A glimpse on tuberculosis and scope of inhalable anti tubercular therapy
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Tuberculosis (TB), is an airborne and notorious disease caused by Mycobacterium tuberculosis. Despite the technological advances, the tubercle bacillus continues to threaten humans. Most patients are noncompliant towards current modes of treatment due to resistance of bacilli for single or multiple drugs. The usual treatment duration ranges from 6-9 months for drug susceptible TB; 18-24 months for multidrug resistant TB. However the long term treatment posses adverse events. To avoid the adverse events and improve the efficacy, alternative modes of drug delivery systems are desired. Among them, the nanotechnology overcomes the limitations of conventional therapy and improves the efficacy. The nanocarriers can be considered for pulmonary application by virtue of their potential advantages. However, nanoparticles meant for lung delivery poses certain challenges such as difficulty in characterization and the extent of utility towards practical applications. It must be noted that the development of nanocarriers for pulmonary application requires an in depth knowledge of the lung, both in its healthy and disease state. Recent developments include in vitro models based on cell line cultures. The present paper describes the development and characterization aspects for inhalable drug delivery systems for the targeted and slow delivery of antitubercular drugs.
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Roflumilast is a selective enzyme inhibitor of phosphodiesterase-4. This drug is recommended for treatment of patients suffering from
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concentration and decreased with an increase in the perchloric acid concentration. This indicates that free
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response variables such as resolution, retention time, and peak tailing were analyzed statistically for the
screening of suitable chromatographic conditions. During this process, various plots such as perturbation,
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2.1 � 100 mm, 1.7-μ column, mobile phase comprised of buffer (5 mM K2HPO4 containing 0.1%
triethylamine, pH 6.8), and acetonitrile (40:60 v/v), the flow rate of 0.5 mL min 1 and UV detection at
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two-parameter isotherm models (Harkins–Jura, Halsey,
Smith, El-Awady and Flory–Huggins) and three-parameter
isotherm models (Redlich–Peterson and Sips) which are
applied to the experimental data. The fitness of the isotherms
describes that both mono- and multilayer adsorptions
occur in the present studied three biosorbents in
preference to the latter. The mechanism of adsorption has
been studied using diffusion kinetic models (viz. liquid film
diffusion, Dunwald–Wagner intra-particle diffusion model
and moving boundary model) and described the possibility
of diffusion in the order of banana bunch–stem powder[
sorghum stem powder[casuarinas fruit powder in
terms of diffusion coefficients. In essence of all the results,
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Caralluma lasiantha is used as a traditional medicine in India to heal body
heat and inflammations. In order to find out a scientific validation for the Indian
traditional knowledge, antibacterial activity of C. lasiantha extracts was studied
against inflammation causing bacteria (viz., Staphylococcus aureus, Escherichia coli,
Streptococcus Sp., Bacillus subtilis, Enterobacter aerogenes, Klebsiella pneumoniae)
along with other Gram-positive and Gram-negative bacteria. Solvents with different
polarity were used for extraction from dry roots and stems. Minimum inhibitory
concentrations (MIC) were also studied. Differential antibacterial activity was
exhibited by extracts and higher inhibition potential against Gram-positive bacteria
was explained. The observed antibacterial activities were correlated with the chemical
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medicine due to their significant role in the treatment of different health problems.
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and 14k against prostate DU-145 cancer cell line.
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dihydroquinazolin-4-ylamino)phenyl)ethanone (11a-b) in the presence of aqueous NaOH. Three
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Rifampicin PLGA nanospheres are
formulated with a specific goal in order to decrease
the dose, adverse effects and to enhance targeted
drug delivery. Rifampicin nanospheres were
prepared and evaluated by emulsion solvent
evaporation method. In vivo bio distribution studies
reveal that there was a long term accumulation of
rifampicin nanospheres in the lungs over other
organs. The increase in Cmax values confirmed that
inhalable PLGA nanospheres are suitable for
targeting and providing sustained release of antitubercular
drugs to lungs. So inhalation is a
selected administration route of Rifampicin PLGA
nanospheres. The in vivo screening of M.
tuberculosis showed good activity as well as its
activity against multidrug-resistant M. tuberculosis
and against M. tuberculosis isolates in a
potentially latent state, makes Rifampicin PLGA
nanospheres as an attractive drug dosage form
for the therapy of tuberculosis. It can be concluded
that there is a significant potential for effective
oral delivery as well as nasal delivery of the
Nanospheres for the treatment of tuberculosis.In-Vivo Evaluation of Rifampicin Loaded Nanospheres: Biodistribution and Myco...
