3. DEFINICIÓN
01
Hace referencia a la cantidad de fármaco que llega en
forma activa a la circulación sistémica y la velocidad a
la que accede a ésta.
02
Es decir, la fracción de medicamento capaz de llegar al lugar
de acción, dependerá de las características fisicoquímicas
del principio activo, de los excipientes del proceso de
fabricación y de la conservación de la forma farmacéutica
03
Y de la conservación de la forma farmacéutica, y
también de las características intrínsecas al individuo,
como la motilidad intestinal o el pH gástrico.
04
Cualquier modificación en alguno de estos factores
puede alterar tanto la cantidad total de principio activo
absorbido como la velocidad a la que se absorbe.
4. FACTORES QUE INFLUYEN LA BIODISPONIBILIDAD
Cuando se habla de biodisponibilidad se
supone que la concentración de un
fármaco en sangre como la cantidad de
fármaco excretada en la orina están
relacionadas.
No se puede orinar más de lo que se
absorbe, aquí es donde se observa la
eficacia clínica de un medicamento
Aquí entra el
principio activo y
la forma
farmacéutica:
manera de
preparación,
excipientes,etc.
Factores
Biológicos
Los más
importantes son
los factores
inherentes al
medicamento
Por ejemplo la
velocidad de
excreción de la
carboxitolbutamida
en la orina que por
tener el tamaño de
particular diferente a
la tolbutamida en la
forma farmaceutica
puede tener una
velocidad acelerada
de excreción
Factores
inherentes a
los
medicamentos Sexo, edad,
condiciones del
organismo, la
enfermedad en sí,
padecimientos,
factores
hormonales y
genéricos.
La
administración
de otros
medicamentos
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