.     Leukemia. In Pediatrics           for FM              By:Prof Dr Hussein Abdeldayem, MD Prof of Pediatrics, Alex , E...
-:Definition                     LeukemiaMalignant invasion                     Arrest of WBC    Appearance of of precurso...
Prevalence   Commonest   malignancy        In        Male < female   Age 2 -8 years(childhood (30%
Etiology      Genetic  & Consideration                              & Drugs   Chromosomal        Ionizing radiation  .Abno...
‫أول حالة مثبتة علميً.. السرطان ينتقل من الم‬                             ‫ا‬                          ‫90/01/31‬         ...
ClassificationAcute                chronic97%                   3%
Acute                          Mixed                         LineageLymphoid   Myeloid         4%  75%      20%           ...
Acute lymphoblastic         leukemiaDisease of early lymphoid cells &commonest type of leukemia in      pediatric age group
Classification of      ALL
– French               – American                  British               classificationcell size   2- chromatid shape   3-...
Immunological             Markers          immunotypingB cell leukemia    T cell leukemia      80%                20%
Manifestation of A L L
Manifestations               of           malignance                BM           Non BMGeneral           infiltration    I...
GeneralWeight               Low grade         Lassitude loss                  fever
BM                            invasion        RBC                  Platelets               WBC                            ...
Non BM                                  invasion           Infiltration                                                   ...
Investigation
Laboratory    Peripheral  findings       Blood                picture -:Platelets     RBC:-          -:WBC                ...
BM          examination RBC          Megakaryocytes     WBCMothers                ↓             ↑  ↓                      ...
Radiological              findings    -:chest                        Skeletal surveymediastinal mass              CT Scan
prognosis                    Good                 Prognostic                   Factors                  includes          ...
Cause            of death                         Infiltrationinfection   hemorrhage        of                         Vit...
-:Treatment                      .I                  Supportive                   Therapy                   General care-:...
II. Specific Therapy                  Aiming                    at Induction of    Maintenance  remission          Of     ...
.IIIBone MarrowTransplantation
Thank You
Upcoming SlideShare
Loading in …5
×

Leukemia For FM

633 views

Published on

for Family Medicine doctotrs, G Pediatrician, Medical students

Published in: Health & Medicine
0 Comments
2 Likes
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
633
On SlideShare
0
From Embeds
0
Number of Embeds
2
Actions
Shares
0
Downloads
35
Comments
0
Likes
2
Embeds 0
No embeds

No notes for slide

Leukemia For FM

  1. 1. . Leukemia. In Pediatrics for FM By:Prof Dr Hussein Abdeldayem, MD Prof of Pediatrics, Alex , Egypt
  2. 2. -:Definition LeukemiaMalignant invasion Arrest of WBC Appearance of of precursor of division Blast cells in WBC to Bone marrow peripheral blood
  3. 3. Prevalence Commonest malignancy In Male < female Age 2 -8 years(childhood (30%
  4. 4. Etiology Genetic & Consideration & Drugs Chromosomal Ionizing radiation .Abnormalities chemicals -:.E.g -:.e.g down syndrome alkylating agent Identical twins E.g.:- Chernobyl heavy metals &Sibling of leukemia patients
  5. 5. ‫أول حالة مثبتة علميً.. السرطان ينتقل من الم‬ ‫ا‬ ‫90/01/31‬ ‫للجنين‬ ‫أظهرت الختبارات المعملية إصابة الرضيعة باللوكيميا، وشرح الوالد بأن الم‬ ‫•‬ ‫توفيت بذات المرض بعد ثلثة أشهر من ولدتها.‬ ‫واكتشف الباحثون باستخدام تقنية "البصمة الوراثية" أن دم الم والطفلة يشتركان‬ ‫•‬ ‫في ذات الخليا السرطانية المتعدية، ما يعني بأن المصدر واحد حيث انتقلت تلك‬ ‫الخليا من الم إلى الجنين عبر المشيمة.‬‫وقالت بروفيسور ميل غريف، التي قادت البحث المنشور في "محاضر الكاديمية‬ ‫•‬ ‫القومية للعلوم" وأوردته صحيفة "التلغراف"، إنها "حالة نادرة بشكل استثنائي."‬ ‫وأضاف معلقة: "نعتقد الخليا السرطانية للم عبرت عن طريق المشيمة إلى‬ ‫•‬ ‫الجنين أثناء النموه ونجحت في الستزراع لنها كانت غير مرئية لجهاز‬ ‫المناعة."‬
  6. 6. ClassificationAcute chronic97% 3%
  7. 7. Acute Mixed LineageLymphoid Myeloid 4% 75% 20% & Undifferentiated 1%
  8. 8. Acute lymphoblastic leukemiaDisease of early lymphoid cells &commonest type of leukemia in pediatric age group
  9. 9. Classification of ALL
  10. 10. – French – American British classificationcell size 2- chromatid shape 3- Nucleoli -1L1 L2 L3
  11. 11. Immunological Markers immunotypingB cell leukemia T cell leukemia 80% 20%
  12. 12. Manifestation of A L L
  13. 13. Manifestations of malignance BM Non BMGeneral infiltration Infiltration
  14. 14. GeneralWeight Low grade Lassitude loss fever
  15. 15. BM invasion RBC Platelets WBC -In Anemia Hge fection -Pete Chae Bleeding Repeate Easy -Tachy SeriousPallor Purpura Of Fever ulcers -in fatigue cardia Hge .ecchym MM fection
  16. 16. Non BM invasion Infiltration Extra Of medullary Lymphoid Infiltration system CNS Hge -Lymph -Genitosplenomegaly hepatomegaly & CVS adenopathy Focal urinary Brain lesion
  17. 17. Investigation
  18. 18. Laboratory Peripheral findings Blood picture -:Platelets RBC:- -:WBC or↓ or N ↑ ↓ ↓ + + + Blast cells Normocytic MainlyAbn Function normochromic lymphocyte
  19. 19. BM examination RBC Megakaryocytes WBCMothers ↓ ↑ ↓ Mainly blasts (80 -100%)
  20. 20. Radiological findings -:chest Skeletal surveymediastinal mass CT Scan
  21. 21. prognosis Good Prognostic Factors includes Leukocytic Age CNS count(years 7- 3) involvement 3 mm/10,000<
  22. 22. Cause of death Infiltrationinfection hemorrhage of Vital organs
  23. 23. -:Treatment .I Supportive Therapy General care-:Psychological Prevent .1 Vaccination Emotional infection (killed vaccine ) support Nutrition .2 Treat Anemia .3
  24. 24. II. Specific Therapy Aiming at Induction of Maintenance remission Of Prevent & remission RelapseCNS protection For 3 years
  25. 25. .IIIBone MarrowTransplantation
  26. 26. Thank You

×