In-Vivo Evaluation of Rifampicin Loaded Nanospheres: Biodistribution and Myco...Ratnakaram Venkata Nadh
58. G. Venkata Narasimha Rao, Muralee Krishna, Ravi Kumar Bellam and R. Venkata Nadh, LC-MS compatible stability indicating RP-UPLC method for the estimation of ester prodrug of mycophenolic acid in injection formulation, Asian Journal of Chemistry, (SCOPUS indexed, ISSN: 0970-7077 (Print), 0975-427X (Online)), 30(8) (2018) 1915-1924, DOI: 10.14233/ajchem.2018.21445 LC-MS compatible stability indicating RP-UPLC method for the estimation of es...
LC-MS compatible stability indicating RP-UPLC method for the estimation of es...Ratnakaram Venkata Nadh
Abstract: A highly efficient and milder protocol for the syntheses of novel series of 2-aminothiazoles
bearing 5-methylisoxazoline and pyridine-piperazine hybrid molecules has been developed. The target
compounds 13a-e were screened for their in vitro cytotoxicity activity against various tumor cell lines
including MCF-7 (human breast adenocarcinoma), HCT-116 (colorectal carcinoma), Jurkat (human Tcell
leukemia) and THP-1 (human acute monocytic leukemia). The bioactive assay showed most of the
new compounds exhibited promising results in comparison with the parental Sunitinib. The synthesized
compounds could well be used in the future as lead anticancer drugs in drug development studies. The
synthesized compounds were fully characterized by IR, 1H NMR, 13C NMR, elemental analysis and
mass spectral data.Synthesis and Antitumor Activity Evaluation of 2-Aminothiazoles Appended 5-me...
Synthesis and Antitumor Activity Evaluation of 2-Aminothiazoles Appended 5-me...Ratnakaram Venkata Nadh
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Three novel and distinct agricultural waste materials, viz., Casuarinas fruit powder (CFP), sorghum stem powder
(SSP) and banana stem powder (BSP) were used as low cost adsorbents for the removal of toxic copper(II) from
aqueous solutions. Acid treated adsorbents were characterized by SEM, EDX and FTIR. Different factors effecting
adsorption capacity were analyzed and the effi ciency order was BSP>SSP>CFP. Based on the extent of compatibility
to Freundlich/Langmuir/D-R/Temkin adsorption isotherm and different models (pseudo-fi rst and second order,
Boyd, Weber’s and Elovich), chemisorption primarily involved in the case of CFP and SSP, whereas, simultaneous
occurrence of chemisorption and physisorption was proposed in the case of BSP. Based on the observations, it was
proposed that three kinetic stages involve in adsorption process viz., diffusion of sorbate to sorbent, intra particle
diffusion and then establishment of equilibrium. These adsorbents have promising role towards removal of Cu(II)
from industrial wastewater to contribute environmental protection.Kinetic, isotherm and thermodynamics investigation on adsorption of divalent ...
Kinetic, isotherm and thermodynamics investigation on adsorption of divalent ...Ratnakaram Venkata Nadh
Removal of Cr(VI) by biosorption on two agro waste materials, casuarinas fruit powder (CFP) and sorghum
stem powder (SSP), has been investigated. The prepared adsorbent materials were characterized by SEM, EDX,
FTIR and BET. These biomaterials effectively removed Cr(VI) with a maximum removal of 93.35% and 63.75% using
15 gL−1 and 5 gL−1 of CFP and SSP, respectively, at 60 oC with 20mgL−1 initial Cr(VI) concentration in solution. In both
cases of adsorbents, kinetic data of adsorption fitted well in pseudo-second-order in terms of correlation coefficient
(R2). This helps in proposing the process of adsorption as chemical coordination, which is correlated with the thermodynamic
study results conducted at different values of temperature. Langmuir, Freundlich and D-R models were evaluated
for description of metal sorption isotherms. Values of coefficients of intra-particle diffusion and mass transfer have
also been determined at different values of temperature.Kinetic, thermodynamic and equilibrium studies on removal of hexavalent chrom...
