanol / THF (80:18:2) 5
1 Column:
5
Kinetex 2.6 µm C18 Temperature: 22 ºC 8
2
6 App ID 18517
Dimensions:
Part No.:
150 x 4.6 mm
00F-4462-E0 7
Detection: UV @ 226 nm
1 mAU
5 7
8
Flow Rate: 0.8 mL/min
Sample: Atenolol Related Substance
1. Impurity B 5. Impurities D and E
0
6
0 2. Impurity A
3. Impurity J
6. Impurity F
7. Impurity G
4. Impurity I 8. Impurity H
0 5 10 15 20 25 30 35 min
5
Decrease Column Length‡
18519 4 0 5
4 10 15 20 25 3
mAU
6
3 66 %
5
Higher Throughput than
4
2 Original EP Method
3
1 Column: Kinetex 2.6 µm C18
App ID 18519
2 Dimensions: 100 x 4.6 mm
6 8 Part No.: 00D-4462-E0
1
5 0
7 Flow Rate: 1.0 mL/min
0
0 5 10 15 20 25 30 35 min
0 5 10 15
* Decrease in column particle within allowable EP and USP pharma particles size change (+/- 50 %)
‡
Decrease in column particle within allowable EP and USP column length change (+/- 50 %)
PHENOMENEX | WEB: www.phenomenex.com
8. Decrease Run Time
Increase Resolution
In the past, the options for fast LC were limited to costly system up- the promise of UHPLC performance via dramatically faster analysis with
grades, compromises in column performance or only modest improve- similar or better resolution on any LC platform.
ments in throughput. Now, Kinetex ™
core-shell technology delivers on
18280 18277
5 µm Kinetex™
Rs10,11 = 3.11 Rs10,11 = 4.96
1
18277
PERFORMANCE
6
4 6
4
1
2 8
1
9
6 8
3 4 9
11
App ID 18280
5 3 11
App ID 18277
6 2
8
7 5
9
10 3 11
2 7
5
12 10 12
13 13
7
10 12
™ 13
0 20 40 60 min 0 2 4 6 8 min
0 2 4 6 8 min
Column: Traditional 5 µm C18 Column: Kinetex 2.6 µm C18
Dimensions: 250 x 4.6 mm Dimensions: 100 x 4.6 mm 1
Mobile Phase: A: Water Part No.: 00D-4462-E0 1
B: Acetonitrile Mobile Phase: A: Water
Gradient: Time (min) %B Time (min) %B B: Acetonitrile 6
64
0 5 66 95 Gradient: Time (min) %B Time (min) %B 4
4.78 5 66.01 5 0 5 8.2 95
51.52 95 86.38 5 0.65 5 8.21 5 8 8
Flow Rate: 0.714 mL/min 7.01 95 10.97 5 9 9
Temperature: 45 °C Flow Rate: 2.1 mL/min 23 253
11 11
Detection: UV @ 258 nm Temperature: 45 °C
Sample: 1. Acetone 8. Hexanophenone Detection: UV @ 258 nm
5
2. 2-Butanone 9. Octanophenone Backpressure: 360 bar 7
10
7
3. 2-Pentanone 10. 2-Tridecanone Sample: 1. Acetone 8. Hexanophenone 12 10
4. Acetophenone 11. Decanophenone 2. 2-Butanone 9. Octanophenone 13 12
5. 2-Heptanone 12. 2-Pentadecanone 3. 2-Pentanone 10. 2-Tridecanone 13
6. Butyrophenone 13. 2-Hexadecanone 4. Acetophenone 11. Decanophenone
7. 2-Nonanone 5. 2-Heptanone 12. 2-Pentadecanone 0 Original min
8
6. Butyrophenone 13. 2-Hexadecanone
7. 2-Nonanone 0 8 min
PHENOMENEX | WEB: www.phenomenex.com
9. Decrease Run Time
Maximize Throughput
For the ultimate sample throughput demands, Kinetex™ columns provide of 13 ketones, a 20-fold increase in productivity is accomplished while still
the efficiency needed to significantly reduce run times. In this separation maintaining resolution.
