This document discusses new models of innovation that are driving growth, commercialization, and social impact in digital health. It identifies four disruptive global trends including urbanization, technology acceleration, changing demographics as populations age, and increased flows of capital, people and information. New models of innovation are addressing unmet needs and frustrations among consumers, providers, researchers and payers. These new models converge healthcare with technologies like AI, VR, and mobile, as well as design, social programs, and business models both public and private. Examples mentioned include social networks, personalized medicine, citizen science, remote monitoring, AI, virtual therapies, video games, and 3D printing.