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ComunicacióN Celular

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ComunicacióN Celular

  1. 1. Comunicación Celular Ramón Reynoso Orozco
  2. 2. CÉLULA SEÑALIZADORA CEL. BLANCO (RECEPTORA) MENSAJE MEDIO EXTRACELULAR RESPUESTA CELULAR COMUNICACIÓN CELULAR
  3. 3. FUNCIONES GENERALES REGULADAS POR LA COMUNICACIÓN ENTRE LAS CÉLULAS
  4. 4. Señales de Comunicación Celular <ul><li>Sustancias químicas: </li></ul><ul><li> Neurotransmisores (células nerviosas) </li></ul><ul><li> Hormonas (células glandulares) </li></ul><ul><li> Interleucinas (células del sistema inmune) </li></ul><ul><li>Corrientes iónicas: </li></ul><ul><li> Sinapsis eléctrica (Células Nerviosas) </li></ul>
  5. 5. Comunicación Celular Química <ul><li>Síntesis de la molécula señal por la célula emisora, </li></ul><ul><li>Liberación de la molécula señal hacia el espacio extracelular, </li></ul><ul><li>Transporte de la molécula señal hacia la célula blanco, </li></ul><ul><li>Detección de la molécula señal por una proteína receptora, </li></ul><ul><li>Modificación del metabolismo celular causada por la interacción molécula señal-receptor, </li></ul><ul><li>Terminación de la respuesta celular. </li></ul>
  6. 6. TIPOS DE COMUNICACIÓN O SEÑALIZACIÓN <ul><li>AUTÓCRINA </li></ul><ul><li>PARÁCRINA </li></ul><ul><li>ENDÓCRINA </li></ul>
  7. 10. FLUJO DE INFORMACIÓN EN LA COMUNICACIÓN POR SEÑALES QUÍMICAS MOL. SEÑALIZADORA (Primer mensajero) RECEPTOR MEMBRANA CELULAR PRIMER EFECTOR (Generador del segundo mensajero) Segundo mensajero Sistema (s) de efectores TRANSDUCTOR
  8. 11. Moléculas Señalizadoras (Primer mensajero) 1.Mensajeros Liposolubles 1.Mensajeros Liposolubles 2.Mensajeros Hidrosolubles
  9. 12. FLUJO DE INFORMACIÓN EN LA COMUNICACIÓN POR SEÑALES QUÍMICAS MOL. SEÑALIZADORA (Primer mensajero) RECEPTOR MEMBRANA CELULAR PRIMER EFECTOR (Generador del segundo mensajero) Segundo mensajero Sistema (s) de efectores TRANSDUCTOR
  10. 13. Receptores Acoplados a Proteínas G
  11. 14. Receptores-canal iónicos
  12. 15. Receptores ligados a Tirosin cinasas
  13. 16. Receptores con Actividad Enzimática
  14. 17. Comunicación Intracelular Mensajero Intercelular (1er. Mensajero) Receptor de Membrana Plasmática Transductor de Señal: Proteína G Efector Primario Mensajero Intracelular (2do. Mensajero) Efectores Secundarios
  15. 18. Proteína G (Transductor)
  16. 19. Proteína G (Transductor)
  17. 21. Mensajeros Intracelulares (2 dos Mensajeros)
  18. 22. Vía de señalización dependiente de AMPc
  19. 23. Vía de señalización dependiente de IP 3
  20. 24. Regulación de glucogenólisis, mediada por diversos segundos mensajeros Cinasa fosforilasa de glucógeno
  21. 26. Comunicación Intracelular Mensajero Intercelular (1er. Mensajero) Receptor de Membrana Plasmática Transductor de Señal: Proteína G Efector Primario Mensajero Intracelular (2do. Mensajero) Efectores Secundarios
  22. 27. Vías de señalización dependientes de MAP-cinasas en Eucariontes
  23. 28. Vía de señalización dependiente de MAPK’s
  24. 31. Comunicación Interneuronal: Sinápsis
  25. 32. Conceptos Básicos <ul><li>Potencial de Membrana en reposo: es el estado electroquímico de una neurona en reposo. </li></ul><ul><li>Las propiedades de señalización de una célula excitable, son determinadas por cambios en el potencial de membrana </li></ul>
  26. 33. Membrane Resting Potential <ul><li>Every neuron has a separation of electrical charge across its cell membrane. </li></ul><ul><li>The membrane potential results from a separation of positive and negative charges across the cell membrane. </li></ul>
  27. 34. Membrane Resting Potential <ul><li>excess of positive charges outside and negative charges inside the membrane </li></ul><ul><li>maintained because the lipid bilayer acts as a barrier to the diffusion of ions </li></ul><ul><li>-70 a -90 mV </li></ul>
  28. 35. Canales Iónicos
  29. 36. Gradiente Químico y Eléctrico
  30. 38. Cambios en el potencial de membrana <ul><li>Despolarización </li></ul><ul><li>Hiperpolarización </li></ul>
  31. 39. Potencial de Acción <ul><li>Es la unidad básica de conducción del impulso eléctrico en el sistema nervioso </li></ul><ul><li>Característico del axon de las células nerviosas </li></ul><ul><li>Conducción no-decremental </li></ul><ul><li>Ley de todo o nada </li></ul>
  32. 40. Secuencia del Potencial de Acción
  33. 43. <ul><li>The voltage-gated K+ channels close, so much Potassium accumulates outside the cell that repolarization occurs </li></ul>
  34. 44. <ul><li>Activación de la bomba electrogénica de Na-K+. </li></ul>
  35. 45. Bomba de Na + -K +
  36. 46. Sinápsis Eléctrica

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