1. Small alpha-helical pores for polar solutes are expected to be: A. hydrophilic B. amphipathic C.integral D. unfolded 2. A small membrane vesicle containing a transmembrane protein is shown. Assume that this membrane vesicle is in the cytoplasm of a cell. Which side is in the cytosolic side A. N B. C z Solution 1. The inside of pores for polar solutes is hydrophillic. Hydrophillic proteins lining the pore bind with the polar solutes and aid their transport across the lipid bilayer. 2. C is the cytosolic side. The side face facing the cytosol faces the cytosol only after insertion of the protein in the membrane the side in the interior of the vesicle that is N in this case faces the extracellular medium or the interior of the organelle..