- TIF B cells and T cells are able to alter their genome. What kind of diversity does this give the variable region? Why would dedicating a part of our genome for this variability not be possible? - Complete immunoglobulin genes are generated by the of separate gene segments. What is this process? - Hypervariable (HV) regions are also known as what? - What segment are CDR1 and CDR2 located on? Where does the CDR3 region originate from? - What is the CDR3 loop formed from? - How are light-chain V regions constructed?.