< 3 min
18276
> 60 min
18280
5 µm Kinetex™
Rs10,11 = 3.11 Resolution maintained
Rs10,11 = 3.12
6
PERFORMANCE
™
4 1 ™ ™ ™
8 6
2 4
1
9
3 8
11 3
App ID 18280
5 9
App ID 18276
2 5 7
7 11
10 7
12 10 12
13 13
™ ™
™
™
0 20 40 60 min 0 1 2 min
Column: Traditional 5 µm C18 Column: Kinetex 2.6 µm C18
Dimensions: 250 x 4.6 mm Dimensions: 50 x 4.6 mm
Mobile Phase: A: Water Part No.: 00B-4462-E0
B: Acetonitrile Mobile Phase: A: Water
Gradient: Time (min) %B Time (min) %B B: Acetonitrile
0 5 66 95 Gradient: Time (min) %B Time (min) %B
4.78 5 66.01 5 0 5 2.75 95
51.52 95 86.38 5 0.23 5 2.76 5
Flow Rate: 0.714 mL/min 2.19 95 3.61 5
Temperature: 45 °C Flow Rate: 3.4 mL/min
Detection: UV @ 258 nm Temperature: 45 °C
Sample: 1. Acetone 8. Hexanophenone Detection: UV @ 258 nm
2. 2-Butanone 9. Octanophenone Backpressure: 350 bar
3. 2-Pentanone 10. 2-Tridecanone Sample: 1. Acetone 8. Hexanophenone
4. Acetophenone 11. Decanophenone 2. 2-Butanone 9. Octanophenone
5. 2-Heptanone 12. 2-Pentadecanone 3. 2-Pentanone 10. 2-Tridecanone
6. Butyrophenone 13. 2-Hexadecanone 4. Acetophenone 11. Decanophenone
7. 2-Nonanone 5. 2-Heptanone 12. 2-Pentadecanone
6. Butyrophenone 13. 2-Hexadecanone
7. 2-Nonanone
Comparative separations may not be representative of all applications.
PHENOMENEX | WEB: www.phenomenex.com
10. Easier Method Transfer
to ANY LC System
Kinetex™ 4.6 mm ID UHPLC methods developed with fully porous sub-2 µm columns
on Agilent 1100 often generate backpressure higher than HPLC system limita-
tions. With Kinetex™ 2.6 µm core-shell technology, you are no
4 longer restricted from developing high performance LC methods
on any instrument and transferring them anywhere.
3 Column: Kinetex 2.6 µm C18
Dimensions: 50 x 4.6 mm
Part No.: 00B-4462-E0
Mobile Phase: Acetonitrile / Water (50:50)
App ID 18565
2 Flow Rate: 2.35 mL/min
PERFORMANCE
Temperature: Ambient
Detection: UV @ 254 nm
1 Sample: 1. Uracil
2. Acetophenone
3. Toluene
4. Naphthalene
0 1 2 min
8
Kinetex™ 2.1 mm ID
on Agilent 1200SL
4
2 3 Column: Kinetex 2.6 µm C18
Dimensions: 50 x 2.1 mm
Part No.: 00B-4462-AN
Mobile Phase: Acetonitrile / Water (50:50)
Flow Rate: 0.49 mL/min
App ID 18566
Temperature: Ambient
Detection: UV @ 254 nm
1 Sample: 1. Uracil
2. Acetophenone
3. Toluene
4. Naphthalene
0 1 2 min
PHENOMENEX | WEB: www.phenomenex.com
11. In these examples different internal diameters of Kinetex™ Kinetex™ 3.0 mm ID
18567
columns are used on various systems to illustrate the versa- on *Shimadzu Prominence™ UFLCXR™
tility of Kinetex™ core-shell technology. Please note the flow
4
rates are scaled to maintain the same linear velocity.
2 3
Column: Kinetex 2.6 µm C18
Dimensions: 50 x 3.0 mm
Part No.: 00B-4462-Y0
Mobile Phase: Acetonitrile / Water (50:50)
Flow Rate: 1.0 mL/min
App ID 18567
PERFORMANCE
Temperature: Ambient
Detection: UV @ 254 nm
Sample: 1. Uracil
1
2. Acetophenone
3. Toluene
4. Naphthalene
0 1 2 min
9
18568
Kinetex™ 2.1 mm ID
on *Waters® ACqUIty® UPLC®
2
3
Column: Kinetex 2.6 µm C18 4
Dimensions: 50 x 2.1 mm
Part No.: 00B-4462-AN
Mobile Phase: Acetonitrile / Water (50:50)
App ID 18568
Flow Rate: 0.49 mL/min
Temperature: Ambient
Detection: UV @ 254 nm 1
Sample: 1. Uracil
2. Acetophenone
3. Toluene
4. Naphthalene
0 1 2 min
* ACQUITY and UPLC are registered trademarks of Waters Corporation. Prominence and UFLC are trademarks of Shimadzu
Corporation. Phenomenex is not affiliated with Agilent Technologies or the above companies.
