Hla dr1 - it has been observed common centenarians

10/2/22, 20:53 HLA-DR1 - Wikipedia
https://en.wikipedia.org/wiki/HLA-DR1 1/11
DR1 binding pocket with ligand PDB:
2G9H (https://www.rcsb.org/struct
ure/2G9H)[1]
major histocompatibility complex,
class II, DR1
Haplotypes
groups
DRA*01:DRB1*0101
DRA*01:DRB1*0102
DRA*01:DRB1*0103
Structure (See HLA-DR)
Identifiers alpha *0101
Symbol(s)
HLA-DRA (http://ww
w.gene.ucl.ac.uk/nom
enclature/data/get_da
ta.php?hgnc_id=HGN
C4947)
EBI-HLA
DRA *0101 (http://ww
w.ebi.ac.uk/cgi-bin/im
gt/hla/get_allele.cgi?
DRA*0101)
Identifiers
beta 1 *0101, *0102,
*0103 . . .
Symbol(s)
HLA-DRB1 (http://ww
w.gene.ucl.ac.uk/nom
enclature/data/get_da
ta.php?hgnc_id=495
3)
Shared data
Locus
chr.6 6p21.31 (https://
www.ncbi.nlm.nih.go
v/Omim/getmap.cgi?c
hromosome=6p21.3
1)
HLA-DR1
HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the
DRB1*01 gene products. It has been observed to be common
among centenarians.[2][3][4]
Serology
Disease associations
By serotype
By allele
By genotype
By haplotype
Rheumatoid arthritis
Genetic linkage
References
The serology for the most common DR1 alleles is excellent. The
serology for alleles *0104 (https://www.ebi.ac.uk/cgi-bin/ipd/i
mgt/hla/get_allele.cgi?DRB1*0104), *0106 (https://www.ebi.ac.
uk/cgi-bin/ipd/imgt/hla/get_allele.cgi?DRB1*0106), *0109 (htt
ps://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/get_allele.cgi?DRB1*
0109), *0110 (https://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/get_
allele.cgi?DRB1*0110), *0112 (https://www.ebi.ac.uk/cgi-bin/ip
d/imgt/hla/get_allele.cgi?DRB1*0112), *0115 (https://www.ebi.
ac.uk/cgi-bin/ipd/imgt/hla/get_allele.cgi?DRB1*0115), and
*0116 (https://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/get_allele.c
gi?DRB1*0116) is unknown.
Contents
Serology

DR1 serotype recognition of Some DRB1*01 allele-group gene products[5]
DRB1* DR1 DR103 Sample
allele % % % size (N)
*0101 (https://www.ebi.ac.uk/cgi-bin/ipd/imgt/
hla/get_allele.cgi?DRB1*0101)
97% 6317
95% 2035
56% 12% 1186
>50% 2
DR1 is associated with seronegative[6]-rheumatoid arthritis,[7][8] penicillamine-induced
myasthenia,[9] and schizophrenia.[10] DR1 is increased in patients with systemic sclerosis and
arthritis[11] and in ulcerative colitis with patients that have articular manifestations.[12]
DRB1*0101 is associated with rheumatoid arthritis,[13] in anti-Jk(a) mediated hemolytic transfusion
reactions,[14] foliaceous pemphigus,[15] HTLV-1-associated myelopathy/tropical spastic paraparesis,
and [16] lichen planus.[17] In lyme disease arthritis, *0101 appears to play a role in
presentation of
triggering microbial antigens.[18]
DRB1*0102 is associated with rheumatoid arthritis,[13] in anti-Jk(a) mediated hemolytic transfusion
reactions,[14] psoriasis vulgaris,[19] and recurrent respiratory papillomatosis[20]
DRB1*0103 is associated with colonic Crohn's disease[21] and ulcerative colitis.[22][23]
DRB1*0101/*0404 and *0101/*0401 increases risk of mortality in rheumatoid arthritis, with
ischemic heart disease and smoking.[24] these same genotypes are associated with rheumatoid
vasculitis.[25]
DRB1*0102:DQB1*0501 is associated with psoriasis vulgaris[19]
and tubulointerstitial nephritis & uveitis syndrome,[26] but is
relatively protective against juvenile diabetes.[27]
DR1-DQ5 is associated with tubulointerstitial nephritis & uveitis
syndrome.[26]
Disease associations
By serotype
By allele
By genotype
By haplotype

