SlideShare a Scribd company logo
1 of 96
Download to read offline
FORENSIC
FORENSIC
TOXICOLOGY-I
TOXICOLOGY-I
Dr Mohd Kaleem Khan
Assistant Professor
Department Of Forensic
Medicine
JNMCH AMU Aligarh
TOXICOLOGY :
 Toxicology is the science dealing with properties,
action, toxicity, fatal dose, detection, estimation of,
interpretation of the result of toxicological analysis
and management of Poisons
Forensic Toxicology:
 Branch of Forensic Medicine dealing with Medical
and Legal aspects of the harmful effects of chemicals
on human beings.
POISON:
 Any substance which when
 Administered in living body through any route
(inhalation, ingestion, injecion, surface absorption etc)
 Will produce ill-health or death by its action which is
due to
 Its physical,
 Chemical or
 Physiological properties.
 Eg: alphos, sulphuric acid, arsenic etc.
Drug (WHO 1996):
“Drug is any substance or product that is used or
intended to be used to
 Modify or
 Explore physiological systems or
 Pathological states
For the benefit of the recipient.”
 Eg: Paracetamol, Ciprofloxacin, Salbutamol, Oestrogen, Insulin
Etc.
Clinical Toxicology:
 Deals with human diseases caused by, or associated
with abnormal exposure to chemical substances.
• Toxinology :
 Refers to toxins produced by living organism which
are dangerous to man,
 E.g.: snake venom, fungal and bacterial toxins etc.
• Acute poisoning
 Caused by an excessive single dose, or several dose
of a poison taken over a short interval of time.
•
• Chronic Poisoning
 Caused by smaller doses over a period of time,
resulting in gradual worsening.
 Eg: arsenic, phosphorus, antimony and opium.
• Sub-acute poisoning
 Shows features of both acute and chronic poisoning.
• Fulminant poisoning:
 Produced by a massive dose.
 In this death occur rapidly, sometimes without
preceding symptoms.
LAWS IN RELATION TO MEDICINE
(1) The drug and cosmetic act, 1940:
 Regulate all kinds of drugs
 Import,
 Manufacture,
 Distribution and
 Sale.
 Its main feature is to control purity, quality and
strength of drug.
(2) The drug and cosmetic rule, 1945:
 Regulate storage, display, dispensing, sale,
labeling, prescribing etc.
Schedule
▫ C- biological and special products,
▫ E- poison,
▫ F- vaccine and sera,
▫ G- hormones,
▫ J- list of diseases for which No drug should be advertised,
▫ H- drugs to be sold on prescription of RMP,
▫ L- antibiotics, antihistaminics and other chemotherapeutic
agents
3. The pharmacy act, 1948 :
 Allows only registered pharmacists to compound, prepare
and dispense medicine
4. The drug control act, 1950 :
 (sale, supply and distribution, fixing of prices )
5. The drug and magic remedies act, 1954
The Narcotic Drugs And Psychotropic Substance
Act, 1985.
 Psychotropic subs alters mental function
 e.g. LSD, amphetamine, barbiturates etc
 Narcotics causes dullness of senses and induces sleep
e.g. cannabis, opium and cocaine.
 The law prohibits of these drugs
 Cultivation,
 Manufacture,
 Possession,
 Sale purchase
 Import export etc
 Except for medical and scientific purpose.
Sources of Poison:
• Domestic or household sources –
 Detergents, Disinfectants, Cleaning Agents, Antiseptics,
Insecticides, Rodenticides Etc.
• Agricultural and horticultural sources-
 Insecticides, Pesticides, Fungicides and Weed Killers.
• Industrial sources –
 Poisons are Manufactured or Poisons are Produced as by Products.
• Commercial sources-
 Store-houses, Distribution Centres and Selling Shops.
• From uses as drugs and medicines
 Wrong Medication, Overmedication And Abuse Of Drugs.
• Food and drink –
 Preservatives of food grains or other food material,
 Additives, colouring and odouring agents
 accidental contamination of food and drink.
• Miscellaneous sources-
 Snakes bite poisoning, city smoke, sewer gas poisoning etc.
INCIDENCE OF POISONING
▫ Homicidal poisoning
▫ Suicidal poisoning
▫ Accidental poisoning:
▫ Household poisons
▫ Stupefying Agents:
 Alcohol, Dhatura, Cannabis Indica, Chloral Hydrate, Rophynol
▫ Aphrodisiacs:
 Canthrides, Opium, Cannabis, Cocain .
▫ Abortificients:
 Calotropis, Croton, Semecardium, Lead, Kmno4,Ergot Etc.
▫ Animal Poisoning:
 Cattle, Stray Dogs, Rodents
Classification of Poisons
(I) Corrosives (it erodes the surface with which it comes in
contact)
(1) Strong Acids:
 Inorganic Or Mineral Acids-
▫ Sulphuric, Nitric, Hydrochloric
 Organic Acids-
▫ Carbolic, Oxalic, Acetic, Salicylic
(2) Strong Alkali:
 Hydrates of – sodium, potassium
 Carbonates of- sodium, potassium, ammonia
(II) Irritants: (they causes inflammation on the site of
contact esp GIT, respiratory tract and skin)
(1) Agricultural
(2) Inorganic :
• Non-metallic – P, I, Cl, Br etc
• Metallic – Ar, Cu, Zn, Pb, Hg
• Mechanical – Powdered Glass, Brick, Hair, Nails, Pins
(3) Organic :
• Vegetable – Abrus Precatorius, Aloes, Croton, Castor,
Calotropis
• Animal – Snake, Bees, Wasps
(III) Systemic: which involves toxic effect on a particular
system
(1) Cerebral
• CNS Depressants- Alcohol, Opiods
• CNS Stimulants- Antidepressants, Amphetamine,
Caffeine
• Deliriants- Dhatura, Balladona, Cocaine
(2) Spinal: Nux Vomica
(3) Peripheral: Curare, Conium
(4) Cardiac: Aconite, Quinine, Tobacco, Cyanide
(5) Asphyxiants: CO, H2S, CO2
• Nephrotoxic:
 Oxalic Acid, Mercury, Cantharides
Hepatotoxic:
 Phosphorus, Carbon tetrachloride, Chloroform
• Miscelanious
 Agrochemicals
 Pesticides: Organophosphorous
 Fumigants: Alphos
 Rhodenticides: Thalium, Zn Phosphide
• Drug dependence
• Petroleum products
• Food poisoning
• Other:
 Analgesic,
 Antipyretic
Classification of Poison according to motive or nature of use:
• Homicidal:
 Arsenic, Aconite, Digitalis, Abrus Precatorius, Strychnos Nux Vomica.
• Suicidal:
 Opium, Barbiturate, Organophosphorus, Carbolic Acid, Copper
Sulphate.
• Accidental:
 Aspirin, Organophosphorus, Copper Sulphate, Snakes Bite, Ergot, Co, Co2,
H2s.
• Abortificient:
 Ergot, Quinine, Calotropis, Plumbago.
• Stupefying Agent:
 Dhatura, Cannabis, Chloral Hydrate.
• Agents Used To Cause Bodily Injury:
 Corrosive Acids and Alkali.
• Cattle Poison:
 Abrus precatorius, Calotropis, Plumbago.
• Used For Malingering:
 Semicarpus Anacardium
Characteristics of Ideal Homicidal
and Suicidal Poison
Characteristics Suicidal Homicidal
Accessibility Cheap & Easy Cheap & Easy
Antidote Difficult Difficult
Lethal Dose Small Small
Lethal Period Small Long
Taste Pleasant Pleasant
Signs / Symptom Few or None Resemble Disease
E.g. Cyanide, Opium , Insulin, Arsenic, Aconite
Barbiturates,
Thallium,
Organophosphorus,
Madar,strychnine
Route of Administration/absorbtion:
 Oral (commonest) e.g. alphos, acids,
 Inhalation: gas poison
 Parenteral
▫ (IM, IV, Sub-Cutaneous, Intra-Dermal)
 Natural Orifices other than mouth
▫ (Nasal, Rectal, Vaginal, Urethral),
 Ulcers, wounds and intact skin.
Fate of poison in body
▫ A part, of the poison eliminated unabsorbed by means of defecation and
vomiting.
▫ Liver detoxify or metabolize the poisons.
▫ By evaporation or oxidized or destroyed in the body.
• Excretion of poisons:
 Unabsorbed poisons are excreted through faeces and vomits.
 Absorbed poisons are excreted mostly by urine.
 A part of volatile poison is exhaled out .
 Some portion of poison is excreted through bile, saliva, milk, sweat,
tear, hair and nails.
Factors influencing the actions of a
poison in the body.
• 1. Quantity:
 A high dose of poison acts quickly and often resulting in fatal
consequences.
 A moderate dose causes acute poisoning.
 A low dose may have sub -clinical effects and causes chronic
poisoning on repeated exposure.
• 2. Form:
▫ Physical state:
 Gaseous or volatile poisons are very quickly absorbed.
 Liquid poisons are more rapid than solid poisons.
 Powder act more quickly than coarse substance.
• Some poisonous vegetable seeds may pass through the intestinal
canal ineffective when taken intact due to their impermeable
pericarp. But when taken crushed, they may be rapidly fatal.
▫ Chemical combination:
 Chemically pure arsenic and mercury are not poisonous because these
are insoluble and are not absorbed.
 But white arsenic(arsenic oxide) and mercuric chloride are deadly
poisonous.
 Barium sulphide is deadly toxic but barium sulphate is non-toxic.
▫ Mechanical combination:
 Action of poison is altered when it combines with mechanically
inert substances.
• 3.Mode of Administration:
 Absorption rate is different for different routes
 GAS > IV > IM > SC/ID > WOUND > SEROUS SURFACE >
INGESTION > NATURAL ORIFICES > UNBROKEN SKIN
• 4. Condition of patient
 Age:
 Poisons have greater effect on two extremes of age
• State of body health:
• A well built person with good health can tolerate the action of
poison better than a weak person.
▫ Presence of disease :
 In certain diseased conditions some drugs are tolerated
exceptionally well e.g.: sedatives and tranquilizers are tolerated in
very high dose by manic and deliriant patients.
•
• Intoxication arid poisoning states –
 In certain poisoning cases some drugs are well tolerated, like, in case
of strychnine poisoning, barbiturates and sedatives are better
tolerated.
 Whereas in case of barbiturate poisoning any sedative or tranquilizer
will accentuate the process of death.
▫ Sleep
 Absorption and action of the poison is also slow.
 But depressant drugs may cause, more harm
▫ Exercise –
 Action of alcohol on C.N.S. is slowed during exercise because more
blood is drawn to the muscles during exercise.
▫ Cumulative action of poisons:
 cumulative poisons (poisons which are not readily
excreted from the body and are retained in different
organs of the body for a long time) like
 Lead may not cause any toxic effect when enters the body in
low dose.
 But when such poisons enter over a long period of time, may
cause harm when their concentration in different tissue
reaches high level due to their cumulative property.
• Tolerance may develop by individuals on long term
exposue to a particular poison.
• Idiosyncracy: some persons may react adversely to a
particular drug though the general population tolerates
the drug well.
Duties of a Doctor
▫ Doctor must record preliminary particulars,
▫ If summoned by the investigating police officer or
magistrate must cooperate.
▫ Notify cases of homicidal poisoning to the nearest police
station as per s. 39 Cr PC
 Failing which he is liable for prosecution proceedings under
section 176 IPC.
▫ In Government Institutions, all types of poisoning cases intimated
to the police station as a routine.
▫ Poisoning must be subjected for autopsy.
▫ body should not be released to the relatives before inquest.
▫ A doctor should never grant a death certificate stating the cause of
death before an autopsy is conducted.
▫ False information, if any, furnished to the police can lead to
prosecution proceedings under section 193 IPC.
▫ Recording of a dying declaration
▫ Material objects like stomach wash, vomits, excreta,
blood, urine etc. are to be preserved for chemical
analysis.
▫ All relevant records connected with poisoning cases
must be kept under safe custody.
Laws in relation to poison and drugs:
• Different sections of Indian penal code related to poisons are as