Kinetic, thermodynamic and equilibrium studies on removal of hexavalent chrom...Ratnakaram Venkata Nadh
A highly efficient and mild protocol for the syntheses of ethyl-3-
[7-benzyloxy-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-
isoxazole carboxylates and ethyl-3-[7-benzyloxy-3-chloro-4-methyl-2-
oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates in
good yields via [3 þ 2] cycloaddition of in situ–generated nitrile
oxides from 7-benzyloxy-4-methyl-coumarin hydroxymoylchlorides
and 7-benzyloxy-3-chloro-4-methyl-coumarin hydroxymoylchlorides
respectively with ethyl-3-aryl prop-2-enoate has been developed.
The new compounds are screened for antibacterial activity.Novel coumarin isoxazoline derivatives: Synthesis and study of antibacterial ...
Novel coumarin isoxazoline derivatives: Synthesis and study of antibacterial ...Ratnakaram Venkata Nadh
Plerixafor (PLX) injections are administered to patients with cancers of lymphocytes
(non-Hodgkin’s lymphoma) and plasma cells (multiple myeloma). The main
objective of the current study was to develop a short reverse phase chromatographic
method for the simultaneous quantification of PLX and its impurities, in an injection
formulation, to reduce the time required for these quality tests. Furthermore, the
present work describes the role of nonalkyl branched nonquaternary ion pair reagent
in improving the peak shape and reducing column equilibration time. The separation
of PLX and its related substances is pH dependent (optimum pH = 2.50) and was
achieved on an octadecylsilyl (C18) column. The method was validated for its intended
purpose in accordance with the current regulatory guidelines for validation. The
proposed method can be applied for quality control, release, and stability analyses of
active pharmaceutical ingredient, PLX, as well as finished products, PLX injectionsUltra performance liquid chromatographic method for simultaneous quantificati...
Ultra performance liquid chromatographic method for simultaneous quantificati...Ratnakaram Venkata Nadh
Caralluma is a genus used as traditional medicine. Caralluma lasiantha is medicinally important due
to existence of pregnane glycosides, which may possess various biological activities. This article thoroughly
reviewed about the usage of C. lasiantha in traditional medicinal system, phytochemicals present in it, profile
identification studies, anti-hyperglycemic effect, antibacterial, antifungal, cytotoxic and antioxidant activitiesCaralluma lasiantha: A review on it’s vital role in Indian Traditional Medicine
Caralluma lasiantha: A review on it’s vital role in Indian Traditional MedicineRatnakaram Venkata Nadh
Stigmasterol, a phytosteroid was isolated for the first time from C. lasiantha using n-hexane as a solvent. Stigmasterol was characterized on the basis of physical, chemical and spectral data (IR, 1H NMR, 13C NMR, 1HNMR, DEPT-45, 90 & 135, and MS) analysis as well as by comparing them to their literature data. A sequence of steps was adopted like saponification, fractional crystallization and gradient elution column chromatography to isolate stigmasterol because some phytosterols possess identical physical properties which makes it difficult to isolate the constituents.Phytochemical Investigation of Caralluma lasiantha: Isolation of Stigmasterol...
Phytochemical Investigation of Caralluma lasiantha: Isolation of Stigmasterol...Ratnakaram Venkata Nadh
Phytochemical screening of Caralluma lasiantha was carried out and one C21 pregnane steroid was isolated from chloroform extract. Based on spectroscopic studies (IR, 1H NMR, 13C NMR and ESI-MS) the isolated compound is 3b,14b-dihydroxy-14b-pregn-5-en-20-one which was earlier isolated from other species.Phytochemical Screening of Caralluma lasiantha Isolation of C21 Pregnane Steroid
Phytochemical Screening of Caralluma lasiantha Isolation of C21 Pregnane SteroidRatnakaram Venkata Nadh
In the present study, two cancer therapeutic drugs (docetaxel and bortezomib) were separated from their
potential impurities on a chromatographic platform by utilizing CO2 gas (supercritical state) and quantified.
The chromatographic separations were achieved on two short columns BEH-2EP (100mm 3mm, 1.7 mm)
and CHIRALPAK AD-3 (100 mm 4.6 mm, 3 mm) for docetaxel and bortezomib, respectively. The present
work describes the role of organic modifiers in the separation of polar compounds by supercritical fluid
chromatography. The two new methods were fully validated in accordance with the current ICH
(International Council for Harmonization of technical requirements for pharmaceuticals for human use)
guidelines. The stability indicating power of the methods was demonstrated from the stress studies
conducted on the injection formulations of the two compounds. The methods are precise with % RSD of
0.4, linear with the correlation coefficient of r2 $ 0.999 and accurate in the range of 50–150% of the
target assay concentration. The two methods can be equally employed for the assay determination of
docetaxel and bortezomib APIs as well.Supercritical fluid (CO2) chromatography for quantitative determination of se...