PHENOMENEX | WEB: www.phenomenex.com
12. Increase Sensitivity 18221 18220
mV
The combination of the small particle size, narrow 1000
Kinetex™ 2.6 µm C18
particle size distribution, and the significantly shorter Traditional 3 µm C18
1
diffusion path results in much higher column efficien- 800
1
PERFORMANCE
cies and increased chromatographic resolution. The
600
increased efficiencies provide an immediate benefit on
App ID 18220 and 18221
sensitivity since higher chromatographic efficiencies 2
400 3
translate into significantly narrower and taller peaks, 4
2
10 making it easier to detect low level impurities. ™ 3
200 4
0
0 1 min
Conditions same except where noted:
Dimensions: 50 x 2.1 mm (Kinetex)
50 x 2.0 mm (Traditional)
Mobile Phase: Acetonitrile / Water (50:50)
Flow Rate: 0.5 mL/min
Temperature: 25 °C
Instrument: Waters® ACQUITY® UPLC®
Detection: UV @ 254 nm
Sample: 1. Acetophenone
2. Benzene
3. Toluene
4. Naphthalene
* ACQUITY and UPLC are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation.
Comparative separations may not be representative of all applications.
PHENOMENEX | WEB: www.phenomenex.com
13. Improved
Resolution and Sensitivity Comparison
18262 18263
*ZORbAX® 3.5 µm Sb-C18 Kinetex™ 2.6 µm C18
mAU mAU
0.8 0.8
0.6 0.6
PERFORMANCE
0.4 0.4
0.2 0.2
App ID 18262
App ID 18263
11
0.0 0.0
4 6 min
4 6 min
Dimensions: 150 x 4.6 mm Dimensions: 150 x 4.6 mm
Mobile Phase: A: Water Part No.: 00F-4462-E0
B: Acetonitrile Mobile Phase: A: Water
Gradient: (95:5) A/B for 1.16 min, then to (5:95) A/B B: Acetonitrile
Flow Rate: 1.5 mL/min Gradient: (95:5) A/B for 1.16 min, then to (5:95) A/B
Temperature: 45 ºC Flow Rate: 1.5 mL/min
Detection: UV @ 254 nm Temperature: 45 ºC
Instrument: Agilent 1200 Detection: UV @ 254 nm
Backpressure: 190 bar Instrument: Agilent 1200
Sample: 1. Pyridine 9. Nortriptyline Backpressure: 300 bar
2. Acetaminophen 10. 4-Chlorobenzoic acid Sample: 1. Pyridine 9. Nortriptyline
3. Pindolol 11. 5-Methyl-2-hydroxy benzaldehyde 2. Acetaminophen 10. 4-Chlorobenzoic acid
4. Quinine 12. 4-Chlorocinnamic acid 3. Pindolol 11. 5-Methyl-2-hydroxy benzaldehyde
5. Acebutolol 13. Diazepam 4. Quinine 12. 4-Chlorocinnamic acid
6. Chlorpheniramine 14. Diflunisal 5. Acebutolol 13. Diazepam
7. Triprolidine 15. Niflumic acid 6. Chlorpheniramine 14. Diflunisal
8. Prednisolone 16. Hexanophenone 7. Triprolidine 15. Niflumic acid
8. Prednisolone 16. Hexanophenone
* ZORBAx is registered trademark of Agilent Technologies. Comparative separations may not be representative of all applications.
Phenomenex is not affiliated with Agilent Technologies.
PHENOMENEX | WEB: www.phenomenex.com
14. Longer
Column Lifetime No Column Degradation
18239_18241
Kinetex™ 2.6 µm Core-Shell C18
mV
2
Have you experienced short lifetime with your 140 3
sub-2 µm columns? 120
1
Even with complex sample mixtures, Kinetex columns maintain consistent
™
100
results over normal use. In this example, b-blockers in human plasma were
extracted after protein crash over the course of 1000 injections in both a 80
App ID 18239 and 18241
Kinetex™ 2.6 µm core-shell column and a traditional sub-2 µm fully porous
60
PERFORMANCE
column intended for UHPLC performance. Virtually no degradation of the
column performance is seen with the Kinetex™ column. 40 Injection 1000
Injection 8
20
12 hmm... 0.4 0.5 0.6 min
Loss of Resolution and Peak Shape
18240 18242
Conditions for both columns:
Dimensions: 50 x 2.1 mm *Waters® ACqUITy® BEH 1.7 µm C18
Mobile Phase: A: 0.1 % Formic acid in Water
B: 0.1 % Formic acid in Acetonitrile mV
Gradient: A/B (95:5) for 1.2 min to (0:100) for 0.01
2
140
min, hold at (95:5)
™ Flow Rate: 0.6 mL/min
1 3
Temperature: 25 °C 120
™ Instrument: Waters® ACQUITY® UPLC®
Detection: UV @ 254 nm
Sample: 1. Metoprolol 100
2. Alprenolol
3. Endogenous
80
App ID 18240 and 18242
60
40 Injection 1000
Injection 8
20
0.4 0.5 0.6 min
* ACQUITY and UPLC are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation.
Comparative separations may not be representative of all applications.
