Sawc Carman Brown Op Poster Orlando, Fl 04.10

The Impact of Autologous Platelet Rich Plasma Gel on Rapid Wound Improvement in the Outpatient Setting Donna R. Carman, MD and Susan Brown, CAPT, USPHS, FNP-BC, CWOCN, Phoenix Indian Medical Center, Phoenix, AZ A Background and Purpose Design and Methods Results Background: Chronic wounds tend to have delayed healing due to remaining in the inflammatory stage of healing for an extended period. Clinicians seek therapies that can advance the wounds in the healing process. A specially formulated Platelet Rich Plasma Gel (PRP)* has been cleared by the FDA for the management of exuding wounds including diabetic ulcers, leg ulcers, pressure ulcers, and mechanically or surgically debrided wounds. Autologous Platelet Rich Plasma Gel contains the patient’s growth factors, cytokines, and chemokines for cell growth and migration, plasma-derived proteins to produce a fibrin matrix scaffold and anti-inflammatory properties to progress the natural healing process. This PRP Gel was used to treat nonhealing wounds in 3 outpatient wound clinics. Twenty seven (27) patients with 34 wounds were treated. Wound etiologies included: 12 venous ulcers, 11 diabetic ulcers, 4 pressure ulcers, 2 trauma wounds, 2 arterial wounds, 2 wound dehiscence, and 1 sickle cell wound. The mean patient age was 61.4 years and previous wound duration was 56.7 weeks. Objective wound measurements were gathered prospectively and documented for the area and volume of the core wound as well as the length of undermining, sinus tracts and tunneling.. The PRP Gel was processed and applied as follows: Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],% Wounds Responded with % Volume Reduction *AutoloGel System, Cytomedix, Inc, Rockville, MD Step 1; Gather the supplies for processing from the custom PRP Gel Wound Dressing Kit Step 2; Perform the venipuncture Step 3; Spin the whole blood in the custom designed centrifuge for 90 sec . Step 4; Add the reagents (included in the reagent kit) to activate the PRP which causes it to become a gel Step 5; Apply the PRP Gel into any undermining, sinus tracts/tunneling, and topically onto the open core wound. Cover with dressings per training. Whole blood Platelet Rich Plasma Red blood cells Rapid size reduction in long standing chronic wounds utilizing PRP Gel allowed the outpatient clinics to achieve their goal of progressing healing at a faster rate than the patients had experienced previously. - Driver VR, Hanft J, Fylling C, Beriou JM. A prospective randomized controlled trial of autologous PRP gel for the treatment of diabetic ulcers. Ostomy & Wound Management . Jun 2006; 52(6):68-87. - Dougherty EJ. An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers. Adv Skin Wound Care. 2008;21(12):568-75 - Gurvich L, Synergism in using negative pressure wound therapy with alternated applications of autologous platelet-derived growth factors in treating post-acute surgical wounds. Wounds 2009; 21(5); 134-140. Positive Impact of Platelet Rich Plasma Gel on Wound Healing Progress in 3.2 Treatments Within 3.5 Weeks % Wounds Responded with % Area Reduction % Wounds Responded with % Sinus Tracts/ Tunneling Reduction % Wounds Responded with % Undermining Reduction Weeks Previous Wound Duration vs Treatment Time All the following data reflects the mean outcomes. In 3.2 treatments over 3.5 weeks, 91.2% of wounds decreased 66.7% in volume, 91.2% of the wounds reduced 52.7% in area. 100% of the wounds with undermining, sinus tracts or tunneling responded positively. Wounds with undermining (8/34 or 24%) had a mean reduction of 95% in 2.5 treatments over 2.9 weeks. Wounds with sinus tracts/tunneling (2/34 or 6%) had a mean reduction of 100% in 2 treatments over 3 weeks. Percentage Percentage Percentage Weeks References Percentage

Sawc Carman Brown Op Poster Orlando, Fl 04.10

Recommended

Recommended

More Related Content

Similar to Sawc Carman Brown Op Poster Orlando, Fl 04.10

Similar to Sawc Carman Brown Op Poster Orlando, Fl 04.10 (20)

Sawc Carman Brown Op Poster Orlando, Fl 04.10