follows
▫ Sec. 272 I.P.C. - Punishment for adulterating food or drink intended for
sale, so as to make the. same noxious, may extend upto 6 months
imprisonment of either term and/or fine upto one thousand rupees.
▫ Sec. 273 I.P.C. - Punishment for selling noxious food or drink may be
imprisonment of either description for a period of 6. months and or fine
upto one thousand rupees.
▫ Sec. 274 I.P.C. - Punishment for adulteration of drugs in any form with
any change in its effect knowing that it Will be sold and used as un-
adulterated drug, may be imprisonment of either description for a period-
of 6 months and or fine.
•
▫ Sec. 275 l.P.C. - Punishment for knowingly selling adulterated
drugs with less efficacy or altered action serving it for use as
unadulterated may be imprisonment of either description for 6
months and or fine.
▫ Sec. 276 I.P.C. - Punishment for selling a drug as a different
drug or Preparation, may be imprisonment of either description
which may extend up to 6 months and or fine. .
▫ Note - In the State of West Bengal, the punishment for these
offences described under sections 272 to 276 may be up to
imprisonment for life with or without fine.
▫ Sec. 277 I.P.C. – Punishment for fouling water of public spring
or reservoir may be imprisonment of either description which
may extend up to a period of 3 months and or fine.
▫ Sec. 278 I.P.C. - Punishment for voluntarily making
atmosphere noxious to health is fine which . may extend upto five
hundred rupees.
▫ Sec. 284 I.P.C. Punishment for negligent conduct with respect
to poisonous substance may be imprisonment of either
description which may extend up to 6 months and or fine which
may extend up to one thousand rupees.
▫
▫ Sec. 328 I.P.C. :Punishment' for causing hurt by means of
poison or any stupefying, intoxicating or unwholesome drug or
any other thing with the intent to commit an offence shall be
imprisonment of either description for a term which may extend
to ten years with or without fine.
If poison is known then treat specific poison
If not known on general lines of management
Main aim to stay the patient alive by supporting
respiration and circulation
Assisted by getting rid of poison by metabolism,
excretion.
Use of antidote by getting rid of poison.
TREATMENT OF POISONING:
Removal of unabsorbed poison
Use of antidote
Elimination of absorbed poison
Treatment of general symptoms
Maintenance of patient's general condition
OBJECTIVES:
Depending Upon Route of Entry
a.INHALEED POISON: (CO,H2,S)
 Remove from sources to fresh air
 Artificial respiration
 Keep airway patent (posture drainage)
REMOVAL OF UNABSORBED POISON:
a. INJECTED POISON: (hypnotics, insulin,
sedatives)
 A tight tourniquet proximal to point of injection
 Must be relaxed for one min after 10 min.
 Wound may be excised and poison removed
a. CONTACT POISON:
 Spilled or sprayed on skin, eyes or wound
 Best way is to wash it out with water
 Neutralize it by an antidote.
a. INGESTED POISIONS
 Remove from stomach as much as possible by Vomiting, and
stomach wash.
 If patient is conscious and cooperative and vomiting is not contra
indicated. Induce it by tickling the fauces and by use of Emetics
 Contraindications are;(corrosive, petroleum, distillates, coma,
Strychnine ) ( cardio-resp. diseases, Advanced pregnancy)
Warm water.
Mustard powder ( Table spoon = 15 gm)
Two table spoons of NaCl + 200ml tepid water)
Apo morphine 6 mg s/c followed by
Nalaxone Hcl 5-10 mg i.m/i.v causes vomiting in 3-5 min.
Facilitate gastric lavage by removing contents.
Produce gastric/intestine reflux (Tab).
HOUSE HOLD EMETICS
• INTRODUCTION
Gastric lavage is a method of gastrointestinal decontamination.
Performed in the setting of an ingested overdose or acute poisoning,
to decrease the absorption of substances in the stomach.
 This technique was first described in 1812.
DEFINITION
Gastric lavage also commonly called stomach wash or gastric
suction, is the process of cleaning out of the contents of the stomach.
It has been used for eliminating poisons from the stomach.
GASTRIC LAVAGE
GASTRIC LAVAGE
If not contra indicated-may be
life saving but should be
undertaken within 6 hours.
Contraindicated in corrosives.
exception in carbolic acid.)
Certain measures should be
taken such as
 Strychnine poisoning ( control fits )
 Kerosene poisoning ( airway
 should be sealed ) Hypothermia
( Body temp should be maintained.)
Abnormal or absent pharyngeal/upper gastrointestinal anatomy
Active or substantial antecedent vomiting
Caustic ingestion.
Coagulopathy.
Decreased mental status
CONTRAINDICATIONS
Inactive or diminished airway reflexes
Large pills
Large or sharp foreign body
Nontoxic or minimally toxic ingestion
Signifiant aspiration risk (e.g., hydrocarboné
ingestion)
Equipments
PROCEDURE (Gastric
Lavage)
 Bowyer's tube
 Bite blocker
 Lignocaine jelly
 Water basin
 Normal water or Oil (generally
coconut oil)
 Ryle’s tube
 Stethoscope
 Multi-para monitor
 Intubation tray
 oxygen
 Activated charcoal
In prone or semi prone position
Head should be down.
Flexible rubber tube about 12.7mm diameter
And 1½ met . in length.
Lips to cardiac end 45 cm.
 Air should be injected (sound heard)
PROCEDURE (Gastric Lavage)
¼ Litters of water (35 C )
First – funnel is up them down.
Subsequent washings e ½ liters of water
1st
washing is preserved.
Color of fluid is noted till it return unchanged.
Last fluid should be kept in stomach.
• Apply the lignocaine gel on tube for lubrication
Insertion of tube
Insert the tube gently up to the marked and tell
the pt to swallow it
Confirm the tube position
• Administer 100 - 300 ml(10 to 15ml/kg bwt) of lavage fluid via the tube
(in children, administer 50 - 100 ml). Then, manually agitate the stomach.
After that, withdraw the fluid.
Repeat this until the lavage return is clear. Generally,
anywhere from 5 to 20 L are required to thoroughly cleanse
the stomach.
Remember to save the aspirate for toxicology screening.
After completion of the lavage, activated charcoal may be
administered via the orogastric lavage tube.
Technique con…..
Aluminium phosphide
Zink phosphide
Lavage with oil (generally with coconut oil)
CONTRAIDICATION OF WATER WASH
Gastric lavage with Oil
Cardiac dysrhythmias
Empyema
Esophageal tear or perforation
Gastric perforation
Hypothermia
Laryngospasm
Complications
Decontamination
Skin
Remove contaminated
clothing / wash
skin completely with soap
water followed by repeat
body wash 4th hourly
Eyes
Hair
Arm pits
Groin
Behind knees
Between toes
Pay special attention to
Around ears
Eyelids
Inside nose
Inside mouth
Neck creases
Decontamination
ACT093©
Do not use force to remove the lavage tube, as this
may injure or rupture the stomach or esophagus
Activated charcoal
• DEFNITION:- Remedies which counteract or
neutralize the effects of poisons without causing
appreciable harm to body .
• IT IS USED WHEN
A poison may not have been completely removed.
The poison is already absorbed.
The poison has been administrated by routes other than
ingestions.
ANTIDOTES
1. Mechanical or physical.
2. Chemical.
3. Physiological or Pharmacological
4. Universal.
CLASSIFICATION
 Impede the absorption of poison such as demulcents,
bulky food and activated charcoal
Demulcents:
These are substances which form a protective coating on the gastric
mucous membrane and thus do not permit the poison to cause any
damage
Examples include Milk, Starch, Egg white, Mineral oil, Milk of
Magnesia, etc.
Fats and oils should not be used for fat soluble poisons like,
Kerosene, Phosphorus, OP compounds, DDT, Phenol, Acetone, etc.
1.MECHANICAL OR PHYSICAL
Bulky Foods:
They act as mechanical antidote to glass powder by imprisoning the
particles within its meshes and thus prevents damage by the sharp
glass particles
 Activated charcoal (alkaloid poison, strychnine)
This is a fine, black, odorless powder
Produced by destructive distillation of various organic materials,
usually from organic pulp and then treating at high temperatures.
This process increases the absorptive capacity
Particles are small but with high absorptive capacity and it acts
mechanically by adsorbing and retaining within its pores organic
and some miner
Usually given mixed with water
Helpful in Barbiturates, Atropine, Benzodiazipine, Opiates,
Quinine, Strychnine, Phenothiazines, Pyrethrins, Aluminium
Phosphide, etc.
Less useful in Corrosives, Heavy metals, Cyanide, Hydrocarbon
and Alcohol poisons
 Dose is 30-60gm in children
 60-100gm in adults
 5-10 % the amount of poison ingested
Charcoal (1g/kg)
First line decontamination method
MDAC- very useful
First dose: 1 g / kg body weight
Subsequent doses: 0.5 g / kg body
weight at 6th
hourly up to 48 hours.
Charcoal dose
C- Caustics, Corrosives
H- Heavy metals
A- Alcohol
R- Rapid onset - cyanide
C-Chlorine
O- others ( Iron)
A- aliphatic hydrocarbon
L- lithium
Doesn’t adsorb
Mg2So4 or Na2So4 ( purging)
NaHCO3 ( Aspirin poisoning )
Activated charcoal (absorbs Alkaloids)
Liquid paraffin (demulcent)
KMnO4 – (oxidizing agent)
IN CHILDREN
8 – 12 fr
25 CM
Stomach wash with 50ml glass syringe
SOLUTIONS USED
By direct chemical reaction
By oxidizing-to non toxic compound as
a. Dilute acetic acid - alkalis
b. Dilute alkalis as milk of magnesia - acids (bicarbonates
are not used - rupture of stomach)
c. Tannin (strong tea)- alkaloids, glycosides, metals
d. Kmno4 oxidizes (barbiturates, phosphorus, cyanide),
(1:1000)-dilution, (100-150ml left in stomach)
2. CHEMICAL
Produce effects which are opposite to that effects of
the poison as
Atropine for pilocarpine
Diazepam for strychnine
Naloxone for morphine
3.PHYSIOLOGICAL OR PHARMACOLOGICAL
Atropine and oximes for organ phosphorus
N-acctylcystine for paracetamol
Mazicon for Benzodiazepines
(however antagonism is always not complete and
undesirable side effects may be there)
 These agents act by forming stable and soluble
complexes by the inner ring structure which can
combine with the metallic poisons
CHELATING AGENT
BAL also called dimercaprol
 It is given deep i.m. As a 10% solution in
arachis oil with benzyl benzoate.
In severe poisoning – 3 mg/kg bw × 4 hourly × 2 days,
then 6 hourly × 1 day, then 12 hourly × 10 days
CI : liver ds, G-6-PD deficiency, cadmium and
Fe poisoning
Uses: ar
 EDTA(EDTA(Ethylene Diamine Tetra acetate) arsenic m(Renal
damage-contra indicated))
 1 gm × BD × 5 days x slow i.v.i. in isotonic glucose saline
 CI : renal ds
 Uses: Pb, Cu,cobalt,cadmium.
Pencillamine (cuprimine)
 It is a degradation product of pencillin
 Uses: cu, pb, hg poisoning, wilson ds
 Dose: 2 gm / day in four divided doses orally
Desferrioxamine
 Uses: iron poisoning, haemachromatosis
Urinary alkalization:
This is also known as alkaline diuresis
IV bicarbonate 1 lit. of 1.26% over 3 hrs is given
Potassium levels can fall, so add 20-40 mmol. potassium to each
lit. of IV fluids given
Aim for a Urinary pH of 7.5-8.5
 Indications: poisoning with chlorpropamide,
phenobarbitone, salicylates, phenoxy acetate herbicides
ELIMINATION OF ABSORBED POISON
Acid diuresis
Whole bowel irrigation
Cathartics
Diaphoratics
Extracorporeal techniques:

 Hemodialysis: can be considered for poisoning with
salicylates, ethylene glycol, methanol, ethanol, theophylline & lithium
 Haemoperfusion: can be considered for poisoning with
theophylline, phenobarbitone & carbamazepine
 This can increase elimination of some drugs by
interrupting their enteroenteric & enterohepatic
circulation
The dose given is 50 gm (1 gm/kg in children) of
activated charcoal every 4 hrs.
 Indications: poisoning with carbamazepine, dapsone,
quinine, phenobarbitone, theophylline
Multiple-dose activated charcoal:
Warm and comfortable
Avoid risk of infection
Administration of antibiotics
Psychiatric counseling
MAINTAINENCE OF PATIENT GENERAL CONDITION
Baby Powder: Boric Acid
Toys: Copper, Lead
Cuticle Remover : KOH
Baking Powder : Tartaric acid
Domestic fuels : Kerosene oil
Fire extinguisher products: Ccl4, methyl bromide
Match sticks: antimony, phosphorus, Kcl
Drain cleaner: NaOH
Dettol : phenol
COMMON HOUSE HOLD POISONS
Fluorescent lamps: Beryllium
 Furniture pol.ish: turpentine
Lavatory cleaner: Acids
Shoe pol.ish: Nitro benzene
Medicine: Aspirin, Paracetamol, Barbiturates,
Anesthetics, Stimulants
• It can be graded in the following way based upon the
amount of substance.
Extremely toxic : 1mg / kg or less.
Highly toxic : 1.5mg /kg
Moderately toxic : 50-500mg/kg
Slightly toxic: 0.5-5.0gm/kg
Non toxic : 5-10gm/kg
Harmless : more than 10gm/kg
W.H.O. Toxicity rating chart
Thank you