Supercritical fluid (CO2) chromatography for quantitative determination of se...Ratnakaram Venkata Nadh
A systematic design-of-experiments was performed by applying quality-by-design concepts to determine
design space for rapid quantification of teriflunomide by the ultraperformance liquid chromatography
(UPLC) method in the presence of degradation products. Response surface and central composite
quadratic were used for statistical evaluation of experimental data using a Design-Expert software. The
response variables such as resolution, retention time, and peak tailing were analyzed statistically for the
screening of suitable chromatographic conditions. During this process, various plots such as perturbation,
contour, 3D, and design space were studied. The method was developed through UPLC BEH C18
2.1 � 100 mm, 1.7-μ column, mobile phase comprised of buffer (5 mM K2HPO4 containing 0.1%
triethylamine, pH 6.8), and acetonitrile (40:60 v/v), the flow rate of 0.5 mL min 1 and UV detection at
250 nm. The method was developed with a short run time of 1 min. Forced degradation studies revealed
that the method was stability-indicating, suitable for both assay and in-vitro dissolution of a drug product.
The method was found to be linear in the range of 28–84 μg mL 1, 2.8–22.7 μg mL 1 with a correlation
coefficient of 0.9999 and 1.000 for assay and dissolution, respectively. The recovery values were found in
the range of 100.1–101.7%. The method was validated according to ICH guidelines.Quality-by-design-based development and validation of a stability-indicating ...
Quality-by-design-based development and validation of a stability-indicating ...Ratnakaram Venkata Nadh
A new and efficient synthetic route for dual-Src/Abl kinase inhibitor
dasatinib (Sprycel®), an anticancer drug, is described. This commercially
viable process yields dasatinib monohydrate free of potential impurities
with consistent yield of 68% in route A and 61% in route B with HPLC
purity >99.80% over four stages.A convenient new and efficient commercial synthetic route for dasatinib (Spry...
A convenient new and efficient commercial synthetic route for dasatinib (Spry...Ratnakaram Venkata Nadh
Abundantly available agricultural waste materials
(banana bunch, sorghum stem and casuarinas fruit) are
processed with negligible cost and are found to be highly
suitable as biosorbents for chromium(VI) removal from
aqueous environment due to high surface area and functional
groups of adsorbents. The equilibrium data have
been analyzed for the adsorbate–adsorbate/adsorbent
interactions and found to be fitted to the data in the order,
Hill–de Boer C Fowler–Guggenheim % Frumkin[Kiselev.
To determine the characteristic parameters for process
design, mass transfer studies have been carried out using
two-parameter isotherm models (Harkins–Jura, Halsey,
Smith, El-Awady and Flory–Huggins) and three-parameter
isotherm models (Redlich–Peterson and Sips) which are
applied to the experimental data. The fitness of the isotherms
describes that both mono- and multilayer adsorptions
occur in the present studied three biosorbents in
preference to the latter. The mechanism of adsorption has
been studied using diffusion kinetic models (viz. liquid film
diffusion, Dunwald–Wagner intra-particle diffusion model
and moving boundary model) and described the possibility
of diffusion in the order of banana bunch–stem powder[
sorghum stem powder[casuarinas fruit powder in
terms of diffusion coefficients. In essence of all the results,
the selected adsorbents can be used as a potential adsorbent
for the removal of Cr(VI) from aqueous solutions.Utilization of agro-waste for removal of toxic hexavalent chromium: surface i...
Utilization of agro-waste for removal of toxic hexavalent chromium: surface i...Ratnakaram Venkata Nadh
Caralluma lasiantha is used as a traditional medicine in India to heal body
heat and inflammations. In order to find out a scientific validation for the Indian
traditional knowledge, antibacterial activity of C. lasiantha extracts was studied
against inflammation causing bacteria (viz., Staphylococcus aureus, Escherichia coli,
Streptococcus Sp., Bacillus subtilis, Enterobacter aerogenes, Klebsiella pneumoniae)
along with other Gram-positive and Gram-negative bacteria. Solvents with different
polarity were used for extraction from dry roots and stems. Minimum inhibitory
concentrations (MIC) were also studied. Differential antibacterial activity was
exhibited by extracts and higher inhibition potential against Gram-positive bacteria
was explained. The observed antibacterial activities were correlated with the chemical
structures of phytochemicals present in C. lasiantha. Anti-inflammation activities
are related to C. lasiantha extracts through their antibacterial activities.Evaluation of in vitro antibacterial activity of Caralluma lasiantha for scie...
