Opiodes

Analgésicos opiodes: ,[object Object]

Existen 2 tipos de opioides: ,[object Object],[object Object]

Sistemas o familias de péptidos opiodes endógenos: ,[object Object],[object Object],[object Object],[object Object]

Precursores endorfínicos: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Precursores endorfínicos: ,[object Object]

Principales localizaciones de los péptidos endógenos: ,[object Object]

Otras localizaciones: ,[object Object],[object Object],[object Object],[object Object],[object Object]

Funciones de los péptidos endógenos: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mecanismos de acción de los opiaceos: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptor Mu 1 : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptor Mu 2 : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptor Kappa: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptor Delta: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptor Sigma 1 : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Receptor Sigma 2 : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clasificación de los opioides exógenos: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clasificación de los opioides exógenos: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clasificación de agonistas: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Selectividad de opioides endógenos sobre los distintos receptores: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Selectividad de opioides exógenos a los distintos receptores: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Efectos farmacológicos de los opioides: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Dosis de narcóticos: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Duración de la infusión (horas) 1 2 3 4 5 6 7 300 220 150 80 0 Fentanilo Sulfentanil Alfentanil Remifenta Vida ½ contexto-sensible (minutos) y duración de la infusión

Naloxona: ,[object Object],[object Object],[object Object]

Reversión con Naloxona: Fentanilo 0 30 45 min. Naloxona Periodo de resedación Modo correcto de reversión: Dosis IV Dosis subcutánea

Por último.... No dejar al paciente con dolor por tener miedo a la depresión respiratoria.... Abre una puerta a un cambio de mentalidad

“ La dosis adecuada de un opioide, es aquella que pruduce analgesia con leves o sin efectos adversos.”

Opiodes

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Opiodes