More Related Content

Similar to forensictoxicology-complete-190610153555.pdf

poison and forensic importance
poison and forensic importancepoison and forensic importance
poison and forensic importanceAnuPriyaSingh65
 
poisoning, its types and emergent management.
 poisoning, its types and emergent management. poisoning, its types and emergent management.
poisoning, its types and emergent management.bhartisharma175
 
Introduction to General toxicology
Introduction to General toxicologyIntroduction to General toxicology
Introduction to General toxicologyBADAR UDDIN UMAR
 
Forensic pharmacy by Feroz Mahmud
Forensic pharmacy by Feroz MahmudForensic pharmacy by Feroz Mahmud
Forensic pharmacy by Feroz MahmudFeroz Mahmud
 
Poisoning in Children by Dr Shamavu Gabriel .pptx
Poisoning in Children by Dr Shamavu Gabriel .pptxPoisoning in Children by Dr Shamavu Gabriel .pptx
Poisoning in Children by Dr Shamavu Gabriel .pptxGabriel Shamavu
 
classification of toxins
classification of toxinsclassification of toxins
classification of toxinsBenedictMartin2
 
Vet toxicology and environmental toxicol
Vet toxicology and environmental toxicolVet toxicology and environmental toxicol
Vet toxicology and environmental toxicolbonifaceetimeojuka
 
Lec 26 poisonings and antidotes.pdf
Lec 26  poisonings and antidotes.pdfLec 26  poisonings and antidotes.pdf
Lec 26 poisonings and antidotes.pdfMohammadBakari
 
23.introduction to TOXICOLOGY.pptx
23.introduction to TOXICOLOGY.pptx23.introduction to TOXICOLOGY.pptx
23.introduction to TOXICOLOGY.pptxSatrajitRoy5
 
Toxic effects of pesticides
Toxic effects of pesticidesToxic effects of pesticides
Toxic effects of pesticidesJaswant Sangar
 
Poisoning Management.(What is poisoning and How to manage poisoning cases..?)
Poisoning Management.(What is poisoning and How to manage poisoning cases..?)Poisoning Management.(What is poisoning and How to manage poisoning cases..?)
Poisoning Management.(What is poisoning and How to manage poisoning cases..?)Muavia Sarwar
 
1-Introduction-Organochlorine-compound.pptx
1-Introduction-Organochlorine-compound.pptx1-Introduction-Organochlorine-compound.pptx
1-Introduction-Organochlorine-compound.pptxAmitSharma3227
 
poisonpptx-140504003359-phpapp01 (1).pdf
poisonpptx-140504003359-phpapp01 (1).pdfpoisonpptx-140504003359-phpapp01 (1).pdf
poisonpptx-140504003359-phpapp01 (1).pdfDrYaqoobBahar
 

Similar to forensictoxicology-complete-190610153555.pdf (20)

poison and forensic importance
poison and forensic importancepoison and forensic importance
poison and forensic importance
 
Toxicology.pdf
Toxicology.pdfToxicology.pdf
Toxicology.pdf
 
General Consideration of Toxicology.pptx
General Consideration of Toxicology.pptxGeneral Consideration of Toxicology.pptx
General Consideration of Toxicology.pptx
 
poisoning, its types and emergent management.
 poisoning, its types and emergent management. poisoning, its types and emergent management.
poisoning, its types and emergent management.
 
Introduction to Toxicology
Introduction to ToxicologyIntroduction to Toxicology
Introduction to Toxicology
 
Toxicology Introduction- APX - SlideShare.pdf
Toxicology Introduction- APX - SlideShare.pdfToxicology Introduction- APX - SlideShare.pdf
Toxicology Introduction- APX - SlideShare.pdf
 
Introduction to General toxicology
Introduction to General toxicologyIntroduction to General toxicology
Introduction to General toxicology
 
Forensic pharmacy
Forensic pharmacyForensic pharmacy
Forensic pharmacy
 
Forensic pharmacy by Feroz Mahmud
Forensic pharmacy by Feroz MahmudForensic pharmacy by Feroz Mahmud
Forensic pharmacy by Feroz Mahmud
 
Poisoning.pptx
Poisoning.pptxPoisoning.pptx
Poisoning.pptx
 
Poisoning in Children by Dr Shamavu Gabriel .pptx
Poisoning in Children by Dr Shamavu Gabriel .pptxPoisoning in Children by Dr Shamavu Gabriel .pptx
Poisoning in Children by Dr Shamavu Gabriel .pptx
 
classification of toxins
classification of toxinsclassification of toxins
classification of toxins
 
Vet toxicology and environmental toxicol
Vet toxicology and environmental toxicolVet toxicology and environmental toxicol
Vet toxicology and environmental toxicol
 
Lec 26 poisonings and antidotes.pdf
Lec 26  poisonings and antidotes.pdfLec 26  poisonings and antidotes.pdf
Lec 26 poisonings and antidotes.pdf
 
23.introduction to TOXICOLOGY.pptx
23.introduction to TOXICOLOGY.pptx23.introduction to TOXICOLOGY.pptx
23.introduction to TOXICOLOGY.pptx
 
Ecopharmacology
EcopharmacologyEcopharmacology
Ecopharmacology
 
Toxic effects of pesticides
Toxic effects of pesticidesToxic effects of pesticides
Toxic effects of pesticides
 
Poisoning Management.(What is poisoning and How to manage poisoning cases..?)
Poisoning Management.(What is poisoning and How to manage poisoning cases..?)Poisoning Management.(What is poisoning and How to manage poisoning cases..?)
Poisoning Management.(What is poisoning and How to manage poisoning cases..?)
 