Evaluation of in vitro antibacterial activity of Caralluma lasiantha for scie...Ratnakaram Venkata Nadh
medicine due to their significant role in the treatment of different health problems.
Methods: We have synthesized new series of isoxazole-chalcone conjugates (14a-m) by the
Claisen-Schmidt condensation of suitable substituted acetophenones with isoxazole aldehydes (12a-d).
In vitro cytotoxic activity of the synthesized compounds was studied against four different selected
human cancer cell lines by using sulforhodamine B (SRB) method.
Results: The adopted scheme resulted in good yields of new series of isoxazole-chalcone
conjugates (14a-m). Potent cytotoxic activity was observed for compounds -14a, 14b, 14e, 14i, 14j
and 14k against prostate DU-145 cancer cell line.
Conclusion: The observed potent cytotoxic activities were due to the presence of 3,4,5-
trimethoxyphenyl group.Novel Hybrid Molecules of Isoxazole Chalcone Derivatives: Synthesis and Study...
Novel Hybrid Molecules of Isoxazole Chalcone Derivatives: Synthesis and Study...Ratnakaram Venkata Nadh
Abstract: Background: A new series of quinazoline linked chalcone conjugates were synthesized
and evaluated for their in vitro cytotoxicity.
Methods: The quinazoline-chalcone derivatives (13a-r) have been prepared by the Claisen-Schmidt
condensation of various substituted benzaldehydes (12a-r) with substituted l-(4-(3,4-
dihydroquinazolin-4-ylamino)phenyl)ethanone (11a-b) in the presence of aqueous NaOH. Three
potential compounds 13f, 13g and 13h exhibited cytotoxicity against leukemia (GI50 value of
1.07, 0.26 and 0.24 μM), Non-small lung (GI50 values of 2.05,1.32 and 0.23 μM), colon (GI50
values of 0.54, 0.34 and 0.34 μM) and breast (GI50 values of 2.17, 1.84 and 0.22 μM) cell line,
respectively.
Results and Conclusion: Based on these biological results, it is evident that compound 13h has the
potential to be considered for further detailed studies either alone or in combination with existing
therapies as potential anticancer agents.Novel Hybrid Molecules of Quinazoline Chalcone Derivatives: Synthesis and Stu...
Novel Hybrid Molecules of Quinazoline Chalcone Derivatives: Synthesis and Stu...Ratnakaram Venkata Nadh
A methodical design-of-experiments were performed by applying quality-by-design concepts to establish
a design-space for simultaneous and rapid quantification of Carvedilol and Ivabradine by UPLC in the
presence of degradation products. Response-surface, central-composite design, and quadratic model
were employed for statistical assessment of experimental data using the Design-Expert software.
Response variables such as resolution and retention time were analyzed statistically for chromatographic
screening. During DoE study, various plots such as perturbation, contour, 3D and design-space plots were
considered for method optimization. The method was developed using C8 [100 � 2.1 mm, 1.8 μ] UPLC
column, mobile phase comprising 0.5% triethylamine buffer [pH 6.4] and acetonitrile in the ratio of 50:50
v/v, the flow rate of 0.4 mL minute−1 and UV detection at 285 nm for both Carvedilol and Ivabradine.
The method was developed with a short run time of two minutes. The method was found to be linear in
the range of 25.0–199.9 μg mL−1 and 8.9–21.3 μg mL−1 for Carvedilol and Ivabradine, respectively with a
correlation coefficient of 0.9998 in each case. The recovery values were found in the range of 99.7–100.8%
and 98.9–100.9% for Carvedilol and Ivabradine, respectively. The method was validated according to ICH
Q2 (R1) guidelines.Development and validation of UPLC method for simultaneous quantification of ...
