This document discusses the role of different adipose tissue types in atherosclerosis development. It describes white adipose tissue (WAT) as the main site for energy storage, brown adipose tissue (BAT) for energy combustion, and perivascular adipose tissue (PVAT) providing mechanical support to blood vessels. Hypercholesterolemia and triglyceride-rich lipoproteins contribute to atherosclerosis. The hypothesis is that reducing lipid storage in WAT and increasing lipid combustion in BAT can lower risk of atherosclerosis. Therapeutic strategies aim to enhance lipid storage in WAT, activate BAT thermogenesis, and increase lipolysis in both tissues to reduce triglyceride levels.

1. TARGETING WHITE, BROWN AND PERIVASCULAR ADIPOSE
TISSUE IN ATHEROSCLEROSIS DEVELOPMENT
Andrea D. van Dama,b, Mariëtte R. Boona,b, Jimmy F.P. Berbéea,b,
Patrick C.N. Rensena,b, Vanessa van Harmelenb,c 2017,⁎
Presented By: Yumna Ali

2. INTRODUCTION
 Obesity is a well-established risk factor for atherosclerosis.
 Adipose tissue comprises various depots including WAT, BAT and
thoracic and abdominal perivascular adipose tissue PVAT.
 Atherosclerosis is promoted by energy-storing adipose depots and
attenuated by energy-combusting adipose tissue

3. HYPOTHESIS
 To understand the mechanistic link between Adipose tissue and
development of atherosclerosis.
 This Article provides an overview of types and function of
adipose tissues, and specific strategies to reduce the risk of
Atherosclerosis.

4. ATHEROSCLEROSIS
 Hypercholestremia
 LDL,VLDL, remenent particles in vessel walls.

5.  Triglyceride-rich lipoproteins contribute to
Atheroscelerosis

6. ADIPOSE TISSUE TYPES
 Adipose tissue is the main site for energy storage
 Composed of adipocytes
 The main adipose tissue depots are classified as white
adipose tissue (WAT), brown adipose tissue (BAT) and
perivascular adipose tissue (PVAT).

7. WHITE ADIPOSE TISSUE

9. BROWN AND BEIGE ADIPOSE TISSUE

11. PERIVASCULAR ADIPOSE TISSUE
 Provide mechanical support to
vessels and regulate vascular
tension and torsion.
 Paracrine effect on the vessel.

13. THERAPEUTIC IMPLICATIONS
 Triglyceride Lowering Strategies
 Lipid storage in WAT enhanced by TZD

14.  Lipid Combustion by BAT
 Activation of B3 adrenergic receptor induce thermogenesis
and lipid combustion

15. INCREASE LIPOLYSIS IN WAT AND BAT
 Lipolysis in WAT fatty acid release hypertriglyceridemia
 Lipolysis in BAT combustion of fatty acid lower plasma
triglyceride levels

17. CONCLUSION
 WAT,BAT, PVAT play important role in development of
atherosclerosis.
 To reduce risk of atherosclerosis , the most favourable
approach to eliminate TRL is,
by increasing combustion of fatty acid in BAT, and reduce lipid
storage in WAT.

18.  Prof. Silvia Biocca (uniroma2.it)
(research methodology)
 First Year Physical Activity and
Health Promotion batch 2016/2017
ACKNOWLEDGMENT