1-Introduction-Organochlorine-compound.pptx
1-Introduction-Organochlorine-compound.pptx1-Introduction-Organochlorine-compound.pptx
1-Introduction-Organochlorine-compound.pptx
 
poisonpptx-140504003359-phpapp01 (1).pdf
poisonpptx-140504003359-phpapp01 (1).pdfpoisonpptx-140504003359-phpapp01 (1).pdf
poisonpptx-140504003359-phpapp01 (1).pdf
 

Recently uploaded

High Profile Call Girls Coimbatore Saanvi☎️ 8250192130 Independent Escort Se...
High Profile Call Girls Coimbatore Saanvi☎️  8250192130 Independent Escort Se...High Profile Call Girls Coimbatore Saanvi☎️  8250192130 Independent Escort Se...
High Profile Call Girls Coimbatore Saanvi☎️ 8250192130 Independent Escort Se...narwatsonia7
 
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...Miss joya
 
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
Call Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...Neha Kaur
 
Aspirin presentation slides by Dr. Rewas Ali
Aspirin presentation slides by Dr. Rewas AliAspirin presentation slides by Dr. Rewas Ali
Aspirin presentation slides by Dr. Rewas AliRewAs ALI
 
Low Rate Call Girls Pune Esha 9907093804 Short 1500 Night 6000 Best call girl...
Low Rate Call Girls Pune Esha 9907093804 Short 1500 Night 6000 Best call girl...Low Rate Call Girls Pune Esha 9907093804 Short 1500 Night 6000 Best call girl...
Low Rate Call Girls Pune Esha 9907093804 Short 1500 Night 6000 Best call girl...Miss joya
 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...narwatsonia7
 
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune) Girls Service
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune)  Girls ServiceCALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune)  Girls Service
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune) Girls ServiceMiss joya
 
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore EscortsVIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escortsaditipandeya
 
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...Miss joya
 
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...indiancallgirl4rent
 
Bangalore Call Girls Marathahalli 📞 9907093804 High Profile Service 100% Safe
Bangalore Call Girls Marathahalli 📞 9907093804 High Profile Service 100% SafeBangalore Call Girls Marathahalli 📞 9907093804 High Profile Service 100% Safe
Bangalore Call Girls Marathahalli 📞 9907093804 High Profile Service 100% Safenarwatsonia7
 
Russian Call Girls in Pune Tanvi 9907093804 Short 1500 Night 6000 Best call g...
Russian Call Girls in Pune Tanvi 9907093804 Short 1500 Night 6000 Best call g...Russian Call Girls in Pune Tanvi 9907093804 Short 1500 Night 6000 Best call g...
Russian Call Girls in Pune Tanvi 9907093804 Short 1500 Night 6000 Best call g...Miss joya
 
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...jageshsingh5554
 
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls ServiceKesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Servicemakika9823
 
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...Garima Khatri
 
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...Taniya Sharma
 

Recently uploaded (20)

High Profile Call Girls Coimbatore Saanvi☎️ 8250192130 Independent Escort Se...
High Profile Call Girls Coimbatore Saanvi☎️  8250192130 Independent Escort Se...High Profile Call Girls Coimbatore Saanvi☎️  8250192130 Independent Escort Se...
High Profile Call Girls Coimbatore Saanvi☎️ 8250192130 Independent Escort Se...
 
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
Russian Call Girls in Pune Riya 9907093804 Short 1500 Night 6000 Best call gi...
 
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Darjeeling Just Call 9907093804 Top Class Call Girl Service Available
 
Call Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Ludhiana Just Call 9907093804 Top Class Call Girl Service Available
 
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
VIP Russian Call Girls in Varanasi Samaira 8250192130 Independent Escort Serv...
 
Aspirin presentation slides by Dr. Rewas Ali
Aspirin presentation slides by Dr. Rewas AliAspirin presentation slides by Dr. Rewas Ali
Aspirin presentation slides by Dr. Rewas Ali
 
Low Rate Call Girls Pune Esha 9907093804 Short 1500 Night 6000 Best call girl...
Low Rate Call Girls Pune Esha 9907093804 Short 1500 Night 6000 Best call girl...Low Rate Call Girls Pune Esha 9907093804 Short 1500 Night 6000 Best call girl...
Low Rate Call Girls Pune Esha 9907093804 Short 1500 Night 6000 Best call girl...
 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
 
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune) Girls Service
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune)  Girls ServiceCALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune)  Girls Service
CALL ON ➥9907093804 🔝 Call Girls Baramati ( Pune) Girls Service
 
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore EscortsVIP Call Girls Indore Kirti 💚😋  9256729539 🚀 Indore Escorts
VIP Call Girls Indore Kirti 💚😋 9256729539 🚀 Indore Escorts
 
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
 
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
 
Bangalore Call Girls Marathahalli 📞 9907093804 High Profile Service 100% Safe
Bangalore Call Girls Marathahalli 📞 9907093804 High Profile Service 100% SafeBangalore Call Girls Marathahalli 📞 9907093804 High Profile Service 100% Safe
Bangalore Call Girls Marathahalli 📞 9907093804 High Profile Service 100% Safe
 
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
Russian Call Girls in Delhi Tanvi ➡️ 9711199012 💋📞 Independent Escort Service...
 
Russian Call Girls in Pune Tanvi 9907093804 Short 1500 Night 6000 Best call g...
Russian Call Girls in Pune Tanvi 9907093804 Short 1500 Night 6000 Best call g...Russian Call Girls in Pune Tanvi 9907093804 Short 1500 Night 6000 Best call g...
Russian Call Girls in Pune Tanvi 9907093804 Short 1500 Night 6000 Best call g...
 
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCREscort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
Escort Service Call Girls In Sarita Vihar,, 99530°56974 Delhi NCR
 
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
VIP Service Call Girls Sindhi Colony 📳 7877925207 For 18+ VIP Call Girl At Th...
 
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls ServiceKesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
 
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
VIP Mumbai Call Girls Hiranandani Gardens Just Call 9920874524 with A/C Room ...
 
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
💎VVIP Kolkata Call Girls Parganas🩱7001035870🩱Independent Girl ( Ac Rooms Avai...
 