Development and validation of UPLC method for simultaneous quantification of ...Ratnakaram Venkata Nadh
Rifampicin PLGA nanospheres are
formulated with a specific goal in order to decrease
the dose, adverse effects and to enhance targeted
drug delivery. Rifampicin nanospheres were
prepared and evaluated by emulsion solvent
evaporation method. In vivo bio distribution studies
reveal that there was a long term accumulation of
rifampicin nanospheres in the lungs over other
organs. The increase in Cmax values confirmed that
inhalable PLGA nanospheres are suitable for
targeting and providing sustained release of antitubercular
drugs to lungs. So inhalation is a
selected administration route of Rifampicin PLGA
nanospheres. The in vivo screening of M.
tuberculosis showed good activity as well as its
activity against multidrug-resistant M. tuberculosis
and against M. tuberculosis isolates in a
potentially latent state, makes Rifampicin PLGA
nanospheres as an attractive drug dosage form
for the therapy of tuberculosis. It can be concluded
that there is a significant potential for effective
oral delivery as well as nasal delivery of the
Nanospheres for the treatment of tuberculosis.In-Vivo Evaluation of Rifampicin Loaded Nanospheres: Biodistribution and Myco...
In-Vivo Evaluation of Rifampicin Loaded Nanospheres: Biodistribution and Myco...Ratnakaram Venkata Nadh
58. G. Venkata Narasimha Rao, Muralee Krishna, Ravi Kumar Bellam and R. Venkata Nadh, LC-MS compatible stability indicating RP-UPLC method for the estimation of ester prodrug of mycophenolic acid in injection formulation, Asian Journal of Chemistry, (SCOPUS indexed, ISSN: 0970-7077 (Print), 0975-427X (Online)), 30(8) (2018) 1915-1924, DOI: 10.14233/ajchem.2018.21445 LC-MS compatible stability indicating RP-UPLC method for the estimation of es...
LC-MS compatible stability indicating RP-UPLC method for the estimation of es...Ratnakaram Venkata Nadh
Abstract: A highly efficient and milder protocol for the syntheses of novel series of 2-aminothiazoles
bearing 5-methylisoxazoline and pyridine-piperazine hybrid molecules has been developed. The target
compounds 13a-e were screened for their in vitro cytotoxicity activity against various tumor cell lines
including MCF-7 (human breast adenocarcinoma), HCT-116 (colorectal carcinoma), Jurkat (human Tcell
leukemia) and THP-1 (human acute monocytic leukemia). The bioactive assay showed most of the
new compounds exhibited promising results in comparison with the parental Sunitinib. The synthesized
compounds could well be used in the future as lead anticancer drugs in drug development studies. The
synthesized compounds were fully characterized by IR, 1H NMR, 13C NMR, elemental analysis and
mass spectral data.Synthesis and Antitumor Activity Evaluation of 2-Aminothiazoles Appended 5-me...
Synthesis and Antitumor Activity Evaluation of 2-Aminothiazoles Appended 5-me...Ratnakaram Venkata Nadh
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Caralluma lasiantha: A review on it’s vital role in Indian Traditional Medicine
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Phytochemical Investigation of Caralluma lasiantha: Isolation of Stigmasterol...
Phytochemical Screening of Caralluma lasiantha Isolation of C21 Pregnane Steroid
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Supercritical fluid (CO2) chromatography for quantitative determination of se...
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A convenient new and efficient commercial synthetic route for dasatinib (Spry...
Utilization of agro-waste for removal of toxic hexavalent chromium: surface i...
Utilization of agro-waste for removal of toxic hexavalent chromium: surface i...
Evaluation of in vitro antibacterial activity of Caralluma lasiantha for scie...
Evaluation of in vitro antibacterial activity of Caralluma lasiantha for scie...
Novel Hybrid Molecules of Isoxazole Chalcone Derivatives: Synthesis and Study...
Novel Hybrid Molecules of Isoxazole Chalcone Derivatives: Synthesis and Study...
Novel Hybrid Molecules of Quinazoline Chalcone Derivatives: Synthesis and Stu...
Novel Hybrid Molecules of Quinazoline Chalcone Derivatives: Synthesis and Stu...
Development and validation of UPLC method for simultaneous quantification of ...
Development and validation of UPLC method for simultaneous quantification of ...
In-Vivo Evaluation of Rifampicin Loaded Nanospheres: Biodistribution and Myco...
In-Vivo Evaluation of Rifampicin Loaded Nanospheres: Biodistribution and Myco...
LC-MS compatible stability indicating RP-UPLC method for the estimation of es...
LC-MS compatible stability indicating RP-UPLC method for the estimation of es...
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