PHENOMENEX | WEB: www.phenomenex.com
15. Further Extend Kinetex ™
Column Lifetime 18588
WItH KrudKatcher™ Ultra In-line Filter
mV
140
KrudKatcher™ Ultra In-line Filter Virtually no change in 4
120
Protect your valuable UHPLC/HPLC column with a reliable and easy- chromatography and backpressure!
to-use, disposable KrudKatcher™ Ultra pre-column filter. Pressure-rated 100
2
3
to 20,000 psi (1,375 bar), the stainless steel filter body houses an inte- 80
grated 0.5 µm 316 stainless steel filter element that efficiently removes 60
microparticulates from the flow stream without contributing to system
App ID 18588
40
PERFORMANCE
backpressure or dead volume (< 0.2 µL). 1
20
0
0 0.15 0.30 0.46 0.61 0.76 0.91 1.06 1.21 1.37 min
13
Reproducible Performance
with KrudKatcher™ Ultra In-Line Filter
Change in tR (%) 18577
Uracil 0.2
WItHOUt KrudKatcher™ Ultra In-line Filter
Acetophenone 0.5 mV
140
Toluene 0.7 4
Naphthalene 0.8 120
n=15 100 2 3
Column: Kinetex 2.6 µm C18 100 Å 80
with and without KrudKatcher Ultra In-Line filter as noted
Dimensions: 50 x 2.1 mm 60
Part No.: 00B-4462-AN
AF0-8497
App ID 18577
Mobile Phase: Acetonitrile / Water (65:35) 40
Flow Rate: 0.5 mL/min 1
Temperature: 22 °C 20
Injection Volume: 0.2 µL
Detection: UV @ 254 nm 0
Backpressure: approx. 248 bar
Sample: Prodigy Test Mix (AL0-3045)
1. Uracil 0 0.15 0.30 0.46 0.61 0.76 0.91 1.06 1.21 1.37 min
2. Acetophenone
3. Toluene
4. Naphthalene
For more details on the test methodology and results, contact Phenomenex.
* See p. 39 for KrudKatcher ordering information.
PHENOMENEX | WEB: www.phenomenex.com
16. Improve Performance typical Method Consumption
Save Solvent
18243
4
6
110 mL
When chromatographic column performance improves you can not only 2 solvent per run!
decrease your analysis time but also decrease your overall solvent con-
5
PERFORMANCE
sumption without compromising your separations. Use Kinetex™ core-
shell technology to dramatically decrease the solvent consumption in 7 8
3
your laboratory and increase sample throughput.
App ID 18243
9
1 10
14
0 20 40 60 80 100 120 min
Column: Traditional 5 µm C18
Dimension: 250 x 4.6 mm
Mobile Phase: A: 20 mM Potassium phosphate pH 7
B: Methanol / Acetonitrile (50:50)
A/B (48:52)
Flow Rate: 1.0 mL/min
Temperature: 40 ºC
Detection: UV @ 254 nm
Sample: 1. Tianeptine 6. Amoxapine
2. Desmethyldoxepin 7. Doxepin
3. Protriptyline 8. Nortriptyline
4. Desipramine 9. Amitriptyline
5. Imipramine 10. Clomipramine
PHENOMENEX | WEB: www.phenomenex.com
17. Substitute specified column with Kinetex™ column
to reduce solvent consumption
18244
4
6
Only 26 mL
solvent per run!
2
5 Column: Kinetex 2.6 µm C18
Dimensions: 100 x 4.6 mm
Part No.: 00D-4462-E0
3 7 Mobile Phase: A: 20 mM Potassium phosphate pH 7
8 B: Methanol / Acetonitrile (50:50)
A/B (48:52)
App ID 18244
1 9 Flow Rate: 2.9 mL/min
Temperature: 40 ºC
10
PERFORMANCE
Detection: UV @ 254 nm
Sample: 1. Tianeptine 6. Amoxapine
2. Desmethyldoxepin 7. Doxepin
3. Protriptyline 8. Nortriptyline
4. Desipramine 9. Amitriptyline
0 2 4 6 8 min
5. Imipramine 10. Clomipramine
15
Further reduce column ID
for even greater solvent savings!
How much could this
< 4 mL
18245
4
save you...annually?
6
solvent per run!
5 Column: Kinetex 2.6 µm C18
2 Dimensions: 50 x 2.1 mm
Part No.: 00B-4462-AN
Mobile Phase: A: 20 mM Potassium phosphate pH 7
3 7 8 B: Methanol / Acetonitrile (50:50)
A/B (48:52)
App ID 18245
Flow Rate: 0.6 mL/min
9
Temperature: 40 ºC
1 10 Detection: UV @ 254 nm ™
Sample: 1. Tianeptine 6. Amoxapine
2. Desmethyldoxepin 7. Doxepin
3. Protriptyline 8. Nortriptyline
4. Desipramine 9. Amitriptyline
0 1 2 3 4 min 5. Imipramine 10. Clomipramine
PHENOMENEX | WEB: www.phenomenex.com