forensictoxicology-complete-190610153555.pdf

  • 1. FORENSIC FORENSIC TOXICOLOGY-I TOXICOLOGY-I Dr Mohd Kaleem Khan Assistant Professor Department Of Forensic Medicine JNMCH AMU Aligarh
  • 2. TOXICOLOGY :  Toxicology is the science dealing with properties, action, toxicity, fatal dose, detection, estimation of, interpretation of the result of toxicological analysis and management of Poisons Forensic Toxicology:  Branch of Forensic Medicine dealing with Medical and Legal aspects of the harmful effects of chemicals on human beings.
  • 3. POISON:  Any substance which when  Administered in living body through any route (inhalation, ingestion, injecion, surface absorption etc)  Will produce ill-health or death by its action which is due to  Its physical,  Chemical or  Physiological properties.  Eg: alphos, sulphuric acid, arsenic etc.
  • 4. Drug (WHO 1996): “Drug is any substance or product that is used or intended to be used to  Modify or  Explore physiological systems or  Pathological states For the benefit of the recipient.”  Eg: Paracetamol, Ciprofloxacin, Salbutamol, Oestrogen, Insulin Etc.
  • 5. Clinical Toxicology:  Deals with human diseases caused by, or associated with abnormal exposure to chemical substances. • Toxinology :  Refers to toxins produced by living organism which are dangerous to man,  E.g.: snake venom, fungal and bacterial toxins etc.
  • 6. • Acute poisoning  Caused by an excessive single dose, or several dose of a poison taken over a short interval of time. • • Chronic Poisoning  Caused by smaller doses over a period of time, resulting in gradual worsening.  Eg: arsenic, phosphorus, antimony and opium.
  • 7. • Sub-acute poisoning  Shows features of both acute and chronic poisoning. • Fulminant poisoning:  Produced by a massive dose.  In this death occur rapidly, sometimes without preceding symptoms.
  • 8. LAWS IN RELATION TO MEDICINE (1) The drug and cosmetic act, 1940:  Regulate all kinds of drugs  Import,  Manufacture,  Distribution and  Sale.  Its main feature is to control purity, quality and strength of drug.
  • 9. (2) The drug and cosmetic rule, 1945:  Regulate storage, display, dispensing, sale, labeling, prescribing etc. Schedule ▫ C- biological and special products, ▫ E- poison, ▫ F- vaccine and sera, ▫ G- hormones, ▫ J- list of diseases for which No drug should be advertised, ▫ H- drugs to be sold on prescription of RMP, ▫ L- antibiotics, antihistaminics and other chemotherapeutic agents
  • 10. 3. The pharmacy act, 1948 :  Allows only registered pharmacists to compound, prepare and dispense medicine 4. The drug control act, 1950 :  (sale, supply and distribution, fixing of prices ) 5. The drug and magic remedies act, 1954
  • 11. The Narcotic Drugs And Psychotropic Substance Act, 1985.  Psychotropic subs alters mental function  e.g. LSD, amphetamine, barbiturates etc  Narcotics causes dullness of senses and induces sleep e.g. cannabis, opium and cocaine.  The law prohibits of these drugs  Cultivation,  Manufacture,  Possession,  Sale purchase  Import export etc  Except for medical and scientific purpose.
  • 12. Sources of Poison: • Domestic or household sources –  Detergents, Disinfectants, Cleaning Agents, Antiseptics, Insecticides, Rodenticides Etc. • Agricultural and horticultural sources-  Insecticides, Pesticides, Fungicides and Weed Killers. • Industrial sources –  Poisons are Manufactured or Poisons are Produced as by Products. • Commercial sources-  Store-houses, Distribution Centres and Selling Shops.
  • 13. • From uses as drugs and medicines  Wrong Medication, Overmedication And Abuse Of Drugs. • Food and drink –  Preservatives of food grains or other food material,  Additives, colouring and odouring agents  accidental contamination of food and drink. • Miscellaneous sources-  Snakes bite poisoning, city smoke, sewer gas poisoning etc.
  • 14. INCIDENCE OF POISONING ▫ Homicidal poisoning ▫ Suicidal poisoning ▫ Accidental poisoning: ▫ Household poisons
  • 15. ▫ Stupefying Agents:  Alcohol, Dhatura, Cannabis Indica, Chloral Hydrate, Rophynol ▫ Aphrodisiacs:  Canthrides, Opium, Cannabis, Cocain . ▫ Abortificients:  Calotropis, Croton, Semecardium, Lead, Kmno4,Ergot Etc. ▫ Animal Poisoning:  Cattle, Stray Dogs, Rodents
  • 16. Classification of Poisons (I) Corrosives (it erodes the surface with which it comes in contact) (1) Strong Acids:  Inorganic Or Mineral Acids- ▫ Sulphuric, Nitric, Hydrochloric  Organic Acids- ▫ Carbolic, Oxalic, Acetic, Salicylic (2) Strong Alkali:  Hydrates of – sodium, potassium  Carbonates of- sodium, potassium, ammonia
  • 17. (II) Irritants: (they causes inflammation on the site of contact esp GIT, respiratory tract and skin) (1) Agricultural (2) Inorganic : • Non-metallic – P, I, Cl, Br etc • Metallic – Ar, Cu, Zn, Pb, Hg • Mechanical – Powdered Glass, Brick, Hair, Nails, Pins (3) Organic : • Vegetable – Abrus Precatorius, Aloes, Croton, Castor, Calotropis • Animal – Snake, Bees, Wasps
  • 18. (III) Systemic: which involves toxic effect on a particular system (1) Cerebral • CNS Depressants- Alcohol, Opiods • CNS Stimulants- Antidepressants, Amphetamine, Caffeine • Deliriants- Dhatura, Balladona, Cocaine (2) Spinal: Nux Vomica (3) Peripheral: Curare, Conium (4) Cardiac: Aconite, Quinine, Tobacco, Cyanide (5) Asphyxiants: CO, H2S, CO2
  • 19. • Nephrotoxic:  Oxalic Acid, Mercury, Cantharides Hepatotoxic:  Phosphorus, Carbon tetrachloride, Chloroform • Miscelanious  Agrochemicals  Pesticides: Organophosphorous  Fumigants: Alphos  Rhodenticides: Thalium, Zn Phosphide
  • 20. • Drug dependence • Petroleum products • Food poisoning • Other:  Analgesic,  Antipyretic
  • 21. Classification of Poison according to motive or nature of use: • Homicidal:  Arsenic, Aconite, Digitalis, Abrus Precatorius, Strychnos Nux Vomica. • Suicidal:  Opium, Barbiturate, Organophosphorus, Carbolic Acid, Copper Sulphate. • Accidental:  Aspirin, Organophosphorus, Copper Sulphate, Snakes Bite, Ergot, Co, Co2, H2s. • Abortificient:  Ergot, Quinine, Calotropis, Plumbago.
  • 22. • Stupefying Agent:  Dhatura, Cannabis, Chloral Hydrate. • Agents Used To Cause Bodily Injury:  Corrosive Acids and Alkali. • Cattle Poison:  Abrus precatorius, Calotropis, Plumbago. • Used For Malingering:  Semicarpus Anacardium
  • 23. Characteristics of Ideal Homicidal and Suicidal Poison Characteristics Suicidal Homicidal Accessibility Cheap & Easy Cheap & Easy Antidote Difficult Difficult Lethal Dose Small Small Lethal Period Small Long Taste Pleasant Pleasant Signs / Symptom Few or None Resemble Disease E.g. Cyanide, Opium , Insulin, Arsenic, Aconite Barbiturates, Thallium, Organophosphorus, Madar,strychnine
  • 24. Route of Administration/absorbtion:  Oral (commonest) e.g. alphos, acids,  Inhalation: gas poison  Parenteral ▫ (IM, IV, Sub-Cutaneous, Intra-Dermal)  Natural Orifices other than mouth ▫ (Nasal, Rectal, Vaginal, Urethral),  Ulcers, wounds and intact skin.
  • 25. Fate of poison in body ▫ A part, of the poison eliminated unabsorbed by means of defecation and vomiting. ▫ Liver detoxify or metabolize the poisons. ▫ By evaporation or oxidized or destroyed in the body. • Excretion of poisons:  Unabsorbed poisons are excreted through faeces and vomits.  Absorbed poisons are excreted mostly by urine.  A part of volatile poison is exhaled out .  Some portion of poison is excreted through bile, saliva, milk, sweat, tear, hair and nails.
  • 26. Factors influencing the actions of a poison in the body. • 1. Quantity:  A high dose of poison acts quickly and often resulting in fatal consequences.  A moderate dose causes acute poisoning.  A low dose may have sub -clinical effects and causes chronic poisoning on repeated exposure.
  • 27. • 2. Form: ▫ Physical state:  Gaseous or volatile poisons are very quickly absorbed.  Liquid poisons are more rapid than solid poisons.  Powder act more quickly than coarse substance. • Some poisonous vegetable seeds may pass through the intestinal canal ineffective when taken intact due to their impermeable pericarp. But when taken crushed, they may be rapidly fatal.
