Cerebral Ischemia overview

Cerebral Ischemia Cellular and Molecular Mechanisms of the Injured Brain Joseph Grenier, MD, PhD Benedictine University The Neurophysiology Foundation

Etiology of Stroke ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Animal Models Global Ischemia Models ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Brain Tissue In Vitro Models ,[object Object],[object Object],[object Object],[object Object]

Advantages/Disadvantages of Animal Models ,[object Object],[object Object],[object Object],[object Object],[object Object]

Excitotoxicity Model ,[object Object],[object Object]

Neurotrophin Biochemistry ,[object Object]

Free Radical Biochemistry ,[object Object],[object Object],[object Object]

Trace Elements Contributing to Excitotoxicity ,[object Object],[object Object],[object Object],[object Object],[object Object]

Apoptosis and Necrosis ,[object Object],[object Object],[object Object]

Neuron Selectivity ,[object Object],[object Object],[object Object],[object Object]

Heat-Shock Proteins ,[object Object],[object Object],[object Object]

Brain Ischemia and Hypothermia ,[object Object],[object Object]

Hypothermia - cont’d ,[object Object],[object Object],[object Object]

Hypothermia - cont’d ,[object Object],[object Object]

Hyperthermia ,[object Object],[object Object],[object Object]

Spinal Cord Ischemia ,[object Object],[object Object]

Mechanisms of Hypothermic Protection ,[object Object],[object Object],[object Object],[object Object]

Hemodynamics of Hypothermia ,[object Object],[object Object]

Acidosis Related Damage ,[object Object],[object Object],[object Object],[object Object],[object Object]

Acidosis Damage - cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object]

Endothelins ,[object Object],[object Object],[object Object]

Cytokines ,[object Object],[object Object],[object Object],[object Object]

Interleukins ,[object Object],[object Object],[object Object]

Blood-Brain Barrier in Ischemia ,[object Object],[object Object],[object Object]

Blood-Brain Barriers in Ischemia cont’d ,[object Object],[object Object],[object Object]

BBB in Ischemia - cont’d ,[object Object],[object Object],[object Object],[object Object]

BBB in Ischemia ,[object Object],[object Object],[object Object]

BBB in Ischemia cont’d ,[object Object],[object Object],[object Object]

Nitric Oxide and Ischemia ,[object Object],[object Object],[object Object]

Nitric Oxide - cont’d ,[object Object],[object Object],[object Object]

Nitric Oxide Interactions ,[object Object],[object Object],[object Object],[object Object]

NO and Superoxide Dismutase ,[object Object],[object Object]

NO and SOD ,[object Object],[object Object],[object Object]

NO Formation in Neurons ,[object Object],[object Object]

Protein Kinase C and Ischemia ,[object Object],[object Object],[object Object]

Protein Kinase C cont’d ,[object Object],[object Object]

Effect of Ischemia on CaMKII ,[object Object],[object Object],[object Object]

MAP Kinase and Ischemia ,[object Object],[object Object]

MAP Kinase and Ischemia ,[object Object],[object Object],[object Object]

Neurotrophins and Cerebral Ischemia ,[object Object],[object Object],[object Object]

Experimental Therapies for Ischemia ,[object Object],[object Object],[object Object],[object Object],[object Object]

Experimental Therapies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cerebral Ischemia overview

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Cerebral Ischemia overview