ASCO-CIM MEDULOBLASTOMA C

1. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

2. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

3. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

4. • Medulloblastoma patients are either classified as
standard-risk patients or otherwise as high-risk
patients . This risk stratification is unsatisfactory in
predicting outcome, with under- or over-treatment as
possible consequences. An improved disease sub-
classification is therefore urgently required. In addition,
a better insight into the molecular biology of
medulloblastoma may lead to the development and
application of novel therapies.
• Cytogenetic studies and comparative genomic
hybridization (CGH) studies have identified at the
mRNA expression level and characterized genomic
abnormalitie many chromosomal aberrations.
Mutations in Sonic Hedgehog (SHH) pathway genes
(PTCH1, SUFU) are found in approximately 25% of
medulloblastomas, and in WNT pathway genes (β-
catenin, APC, AXIN) in approximately 15% of the cases

5. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

6. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

7. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

8. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

9. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

10. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

11. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

12. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

13. [TITLE]
Presented By Larry E. Kun, MD at 2013 ASCO Annual Meeting

14. [TITLE]
Presented By Clare Twist, MD at 2013 ASCO Annual Meeting

15. [TITLE]
Presented By Clare Twist, MD at 2013 ASCO Annual Meeting

16. [TITLE]
Presented By Clare Twist, MD at 2013 ASCO Annual Meeting

17. [TITLE]
Presented By Clare Twist, MD at 2013 ASCO Annual Meeting

18. [TITLE]
Presented By Clare Twist, MD at 2013 ASCO Annual Meeting

19. [TITLE]
Presented By Clare Twist, MD at 2013 ASCO Annual Meeting

20. [TITLE]
Presented By Clare Twist, MD at 2013 ASCO Annual Meeting

21. [TITLE]
Presented By Clare Twist, MD at 2013 ASCO Annual Meeting