Antibióticos

ANTIBIÓTICOS Bacteriología Alejandra Olguín Pelayo

Historia ,[object Object],[object Object],[object Object]

Historia ,[object Object],[object Object],[object Object],[object Object]

Bacteriostáticos vs Bactericidas ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Inhibición de la síntesis de pared celular ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antibióticos β-lactámicos ,[object Object],[object Object]

Antibióticos β-lactámicos PBP β-lactámicos La formación de puentes entre las cadenas de peptidoglucano Se activan autolisinas que participan en la degradación de pared bacteriana

Resistencia a β-lactámicos PBP β-lactámicos 1 2 3 β- lactamasas

Resistencia a β-lactámicos ,[object Object],[object Object],[object Object],[object Object],[object Object]

Penicilinas ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cefalosporinas y cefamicinas ,[object Object],[object Object],[object Object],[object Object],[object Object]

Carbapenémicos, Monobactámicos, ,[object Object],[object Object],[object Object],[object Object]

Glucopéptidos: vancomicina ,[object Object],[object Object],[object Object],[object Object]

Polipéptidos: Bacitracina y Polimixina ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Isoniacida, etioniamida etambutol y cicloserina ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Inhibición de la síntesis de proteínas: Aminoglucósidos ,[object Object],[object Object],[object Object],[object Object],[object Object]

Mecanismo de acción de aminoglucósidos Producción de proteínas anómalas por lectura incorrecta del RNAm 30 s Aminoglucósidos As Interrupción de la síntesis de proteínas por la separación precoz del ribosoma del RNAm. Paso a través de la membrana es un proceso aerobio dependiente de energía β-lac MUERTE DE LA BACTERIA

Resistencia a aminoglucósidos Aminoglucósidos 1 30 s As 2 As 3 4 ,[object Object],[object Object],[object Object],[object Object]

Tetraciclinas ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Oxazolidonas clines oxaclor ma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cloranfenicol ,[object Object],[object Object],[object Object],[object Object]

Macrólidos ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clindamicina ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Estreptograminas ,[object Object],[object Object],[object Object],[object Object]

Inhibición de la síntesis de ácidos nucleicos: quinolonas ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Rifampicina y rifabutina ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Metronidazol ,[object Object],[object Object],[object Object]

Antimetabolitos ,[object Object],[object Object],[object Object],[object Object],[object Object]

Ot ro s a nt ib ió ti co s ... ,[object Object],[object Object]

Antibióticos

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Antibióticos