Anthelmintic drugs acting in Sichistosomiasis

1. ANTHELMINTIC DRUGS

2. Anthelmintic drugs for schistosomiasis
• Praziquantel

3. Praziquantel
• INDICATIONS AND DOSE
• Tapeworm infections (Taenia solium)
• ▶ BY MOUTH
• ▶ Adult: 5–10 mg/kg for 1 dose, to be taken after a light
• breakfast
• Tapeworm infections (Hymenolepis nana)
• ▶ BY MOUTH
• ▶ Adult: 25 mg/kg for 1 dose, to be taken after a light
• breakfast

4. • Schistosoma haematobium worm infections | Schistosoma
• mansoni worm infections
• ▶ BY MOUTH
• ▶ Adult: 20 mg/kg, followed by 20 mg/kg after 4–6 hours
• Schistosoma japonicum worm infections
• ▶ BY MOUTH
• ▶ Adult: 20 mg/kg 3 times a day for 1 day

5. • MODE OF ACTION
• Praziquantel works by causing severe spasms and paralysis of the
worms' muscles. This paralysis is accompanied - and probably caused
- by a rapid Ca 2+ influx inside the schistosome. Morphological
alterations are another early effect of praziquantel.

6. • Side Effects
• Black, tarry stools.
• blistering, peeling, or loosening of the skin.
• bloody diarrhea.
• blurred or loss of vision.
• chest pain or discomfort.
• difficulty swallowing.
• difficulty with moving.
• disturbed color perception.

7. • Contraindications
• Patients who have previously shown hypersensitivity to the drug.
Since parasite destruction within the eye may cause irreparable
lesions, ocular cysticercosis should not be treated with praziquantel.

8. Anthelmintics used in neurocysticercosis
• Praziquantel and Albendazole

9. Albendazole
• INDICATIONS AND DOSE
• Chronic Strongyloides infection
• ▶ BY MOUTH
• ▶ Adult: 400 mg twice daily for 3 days, dose may be
• repeated after 3 weeks if necessary
• Hydatid disease, in conjunction with surgery to reduce the
• risk of recurrence or as primary treatment in inoperable
• cases

10. • ▶ BY MOUTH
• ▶ Adult: (consult product literature)
• Hookworm infections
• ▶ BY MOUTH
• ▶ Adult: 400 mg for 1 dose

11. • Mode of Action
• The principal mode of action for albendazole is by its inhibitory effect
on tubulin polymerization which results in the loss of cytoplasmic
microtubules in the intestines of nematodes worms, ultimately
causing energy depletion and death of the organism.

12. • Side effects
• sore throat, fever, chills, and other signs of infection.
• unusual bleeding or bruising.
• weakness.
• fatigue.
• pale skin.
• shortness of breath.
• rash.
• hives.

13. • Contraindications
• Albendazole is contraindicated in any person with known
hypersensitivity to albendazole, the benzimidazole class of
compounds, or any product components. Use albendazole with
caution in patients with hepatic disease or biliary tract disease.

14. OTHERS INCLUDE
• Diethylcarbamazine
• Ivermectin
• Mebendazole
• Levamisole
•