  • 28. ▫ Chemical combination:  Chemically pure arsenic and mercury are not poisonous because these are insoluble and are not absorbed.  But white arsenic(arsenic oxide) and mercuric chloride are deadly poisonous.  Barium sulphide is deadly toxic but barium sulphate is non-toxic. ▫ Mechanical combination:  Action of poison is altered when it combines with mechanically inert substances.
  • 29. • 3.Mode of Administration:  Absorption rate is different for different routes  GAS > IV > IM > SC/ID > WOUND > SEROUS SURFACE > INGESTION > NATURAL ORIFICES > UNBROKEN SKIN • 4. Condition of patient  Age:  Poisons have greater effect on two extremes of age
  • 30. • State of body health: • A well built person with good health can tolerate the action of poison better than a weak person. ▫ Presence of disease :  In certain diseased conditions some drugs are tolerated exceptionally well e.g.: sedatives and tranquilizers are tolerated in very high dose by manic and deliriant patients. •
  • 31. • Intoxication arid poisoning states –  In certain poisoning cases some drugs are well tolerated, like, in case of strychnine poisoning, barbiturates and sedatives are better tolerated.  Whereas in case of barbiturate poisoning any sedative or tranquilizer will accentuate the process of death.
  • 32. ▫ Sleep  Absorption and action of the poison is also slow.  But depressant drugs may cause, more harm ▫ Exercise –  Action of alcohol on C.N.S. is slowed during exercise because more blood is drawn to the muscles during exercise.
  • 33. ▫ Cumulative action of poisons:  cumulative poisons (poisons which are not readily excreted from the body and are retained in different organs of the body for a long time) like  Lead may not cause any toxic effect when enters the body in low dose.  But when such poisons enter over a long period of time, may cause harm when their concentration in different tissue reaches high level due to their cumulative property.
  • 34. • Tolerance may develop by individuals on long term exposue to a particular poison. • Idiosyncracy: some persons may react adversely to a particular drug though the general population tolerates the drug well.
  • 35. Duties of a Doctor ▫ Doctor must record preliminary particulars, ▫ If summoned by the investigating police officer or magistrate must cooperate. ▫ Notify cases of homicidal poisoning to the nearest police station as per s. 39 Cr PC  Failing which he is liable for prosecution proceedings under section 176 IPC.
  • 36. ▫ In Government Institutions, all types of poisoning cases intimated to the police station as a routine. ▫ Poisoning must be subjected for autopsy. ▫ body should not be released to the relatives before inquest. ▫ A doctor should never grant a death certificate stating the cause of death before an autopsy is conducted. ▫ False information, if any, furnished to the police can lead to prosecution proceedings under section 193 IPC.
  • 37. ▫ Recording of a dying declaration ▫ Material objects like stomach wash, vomits, excreta, blood, urine etc. are to be preserved for chemical analysis. ▫ All relevant records connected with poisoning cases must be kept under safe custody.
  • 38. Laws in relation to poison and drugs: • Different sections of Indian penal code related to poisons are as follows ▫ Sec. 272 I.P.C. - Punishment for adulterating food or drink intended for sale, so as to make the. same noxious, may extend upto 6 months imprisonment of either term and/or fine upto one thousand rupees. ▫ Sec. 273 I.P.C. - Punishment for selling noxious food or drink may be imprisonment of either description for a period of 6. months and or fine upto one thousand rupees. ▫ Sec. 274 I.P.C. - Punishment for adulteration of drugs in any form with any change in its effect knowing that it Will be sold and used as un- adulterated drug, may be imprisonment of either description for a period- of 6 months and or fine. •
  • 39. ▫ Sec. 275 l.P.C. - Punishment for knowingly selling adulterated drugs with less efficacy or altered action serving it for use as unadulterated may be imprisonment of either description for 6 months and or fine. ▫ Sec. 276 I.P.C. - Punishment for selling a drug as a different drug or Preparation, may be imprisonment of either description which may extend up to 6 months and or fine. . ▫ Note - In the State of West Bengal, the punishment for these offences described under sections 272 to 276 may be up to imprisonment for life with or without fine. ▫ Sec. 277 I.P.C. – Punishment for fouling water of public spring or reservoir may be imprisonment of either description which may extend up to a period of 3 months and or fine.
  • 40. ▫ Sec. 278 I.P.C. - Punishment for voluntarily making atmosphere noxious to health is fine which . may extend upto five hundred rupees. ▫ Sec. 284 I.P.C. Punishment for negligent conduct with respect to poisonous substance may be imprisonment of either description which may extend up to 6 months and or fine which may extend up to one thousand rupees. ▫ ▫ Sec. 328 I.P.C. :Punishment' for causing hurt by means of poison or any stupefying, intoxicating or unwholesome drug or any other thing with the intent to commit an offence shall be imprisonment of either description for a term which may extend to ten years with or without fine.
  • 41. If poison is known then treat specific poison If not known on general lines of management Main aim to stay the patient alive by supporting respiration and circulation Assisted by getting rid of poison by metabolism, excretion. Use of antidote by getting rid of poison. TREATMENT OF POISONING:
  • 42. Removal of unabsorbed poison Use of antidote Elimination of absorbed poison Treatment of general symptoms Maintenance of patient's general condition OBJECTIVES:
  • 43. Depending Upon Route of Entry a.INHALEED POISON: (CO,H2,S)  Remove from sources to fresh air  Artificial respiration  Keep airway patent (posture drainage) REMOVAL OF UNABSORBED POISON:
  • 44. a. INJECTED POISON: (hypnotics, insulin, sedatives)  A tight tourniquet proximal to point of injection  Must be relaxed for one min after 10 min.  Wound may be excised and poison removed
  • 45. a. CONTACT POISON:  Spilled or sprayed on skin, eyes or wound  Best way is to wash it out with water  Neutralize it by an antidote.
  • 46. a. INGESTED POISIONS  Remove from stomach as much as possible by Vomiting, and stomach wash.  If patient is conscious and cooperative and vomiting is not contra indicated. Induce it by tickling the fauces and by use of Emetics  Contraindications are;(corrosive, petroleum, distillates, coma, Strychnine ) ( cardio-resp. diseases, Advanced pregnancy)
  • 47. Warm water. Mustard powder ( Table spoon = 15 gm) Two table spoons of NaCl + 200ml tepid water) Apo morphine 6 mg s/c followed by Nalaxone Hcl 5-10 mg i.m/i.v causes vomiting in 3-5 min. Facilitate gastric lavage by removing contents. Produce gastric/intestine reflux (Tab). HOUSE HOLD EMETICS
  • 48. • INTRODUCTION Gastric lavage is a method of gastrointestinal decontamination. Performed in the setting of an ingested overdose or acute poisoning, to decrease the absorption of substances in the stomach.  This technique was first described in 1812. DEFINITION Gastric lavage also commonly called stomach wash or gastric suction, is the process of cleaning out of the contents of the stomach. It has been used for eliminating poisons from the stomach. GASTRIC LAVAGE
  • 49. GASTRIC LAVAGE If not contra indicated-may be life saving but should be undertaken within 6 hours. Contraindicated in corrosives. exception in carbolic acid.) Certain measures should be taken such as  Strychnine poisoning ( control fits )  Kerosene poisoning ( airway  should be sealed ) Hypothermia ( Body temp should be maintained.)
  • 50. Abnormal or absent pharyngeal/upper gastrointestinal anatomy Active or substantial antecedent vomiting Caustic ingestion. Coagulopathy. Decreased mental status CONTRAINDICATIONS
  • 51. Inactive or diminished airway reflexes Large pills Large or sharp foreign body Nontoxic or minimally toxic ingestion Signifiant aspiration risk (e.g., hydrocarboné ingestion)
