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1
Real-time Extreme Exercise
Dr Mark Homer, Dr Melanie Wilson, Dr Tom Evens
@DocTomEvens
@MarkRHomer
2
bit.ly/RealTimeExtremePhysiology
3
Power x Technique x Performance = Results
4
Power at VO2
Power at VO2max
Ergo Power
Ergo Rate
5
Strength
Endurance
6
7
8
Anaerobic Contribution
Aerobic Contribution
VO2 Kinetics
VO2max Anaerobic
Capacity
9
10
11
Big Economical Engine
Big Uneconomical EngineSmall Uneconomical Engine
Small Economical Engine
8L / 15mpg
1.8L / 18mpg
2.7L / 35mpg
0.8L / 70mpg
3.5L / 28mpg
12
13
pH 6.74
Lactate 32
Bicarb Undetectable
Nielsen, Acta Physiolog Scand
1999
14
What’s going on in the unsustainable zone?
What does it feel like?
Why are they not dead?
What’s with the lactate?
15
Central Peripheral
Chemoceptive and Nociceptive
Afferents
Sarcolemmal Pi
Seratonin effect Sarcolemmal H+
IL-6 Impaired Calcium re-uptake
Ammonia Muscle Contraction
Brain Glycogen Depletion Heat
After Boyas et al. Ann Phys Rehab. 2011
“Like you're in the
middle of a fire.
And someone is
still asking you to
row”
“My teeth feel like
they’re going to
fall out”
“like there is no
way out no
matter how hard
you pray”
“My legs feel
heavy and hard.
Like tree trunks”
“An overwhelming feeling that I might
poo myself”
“Never did”
Anon
23
It’s probably not the lactate..
24
It’s probably not the lactate..
Extra mitochondrial ATP hydrolysis / Glycolysis are the primary so
25
It’s probably not the lactate..
Extra mitochondrial ATP hydrolysis / Glycolysis are the primary so
Lactate production consumes protons and yields NAD+
- Glucose - 2
- Glycogen -1
26
It’s probably not the lactate..
Extra mitochondrial ATP hydrolysis / Glycolysis are the primary so
Lactate production consumes protons and yields NAD+
- Glucose - 2
- Glycogen -1
Lactate co-transported with a proton
- 75% oxidised in tissue / 25% gluconeogensis
Roth. Arch Biochem Biophis 1990
27
Lactate is an advantage
/ AAm
Lactate/H+ pump increased 12%
MCT pump increased 65% Pilegaard Am J Phys. 1999
28
Why don’t they die?
29
30
Thank You

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