2. Barium swallow -- esophagus
Barium meal--- stomach and duodenum
Barium meal follow through--- small and large gut
3.
4.
5.
6.
7.
8.
9.
10.
11. Smooth narrowing, no irregularity of mucosal lining
Due to loss of ganglion cells in myenteric plexus
Retention of food and fluids– dilatation of esophagus– recurrent aspiration
pneumonitis--- increased incidence of CA
Pseudoachalasia– due to intraluminal growth/ extraluminal compression
Presentation: young adults/ dysphagia to liquids– solids & liquids/ retrosternal
discomfort/ regurgitation/ aspiration pneumonia/ weight loss and anemia
Inv: endoscopy, manometry
Medical mx: CCB oral nifedipine, botulinum toxin inj
Surgical Mx: endoscopic dilatation, Hellers cardiomyotomy with partial fundoplication
12.
13. Irregular/ incoordinated contractions – high intraesophageal pressure (400-500 mm
Hg)
Marked hypertrophy of circular muscles
Presentation: Dysphagia, chest pain
Cork screw esophagus
Treatment: esophageal dilatation, long esophageal myotomy
62. Based on cells of origin:
Ductal – epth cells lining the ducts
Lobular-- cells lining lobules/acini
Pathological types:
Carcinoma in situ– upto basement memb
Infiltrating– basement memb breached; invade connective tissue
Scirrhous– small unencapsulated tumor with diminished vascularity; cuts with gritty sensation
Medullary– young women; tumor bulky but softer
Colloidal– bulky, soft tumor; microscopically cells abundant in mucin; signet cells
Inflammatory– highly aggressive, poor prognosis, breast swollen, warm, painful with rich
vascularity
Pagets disease of nipple– eczema over NAC– eventual destruction, large ovoid pagets cells
with abundant cytoplasm
63. Skin changes:
Peau d’ Orange: orange peel appearance–
subdermal lymphatics– skin tense, thickened and
edematous
Tethering: coopers ligament, skin dimples on
pushing the lump
Skin nodules: direct invasion of the skin
Cancer en cuirasse: advanced stage; skin
become fixed and indurated, satellite nodules,
involves whole of breast
64. Risk factors:
Age
Sex
SES
Diet
Addiction
Early menarche, late menopause, late first pregnancy
HRT/OCP
Prior radiation
Family history
Genetic
Prior breast CA
65. Modes of spread:
Direct: adjacent quadrant; chest wall; pectoral muscles; serratus anterior; overlying
skin
Lymphatic: permeation and embolization; axillary and internal mammary nodes; supra
and infraclavicular nodes, opposite breast and axilla; peritoneum and ovaries
Hematogenous: bones (lumbar vertebra, femur, thoracic vertebra, ribs, skull); liver;
lungs; brain; adrenal; ovaries