  • 52. Equipments PROCEDURE (Gastric Lavage)  Bowyer's tube  Bite blocker  Lignocaine jelly  Water basin  Normal water or Oil (generally coconut oil)  Ryle’s tube  Stethoscope  Multi-para monitor  Intubation tray  oxygen  Activated charcoal
  • 53. In prone or semi prone position Head should be down. Flexible rubber tube about 12.7mm diameter And 1½ met . in length. Lips to cardiac end 45 cm.  Air should be injected (sound heard) PROCEDURE (Gastric Lavage)
  • 54. ¼ Litters of water (35 C ) First – funnel is up them down. Subsequent washings e ½ liters of water 1st washing is preserved. Color of fluid is noted till it return unchanged. Last fluid should be kept in stomach.
  • 55.
  • 56.
  • 57.
  • 58. • Apply the lignocaine gel on tube for lubrication Insertion of tube
  • 59. Insert the tube gently up to the marked and tell the pt to swallow it
  • 60. Confirm the tube position
  • 61. • Administer 100 - 300 ml(10 to 15ml/kg bwt) of lavage fluid via the tube (in children, administer 50 - 100 ml). Then, manually agitate the stomach. After that, withdraw the fluid.
  • 62. Repeat this until the lavage return is clear. Generally, anywhere from 5 to 20 L are required to thoroughly cleanse the stomach. Remember to save the aspirate for toxicology screening. After completion of the lavage, activated charcoal may be administered via the orogastric lavage tube. Technique con…..
  • 63. Aluminium phosphide Zink phosphide Lavage with oil (generally with coconut oil) CONTRAIDICATION OF WATER WASH
  • 65. Cardiac dysrhythmias Empyema Esophageal tear or perforation Gastric perforation Hypothermia Laryngospasm Complications
  • 66. Decontamination Skin Remove contaminated clothing / wash skin completely with soap water followed by repeat body wash 4th hourly Eyes Hair
  • 67. Arm pits Groin Behind knees Between toes Pay special attention to Around ears Eyelids Inside nose Inside mouth Neck creases Decontamination ACT093©
  • 68.
  • 69. Do not use force to remove the lavage tube, as this may injure or rupture the stomach or esophagus
  • 71.
  • 72.
  • 73. • DEFNITION:- Remedies which counteract or neutralize the effects of poisons without causing appreciable harm to body . • IT IS USED WHEN A poison may not have been completely removed. The poison is already absorbed. The poison has been administrated by routes other than ingestions. ANTIDOTES
  • 74. 1. Mechanical or physical. 2. Chemical. 3. Physiological or Pharmacological 4. Universal. CLASSIFICATION
  • 75.  Impede the absorption of poison such as demulcents, bulky food and activated charcoal Demulcents: These are substances which form a protective coating on the gastric mucous membrane and thus do not permit the poison to cause any damage Examples include Milk, Starch, Egg white, Mineral oil, Milk of Magnesia, etc. Fats and oils should not be used for fat soluble poisons like, Kerosene, Phosphorus, OP compounds, DDT, Phenol, Acetone, etc. 1.MECHANICAL OR PHYSICAL
  • 76. Bulky Foods: They act as mechanical antidote to glass powder by imprisoning the particles within its meshes and thus prevents damage by the sharp glass particles  Activated charcoal (alkaloid poison, strychnine) This is a fine, black, odorless powder Produced by destructive distillation of various organic materials, usually from organic pulp and then treating at high temperatures. This process increases the absorptive capacity Particles are small but with high absorptive capacity and it acts mechanically by adsorbing and retaining within its pores organic and some miner Usually given mixed with water
  • 77. Helpful in Barbiturates, Atropine, Benzodiazipine, Opiates, Quinine, Strychnine, Phenothiazines, Pyrethrins, Aluminium Phosphide, etc. Less useful in Corrosives, Heavy metals, Cyanide, Hydrocarbon and Alcohol poisons  Dose is 30-60gm in children  60-100gm in adults  5-10 % the amount of poison ingested
  • 78. Charcoal (1g/kg) First line decontamination method MDAC- very useful First dose: 1 g / kg body weight Subsequent doses: 0.5 g / kg body weight at 6th hourly up to 48 hours. Charcoal dose
  • 79. C- Caustics, Corrosives H- Heavy metals A- Alcohol R- Rapid onset - cyanide C-Chlorine O- others ( Iron) A- aliphatic hydrocarbon L- lithium Doesn’t adsorb
  • 80. Mg2So4 or Na2So4 ( purging) NaHCO3 ( Aspirin poisoning ) Activated charcoal (absorbs Alkaloids) Liquid paraffin (demulcent) KMnO4 – (oxidizing agent) IN CHILDREN 8 – 12 fr 25 CM Stomach wash with 50ml glass syringe SOLUTIONS USED
  • 81. By direct chemical reaction By oxidizing-to non toxic compound as a. Dilute acetic acid - alkalis b. Dilute alkalis as milk of magnesia - acids (bicarbonates are not used - rupture of stomach) c. Tannin (strong tea)- alkaloids, glycosides, metals d. Kmno4 oxidizes (barbiturates, phosphorus, cyanide), (1:1000)-dilution, (100-150ml left in stomach) 2. CHEMICAL
  • 82. Produce effects which are opposite to that effects of the poison as Atropine for pilocarpine Diazepam for strychnine Naloxone for morphine 3.PHYSIOLOGICAL OR PHARMACOLOGICAL
  • 83. Atropine and oximes for organ phosphorus N-acctylcystine for paracetamol Mazicon for Benzodiazepines (however antagonism is always not complete and undesirable side effects may be there)
  • 84.  These agents act by forming stable and soluble complexes by the inner ring structure which can combine with the metallic poisons CHELATING AGENT
  • 85. BAL also called dimercaprol  It is given deep i.m. As a 10% solution in arachis oil with benzyl benzoate. In severe poisoning – 3 mg/kg bw × 4 hourly × 2 days, then 6 hourly × 1 day, then 12 hourly × 10 days CI : liver ds, G-6-PD deficiency, cadmium and Fe poisoning Uses: ar
  • 86.  EDTA(EDTA(Ethylene Diamine Tetra acetate) arsenic m(Renal damage-contra indicated))  1 gm × BD × 5 days x slow i.v.i. in isotonic glucose saline  CI : renal ds  Uses: Pb, Cu,cobalt,cadmium. Pencillamine (cuprimine)  It is a degradation product of pencillin  Uses: cu, pb, hg poisoning, wilson ds  Dose: 2 gm / day in four divided doses orally Desferrioxamine  Uses: iron poisoning, haemachromatosis
  • 87.
  • 88. Urinary alkalization: This is also known as alkaline diuresis IV bicarbonate 1 lit. of 1.26% over 3 hrs is given Potassium levels can fall, so add 20-40 mmol. potassium to each lit. of IV fluids given Aim for a Urinary pH of 7.5-8.5  Indications: poisoning with chlorpropamide, phenobarbitone, salicylates, phenoxy acetate herbicides ELIMINATION OF ABSORBED POISON
  • 89. Acid diuresis Whole bowel irrigation Cathartics Diaphoratics
  • 90. Extracorporeal techniques:   Hemodialysis: can be considered for poisoning with salicylates, ethylene glycol, methanol, ethanol, theophylline & lithium  Haemoperfusion: can be considered for poisoning with theophylline, phenobarbitone & carbamazepine
  • 91.  This can increase elimination of some drugs by interrupting their enteroenteric & enterohepatic circulation The dose given is 50 gm (1 gm/kg in children) of activated charcoal every 4 hrs.  Indications: poisoning with carbamazepine, dapsone, quinine, phenobarbitone, theophylline Multiple-dose activated charcoal:
  • 92. Warm and comfortable Avoid risk of infection Administration of antibiotics Psychiatric counseling MAINTAINENCE OF PATIENT GENERAL CONDITION
  • 93. Baby Powder: Boric Acid Toys: Copper, Lead Cuticle Remover : KOH Baking Powder : Tartaric acid Domestic fuels : Kerosene oil Fire extinguisher products: Ccl4, methyl bromide Match sticks: antimony, phosphorus, Kcl Drain cleaner: NaOH Dettol : phenol COMMON HOUSE HOLD POISONS
  • 94. Fluorescent lamps: Beryllium  Furniture pol.ish: turpentine Lavatory cleaner: Acids Shoe pol.ish: Nitro benzene Medicine: Aspirin, Paracetamol, Barbiturates, Anesthetics, Stimulants
  • 95. • It can be graded in the following way based upon the amount of substance. Extremely toxic : 1mg / kg or less. Highly toxic : 1.5mg /kg Moderately toxic : 50-500mg/kg Slightly toxic: 0.5-5.0gm/kg Non toxic : 5-10gm/kg Harmless : more than 10gm/kg W.H.O. Toxicity rating chart