Diseases associated with HLA-DR and links to DR subpages(V - T)
Class Disease Associated DR 2 3 4
alopecia areata DR5
anemia pernicious DR15
antiphospholipid syndrome, primary DR5 DR12
aneurysm coronary artery DR16
arteritis Takayasu's DR16
arthritis, rheumatoid
juvenile DR4 DR5 DR14 DR15
pauciarticular, juv. DR8
Still's disease DR12
iritis w/juv. arthritis DR12
seropositive DR1 DR4 DR10
w/systemic sclerosis DR1
lyme disease induced DR4
tiopronin intolerance DR5 DR11 DR12
cardiomyopathy
hypertrophic DR4 DR17
T. cruzi induced DR4 DR7 DR15
colitis
Crohn's DR1
ulcerative DR1
diabetes
juvenile (type 1) DR3 DR4 DR17 DR18
fatty liver (type 2) DR8
encephalomyelitis rabies vaccine-induced DR17
encephalopathy acute necrotizing DR52
epilepsy
childhood DR5
infantile/spasm DR17
heart disease rheumatic DR16
hepatitis
autoimmune DR2 DR4 DR17
primary biliary cirrhosis DR2 DR8
chronic type C DR11
lichen planus DR1 DR10
lupus,
systemic DR3 DR4 DR52
hydralazine-induced DR4
with Sjögren syndrome DR15
lymphadenopathy generalized DR5
lymphoma, mycosis fungoides DR5
melioidosis DR16
myasthenia gravis DR3 DR6 DR13 DR14

Class Disease Associated DR 2 3 4
penicillamine-induced DR1
myositis inflammatory inclusion body DR17 DR18 DR52
narcolepsy DR2 DR12
nephritis, tubulointerstitial DR1
nephropathy IgA-mediated DR4
polyglandular deficiency syndrome DR5
pemphigus
foliaceous DR1
vulgaris DR4
psoriasis vulgaris DR1 DR7
papillomatosis, respiratory DR1
sarcoidosis non-chronic DR17 DR52
sclerosis,
multiple DR2 DR15 DR53
"bout onset" multiple DR3
systemic DR4 DR11 DR16 DR52
vulval lichen DR12
schizophrenia DR1
susceptibility
leprosy DR2
tuberculosis DR2
ragweed Ra6 allergy DR5
asthma, mite sensitive DR11
2ndary infection, AIDS DR3
aspergillosis DR15
Kaposi's sarcoma DR5
thyroid carcinomas DR8 DR11
ovarian/cervical cancer DR10 DR11 DR15
grape induced anaphylaxis DR11
Chlamydia pneumoniae DR52
thyroiditis
Hashimoto's DR3 DR5
Graves' DR3 DR17 DR52
uveitis tubulointerstitial DR1
*references are provided on linked subpages
DR1 are associated with rheumatoid arthritis, and while not the strongest association with the highest
risk for early onset arthritis is within the DR4-bearing Native American population. There frequency
of DR4-DQ8 haplotypes reach extreme nodal levels. Arthritis has been identified in a pre-Columbian
Rheumatoid arthritis

DR1 Haplotypes
Serotypes DRA DRB1
DR1
*0101 *0101
*0101 *0102
*0101 *0103
Serotypes DQA1 DQB1 DRB1
DR1-DQ5 (5.1, 1)
*0101 *0501 *0101
*0101 *0501 *0102
*0101 *0501 *0103
Serotypes
HLA-
A
HLA
C
HLA
B
DRB1
A3-Cw4-B35-
DR1
*0301 *0401 *3501 *0101
A11-Cw4-B35-
DR1
*1101 *0401 *3501 *0103
A33-Cw8-B14-
DR1
*3301 *0802 *1402 *0102
remains from Italy, the affected individual bearing the DRB1*0101 allele.[28] DRB1*0101 and most
DR4 have in common a 'shared epitope'.[29][30] In this hypothesis a common region of the beta chain,
positions 67 to 74, are common and may be integral to presenting auto-immunological peptides.
HLA-DR1 is not genetically linked to DR51, DR52 or
DR53, but is linked to HLA-DQ1 and DQ5 serotypes.
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5. derived from IMGT/HLA (http://www.ebi.ac.uk/img
t/hla/allele.html)
Genetic linkage
References

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